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Mesenchymal stem cells induce tumor stroma formation and epithelial-mesenchymal transition through SPARC expression in colorectal cancer

内藤 聡雄 広島大学

2021.05.27

概要

Colorectal cancer (CRC) is the third most common type of
cancer worldwide, and the fourth leading cause of cancer‑asso‑
ciated mortality (1). Between 1 and 2 million new CRC
cases were diagnosed annually between 2012 and 2016, and
>700,000 individuals with CRC died each year between 2012
and 2016 (2). Despite improved diagnostic and therapeutic
methods, the prognosis of CRC remains poor, primarily due to
local recurrence and distant metastasis (3). Therefore, a more
detailed understanding of the factors involved in the develop‑
ment and progression of CRC is required to identify novel
biomarkers and to develop novel anticancer strategies.
Tumors are not solely composed of cancer cells but also
contain a tumor stroma comprising cellular components, such
as fibroblasts, smooth muscle cells, vascular cells (vascular
endothelial cells and pericytes), inflammatory cells, and
an extracellular matrix (ECM) containing cytokines and
cellular growth factors (4). ...

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