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大学・研究所にある論文を検索できる 「Clinical Characteristics and Surgical Outcomes of Metastatic Spine Tumors in the Very Elderly: A Prospective Cohort Study in a Super-Aged Society」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

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Clinical Characteristics and Surgical Outcomes of Metastatic Spine Tumors in the Very Elderly: A Prospective Cohort Study in a Super-Aged Society

Kanda, Yutaro Kakutani, Kenichiro Sakai, Yoshitada Miyazaki, Kunihiko Matsuo, Tomoya Yurube, Takashi Takeoka, Yoshiki Ohnishi, Hiroki Ryu, Masao Kumagai, Naotoshi Kuroshima, Kohei Hiranaka, Yoshiaki Kawamoto, Teruya Hara, Hitomi Hoshino, Yuichi Hayashi, Shinya Akisue, Toshihiro Kuroda, Ryosuke 神戸大学

2023.07

概要

The number of advanced-age patients with spinal metastases is rising. This study was performed to clarify the characteristics and surgical outcomes of spinal metastases in advanced-age patients. We prospectively analyzed 216 patients with spinal metastases from 2015 to 2020 and divided them into three age groups: <70 years (n = 119), 70–79 years (n = 73), and ≥80 years (n = 24). Although there were no significant intergroup differences in preoperative characteristics and surgery-related factors except for age, patients aged ≥80 years tended to have a worse performance status (PS), Barthel index, and EuroQol-5 dimension (EQ-5D) before and after surgery than the other two groups. Although the median PS, mean Barthel index and mean EQ-5D greatly improved postoperatively in each group, the median PS and mean Barthel index at 6 months and the mean EQ-5D at 1 month postoperatively were significantly poorer in the ≥80-year group than the 70–79-year group. The rates of postoperative complications and re-deterioration of the EQ-5D were significantly higher in the oldest group than in the other two groups. Although surgery for spinal metastases improved the PS, Barthel index, and EQ-5D regardless of age, clinicians should be aware of the poorer outcomes and higher complication rates in advanced-age patients.

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参考文献

1.

2.

3.

4.

5.

6.

7.

8.

Harel, R.; Angelov, L. Spine metastases: Current treatments and future directions. Eur. J. Cancer 2010, 46, 2696–2707. [CrossRef]

Klimo, P., Jr.; Schmidt, M.H. Surgical management of spinal metastases. Oncologist 2004, 9, 188–196. [CrossRef] [PubMed]

Kakutani, K.; Sakai, Y.; Maeno, K.; Takada, T.; Yurube, T.; Kurakawa, T.; Miyazaki, S.; Terashima, Y.; Ito, M.; Hara, H.; et al.

Prospective Cohort Study of Performance Status and Activities of Daily Living After Surgery for Spinal Metastasis. Clin. Spine

Surg. 2017, 30, E1026–E1032. [CrossRef] [PubMed]

Kanda, Y.; Kakutani, K.; Sakai, Y.; Yurube, T.; Miyazaki, S.; Takada, T.; Hoshino, Y.; Kuroda, R. Prospective cohort study of surgical

outcome for spinal metastases in patients aged 70 years or older. Bone Jt. J. 2020, 102, 1709–1716. [CrossRef] [PubMed]

Kanda, Y.; Kakutani, K.; Sakai, Y.; Zhang, Z.; Yurube, T.; Miyazaki, S.; Kakiuchi, Y.; Takeoka, Y.; Tsujimoto, R.; Miyazaki, K.; et al.

Surgical outcomes and risk factors for poor outcomes in patients with cervical spine metastasis: A prospective study. J. Orthop.

Surg. Res. 2021, 16, 423. [CrossRef]

Ma, Y.; He, S.; Liu, T.; Yang, X.; Zhao, J.; Yu, H.; Feng, J.; Xu, W.; Xiao, J. Quality of Life of Patients with Spinal Metastasis from

Cancer of Unknown Primary Origin: A Longitudinal Study of Surgical Management Combined with Postoperative Radiation

Therapy. J. Bone Jt. Surg. Am. 2017, 99, 1629–1639. [CrossRef]

Miyazaki, S.; Kakutani, K.; Sakai, Y.; Ejima, Y.; Maeno, K.; Takada, T.; Yurube, T.; Terashima, Y.; Ito, M.; Kakiuchi, Y.; et al. Quality

of life and cost-utility of surgical treatment for patients with spinal metastases: Prospective cohort study. Int. Orthop. 2017, 41,

1265–1271. [CrossRef]

Kakutani, K.; Sakai, Y.; Zhang, Z.; Yurube, T.; Takeoka, Y.; Kanda, Y.; Miyazaki, K.; Ohnishi, H.; Matsuo, T.; Ryu, M.; et al. Survival

Rate after Palliative Surgery Alone for Symptomatic Spinal Metastases: A Prospective Cohort Study. J. Clin. Med. 2022, 11, 6227.

[CrossRef] [PubMed]

J. Clin. Med. 2023, 12, 4747

9.

10.

11.

12.

13.

14.

15.

16.

17.

18.

19.

20.

21.

22.

23.

24.

25.

26.

27.

28.

29.

30.

31.

12 of 13

Patchell, R.A.; Tibbs, P.A.; Regine, W.F.; Payne, R.; Saris, S.; Kryscio, R.J.; Mohiuddin, M.; Young, B. Direct decompressive surgical

resection in the treatment of spinal cord compression caused by metastatic cancer: A randomised trial. Lancet 2005, 366, 643–648.

[CrossRef] [PubMed]

Schoenfeld, A.J.; Losina, E.; Ferrone, M.L.; Schwab, J.H.; Chi, J.H.; Blucher, J.A.; Silva, G.S.; Chen, A.T.; Harris, M.B.;

Kang, J.D.; et al. Ambulatory status after surgical and nonsurgical treatment for spinal metastasis. Cancer 2019, 125, 2631–2637.

Rades, D.; Huttenlocher, S.; Dunst, J.; Bajrovic, A.; Karstens, J.H.; Rudat, V.; Schild, S.E. Matched pair analysis comparing surgery

followed by radiotherapy and radiotherapy alone for metastatic spinal cord compression. J. Clin. Oncol. 2010, 28, 3597–3604.

[CrossRef] [PubMed]

Rades, D.; Küchler, J.; Graumüller, L.; Abusamha, A.; Schild, S.E.; Gliemroth, J. Radiotherapy with or without Decompressive

Surgery for Metastatic Spinal Cord Compression: A Retrospective Matched-Pair Study Including Data from Prospectively

Evaluated Patients. Cancers 2022, 14, 1260. [CrossRef]

Carreon, L.Y.; Puno, R.M.; Dimar, J.R., 2nd; Glassman, S.D.; Johnson, J.R. Perioperative complications of posterior lumbar

decompression and arthrodesis in older adults. J. Bone Jt. Surg. Am. 2003, 85, 2089–2092. [CrossRef] [PubMed]

Kobayashi, K.; Imagama, S.; Ando, K.; Ishiguro, N.; Yamashita, M.; Eguchi, Y.; Matsumoto, M.; Ishii, K.; Hikata, T.; Seki, S.; et al.

Complications Associated with Spine Surgery in Patients Aged 80 Years or Older: Japan Association of Spine Surgeons with

Ambition (JASA) Multicenter Study. Global Spine J. 2017, 7, 636–641. [CrossRef] [PubMed]

Yagi, M.; Fujita, N.; Okada, E.; Tsuji, O.; Nagoshi, N.; Asazuma, T.; Nakamura, M.; Matsumoto, M.; Watanabe, K. Clinical

Outcomes, Complications, and Cost-effectiveness in Surgically Treated Adult Spinal Deformity Over 70 Years: A Propensity

score-Matched Analysis. Clin. Spine Surg. 2020, 33, E14–E20. [CrossRef] [PubMed]

Fisher, C.G.; DiPaola, C.P.; Ryken, T.C.; Bilsky, M.H.; Shaffrey, C.I.; Berven, S.H.; Harrop, J.S.; Fehlings, M.G.; Boriani, S.;

Chou, D.; et al. A novel classification system for spinal instability in neoplastic disease: An evidence-based approach and expert

consensus from the Spine Oncology Study Group. Spine 2010, 35, E1221–E1229. [CrossRef]

Quraishi, N.A.; Ramoutar, D.; Sureshkumar, D.; Manoharan, S.R.; Spencer, A.; Arealis, G.; Edwards, K.L.; Boszczyk, B.M.

Metastatic spinal cord compression as a result of the unknown primary tumour. Eur. Spine J. 2014, 23, 1502–1507. [CrossRef]

[PubMed]

Katagiri, H.; Okada, R.; Takagi, T.; Takahashi, M.; Murata, H.; Harada, H.; Nishimura, T.; Asakura, H.; Ogawa, H. New prognostic

factors and scoring system for patients with skeletal metastasis. Cancer Med. 2014, 3, 1359–1367. [CrossRef] [PubMed]

Tokuhashi, Y.; Matsuzaki, H.; Oda, H.; Oshima, M.; Ryu, J. A revised scoring system for preoperative evaluation of metastatic

spine tumor prognosis. Spine 2005, 30, 2186–2191. [CrossRef]

Dindo, D.; Demartines, N.; Clavien, P.A. Classification of surgical complications: A new proposal with evaluation in a cohort of

6336 patients and results of a survey. Ann. Surg. 2004, 240, 205–213. [CrossRef] [PubMed]

Oken, M.M.; Creech, R.H.; Tormey, D.C.; Horton, J.; Davis, T.E.; McFadden, E.T.; Carbone, P.P. Toxicity and response criteria of

the Eastern Cooperative Oncology Group. Am. J. Clin. Oncol. 1982, 5, 649–655. [CrossRef]

Mahoney, F.I.; Barthel, D.W. Functional evaluation: The barthel index. Md. State Med. J. 1965, 14, 61–65. [PubMed]

EuroQol—A new facility for the measurement of health-related quality of life. Health Policy 1990, 16, 199–208. [CrossRef]

Frankel, H.L.; Hancock, D.O.; Hyslop, G.; Melzak, J.; Michaelis, L.S.; Ungar, G.H.; Vernon, J.D.; Walsh, J.J. The value of postural

reduction in the initial management of closed injuries of the spine with paraplegia and tetraplegia. I. Paraplegia 1969, 7, 179–192.

[CrossRef] [PubMed]

Liang, T.; Wan, Y.; Zou, X.; Peng, X.; Liu, S. Is surgery for spine metastasis reasonable in patients older than 60 years? Clin. Orthop.

Relat. Res. 2013, 471, 628–639. [CrossRef] [PubMed]

Nanjo, Y.; Nagashima, H.; Dokai, T.; Hamamoto, Y.; Hashiguchi, H.; Ishii, H.; Kameyama, Y.; Morio, Y.; Murata, M.;

Tanida, A.; et al. Clinical features and surgical outcomes of lumbar spinal stenosis in patients aged 80 years or older: A

multi-center retrospective study. Arch. Orthop. Trauma Surg. 2013, 133, 1243–1248. [CrossRef]

Rihn, J.A.; Hilibrand, A.S.; Zhao, W.; Lurie, J.D.; Vaccaro, A.R.; Albert, T.J.; Weinstein, J. Effectiveness of surgery for lumbar

stenosis and degenerative spondylolisthesis in the octogenarian population: Analysis of the Spine Patient Outcomes Research

Trial (SPORT) data. J. Bone Jt. Surg. Am. 2015, 97, 177–185. [CrossRef]

Isogai, N.; Nagoshi, N.; Iwanami, A.; Kono, H.; Kobayashi, Y.; Tsuji, T.; Fujita, N.; Yagi, M.; Watanabe, K.; Kitamura, K.; et al.

Surgical Treatment of Cervical Spondylotic Myelopathy in the Elderly: Outcomes in Patients Aged 80 Years or Older. Spine 2018,

43, E1430–E1436. [CrossRef] [PubMed]

Lau, D.; Leach, M.R.; Than, K.D.; Ziewacz, J.; La Marca, F.; Park, P. Independent predictors of complication following surgery for

spinal metastasis. Eur. Spine J. 2013, 22, 1402–1407. [CrossRef]

Luksanapruksa, P.; Buchowski, J.M.; Zebala, L.P.; Kepler, C.K.; Singhatanadgige, W.; Bumpass, D.B. Perioperative Complications

of Spinal Metastases Surgery. Clin. Spine Surg. 2017, 30, 4–13. [CrossRef]

Paulino Pereira, N.R.; Ogink, P.T.; Groot, O.Q.; Ferrone, M.L.; Hornicek, F.J.; van Dijk, C.N.; Bramer, J.A.M.; Schwab, J.H.

Complications and reoperations after surgery for 647 patients with spine metastatic disease. Spine J. 2019, 19, 144–156. [CrossRef]

[PubMed]

J. Clin. Med. 2023, 12, 4747

32.

33.

13 of 13

Amelot, A.; Balabaud, L.; Choi, D.; Fox, Z.; Crockard, H.A.; Albert, T.; Arts, C.M.; Buchowski, J.M.; Bunger, C.; Chung, C.K.; et al.

Surgery for metastatic spine tumors in the elderly. Advanced age is not a contraindication to surgery! Spine J. 2017, 17, 759–767.

[CrossRef] [PubMed]

Kato, S.; Takaki, Y.; Yamakawa, K.; Goto, T.; Kondo, T. Optimal schedule of preoperative embolization for spinal metastasis

surgery. Spine 2013, 38, 1964–1969. [CrossRef] [PubMed]

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