1. Rodriguez-Galindo C. Clinical features and treatment of Langerhans
cell histiocytosis. Acta Paediatr. 2021;110(11):2892-2902.
2. McClain KL, Bigenwald C, Collin M, et al. Histiocytic disorders. Nat
Rev Dis Primers. 2021;7(1):73.
3. Allen CE, Li L, Peters TL, et al. Cell-specific gene expression in
Langerhans cell histiocytosis lesions reveals a distinct profile compared with epidermal Langerhans cells. J Immunol. 2010;184(8):
4557-4567.
4. Baumgartner I, von Hochstetter A, Baumert B, Luetolf U, Follath
F. Langerhans'-cell histiocytosis in adults. Med Pediatr Oncol.
1997;28(1):9-14.
5. Goyal G, Shah MV, Hook CC, et al. Adult disseminated Langerhans
cell histiocytosis: incidence, racial disparities and long-term outcomes. Br J Haematol. 2018;182(4):579-581.
6. Badalian-Very G, Vergilio JA, Degar BA, et al. Recurrent
BRAF mutations in Langerhans cell histiocytosis. Blood.
2010;116(11):1919-1923.
7. Berres ML, Lim KP, Peters T, et al. BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct
LCH risk groups. J Exp Med. 2014;211(4):669-683.
8. Rigaud C, Barkaoui MA, Thomas C, et al. Langerhans cell histiocytosis: therapeutic strategy and outcome in a 30-year nationwide
20. 21. 22. 23. 24. 25. 26. 27. cohort of 1478 patients under 18 years of age. Br J Haematol.
2016;174(6):887-898.
Heritier S, Emile JF, Barkaoui MA, et al. BRAF mutation correlates
with high-risk Langerhans cell histiocytosis and increased resistance to first-line therapy. J Clin Oncol. 2016;34(25):3023-3 030.
Ozer E, Sevinc A, Ince D, Yuzuguldu R, Olgun N. BRAF V600E
mutation: a significant biomarker for prediction of disease relapse in pediatric Langerhans cell histiocytosis. Pediatr Dev Pathol.
2019;22(5):449-455.
Veillette A, Thibaudeau E, Latour S. High expression of inhibitory receptor SHPS-1 and its association with protein-
tyrosine phosphatase SHP-1 in macrophages. J Biol Chem.
1998;273(35):22719-2 2728.
Adams S, van der Laan LJ, Vernon-Wilson E, et al. Signal-regulatory
protein is selectively expressed by myeloid and neuronal cells. J
Immunol. 1998;161(4):1853-1859.
Seiffert M, Cant C, Chen Z, et al. Human signal-regulatory protein is
expressed on normal, but not on subsets of leukemic myeloid cells
and mediates cellular adhesion involving its counterreceptor CD47.
Blood. 1999;94(11):3633-3643.
Jiang P, Lagenaur CF, Narayanan V. Integrin-associated protein
is a ligand for the P84 neural adhesion molecule. J Biol Chem.
1999;274(2):559-562.
Han X, Sterling H, Chen Y, et al. CD47, a ligand for the macrophage
fusion receptor, participates in macrophage multinucleation. J Biol
Chem. 2000;275(48):37984-37992.
Vernon-Wilson EF, Kee WJ, Willis AC, Barclay AN, Simmons DL,
Brown MH. CD47 is a ligand for rat macrophage membrane signal
regulatory protein SIRP (OX41) and human SIRPα 1. Eur J Immunol.
2000;30(8):2130-2137.
Matozaki T, Murata Y, Okazawa H, Ohnishi H. Functions and molecular mechanisms of the CD47-SIRPα signalling pathway. Trends Cell
Biol. 2009;19(2):72-8 0.
Barclay AN, Van den Berg TK. The interaction between signal regulatory protein alpha (SIRPα) and CD47: structure, function, and
therapeutic target. Annu Rev Immunol. 2014;32:25-50.
Reinhold MI, Lindberg FP, Plas D, Reynolds S, Peters MG, Brown
EJ. In vivo expression of alternatively spliced forms of integrin-
associated protein (CD47). J Cell Sci. 1995;108(Pt11):3419-3 425.
Brown EJ, Frazier WA. Integrin-associated protein (CD47) and its
ligands. Trends Cell Biol. 2001;11(3):130-135.
Jaiswal S, Jamieson CH, Pang WW, et al. CD47 is upregulated on
circulating hematopoietic stem cells and leukemia cells to avoid
phagocytosis. Cell. 2009;138(2):271-285.
Majeti R, Chao MP, Alizadeh AA, et al. CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid
leukemia stem cells. Cell. 2009;138(2):286-299.
Willingham SB, Volkmer JP, Gentles AJ, et al. The CD47-
signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proc Natl Acad Sci USA.
2012;109(17):6662-6667.
Zhao XW, van Beek EM, Schornagel K, et al. CD47-signal regulatory protein-α (SIRPα) interactions form a barrier for antibody-
mediated tumor cell destruction. Proc Natl Acad Sci U S A.
2011;108(45):18342-18347.
Murata Y, Saito Y, Kotani T, Matozaki T. CD47-signal regulatory protein α signaling system and its application to cancer immunotherapy. Cancer Sci. 2018;109(8):2349-2357.
Chao MP, Alizadeh AA, Tang C, et al. Anti-CD47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-
Hodgkin lymphoma. Cell. 2010;142(5):699-713.
Yanagita T, Murata Y, Tanaka D, et al. Anti-SIRPα antibodies
as a potential new tool for cancer immunotherapy. JCI Insight.
2017;2(1):e89140.
13497006, 2023, 5, Downloaded from https://onlinelibrary.wiley.com/doi/10.1111/cas.15758 by Kobe University, Wiley Online Library on [08/05/2023]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License
1880 28. Ring NG, Herndler-Brandstetter D, Weiskopf K, et al. Anti-SIRPα
antibody immunotherapy enhances neutrophil and macrophage
antitumor activity. Proc Natl Acad Sci USA. 2017;114(49):E10578
-E10585.
29. Matlung HL, Szilagyi K, Barclay NA, van den Berg TK. The CD47-
SIRPα signaling axis as an innate immune checkpoint in cancer.
Immunol Rev. 2017;276(1):145-164.
3 0. Fukunaga A, Nagai H, Noguchi T, et al. Src homology 2 domain-
containing protein tyrosine phosphatase substrate 1 regulates the
migration of Langerhans cells from the epidermis to draining lymph
nodes. J Immunol. 2004;172(7):4091-4 099.
31. Okajo J, Kaneko Y, Murata Y, et al. Regulation by Src homology 2
domain-containing protein tyrosine phosphatase substrate-1 of α-
galactosylceramide-induced antimetastatic activity and Th1 and
Th2 responses of NKT cells. J Immunol. 2007;178(10):6164-6172.
32. Gruijs M, Sewnath CAN, van Egmond M. Therapeutic exploitation
of neutrophils to fight cancer. Semin Immunol. 2021;57:101581.
33. Hogstad B, Berres ML, Chakraborty R, et al. RAF/MEK/extracellular signal-related kinase pathway suppresses dendritic cell migration and traps dendritic cells in Langerhans cell histiocytosis
lesions. J Exp Med. 2018;215(1):319-336.
34. Saito Y, Respatika D, Komori S, et al. SIRPα+ dendritic cells regulate homeostasis of fibroblastic reticular cells via TNF receptor ligands in the
adult spleen. Proc Natl Acad Sci USA. 2017;114(47):E10151-E10160.
35. Laman JD, Leenen PJ, Annels NE, Hogendoorn PC, Egeler RM.
Langerhans-cell histiocytosis ‘insight into DC biology’. Trends
Immunol. 2003;24(4):190-196.
36. Morimoto A, Oh Y, Shioda Y, Kudo K, Imamura T. Recent advances
in Langerhans cell histiocytosis. Pediatr Int. 2014;56(4):451-461.
37. Allen CE, Beverley PCL, Collin M, et al. The coming of age of
Langerhans cell histiocytosis. Nat Immunol. 2020;21(1):1-7.
38. Annels NE, Da Costa CE, Prins FA, Willemze A, Hogendoorn PC,
Egeler RM. Aberrant chemokine receptor expression and chemokine production by Langerhans cells underlies the pathogenesis of
Langerhans cell histiocytosis. J Exp Med. 2003;197(10):1385-1390.
39. Quispel WT, Stegehuis-Kamp JA, Blijleven L, et al. The presence
of CXCR4 + CD1a+ cells at onset of Langerhans cell histiocytosis
is associated with a less favorable outcome. Onco Targets Ther.
2016;5(3):e1084463.
4 0. Griffith JW, Sokol CL, Luster AD. Chemokines and chemokine receptors: positioning cells for host defense and immunity. Annu Rev
Immunol. 2014;32:659-702.
41. Eckstein OS, Visser J, Rodriguez-Galindo C, Allen CE, Group N-
LS. Clinical responses and persistent BRAF V600E+ blood cells in
children with LCH treated with MAPK pathway inhibition. Blood.
2019;133(15):1691-1694.
42. Donadieu J, Larabi IA, Tardieu M, et al. Vemurafenib for refractory
multisystem Langerhans cell histiocytosis in children: an international observational study. J Clin Oncol. 2019;37(31):2857-2865.
43. Xu MM, Pu Y, Han D, et al. Dendritic cells but not macrophages
sense tumor mtochondrial DNA for cross-priming through signal
regulatory protein α signaling. Immunity. 2017;47(2):363-373 e365.
4 4. Schall TJ, Bacon K, Toy KJ, Goeddel DV. Selective attraction of
monocytes and T lymphocytes of the memory phenotype by cytokine RANTES. Nature. 1990;347(6294):669-671.
45. Bleul CC, Fuhlbrigge RC, Casasnovas JM, Aiuti A, Springer TA.
A highly efficacious lymphocyte chemoattractant, stromal cell-
derived factor 1 (SDF-1). J Exp Med. 1996;184(3):1101-1109.
46. Cole KE, Strick CA, Paradis TJ, et al. Interferon-inducible T cell
alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine
with potent activity on activated T cells through selective high affinity binding to CXCR3. J Exp Med. 1998;187(12):2009-2021.
47. Liao F, Rabin RL, Smith CS, Sharma G, Nutman TB, Farber JM. CC-
chemokine receptor 6 is expressed on diverse memory subsets of T
cells and determines responsiveness to macrophage inflammatory
protein 3α. J Immunol. 1999;162(1):186-194.
4 8. van Rees DJ, Brinkhaus M, Klein B, et al. Sodium stibogluconate
and CD47-SIRPα blockade overcome resistance of anti-CD20-
opsonized B cells to neutrophil killing. Blood Adv. 2022;6(7):
2156-2166.
49. Gauttier V, Pengam S, Durand J, et al. Selective SIRPα blockade reverses tumor T cell exclusion and overcomes cancer immunotherapy resistance. J Clin Invest. 2020;130(11):6109-6123.
50. Sakamoto M, Murata Y, Tanaka D, et al. Anticancer efficacy of
monotherapy with antibodies to SIRPα/SIRPβ1 mediated by induction of antitumorigenic macrophages. Proc Natl Acad Sci USA.
2022;119(1):e2109923118.
51. Hayashi A, Ohnishi H, Okazawa H, et al. Positive regulation of
phagocytosis by SIRPβ and its signaling mechanism in macrophages.
J Biol Chem. 2004;279(28):29450-29460.
S U P P O R T I N G I N FO R M AT I O N
Additional supporting information can be found online in the
Supporting Information section at the end of this article.
How to cite this article: Okamoto T, Murata Y, Hasegawa D,
et al. Targeting of SIRPα as a potential therapy for
Langerhans cell histiocytosis. Cancer Sci. 2023;114:18711881. doi:10.1111/cas.15758
13497006, 2023, 5, Downloaded from https://onlinelibrary.wiley.com/doi/10.1111/cas.15758 by Kobe University, Wiley Online Library on [08/05/2023]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License
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