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Association of Red Meat Intake with the Risk of Cardiovascular Mortality in General Japanese Stratified by Kidney Function: NIPPON DATA80.

SEGAWA Hiroyoshi 0000-0001-9631-9769 KONDO Keiko 20566567 KADOTA Aya 60546068 0000-0001-7378-0544 YAMAUCHI Hiromi OHNO Seiko 20610025 0000-0003-1209-8896 TANAKA-MIZUNO Sachiko 50453824 OKUDA Nagako 80452233 0000-0002-6893-0509 MIYAGAWA Naoko 20388169 0000-0002-9148-1078 ARIMA Hisatomi 20437784 0000-0002-2064-2014 OKAMURA Tomonori 00324567 MIURA Katsuyuki 90257452 0000-0002-2646-9582 OKAYAMA Akira 60169159 UESHIMA Hirotsugu 70144483 0000-0002-7742-4253 NIPPON DATA80 Research Group 滋賀医科大学

2020.11.30

概要

The consumption of red meat has been recommended for individuals with reduced kidney function. However, red meat intake was recently suspected to increase cardiovascular disease (CVD) risk. We evaluated the association of red meat intake with CVD mortality risk in Japanese with/without reduced kidney function. Overall, 9112 participants of a Japanese national survey in 1980, aged ≥30 years, were followed for 29 years. Red meat intake was assessed using weighed dietary record. Cox proportional hazards models were used to estimate the hazard ratio (HR) of CVD mortality according to sex-specific tertiles of red meat intake. We also performed stratified analyses with/without reduced kidney function defined as estimated glomerular filtration rate less than 60 mL/min/1.73 m2. Red meat intake was not associated with CVD mortality risk in men and women. In stratified analyses, the HR of the highest compared with the lowest tertile of red meat intake was lower only in women with reduced kidney function (0.67, 95% confidence interval 0.46-0.98). In conclusion, there were no clear associations between red meat intake and CVD mortality risk in Japanese population; however, a higher intake of red meat was associated with lower risk of future CVD mortality in women with reduced kidney function.

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