1 American Diabeties Association. 2. Classification and diagnosis of diabetes: Standards of Medical Care in
Diabetes-2018. Diabetes care. 2018;41(Suppl 1):S13-S27. doi:10.2337/dc18-S002.
2 World Health Organization. Definition and diagnosis of diabetes mellitus and intermediate hyperglycaemia:
report of a WHO/IDF consultation. https://apps.who.int/iris/handle/10665/43588. Accessed April 21, 2006.
3 Patterson CC, Karuranga S, Salpea P, et al. Worldwide estimates of incidence, prevalence and mortality of
type 1 diabetes in children and adolescents: Results from the International Diabetes Federation Diabetes
Atlas, 9th edition. Diabetes Res Clin Pract. 2019;157:107842. doi:10.1016/j.diabres.2019.107842.
4 Standl E, Khunti K, Hansen TB, Schnell O. The global epidemics of diabetes in the 21st century: Current
situation and perspectives. Eur J Prev Cardiol. 2019;26(2_suppl):7–14. doi:10.1177/2047487319881021.
5 Patel S, Srivastava S, Singh MR, Singh D. Mechanistic insight into diabetic wounds: Pathogenesis,
molecular targets and treatment strategies to pace wound healing. Biomed Pharmacother. 2019;112:108615.
doi:10.1016/j.biopha.2019.108615.
6 Bilgiç T, İnce Ü, Narter F. Autologous omentum transposition for regeneration of a renal injury model in
rats. Mil Med Res. 2022;9(1):1. doi:10.1186/s40779-021-00361-0.
7 Krist LF, Eestermans IL, Steenbergen JJ, et al. Cellular composition of milky spots in the human greater
omentum: an immunochemical and ultrastructural study. Anat Rec. 1995;241(2):163–174. doi:10.1002/
ar.1092410204.
8 Zhang QX, Magovern CJ, Mack CA, Budenbender KT, Ko W, Rosengart TK. Vascular endothelial growth
factor is the major angiogenic factor in omentum: mechanism of the omentum-mediated angiogenesis. J
Surg Res. 1997;67(2):147–154. doi:10.1006/jsre.1996.4983.
9 Goldsmith HS, Brandt M, Waltz T. Near total transaction of human spinal cord: a functional return following
omentum-collagen reconstruction. In: Goldsmith HS, ed. The omentum: application to brain and spinal
Nagoya J. Med. Sci. 85. 528–541, 2023
539
doi:10.18999/nagjms.85.3.528
Yu Li et al
cord. Wilton: Forefront Publishing; 2000:76–92.
10 Goldsmith HS. The evolution of omentum transposition: from lymphedema to spinal cord, stroke and
Alzheimer’s disease. Neurol Res. 2004;26(5):586–593. doi:10.1179/016164104225017622.
11 Goldsmith HS, de la Torre JC. Axonal regeneration after spinal cord transection and reconstruction. Brain
Res. 1992;589(2):217–224. doi:10.1016/0006-8993(92)91280-R.
12 Castañeda F, Kinne RK. Omental graft improves functional recovery of transected peripheral nerve. Muscle
Nerve. 2002;26(4):527–532. doi:10.1002/mus.10229.
13 Mohammadi R, Azizi S, Delirezh N, Hobbenaghi R, Amini K. Transplantation of uncultured omental
adipose-derived stromal vascular fraction improves sciatic nerve regeneration and functional recovery
through inside-out vein graft in rats. J Trauma Acute Care Surg. 2012;72(2):390–396. doi:10.1097/
TA.0b013e31821181dd.
14 Zhang YG, Huang JH, Hu XY, Sheng QS, Zhao W, Luo ZJ. Omentum-wrapped scaffold with longitudinally
oriented micro-channels promotes axonal regeneration and motor functional recovery in rats. PLoS One.
2011;6(12):e29184. doi:10.1371/journal.pone.0029184.
15 García-Gómez I, Goldsmith HS, Angulo J, et al. Angiogenic capacity of human omental stem cells. Neurol
Res. 2005;27(8):807–811. doi:10.1179/016164105X63674.
16 Litbarg NO, Gudehithlu KP, Sethupathi P, Arruda JA, Dunea G, Singh AK. Activated omentum becomes rich
in factors that promote healing and tissue regeneration. Cell Tissue Res. 2007;328(3):487–497. doi:10.1007/
s00441-006-0356-4.
17 Singh AK, Patel J, Litbarg NO, et al. Stromal cells cultured from omentum express pluripotent markers, produce high amounts of VEGF, and engraft to injured sites. Cell Tissue Res. 2008;332(1):81–88.
doi:10.1007/s00441-007-0560-x.
18 Jones CG, Daniel Hare J, Compton SJ. Measuring plant protein with the Bradford assay: 1. Evaluation
and standard method. J Chem Ecol. 1989;15(3):979–992. doi:10.1007/BF01015193.
19 Chen L, Mirza R, Kwon Y, DiPietro LA, Koh TJ. The murine excisional wound model: Contraction revisited.
Wound Repair Regen. 2015;23(6):874–877. doi:10.1111/wrr.12338.
20 Yang YW, Zhang CN, Cao YJ, et al. Bidirectional regulation of i-type lysozyme on cutaneous wound
healing. Biomed Pharmacother. 2020;131:110700. doi:10.1016/j.biopha.2020.110700.
21 Kobayashi H, Ebisawa K, Kambe M, et al. Effects of exosomes derived from the induced pluripotent stem
cells on skin wound healing. Nagoya J Med Sci. 2018;80(2):141–153. doi:10.18999/nagjms.80.2.141.
22 Stump A, Bedri M, Goldberg NH, Slezak S, Silverman RP. Omental transposition flap for sternal wound
reconstruction in diabetic patients. Ann Plast Surg. 2010;65(2):206–210. doi:10.1097/SAP.0b013e3181c9c31a.
23 Mazzaferro D, Song P, Massand S, Mirmanesh M, Jaiswal R, Pu LLQ. The Omental Free Flap—A Review
of Usage and Physiology. J Reconstr Microsurg. 2018;34(3):151–169. doi:10.1055/s-0037-1608008.
24 De Siena R, Balducci L, Blasi A, et al. Omentum-derived stromal cells improve myocardial regeneration
in pig post-infarcted heart through a potent paracrine mechanism. Exp Cell Res. 2010;316(11):1804–1815.
doi:10.1016/j.yexcr.2010.02.009.
25 Bahamondes F, Flores E, Cattaneo G, Bruna F, Conget P. Omental adipose tissue is a more suitable source
of canine Mesenchymal stem cells. BMC Vet Res. 2017;13(1):166. doi:10.1186/s12917-017-1053-0.
26 Singh AK, Pancholi N, Patel J, et al. Omentum facilitates liver regeneration. World J Gastroenterol.
2009;15(9):1057–1064. doi:10.3748/wjg.15.1057.
27 Zhang J, Guan J, Niu X, et al. Exosomes released from human induced pluripotent stem cells-derived
MSCs facilitate cutaneous wound healing by promoting collagen synthesis and angiogenesis. J Transl Med.
2015;13:49. doi:10.1186/s12967-015-0417-0.
28 Memmert S, Nokhbehsaim M, Damanaki A, et al. Role of cathepsin S In periodontal wound healing-an in
vitro study on human PDL cells. BMC Oral Health. 2018;18(1):60. doi:10.1186/s12903-018-0518-2.
29 Flynn CM, Garbers Y, Düsterhöft S, et al. Cathepsin S provokes interleukin-6 (IL-6) trans-signaling through
cleavage of the IL-6 receptor in vitro. Sci Rep. 2020;10(1):21612. doi:10.1038/s41598-020-77884-4.
30 Shi GP, Sukhova GK, Kuzuya M, et al. Deficiency of the cysteine protease cathepsin S impairs microvessel
growth. Circ Res. 2003;92(5):493–500. doi:10.1161/01.RES.0000060485.20318.96.
31 Iorio V, Troughton LD, Hamill KJ. Laminins: Roles and Utility in Wound Repair. Adv Wound Care (New
Rochelle). 2015;4(4):250–263. doi:10.1089/wound.2014.0533.
32 Swerts JP, Soula C, Sagot Y, et al. Hemopexin is synthesized in peripheral nerves but not in central
nervous system and accumulates after axotomy. J Biol Chem. 1992;267(15):10596–10600. doi:10.1016/
S0021-9528(19)50058-8.
33 Zhu Y, Qiu Y, Chen M, et al. Hemopexin is required for adult neurogenesis in the subventricular zone/
olfactory bulb pathway. Cell Death Dis. 2018;9(3):268. doi:10.1038/s41419-018-0328-0.
Nagoya J. Med. Sci. 85. 528–541, 2023
540
doi:10.18999/nagjms.85.3.528
Wound healing using activated omentum
34 Dong B, Zhang Z, Xie K, et al. Hemopexin promotes angiogenesis via up-regulating HO-1 in rats after
cerebral ischemia-reperfusion injury. BMC Anesthesiol. 2018;18(1):2. doi:10.1186/s12871-017-0466-4.
35 Siriwach R, Ngo AQ, Higuchi M, et al. Single-cell RNA sequencing identifies a migratory keratinocyte
subpopulation expressing THBS1 in epidermal wound healing. iScience. 2022;25(4):104130. doi:10.1016/j.
isci.2022.104130.
36 Ashcroft GS, Kielty CM, Horan MA, Ferguson MW. Age-related changes in the temporal and spatial
distributions of fibrillin and elastin mRNAs and proteins in acute cutaneous wounds of healthy humans. J
Pathol. 1997;183(1):80–89. doi:10.1002/(SICI)1096-9896(199709)183:1<80::AID-PATH1104>3.0.CO;2-N.
37 Handa K, Abe S, Suresh VV, et al. Fibrillin-1 insufficiency alters periodontal wound healing failure in a
mouse model of Marfan syndrome. Arch Oral Biol. 2018;90:53–60. doi:10.1016/j.archoralbio.2018.02.017.
38 Zuliani-Alvarez L, Midwood KS. Fibrinogen-Related Proteins in Tissue Repair: How a Unique Domain
with a Common Structure Controls Diverse Aspects of Wound Healing. Adv Wound Care (New Rochelle).
2015;4(5):273–285. doi:10.1089/wound.2014.0599.
39 Farrell DH. Pathophysiologic roles of the fibrinogen gamma chain. Curr Opin Hematol. 2004;11(3):151–155.
doi:10.1097/01.moh.0000131440.02397.a4.
40 Juhasz I, Murphy GF, Yan HC, Herlyn M, Albelda SM. Regulation of extracellular matrix proteins and
integrin cell substratum adhesion receptors on epithelium during cutaneous human wound healing in vivo.
Am J Pathol. 1993;143(5):1458–1469.
41 Schneider H, Mühle C, Pacho F. Biological function of laminin-5 and pathogenic impact of its deficiency.
Eur J Cell Biol. 2007;86(11–12):701–717. doi:10.1016/j.ejcb.2006.07.004.
42 Sinno H, Malholtra M, Lutfy J, et al. Topical application of complement C3 in collagen formulation
increases early wound healing. J Dermatolog Treat. 2013;24(2):141–147. doi:10.3109/09546634.2011.6319
77.
43 Lenselink EA. Role of fibronectin in normal wound healing. Int Wound J. 2015;12(3):313–316. doi:10.1111/
iwj.12109.
44 Tonnesen MG, Feng X, Clark RA. Angiogenesis in wound healing. J Investig Dermatol Symp Proc.
2000;5(1):40–46. doi:10.1046/j.1087-0024.2000.00014.x.
45 Nikoloudaki G, Creber K, Hamilton DW. Wound healing and fibrosis: a contrasting role for periostin in skin
and the oral mucosa. Am J Physiol Cell Physiol. 2020;318(6):C1065-C1077. doi:10.1152/ajpcell.00035.2020.
46 Yin SL, Qin ZL, Yang X. Role of periostin in skin wound healing and pathologic scar formation. Chin
Med J (Engl). 2020;133(18):2236–2238. doi:10.1097/CM9.0000000000000949.
47 Argüeso P, Mauris J, Uchino Y. Galectin-3 as a regulator of the epithelial junction: Implications to wound
repair and cancer. Tissue Barriers. 2015;3(3):e1026505. doi:10.1080/21688370.2015.1026505.
48 Takaku S, Niimi N, Kadoya T, et al. Galectin-1 and galectin-3 as key molecules for peripheral nerve
degeneration and regeneration. AIMS Mol Sci. 2016;3(3):325–337. doi:10/3934/molsci.2016.3.325.
49 McLeod K, Walker JT, Hamilton DW. Galectin-3 regulation of wound healing and fibrotic processes:
insights for chronic skin wound therapeutics. J Cell Commun Signal. 2018;12(1):281–287. doi:10.1007/
s12079-018-0453-7.
50 Pastar I, Stojadinovic O, Yin NC, et al. Epithelialization in Wound Healing: A Comprehensive Review. Adv
Wound Care (New Rochelle). 2014;3(7):445–464. doi:10.1089/wound.2013.0473.
51 Klasan GS, Ivanac D, Erzen DJ, et al. Reg3G gene expression in regenerating skeletal muscle and corresponding nerve. Muscle Nerve. 2014;49(1):61–68. doi:10.1002/mus.23877.
52 Hennebry SC, Eikelis N, Socratous F, Desir G, Lambert G, Schlaich M. Renalase, a novel soluble FADdependent protein, is synthesized in the brain and peripheral nerves. Mol Psychiatry. 2010;15(3):234–236.
doi:10.1038/mp.2009.74.
53 Barrett PM, Topol EJ. The fibrillin-1 gene: unlocking new therapeutic pathways in cardiovascular disease.
Heart. 2013;99(2):83–90. doi:10.1136/heartjnl-2012-301840.
54 Sabatino M, Kim-Schulze S, Panelli MC, et al. Serum vascular endothelial growth factor and fibronectin
predict clinical response to high-dose interleukin-2 therapy. J Clin Oncol. 2009;27(16):2645–2652.
doi:10.1200/JCO.2008.19.1106.
55 Fu H. Interleukin 35 Inhibits Ischemia-Induced Angiogenesis Essentially through the Key Receptor Subunit
Interleukin 12 Receptor Beta 2. Dissertation. Temple University; 2019. doi:10.34944/dspace/519.
56 Chamorro M, Carceller F, Llanos C, Rodríguez-Alvariño A, Colmenero C, Burgueño M. The effect of
omental wrapping on nerve graft regeneration. Br J Plast Surg. 1993;46(5):426–429. doi:10.1016/00071226(93)90050-L.
References End
Nagoya J. Med. Sci. 85. 528–541, 2023
541
doi:10.18999/nagjms.85.3.528
...