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Acknowledgements

First, I would like to express my deepest gratitude to my supervisor, Prof.

Takeshi Noda, for his continuous support, insightful guidance, and constructive

feedback, throughout my research journey. I would like to express my deep gratitude to

assistant professor Dr. Araki for his invaluable guidance and insightful discussion in

this study. I am thankful to all members of Noda-Lab for valuable discussion.

I would like to thank for Prof. Takayuki Sekito and Prof. Nobuo Noda for their

scientific discussions.

My heartfelt thanks go to my parents, for their unwavering love, support, and

encouragement throughout my academic journey. I am immensely grateful to my

spouse for her endless support, patience, and belief, and for always standing by my side,

providing unwavering support in both the good times and the challenging moments.

Finally, I want to express my gratitude to everyone who took the time to read

this thesis and provide me with valuable suggestions that will help me in my future

studies.

88

Achievements

Publications

First author publication:

[1]．Qingzhong Zeng, Yasuhiro Araki, Takeshi Noda. Pib2 is a cysteine sensor

involved in TORC1 activation. 投稿中.

[2]. Qingzhong Zeng, Yasuhiro Araki, Takeshi Noda. TORC1 represses SER3

expression by inducing lncRNA SRG1 transcriptional interference. 投稿準備中

[3]. Zhang, H.-T., Zeng, Q., Wu, B., Lu, J., Tong, K.-L., Lin, J., Liu, Q.-Y., Xu, L.,

Yang, J., Liu, X., et al. (2021). TRIM21-regulated Annexin A2 plasma membrane

trafficking facilitates osteosarcoma cell differentiation through the TFEB-mediated

autophagy. Cell Death Dis. 12, 21. 10.1038/s41419-020-03364-2. (Co-first author)

[4]. Zeng, Q., Liu, W.T., Lu, J.L., Liu, X.H., Zhang, Y.F., Liu, L.X., and Gao, X.J.

(2018). YWHAZ Binds to TRIM21 but Is Not Involved in TRIM21-stimulated

Osteosarcoma Cell Proliferation. Biomed. Environ. Sci. BES 31, 186–196.

10.3967/bes2018.024.

Co-author publication:

89

[1]. Xu, G.-S., Lin, Y.-N., Zeng, Q., Li, Z.-P., Xiao, T., Ye, Y.-S., Li, Z.-Y., and Gao,

X. HSP90-regulated CHIP/TRIM21/p21 Axis Involves in the Senescence of

Osteosarcoma Cells. Protein Pept. Lett. 30, 1–7.

[2]. Si, H.W., Mei, X.F., Zeng, Q., Hui, L.X., Juan, G.X., and Xia, L.L. (2017).

ERK1/2-mediated Cytoplasmic Accumulation of hnRNPK Antagonizes TRAILinduced Apoptosis through Upregulation of XIAP in H1299 Cells. Biomed. Environ.

Sci. 30, 473–481. 10.3967/bes2017.063.

[3]. Gao, X., Xu, F., Zhang, H.-T., Chen, M., Huang, W., Zhang, Q., Zeng, Q., and Liu,

L. (2016). PKCα–GSK3β–NF-κB signaling pathway and the possible involvement of

TRIM21 in TRAIL-induced apoptosis. Biochem. Cell Biol. 94, 256–264. 10.1139/bcb2016-0009.

[4]. Huang CQ, Li W, Wu B, Chen WM, Chen LH, Mo GW, Zhang QF, Gong L, Li J,

Zhang HC, Zhu HM, Zeng Q. (2016). Pheretima aspergillum decoction suppresses

inflammation and relieves asthma in a mouse model of bronchial asthma by NF-κB

inhibition. J. Ethnopharmacol. 189, 22–30. 10.1016/j.jep.2016.05.028.

Conference Presentation

Qingzhong Zeng、荒木保弘、野田健司. 二つの TORC1 活性化経路の上流に位置

するアミノ酸の同定. 第 11 回 TOR 研究会. (2021/7/15-16)

90

Qingzhong Zeng、荒木保弘、野田健司. オートファジーを抑制する TORC1 の活

性化経路の上流に位置するアミノ酸の同定. 「マルチモードオートファジー」

第 3 回班会議・第 14 回オートファジー研究会. (2021/10/24-27)

Qingzhong Zeng, Yasuhiro Araki, Takeshi Noda. TORC1 senses amino acids through

distinct upstream pathways to inhibit autophagy. The 10th International Symposium on

Autophagy. (2022/10/23-27)

Qingzhong Zeng, Yasuhiro Araki, Takeshi Noda. Cysteine-activated TORC1 is

dependent on the Pib2 pathway in Saccharomyces cerevisiae. 第 12 回 TOR 研究会.

(2022/10/29-30)

Qingzhong Zeng, Yasuhiro Araki, Takeshi Noda. Cysteine-activated TORC1 is

dependent on the Pib2 pathway. The 45th Annual Meeting of the Molecular Biology

Society of Japan. (2022/11/30-12/2)

91

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