357
Akhand AA, Kato M, Suzuki H, Liu W, Du J, Hamaguchi M, Miyata T, Kurokawa K,
358
Nakashima I., 1999a. Carbonyl compounds cross-link cellular proteins and activate
14
359
360
protein-tyrosine kinase p60c-Src. J Cell Biochem 72: 1-7
Akhand AA, Pu M, Senga T, Kato M, Suzuki H, Miyata T, Hamaguchi M, Nakashima I.,
361
1999b. Nitric oxide controls src kinase activity through a sulfhydryl group modification-
362
mediated Tyr-527-independent and Tyr-416-linked mechanism. J Biol Chem 274:
363
25821-25826
364
Al Hossain MMA, Yajima I, Tazaki A, Xu H, Saheduzzaman M, Ohgami N, Ahsan N,
365
Akhand AA, Kato M., 2019. Chromium-mediated hyperpigmentation of skin in male
366
tannery workers in Bangladesh. Chemosphere 229: 611-617
367
Amini M, Abbaspour KC, Berg M, Winkel L, Hug SJ, Hoehn E, Yang H, Johnson CA.,2008.
368
Statistical modeling of global geogenic arsenic contamination in groundwater. Environ
369
Sci Technol 42: 3669-75
370
Barr RD, Clarke WB, Clarke RM, Venturelli J, Norman GR, Downing RG., 1993.
371
Regulation of lithium and boron levels in normal human blood: environmental and
372
genetic considerations. J Lab Clin Med 121: 614-9
373
Boukamp P, Petrussevska RT, Breitkreutz D, Hornung J, Markham A, Fusenig NE., 1988.
374
Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte
375
cell line. J Cell Biol 106: 761-71
376
Cabrera O, Dougherty J, Singh S, Swiney BS, Farber NB, Noguchi KK., 2014. Lithium
377
protects against glucocorticoid induced neural progenitor cell apoptosis in the
378
developing cerebellum. Brain Res 1545: 54-63
379
380
381
Chiarugi P., 2008. From anchorage dependent proliferation to survival: lessons from redox
signalling. IUBMB Life 60: 301-307
Durbano F, Mencacci C, Dorigo D, Riva M, Buffa G., 2002. The long-term efficacy and
382
tolerability of carbolithium once a day: an interim analysis at 6 months. Clin Ter 153:
383
161-6
15
384
El Khoury D, Destouches D, Lengagne R, Krust B, Hamma-Kourbali Y, Garcette M, Niro S,
385
Kato M, Briand JP, Courty J et al., 2010. Targeting surface nucleolin with a multivalent
386
pseudopeptide delays development of spontaneous melanoma in RET transgenic mice.
387
BMC Cancer 10: 325
388
389
390
391
392
Gadgil A., 1988 DRINKING WATER IN DEVELOPING COUNTRIES. Ann Rev Energy
Environ 23: 253-286
Girardi P, Brugnoli R, Manfredi G, Sani G., 2016. Lithium in Bipolar Disorder: Optimizing
Therapy Using Prolonged-Release Formulations. Drugs R D 16: 293-302
Harari F, Ronco AM, Concha G, Llanos M, Grander M, Castro F, Palm B, Nermell B,
393
Vahter M., 2012. Early-life exposure to lithium and boron from drinking water. Reprod
394
Toxicol 34: 552-60
395
He T, Ohgami N, Li X, Yajima I, Negishi-Oshino R, Kato Y, Ohgami K, Xu H, Ahsan N,
396
Akhand AA, Kato M., 2019. Hearing loss in humans drinking tube well water with high
397
levels of iron in arsenic-polluted area. Sci Rep 9: 9028
398
399
400
Hunter R., 1988 Steady-state pharmacokinetics of lithium carbonate in healthy subjects. Br
J Clin Pharmacol 25: 375-80
Kato M, Azimi MD, Fayaz SH, Shah MD, Hoque MZ, Hamajima N, Ohnuma S, Ohtsuka T,
401
Maeda M, Yoshinaga M., 2016. Uranium in well drinking water of Kabul, Afghanistan
402
and its effective, low-cost depuration using Mg-Fe based hydrotalcite-like compounds.
403
Chemosphere 165: 27-32
404
Kato M, Kumasaka MY, Ohnuma S, Furuta A, Kato Y, Shekhar HU, Kojima M, Koike Y,
405
Dinh Thang N, Ohgami N, Ly TB, Jia X, Yetti H, Naito H, Ichihara G, Yajima I., 2013.
406
Comparison of Barium and Arsenic Concentrations in Well Drinking Water and in
407
Human Body Samples and a Novel Remediation System for These Elements in Well
408
Drinking Water. PLoS One 8: e66681
16
409
Kato M, Ohgami N, Ohnuma S, Hashimoto K, Tazaki A, Xu H, Kondo-Ida L, Yuan T,
410
Tsuchiyama T, He T, Kurniasari F, Gu Y, Chen W, Deng Y, Komuro K, Tong K, Yajima
411
I., 2020. Multidisciplinary approach to assess the toxicities of arsenic and barium in
412
drinking water. Environ Health Prev Med 25: 16.
413
Kato M, Takeda K, Kawamoto Y, Tsuzuki T, Hossain K, Tamakoshi A, Kunisada T,
414
Kambayashi Y, Ogino K, Suzuki H, Takahashi M, Nakashima I., 2004. c-Kit-targeting
415
immunotherapy for hereditary melanoma in a mouse model. Cancer Res 64: 801-6
416
Kato M, Takeda K, Kawamoto Y, Iwashita T, Akhand AA, Senga T, Yamamoto M, Sobue G,
417
Hamaguchi M, Takahashi M, Nakashima I., 2002. Repair by Src kinase of function-
418
impaired RET with multiple endocrine neoplasia type 2A mutation with substitutions of
419
tyrosines in the COOH-terminal kinase domain for phenylalanine. Cancer Res 62:
420
2414-22
421
Kavanagh L, Keohane J, Garcia Cabellos G, Lloyd A, Cleary J., 2018. Global Lithium
422
Sources-Industrial Use and Future in the Electric Vehicle Industry: A Review.
423
Resources 7: 57
424
Kumasaka MY, Yamanoshita O, Shimizu S, Ohnuma S, Furuta A, Yajima I, Nizam S,
425
Khalequzzaman M, Shekhar HU, Nakajima T, Kato M., 2013. Enhanced carcinogenicity
426
by coexposure to arsenic and iron and a novel remediation system for the elements in
427
well drinking water. Arch Toxicol 87: 439-47
428
Li X, Ohgami N, Omata Y, Yajima I, Iida M, Oshino R, Ohnuma S, Ahsan N, Akhand AA,
429
Kato M., 2017. Oral exposure to arsenic causes hearing loss in young people aged 12-
430
29 years and in young mice. Sci Rep 7: 6844
431
Li X, Ohgami N, Yajima I, Xu H, Iida M, Oshino R, Ninomiya H, Shen D, Ahsan N,
432
Akhand AA, Kato M., 2018. Arsenic level in toenails is associated with hearing loss in
433
humans. PLoS One 13: e0198743
434
Liu C, Li Y, Semenov M, Han C, Baeg GH, Tan Y, Zhang Z, Lin X, He X., 2002. Control of
17
435
beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 108: 837-
436
47
437
Liu W, Kato M, Akhand AA, Hayakawa A, Takemura M, Yoshida S, Suzuki H, Nakashima I.,
438
1998. The herbal medicine sho-saiko-to inhibits the growth of malignant melanoma
439
cells by upregulating Fas-mediated apoptosis and arresting cell cycle through
440
downregulation of cyclin dependent kinases. Int J Oncol 12: 1321-6
441
442
443
Muneer A., 2017. Wnt and GSK3 Signaling Pathways in Bipolar Disorder: Clinical and
Therapeutic Implications. Clin Psychopharmacol Neurosci 15: 100-114
Nishihama S, Onishi K, Yoshizuka K., 2011. Selective Recovery Process of Lithium from
444
Seawater Using Integrated Ion Exchange Methods. Solvent Extraction and Ion
445
Exchange 29: 421-431
446
447
448
449
450
Ohgami H, Terao T, Shiotsuki I, Ishii N, Iwata N., 2009. Lithium levels in drinking water and
risk of suicide. Br J Psychiatry 194: 464-5; discussion 446
Ohgami N, Yajima I, Iida M, Li X, Oshino R, Kumasaka MY, Kato M., 2016. Manganesemediated acceleration of age-related hearing loss in mice. Sci Rep 6: 36306
Ohgami N, Mitsumatsu Y, Ahsan N, Akhand AA, Li X, Iida M, Yajima I, Naito M, Wakai K,
451
Ohnuma S, Kato M., 2016. Epidemiological analysis of the association between
452
hearing and barium in humans. J Expo Sci Environ Epidemiol 26: 488-93
453
Ohgami N, Yamanoshita O, Thang ND, Yajima I, Nakano C, Wenting W, Ohnuma S,
454
Kato M., 2015. Carcinogenic risk of chromium, copper and arsenic in CCA-treated
455
wood. Environ Pollut 206: 456-60
456
Peters DH, Noor AA, Singh LP, Kakar FK, Hansen PM, Burnham G., 2007. A balanced
457
scorecard for health services in Afghanistan. Bull World Health Organ 85: 146-151
458
459
Roy JS, Chatterjee D, Das N, Giri AK., 2018. Substantial Evidences Indicate That
Inorganic Arsenic Is a Genotoxic Carcinogen: a Review. Toxicol Res 34: 311-324
18
460
Thang ND, Yajima I, Kumasaka MY, Iida M, Suzuki T, Kato M., 2015. Deltex-3-like (DTX3L)
461
stimulates metastasis of melanoma through FAK/PI3K/AKT but not MEK/ERK pathway.
462
Oncotarget 6: 14290-9
463
Thang ND, Yajima I, Kumasaka MY, Ohnuma S, Yanagishita T, Hayashi R, Shekhar HU,
464
Watanabe D, Kato M., 2011. Barium promotes anchorage-independent growth and
465
invasion of human HaCaT keratinocytes via activation of c-SRC kinase. PLoS One 6:
466
e25636
467
Yajima I, Ahsan N, Akhand AA, Al Hossain MA, Yoshinaga M, Ohgami N, Iida M, Oshino R,
468
Naito M, Wakai K, Kato M., 2018. Arsenic levels in cutaneous appendicular organs are
469
correlated with digitally evaluated hyperpigmented skin of the forehead but not the sole
470
in Bangladesh residents. J Expo Sci Environ Epidemiol 28: 64-68
471
Yajima I, Kumasaka MY, Iida M, Oshino R, Tanihata H, Al Hossain A, Ohgami N, Kato M.,
472
2017. Arsenic-mediated hyperpigmentation in skin via NF-kappa B/endothelin-1
473
signaling in an originally developed hairless mouse model. Arch Toxicol 91: 3507-3516
474
Yajima I, Kumasaka MY, Ohnuma S, Ohgami N, Naito H, Shekhar HU, Omata Y, Kato M.,
475
2015. Arsenite-mediated promotion of anchorage-independent growth of HaCaT cells
476
through placental growth factor. J Invest Dermatol 135: 1147-1156
477
Yajima I, Uemura N, Nizam S, Khalequzzaman M, Thang ND, Kumasaka MY, Akhand AA,
478
Shekhar HU, Nakajima T, Kato M., 2012. Barium inhibits arsenic-mediated apoptotic
479
cell death in human squamous cell carcinoma cells. Arch Toxicol 86: 961-73
480
Yoshinaga M, Ninomiya H, Al Hossain MMA, Sudo M, Akhand AA, Ahsan N, Alim MA,
481
Khalequzzaman M, Iida M, Yajima I, Ohgami N, Kato M., 2018. A comprehensive study
482
including monitoring, assessment of health effects and development of a remediation
483
method for chromium pollution. Chemosphere 201: 667-675
484
485
Zaidan M, Stucker F, Stengel B, Vasiliu V, Hummel A, Landais P, Boffa JJ, Ronco P,
Grunfeld JP, Servais A., 2014. Increased risk of solid renal tumors in lithium-treated
19
486
487
488
patients. Kidney Int 86: 184-90
Zarse K, Terao T, Tian J, Iwata N, Ishii N, Ristow M., 2011. Low-dose lithium uptake
promotes longevity in humans and metazoans. Eur J Nutr 50: 387-9
489
490
Kapusta ND, Mossaheb N, Etzersdorfer E, Hlavin G, Thau K, Willeit M, Praschak-Rieder
491
N, Sonneck G, Leithner-Dziubas K., 2011. Lithium in drinking water and suicide
492
mortality. Br J Psychiatry. 198: 346-50.
493
494
Sugawara N, Yasui-Furukori N, Ishii N, Iwata N, Terao T., 2013. Lithium in tap water and
suicide mortality in Japan. Int J Environ Res Public Health. 10: 6044-8.
495
Knudsen NN, Schullehner J, Hansen B, Jørgensen LF, Kristiansen SM, Voutchkova DD,
496
Gerds TA, Andersen PK, Bihrmann K, Grønbæk M, Kessing LV, Ersbøll AK., 2017.
497
Lithium in Drinking Water and Incidence of Suicide: A Nationwide Individual-Level
498
Cohort Study with 22 Years of Follow-Up. Int J Environ Res Public Health. 2017. 14:
499
627.
500
501
502
503
504
505
506
Kabacs N, Memon A, Obinwa T, Stochl J, Perez J., 2011. Lithium in drinking water and
suicide rates across the East of England. Br J Psychiatry. 198: 406-7.
Giotakos O, Nisianakis P, Tsouvelas G, Giakalou VV., 2013. Lithium in the public water
supply and suicide mortality in Greece. Biol Trace Elem Res. 156: 376-9.
Ohgami H, Terao T, Shiotsuki I, Ishii N, Iwata N., 2009. Lithium levels in drinking water and
risk of suicide. Br J Psychiatry. 194:464-5; discussion 446.
Blüml V, Regier MD, Hlavin G, Rockett IR, König F, Vyssoki B, Bschor T, Kapusta ND.,
507
2013. Lithium in the public water supply and suicide mortality in Texas. J Psychiatr Res.
508
47: 407-11.
509
Xu H, Hashimoto K, Maeda M, Azimi MD, Fayaz SH, Chen W, Hamajima N, Kato M.,
510
2020. High levels of boron promote anchorage-independent growth of nontumorigenic
511
cells. Environ Pollut. 266(Pt 3):115094.
20
Fig. 1
HaCaT
HSC-5
Relative cell viability (Ratio)
12
10
12
10
7 (Day)
7 (Day)
BEAS-2B
25
Relative cell viability (Ratio)
0 (µM)
10
100
1,000
10,000
50,000
14
20
15
10
A549
40
Relative cell viability (Ratio)
Relative cell viability (Ratio)
14
30
20
10
(Day)
7 (Day)
Fig. 2
Number of colonies
(ratio)
(ratio)
10 100 500 000
LiCl (µM)
HSC-5
10 100 500 000
LiCl (µM)
1 µM
10 µM
0 µM
1 µM
10 µM
100 µM
500 µM
1000 µM
100 µM
500 µM
1000 µM
(ratio)
BEAS-2B
10 100 500 000
LiCl (µM)
Number of colonies
0 µM
Number of colonies
HaCaT
Number of colonies
(ratio)
A549
10 100 500 000
LiCl (µM)
0 µM
1 µM
10 µM
0 µM
1 µM
10 µM
100 µM
500 µM
1000 µM
100 µM
500 µM
1000 µM
Fig. 3
HSC-5
HaCaT
LiCl (μM) 0
pSRC
SRC
pAKT
AKT
pMEK
MEK
pERK
ERK
GAPDH
100 500
100 500
Fig. 4
LiCl
PP2
500
500
(µM)
(µM)
pSRC
SRC
GAPDH
Number of colonies (ratio)
2.5
1.5
ns
0.5
LiCl
500
500
(µM)
PP2
(µM)
LiCl
500
500
(µM)
PP2
(µM)
Fig. 5
LiCl
500
10
20
PD98059 -
500 500 500 (µM)
10
20
(µM)
pERK
ERK
GAPDH
Number of colonies (ratio)
2.5
1.5
ns
0.5
LiCl
500
500
(µM)
PD98059
10
10
(µM)
LiCl
500
500
(µM)
PD98059
10
10
(µM)
Suppl. Fig.1
LiCl
100
500
(µM)
b-catenin
GAPDH
Suppl. Fig.2
mRNA expression
1.5
c-SRC
N.S.
MEK1
1.5
N.S.
0.5
0.5
0.5
Li (μM) 0
100 500
100 500
MEK2
1.5
N.S.
100 500
...
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