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Concepts of Regeneration for Spinal Diseases in 2021

Yurube, Takashi Han, Inbo Sakai, Daisuke 神戸大学

2021.08.04

概要

It is our pleasure to announce the publication of the Special Issue “Regeneration for Spinal Diseases” in the International Journal of Molecular Sciences (IJMS, ISSN 1422-0067). Spinal diseases place a significant burden on the general population. The prevalence of degenerative spinal diseases, including intervertebral disc degeneration and osteoporosis, is quite high and increases with age, and the affected population may suffer from a long-term disability. Furthermore, the most serious spine-related conditions can reach spinal cord injury due to traumatic or non-traumatic causes. Despite recent advances in the management of these common but problematic spinal pathologies, there is growing research interest in discovering novel therapeutic strategies.

This IJMS Special Issue “Regeneration for Spinal Diseases” includes 10 cutting-edge original research articles consisting of six papers for degenerative disc disease and four for spinal cord injury. Moreover, five expertized review articles targeting the intervertebral disc, neuropathic pain, pyogenic spondylodiscitis, and surgical bone fusion have been compiled. All of these 15 articles should provide helpful insights for the current clinical management and future basic science development of regenerative treatment strategies for intractable spinal diseases.

These articles have been published in the IJMS (https://www.mdpi.com/journal/ijms, 1 August 2021), Section: Molecular Pathology, Diagnostics, and Therapeutics (https://www. mdpi.com/journal/ijms/sections/Pathology_Diagnostics_Therapeutics, 1 August 2021), Topic: Regeneration for Spinal Diseases (https://www.mdpi.com/journal/ijms/special_ issues/Spinal_Diseases, 1 August 2021). The IJMS is an international, peer-reviewed, open access journal published by the Multidisciplinary Digital Publishing Institute (MDPI), universally and freely accessible online.

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参考文献

1. Kim, J.W.; Jeon, N.; Shin, D.E.; Lee, S.Y.; Kim, M.; Han, D.H.; Shin, J.Y.; Lee, S. Regeneration in Spinal Disease: Therapeutic Role of Hypoxia-Inducible Factor-1 Alpha in Regeneration of Degenerative Intervertebral Disc. Int. J. Mol. Sci. 2021, 22, 5281. [CrossRef]

2. Ito, M.; Yurube, T.; Kanda, Y.; Kakiuchi, Y.; Takeoka, Y.; Takada, T.; Kuroda, R.; Kakutani, K. Inhibition of Autophagy at Different Stages by ATG5 Knockdown and Chloroquine Supplementation Enhances Consistent Human Disc Cellular Apoptosis and Senescence Induction rather than Extracellular Matrix Catabolism. Int. J. Mol. Sci. 2021, 22, 3965. [CrossRef] [PubMed]

3. Yurube, T.; Hirata, H.; Ito, M.; Terashima, Y.; Kakiuchi, Y.; Kuroda, R.; Kakutani, K. Involvement of Autophagy in Rat Tail Static Compression-Induced Intervertebral Disc Degeneration and Notochordal Cell Disappearance. Int. J. Mol. Sci. 2021, 22, 5648. [CrossRef] [PubMed]

4. Calio, M.; Gantenbein, B.; Egli, M.; Poveda, L.; Ille, F. The Cellular Composition of Bovine Coccygeal Intervertebral Discs: A Comprehensive Single-Cell RNAseq Analysis. Int. J. Mol. Sci. 2021, 22, 4917. [CrossRef]

5. Takeoka, Y.; Paladugu, P.; Kang, J.D.; Mizuno, S. Augmented Chondroitin Sulfate Proteoglycan Has Therapeutic Potential for Intervertebral Disc Degeneration by Stimulating Anabolic Turnover in Bovine Nucleus Pulposus Cells under Changes in Hydrostatic Pressure. Int. J. Mol. Sci. 2021, 22, 6015. [CrossRef] [PubMed]

6. Croft, A.S.; Illien-Junger, S.; Grad, S.; Guerrero, J.; Wangler, S.; Gantenbein, B. The Application of Mesenchymal Stromal Cells and Their Homing Capabilities to Regenerate the Intervertebral Disc. Int. J. Mol. Sci. 2021, 22, 3519. [CrossRef] [PubMed]

7. Friedmann, A.; Baertel, A.; Schmitt, C.; Ludtka, C.; Milosevic, J.; Meisel, H.J.; Goehre, F.; Schwan, S. Intervertebral Disc Regeneration Injection of a Cell-Loaded Collagen Hydrogel in a Sheep Model. Int. J. Mol. Sci. 2021, 22, 4248. [CrossRef] [PubMed]

8. Sako, K.; Sakai, D.; Nakamura, Y.; Schol, J.; Matsushita, E.; Warita, T.; Horikita, N.; Sato, M.; Watanabe, M. Effect of Whole Tissue Culture and Basic Fibroblast Growth Factor on Maintenance of Tie2 Molecule Expression in Human Nucleus Pulposus Cells. Int. J. Mol. Sci. 2021, 22, 4723. [CrossRef] [PubMed]

9. Chang, D.J.; Cho, H.Y.; Hwang, S.; Lee, N.; Choi, C.; Lee, H.; Hong, K.S.; Oh, S.H.; Kim, H.S.; Shin, D.A.; et al. Therapeutic Effect of BDNF-Overexpressing Human Neural Stem Cells (F3.BDNF) in a Contusion Model of Spinal Cord Injury in Rats. Int. J. Mol. Sci. 2021, 22, 6970. [CrossRef] [PubMed]

10. Lee, H.L.; Yeum, C.E.; Lee, H.; Oh, J.; Kim, J.T.; Lee, W.J.; Ha, Y.; Yang, Y.I.; Kim, K.N. Peripheral Nerve-Derived Stem Cell Spheroids Induce Functional Recovery and Repair after Spinal Cord Injury in Rodents. Int. J. Mol. Sci. 2021, 22, 4141. [CrossRef] [PubMed]

11. Won, J.S.; Yeon, J.Y.; Pyeon, H.J.; Noh, Y.J.; Hwang, J.Y.; Kim, C.K.; Nam, H.; Lee, K.H.; Lee, S.H.; Joo, K.M. Optimal Preclinical Conditions for Using Adult Human Multipotent Neural Cells in the Treatment of Spinal Cord Injury. Int. J. Mol. Sci. 2021, 22, 2579. [CrossRef] [PubMed]

12. Bighinati, A.; Khalajzeyqami, Z.; Baldassarro, V.A.; Lorenzini, L.; Cescatti, M.; Moretti, M.; Giardino, L.; Calza, L. Time-Course Changes of Extracellular Matrix Encoding Genes Expression Level in the Spinal Cord Following Contusion Injury-A Data-Driven Approach. Int. J. Mol. Sci. 2021, 22, 1744. [CrossRef] [PubMed]

13. Joshi, H.P.; Jo, H.J.; Kim, Y.H.; An, S.B.; Park, C.K.; Han, I. Stem Cell Therapy for Modulating Neuroinflammation in Neuropathic Pain. Int. J. Mol. Sci. 2021, 22, 4853. [CrossRef] [PubMed]

14. Ohnishi, T.; Ogawa, Y.; Suda, K.; Komatsu, M.; Harmon, S.M.; Asukai, M.; Takahata, M.; Iwasaki, N.; Minami, A. Molecular Targeted Therapy for the Bone Loss Secondary to Pyogenic Spondylodiscitis Using Medications for Osteoporosis: A Literature Review. Int. J. Mol. Sci. 2021, 22, 4453. [CrossRef] [PubMed]

15. Lo, W.C.; Tsai, L.W.; Yang, Y.S.; Chan, R.W.Y. Understanding the Future Prospects of Synergizing Minimally Invasive Trans- foraminal Lumbar Interbody Fusion Surgery with Ceramics and Regenerative Cellular Therapies. Int. J. Mol. Sci. 2021, 22, 3638. [CrossRef] [PubMed]

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