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Conflict of Interest: HK owns equity and is a scientific consultant for

Therabiopharma.

The remaining authors declare that the research was conducted in the absence of

any commercial or financial relationships that could be construed as a potential

conflict of interest.

This study received funding from Novartis Pharma. The funder was not involved

in the study design, collection, analysis, interpretation of data, the writing of this

article or the decision to submit it for publication.

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