1. Moberg L, Johansson H, Lukinius A, et al. Production of tissue factor by pancreatic islet cells as a trigger of detrimental thrombotic reactions in clinical islet transplantation. Lancet. 2002;360:2039–2045.
2. Hwa AJ, Weir GC. Transplantation of macroencapsulated insulin-producing cells. Curr Diab Rep. 2018;18:50.
3. Kawakami Y, Iwata H, Gu YJ, et al. Successful subcutaneous pancreatic islet transplantation using an angiogenic growth factor-releasing device. Pancreas. 2001;23:375–381.
4. Yang S-Y, Yang K-C, Sumi S. Effect of basic fibroblast growth factor on xenogeneic islets in subcutaneous transplantation—A murine model. Transplant Proc. 2019;51:1458–1462.
5. García-Ocaña A, Vasavada RC, Cebrian A, et al. Transgenic overexpression of hepatocyte growth factor in the beta-cell markedly improves islet function and islet transplant outcomes in mice. Diabetes. 2001;50:2752–2762.
6. Lopez-Talavera JC, Garcia-Ocaña A, Sipula I, et al. Hepatocyte growth factor gene therapy for pancreatic islets in diabetes: reducing the minimal islet transplant mass required in a glucocorticoid-free rat model of allogeneic portal vein islet transplantation. Endocrinology. 2004;145:467–474.
7. Garcia-Ocaña A, Takane KK, Syed MA, et al. Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia. J Biol Chem. 2000;275:1226–1232.
8. Hayek A, Beattie GM, Cirulli V, et al. Growth factor/matrix-induced proliferation of human adult beta-cells. Diabetes. 1995;44:1458–1460.
9. Demirci C, Ernst S, Alvarez-Perez JC, et al. Loss of HGF/c-Met signaling in pancreatic β-cells leads to incomplete maternal β-cell adaptation and gestational diabetes mellitus. Diabetes. 2012;61:1143–1152.
10. Oliveira AG, Araújo TG, Carvalho BM, et al. The role of hepatocyte growth factor (HGF) in insulin resistance and diabetes. Front Endocrinol (Lausanne). 2018;9:503.
11. Trusolino L, Bertotti A, Comoglio PM. MET signalling: principles and functions in development, organ regeneration and cancer. Nat Rev Mol Cell Biol. 2010;11:834–848.
12. Fiaschi-Taesch N, Stewart AF, Garcia-Ocaña A. Improving islet transplantation by gene delivery of hepatocyte growth factor (HGF) and its downstream target, protein kinase B (PKB)/Akt. Cell Biochem Biophys. 2007;48(2-3):191–199.
13. Mellado-Gil J, Rosa TC, Demirci C, et al. Disruption of hepatocyte growth factor/c-Met signaling enhances pancreatic beta-cell death and accelerates the onset of diabetes. Diabetes. 2011;60:525–536.
14. Ozaki M, Haga S, Zhang HQ, et al. Inhibition of hypoxia/reoxygenenation-induced oxidative stress in HGF-stimulated antiapoptotic signaling: role of PI3-K and Akt kinase upon rac1. Cell Death Differ. 2003;10:508–515.
15. He F, Wu LX, Shu KX, et al. HGF protects cultured cortical neurons against hypoxia/reoxygenation induced cell injury via ERK1/2 and PI-3K/Akt pathways. Colloids Surf B Biointerfaces. 2008;61:290–297.
16. Garcia-Ocana A, Takane KK, Reddy VT, et al. Adenovirus-mediated hepatocyte growth factor expression in mouse islets improves pancreatic islet transplant performance and reduces beta cell death. J Biol Chem. 2003;278:343–351.
17. Dai C, Huh CG, Thorgeirsson SS, et al. Beta-cell-specific ablation of the hepatocyte growth factor receptor results in reduced islet size, impaired insulin secretion, and glucose intolerance. Am J Pathol. 2005;167:429–436.
18. Wu H, Yoon AR, Li F, et al. RGD peptide-modified adenovirus expressing hepatocyte growth factor and X-linked inhibitor of apoptosis improves islet transplantation. J Gene Med. 2011;13:658–669.
19. Kilkenny C, Browne WJ, Cuthill IC, et al. Improving bioscience research reporting: The arrive guidelines for reporting animal research. Animals. 2013;4:35–44.
20. Yang KC, Yanai G, Yang SY, et al. Low-adhesive ethylene vinyl alcoholbased packaging to xenogeneic islet encapsulation for type 1 diabetes treatment. Biotechnol Bioeng. 2018;115:2341–2355.
21. Wang W, Gu Y, Tabata Y, et al. Reversal of diabetes in mice by xenotransplantation of a bioartificial pancreas in a prevascularized subcutaneous site. Transplantation. 2002;73:122–129.
22. Wang W, Gu Y, Hori H, et al. Subcutaneous transplantation of macroencapsulated porcine pancreatic endocrine cells normalizes hyperglycemia in diabetic mice. Transplantation. 2003;76:290–296.
23. Kim KH, Kim H. Progress of antibody-based inhibitors of the HGFcMET axis in cancer therapy. Exp Mol Med. 2017;49:e307.
24. Vaithilingam V, Evans MDM, Lewy DM, et al. Co-encapsulation and co-transplantation of mesenchymal stem cells reduces pericapsular fibrosis and improves encapsulated islet survival and function when allografted. Sci Rep. 2017;7:1–13.
25. Jourdan G, Dusseault J, Benhamou PY, et al. Co-encapsulation of bioengineered IGF-II-producing cells and pancreatic islets: effect on beta-cell survival. Gene Ther. 2011;18:539–545.
26. Perez-Basterrechea M, Esteban MM, Alvarez-Viejo M, et al. Fibroblasts accelerate islet revascularization and improve long-term graft survival in a mouse model of subcutaneous islet transplantation. PLoS One. 2017;12:e0180695.
27. Yeung TY, Seeberger KL, Kin T, et al. Human mesenchymal stem cells protect human islets from pro-inflammatory cytokines. PLoS One. 2012;7:e38189.
28. Wimmer RA, Leopoldi A, Aichinger M, et al. Human blood vessel organoids as a model of diabetic vasculopathy. Nature. 2019;565:505–510.
29. Brem H, Tomic-Canic M. Cellular and molecular basis of wound healing in diabetes. J Clin Invest. 2007;117:1219–1222.
30. Qi Y, Li M, Xu L, et al. Therapeutic role of human hepatocyte growth factor (HGF) in treating hair loss. PeerJ. 2016;4:e2624.