リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

大学・研究所にある論文を検索できる 「Maternal exposure to environmental endocrine disruptors during pregnancy is associated with pediatric germ cell tumors」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。
リケラボ

コピーが完了しました

URLをコピーしました

論文の公開元へ論文の公開元へ
書き出し

Maternal exposure to environmental endocrine disruptors during pregnancy is associated with pediatric germ cell tumors

Lin, Hou-Wei Feng, Hai-Xia Chen, Lin Yuan, Xiao-Jun Tan, Zhen 名古屋大学

2020.05

概要

Environmental endocrine disruptors (EEDs) are natural or synthetic chemical compounds that interfere with normal endocrine function in both wildlife and humans. Previous studies have indicated that EEDs may contribute to oncogenesis. This study explores the relationship between EEDs and pediatric germ cell tumors (GCTs). A case-control study was conducted in 84 pediatric patients from 2014 to 2017, including 42 subjects with immature teratoma, yolk sac tumor, or germinoma, and 42 controls who experienced pneumonia or trauma. Serum PFASs, including PFBS, PFHpA, PFHxS, PFOA, PFOS, PFNA, PFDA, PFUA, PFOSA, and PFDoA, were measured in each subject, and their history of possible EED exposure was reviewed. Six of the 10 measured PFASs were significantly increased in the GCT group relative to the control group. With respect to lifestyle history, only PFHxS levels were statistically significantly associated with GCTs as determined by logistic regression analysis. The odds ratio for a 1 ng/L increase in PFHxS was 19.47 (95% CI: 4.20–90.26). Furthermore, in the GCT and control groups, both parental consumption of barbecued foods and hair dye use among parents were significantly correlated with elevated serum PFHxS levels (ρ= 0.383, 0.325 in the patient group and ρ= 0.370, 0.339 in the control group; p < 0.05). Our study confirmed that children with GCTs from our institute had relatively high serum levels of PFASs relative to those of tumor-free pediatric patients. Serum PFHxS levels were independently associated with germ cell tumor occurrence.

論文の公開元へ

関連論文

関連論文をもっと見る

参考文献

1. Gobel U, Schneider DT, Calaminus G, Haas RJ, Schmidt P, Harms D. Germ-cell tumors in childhood

and adolescence: GPOH MAKEI and the MAHO study groups. Ann Oncol. 2000;11(3):263–271 doi:

10.1023/A:1008360523160.

2. Bokemeyer C, Nichols CR, Droz JP, et al. Extragonadal germ cell tumors of the mediastinum and

retroperitoneum: results from an international analysis. J Clin Oncol. 2002;20(7):1864–1873. doi: 10.1200/

JCO.2002.07.062.

3. Makino T, Konaka H, Namiki M. Clinical features and treatment outcomes in patients with extragonadal

germ cell tumors: a single-center experience. Anticancer Res. 2016;36(1):313–317.

4. Albany C, Adra N, Snavely AC, et al. Multidisciplinary clinic approach improves overall survival outcomes

of patients with metastatic germ-cell tumors. Ann Oncol. 2018;29(2):341–346. doi: 10.1093/annonc/mdx731.

5. Bahrami A, Ro JY, Ayala AG. An overview of testicular germ cell tumors. Arch Pathol Lab Med.

2007;131(8):1267–1280. doi: 10.1043/1543-2165(2007)131[1267:AOOTGC]2.0.CO;2.

6. Heindel JJ, Newbold R, Schug TT. Endocrine disruptors and obesity. Nat Rev Endocrinol. 2015;11(11):653–

661. doi: 10.1038/nrendo.2015.163.

7. Herbst AL, Ulfelder H, Poskanzer DC. Adenocarcinoma of the vagina. Association of maternal stilbestrol

therapy with tumor appearance in young women. N Engl J Med. 1971;284(15):878–881. doi: 10.1056/

nejm197104222841604.

8. Elobeid MA, Allison DB. Putative environmental-endocrine disruptors and obesity: a review. Curr Opin

Endocrinol Diabetes Obes. 2008;15(5):403–408. doi: 10.1097/MED.0b013e32830ce95c.

9. Soto AM, Sonnenschein C. Environmental causes of cancer: endocrine disruptors as carcinogens. Nat Rev

Endocrinol. 2010;6(7):363–370. doi: 10.1038/nrendo.2010.87.

10. Sharpe RM, Skakkebaek NE. Are oestrogens involved in falling sperm counts and disorders of the male

reproductive tract? Lancet. 1993;341(8857):1392–1395. doi: 10.1016/0140-6736(93)90953-E.

11. Marques-Pinto A, Carvalho D. Human infertility: are endocrine disruptors to blame? Endocr Connect.

2013;2(3):R15–29. doi: 10.1530/EC-13-0036.

12. Knower KC, To SQ, Leung YK, Ho SM, Clyne CD. Endocrine disruption of the epigenome: a breast cancer

link. Endocr Relat Cancer. 2014;21(2):T33–55. doi: 10.1530/ERC-13-0513.

13. Zhu H, Zheng J, Xiao X, et al. Environmental endocrine disruptors promote invasion and metastasis of

SK-N-SH human neuroblastoma cells. Oncol Rep. 2010;23(1):129–139. doi: 10.3892/or_00000614.

14. Hoffman K, Lorenzo A, Butt CM, et al. Exposure to flame retardant chemicals and occurrence and

severity of papillary thyroid cancer: a case-control study. Environ Int. 2017;107:235–242. doi: 10.1016/j.

envint.2017.06.021.

15. Del-Mazo J, Brieno-Enriquez MA, Garcia-Lopez J, Lopez-Fernandez LA, De-Felici M. Endocrine disruptors, gene deregulation and male germ cell tumors. Int J Dev Biol. 2013;57(2-4):225–239. doi: 10.1387/

ijdb.130042jd.

16. Hardell L, Van Bavel B, Lindstrom G, et al. Concentrations of polychlorinated biphenyls in blood and the

risk for testicular cancer. Int J Androl. 2004;27(5):282–290. doi: 10.1111/j.1365-2605.2004.00489.x.

17. Beranger R, Le Cornet C, Schuz J, Fervers B. Occupational and environmental exposures associated

with testicular germ cell tumours: systematic review of prenatal and life-long exposures. PLoS One.

2013;8(10):e77130. doi: 10.1371/journal.pone.0077130.

18. Morimoto LM, Zava D, McGlynn KA, et al. Neonatal hormone concentrations and risk of testicular germ

cell tumors (TGCT). Cancer Epidemiol Biomarkers Prev. 2018;27(4):488–495. doi: 10.1158/1055-9965.

EPI-17-0879.

19. Zhou Y, Wang H, Chen Y, Jiang Q. Environmental and food contamination with plasticisers in China.

Lancet. 2011;378(9803):e4. doi: 10.1016/S0140-6736(11)61700-5.

20. Fan Y, Zhang M, Da SL, Feng YQ. Determination of endocrine disruptors in environmental waters using

poly(acrylamide-vinylpyridine) monolithic capillary for in-tube solid-phase microextraction coupled to

high-performance liquid chromatography with fluorescence detection. Analyst. 2005;130(7):1065–1069. doi:

10.1039/B502311D.

21. Siebenaler R, Cameron R, Butt CM, Hoffman K, Higgins CP, Stapleton HM. Serum perfluoroalkyl acids

(PFAAs) and associations with behavioral attributes. Chemosphere. 2017;184:687–693. doi: 10.1016/j.

chemosphere.2017.06.023.

22. Zhou W, Zhang L, Tong C, et al. Plasma perfluoroalkyl and polyfluoroalkyl substances concentration and

menstrual cycle characteristics in preconception women. Environ Health Perspect. 2017;125(6):067012. doi:

10.1289/EHP1203.

333

Environmental endocrine disruptors and pediatric germ cell tumors

23. Chen Q, Huang R, Hua L, et al. Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances and

childhood atopic dermatitis: a prospective birth cohort study. Environ Health. 2018;17(1):8. doi: 10.1186/

s12940-018-0352-7.

24. Hu XY, Wen B, Shan XQ. Survey of phthalate pollution in arable soils in China. J Environ Monit.

2003;5(4):649–653. doi: 10.1039/B304669A.

25. Liu JL, Wong MH. Pharmaceuticals and personal care products (PPCPs): a review on environmental

contamination in China. Environ Int. 2013;59:208–224.doi: 10.1016/j.envint.2013.06.012.

26. Huang YQ, Wong CK, Zheng JS, et al. Bisphenol A (BPA) in China: a review of sources, environmental

levels, and potential human health impacts. Environ Int. 2012;42:91–99. doi: 10.1016/j.envint.2011.04.010.

27. Lv X, Xiao S, Zhang G, Jiang P, Tang F. Occurrence and removal of phenolic endocrine disrupting chemicals

in the water treatment processes. Sci Rep. 2016;6:22860. doi: 10.1038/srep22860.

28. Yang B, Ying GG, Zhao JL, Liu S, Zhou LJ, Chen F. Removal of selected endocrine disrupting chemicals

(EDCs) and pharmaceuticals and personal care products (PPCPs) during ferrate(VI) treatment of secondary

wastewater effluents. Water Res. 2012;46(7):2194–2204. doi: 10.1016/j.watres.2012.01.047.

29. Yang Y, Ok YS, Kim KH, Kwon EE, Tsang YF. Occurrences and removal of pharmaceuticals and personal

care products (PPCPs) in drinking water and water/sewage treatment plants: a review. Sci Total Environ.

2017;596-597:303–320. doi: 10.1016/j.scitotenv.2017.04.102.

30. Nie M, Yang Y, Liu M, et al. Environmental estrogens in a drinking water reservoir area in Shanghai:

occurrence, colloidal contribution and risk assessment. Sci Total Environ. 2014;487:785–791. doi: 10.1016/j.

scitotenv.2013.12.010.

31. Wang Z, DeWitt JC, Higgins CP, Cousins IT. A never-ending story of per- and polyfluoroalkyl substances

(PFASs)? Environ Sci Technol. 2017;51(5):2508–2518. doi: 10.1021/acs.est.6b04806.

32. Butt CM, Muir DC, Mabury SA. Biotransformation pathways of fluorotelomer-based polyfluoroalkyl

substances: a review. Environ Toxicol Chem. 2014;33(2):243–267. doi: 10.1002/etc.2407.

33. Scheringer M, Trier X, Cousins IT, et al. Helsingor statement on poly- and perfluorinated alkyl substances

(PFASs). Chemosphere. 2014;114:337–339. doi: 10.1016/j.chemosphere.2014.05.044.

34. Blum A, Balan SA, Scheringer M, et al. The Madrid statement on poly- and perfluoroalkyl substances

(PFASs). Environ Health Perspect. 2015;123(5):A107–111. doi: 10.1289/ehp.1509934.

35. Grandjean P, Clapp R. Perfluorinated alkyl substances: emerging insights into health risks. New Solut.

2015;25(2):147–163. doi: 10.1177/1048291115590506.

36. Boronow KE, Brody JG, Schaider LA, Peaslee GF, Havas L, Cohn BA. Serum concentrations of PFASs

and exposure-related behaviors in African American and non-Hispanic white women. J Expo Sci Environ

Epidemiol. 2019;29(2):206–217. doi: 10.1038/s41370-018-0109-y.

37. Noorlander CW, van Leeuwen SP, Te Biesebeek JD, Mengelers MJ, Zeilmaker MJ. Levels of perfluorinated

compounds in food and dietary intake of PFOS and PFOA in the Netherlands. J Agric Food Chem.

2011;59(13):7496–7505. doi: 10.1021/jf104943p.

38. Authority EFS. Perfluoroalkylated substances in food: occurrence and dietary exposure. EFSA journal.

2012;10(6):2743. doi: 10.2903/j.efsa.2012.2743.

39. Vassiliadou I, Costopoulou D, Kalogeropoulos N, et al. Levels of perfluorinated compounds in raw

and cooked Mediterranean finfish and shellfish. Chemosphere. 2015;127:117–126. doi: 10.1016/j.chemosphere.2014.12.081.

40. Jogsten IE, Perello G, Llebaria X, et al. Exposure to perfluorinated compounds in Catalonia, Spain,

through consumption of various raw and cooked foodstuffs, including packaged food. Food Chem Toxicol.

2009;47(7):1577–1583. doi: 10.1016/j.fct.2009.04.004.

41. Wang L, Xiang Z, Stevanovic S, et al. Role of Chinese cooking emissions on ambient air quality and

human health. Sci Total Environ. 2017;589:173–181. doi: 10.1016/j.scitotenv.2017.02.124.

42. Chen WL, Bai FY, Chang YC, Chen PC, Chen CY. Concentrations of perfluoroalkyl substances in foods

and the dietary exposure among Taiwan general population and pregnant women. J Food Drug Anal.

2018;26(3):994–1004. doi: 10.1016/j.jfda.2017.12.011.

43. Haraux E, Braun K, Buisson P, et al. Maternal exposure to domestic hair cosmetics and occupational

endocrine disruptors is associated with a higher risk of hypospadias in the offspring. Int J Environ Res

Public Health. 2016;14(1). doi: 10.3390/ijerph14010027.

44. Anway MD, Skinner MK. Epigenetic programming of the germ line: effects of endocrine disruptors on

the development of transgenerational disease. Reprod Biomed Online. 2008;16(1):23–25. doi: 10.1016/

S1472-6483(10)60553-6.

...

参考文献をもっと見る

全国の大学の
卒論・修論・学位論文
を
一発検索！

この論文の関連論文を見る