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Factors Associated with Cancer-Related Pain Requiring High-Dose Opioid Use in Palliative Cancer Patients

SUMIMOTO Hidetoshi 00306838 HAYASHI Komaki KIMURA Yuri NISHIKAWA Akihito HATTORI Seiko 10437121 HASEGAWA Chiaki MORII Hiroaki TERAMOTO Koji 10452244 MORITA Sachiyo 50335171 DAIGO Yataro 30345029 滋賀医科大学

2021.09.15

概要

Background:
There are no universal tools to predict the necessity of high-dose opioid use for cancer-related pain. Early recognition and interventions for intractable cancer pain could minimize the distress of palliative patients.
Objective:
We sought to identify the clinical factors associated with high-dose opioid use in advanced cancer patients to recognize palliative patients who would develop intractable cancer pain, as early as possible.
Setting/Subjects:
Among 385 in-hospital cancer patients from April 1, 2014 to July 31, 2019, who were referred to the palliative care team for cancer-related pain, clinical factors significantly correlated to high-dose opioid use were retrospectively analyzed.
Measurements:
We conducted a multiple logistic regression analysis to identify variables significantly related to high-dose opioid use (>120 mg/day oral morphine equivalent dose).
Results:
Independent factors of high-dose opioid use included younger age (odds ratio [OR] 0.965, 95% confidence interval [CI] 0.944-0.986, p = 0.001), respiratory cancers (OR 1.882, 95% CI 1.069-3.312, p < 0.001), and opioid switch (OR 2.869, 95% CI 1.497-5.497, p = 0.001). The percentage of correct classifications of the regression equation was 86.9%.
Conclusions:
Younger age, respiratory cancers, and opioid switch were related to high-dose opioid use. Our findings may help palliative caregivers to deal with intractable cancer pain in palliative patients, and thus relieve their distress.

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241

Cite this article as: Sumimoto H, Hayashi K, Kimura Y, Nishikawa M,

Hattori S, Hasegawa C, Morii H, Teramoto K, Morita S, and Daigo Y

(2021) Factors associated with cancer-related pain requiring highdose opioid use in palliative cancer patients, Palliative Medicine

Reports 2:1, 237–241, DOI: 10.1089/pmr.2021.0037.

Abbreviations Used

CI

G-I

NSAIDs

OR

PS

RT

confidence interval

gastrointestinal

nonsteroidal anti-inflammatory drugs

odds ratio

performance status

radiotherapy

Publish in Palliative Medicine Reports

Immediate, unrestricted online access

Rigorous peer review

- Compliance with open access mandates

- Authors retain copyright

- Highly indexed

- Targeted email marketing

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