1. Herzog, E. D., Hermanstyne, T., Smyllie, N. J. & Hastings, M. H. Regulating the suprachiasmatic nucleus (SCN) circadian clockwork:
Interplay between cell-autonomous and circuit-level mechanisms. Cold Spring Harb. Perspect. Biol. 9, a027706 (2017).
2. LeGates, T. A., Fernandez, D. C. & Hattar, S. Light as a central modulator of circadian rhythms, sleep and affect. Nat. Rev. Neurosci.
15, 443–454 (2014).
3. Takahashi, J. S. Transcriptional architecture of the mammalian circadian clock. Nat. Rev. Genet. 18, 164–179 (2017).
4. Colwell, C. S. et al. Disrupted circadian rhythms in VIP- and PHI-deficient mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 285,
R939-949 (2003).
5. Harmar, A. J. et al. The VPAC(2) receptor is essential for circadian function in the mouse suprachiasmatic nuclei. Cell 109, 497–508
(2002).
6. Aton, S. J., Colwell, C. S., Harmar, A. J., Waschek, J. & Herzog, E. D. Vasoactive intestinal polypeptide mediates circadian rhythmicity and synchrony in mammalian clock neurons. Nat. Neurosci. 8, 476–483 (2005).
7. An, S., Irwin, R. P., Allen, C. N., Tsai, C. & Herzog, E. D. Vasoactive intestinal polypeptide requires parallel changes in adenylate
cyclase and phospholipase C to entrain circadian rhythms to a predictable phase. J. Neurophysiol. 105, 2289–2296 (2011).
8. Yamaguchi, Y. et al. Mice genetically deficient in vasopressin V1a and V1b receptors are resistant to jet lag. Science 342, 85–90
(2013).
9. Parsons, M. J. et al. The regulatory factor ZFHX3 modifies circadian function in SCN via an AT motif-driven axis. Cell 162, 607–621
(2015).
10. Hatori, M. et al. Lhx1 maintains synchrony among circadian oscillator neurons of the SCN. Elife 3, e03357 (2014).
11. Bedont, J. L. et al. Lhx1 controls terminal differentiation and circadian function of the suprachiasmatic nucleus. Cell Rep. 7, 609–622
(2014).
12. Doi, M. et al. Circadian regulation of intracellular G-protein signalling mediates intercellular synchrony and rhythmicity in the
suprachiasmatic nucleus. Nat. Commun. 2, 327 (2011).
13. Hayasaka, N. et al. Attenuated food anticipatory activity and abnormal circadian locomotor rhythms in Rgs16 knockdown mice.
PLoS ONE 6, e17655 (2011).
14. Doi, M. et al. Gpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behaviour. Nat. Commun.
7, 10583 (2016).
15. Liu, C. & Reppert, S. M. GABA synchronizes clock cells within the suprachiasmatic circadian clock. Neuron 25, 123–128 (2000).
Scientific Reports |
(2021) 11:22406 |
https://doi.org/10.1038/s41598-021-01764-8
11
Vol.:(0123456789)
www.nature.com/scientificreports/
A Self-archived copy in
Kyoto University Research Information Repository
https://repository.kulib.kyoto-u.ac.jp
16. Albus, H., Vansteensel, M. J., Michel, S., Block, G. D. & Meijer, J. H. A GABAergic mechanism is necessary for coupling dissociable
ventral and dorsal regional oscillators within the circadian clock. Curr. Biol. 15, 886–893 (2005).
17. Myung, J. et al. GABA-mediated repulsive coupling between circadian clock neurons in the SCN encodes seasonal time. Proc. Natl.
Acad. Sci. U. S. A. 112, E3920-3929 (2015).
18. Lall, G. S. & Biello, S. M. Neuropeptide Y, GABA and circadian phase shifts to photic stimuli. Neuroscience 120, 915–921 (2003).
19. Mazuski, C. et al. Entrainment of circadian rhythms depends on firing rates and neuropeptide release of VIP SCN neurons. Neuron
99, 555-563.e555 (2018).
20. Hamnett, R., Crosby, P., Chesham, J. E. & Hastings, M. H. Vasoactive intestinal peptide controls the suprachiasmatic circadian
clock network via ERK1/2 and DUSP4 signalling. Nat. Commun. 10, 542 (2019).
21. Patton, A. P. et al. The VIP-VPAC2 neuropeptidergic axis is a cellular pacemaking hub of the suprachiasmatic nucleus circadian
circuit. Nat. Commun. 11, 3394 (2020).
22. Hughes, A. T. & Piggins, H. D. Behavioral responses of Vipr2-/- mice to light. J. Biol. Rhythms 23, 211–219 (2008).
23. Aten, S. et al. SynGAP is expressed in the murine suprachiasmatic nucleus and regulates circadian-gated locomotor activity and
light-entrainment capacity. Eur. J. Neurosci. 53, 732–749 (2021).
24. Cheng, H. Y. et al. Dexras1 potentiates photic and suppresses nonphotic responses of the circadian clock. Neuron 43, 715–728
(2004).
25. Han, S. et al. Na(V)1.1 channels are critical for intercellular communication in the suprachiasmatic nucleus and for normal circadian rhythms. Proc. Natl. Acad. Sci. U. S. A. 109, E368–E377 (2012).
26. O’Dowd, B. F. et al. A novel gene codes for a putative G protein-coupled receptor with an abundant expression in brain. FEBS Lett.
394, 325–329 (1996).
27. Hoffmeister-Ullerich, S. A., Susens, U. & Schaller, H. C. The orphan G-protein-coupled receptor GPR19 is expressed predominantly
in neuronal cells during mouse embryogenesis. Cell Tissue Res. 318, 459–463 (2004).
28. Lein, E. S. et al. Genome-wide atlas of gene expression in the adult mouse brain. Nature 445, 168–176 (2007).
29. Riker, A. I. et al. The gene expression profiles of primary and metastatic melanoma yields a transition point of tumor progression
and metastasis. BMC Med. Genomics 1, 13 (2008).
30. Kastner, S. et al. Expression of G protein-coupled receptor 19 in human lung cancer cells is triggered by entry into S-phase and
supports G(2)-M cell-cycle progression. Mol. Cancer Res. 10, 1343–1358 (2012).
31. Rao, A. & Herr, D. R. G protein-coupled receptor GPR19 regulates E-cadherin expression and invasion of breast cancer cells.
Biochim. Biophys. Acta Mol. Cell Res. 1864, 1318–1327 (2017).
32. Nakagawa, S., Nguyen Pham, K. T., Shao, X. & Doi, M. Time-restricted G-protein signaling pathways via GPR176, G(z), and RGS16
set the pace of the master circadian clock in the suprachiasmatic nucleus. Int. J. Mol. Sci. 21, 5055 (2020).
33. Pilorz, V., Astiz, M., Heinen, K. O., Rawashdeh, O. & Oster, H. The concept of coupling in the mammalian circadian clock network.
J. Mol. Biol. 432, 3618–3638 (2020).
34. Johnson, C. H., Elliott, J. A. & Foster, R. Entrainment of circadian programs. Chronobiol. Int. 20, 741–774 (2003).
35. Micic, G. et al. The etiology of delayed sleep phase disorder. Sleep Med. Rev. 27, 29–38 (2016).
36. Harrington, M. et al. Behavioral and neurochemical sources of variability of circadian period and phase: Studies of circadian
rhythms of npy-/- mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 292, R1306-1314 (2007).
37. Iwahana, E. et al. Effect of lithium on the circadian rhythms of locomotor activity and glycogen synthase kinase-3 protein expression in the mouse suprachiasmatic nuclei. Eur. J. Neurosci. 19, 2281–2287 (2004).
38. Mieda, M. et al. Cellular clocks in AVP neurons of the SCN are critical for interneuronal coupling regulating circadian behavior
rhythm. Neuron 85, 1103–1116 (2015).
39. Shan, Y. et al. Dual-color single-cell imaging of the suprachiasmatic nucleus reveals a circadian role in network synchrony. Neuron
108, 164-179.e167 (2020).
40. DeBruyne, J. P., Weaver, D. R. & Reppert, S. M. CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock.
Nat. Neurosci. 10, 543–545 (2007).
41. Fukuhara, C. et al. Phase advances of circadian rhythms in somatostatin depleted rats: Effects of cysteamine on rhythms of locomotor activity and electrical discharge of the suprachiasmatic nucleus. J. Comp. Physiol. A 175, 677–685 (1994).
42. Jakubcakova, V. et al. Light entrainment of the mammalian circadian clock by a PRKCA-dependent posttranslational mechanism.
Neuron 54, 831–843 (2007).
43. Kawaguchi, C. et al. Lipocalin-type prostaglandin D synthase regulates light-induced phase advance of the central circadian rhythm
in mice. Commun. Biol. 3, 557 (2020).
44. Hamada, T., Shibata, S., Tsuneyoshi, A., Tominaga, K. & Watanabe, S. Effect of somatostatin on circadian rhythms of firing and
2-deoxyglucose uptake in rat suprachiasmatic slices. Am. J. Physiol. 265, R1199-1204 (1993).
45. Cheng, A. H. et al. SOX2-dependent transcription in clock neurons promotes the robustness of the central circadian pacemaker.
Cell Rep. 26, 3191-3202.e3198 (2019).
46. Kroeze, W. K. et al. PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome. Nat. Struct.
Mol. Biol. 22, 362–369 (2015).
47. Foster, S. R. et al. Discovery of human signaling systems: Pairing peptides to G protein-coupled receptors. Cell 179, 895-908.e821
(2019).
48. Colosimo, D. A. et al. Mapping interactions of microbial metabolites with human G-protein-coupled receptors. Cell Host Microbe
26, 273-282.e277 (2019).
49. Stein, L. M., Yosten, G. L. & Samson, W. K. Adropin acts in brain to inhibit water drinking: Potential interaction with the orphan
G protein-coupled receptor, GPR19. Am. J. Physiol. Regul. Integr. Comp. Physiol. 310, R476-480 (2016).
50. Hossain, M. S., Mineno, K. & Katafuchi, T. Neuronal orphan G-protein coupled receptor proteins mediate plasmalogens-induced
activation of ERK and Akt signaling. PLoS ONE 11, e0150846 (2016).
51. Thapa, D. et al. Adropin regulates pyruvate dehydrogenase in cardiac cells via a novel GPCR-MAPK-PDK4 signaling pathway.
Redox Biol. 18, 25–32 (2018).
52. Wen, S. et al. Spatiotemporal single-cell analysis of gene expression in the mouse suprachiasmatic nucleus. Nat. Neurosci. 23,
456–467 (2020).
53. Park, J. et al. Single-cell transcriptional analysis reveals novel neuronal phenotypes and interaction networks involved in the central
circadian clock. Front. Neurosci. 10, 481 (2016).
54. Morris, E. L. et al. Single-cell transcriptomics of suprachiasmatic nuclei reveal a Prokineticin-driven circadian network. EMBO J.
40, e108614 (2021).
55. Xu, P. et al. NPAS4 regulates the transcriptional response of the suprachiasmatic nucleus to light and circadian behavior. Neuron
109, 3268-3282.e6 (2021).
56. Kilkenny, C., Browne, W. J., Cuthill, I. C., Emerson, M. & Altman, D. G. Improving bioscience research reporting: The ARRIVE
guidelines for reporting animal research. PLoS Biol. 8, e1000412 (2010).
57. Shigeyoshi, Y. et al. Light-induced resetting of a mammalian circadian clock is associated with rapid induction of the mPer1
transcript. Cell 91, 1043–1053 (1997).
58. Nakanishi, H., Higuchi, Y., Kawakami, S., Yamashita, F. & Hashida, M. piggyBac transposon-mediated long-term gene expression
in mice. Mol. Ther. 18, 707–714 (2010).
Scientific Reports |
Vol:.(1234567890)
(2021) 11:22406 |
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www.nature.com/scientificreports/
A Self-archived copy in
Kyoto University Research Information Repository
https://repository.kulib.kyoto-u.ac.jp
59. Doi, M. et al. Non-coding cis-element of Period2 is essential for maintaining organismal circadian behaviour and body temperature
rhythmicity. Nat. Commun. 10, 2563 (2019).
Acknowledgements
The authors thank Ichie Nishimura for technical support. This work was supported in part by research Grants
from the Project for Elucidating and Controlling Mechanisms of Ageing and Longevity, the Basis for Supporting Innovative Drug Discovery and Life Science Research program of the Japan Agency for Medical Research
and Development (JP21gm5010002 and JP21am0101092), the Ministry of Education, Culture, Sports, Science
and Technology of Japan (17H01524, 18H04015, 20B307), the Kobayashi Foundation, and the Kusunoki 125 of
Kyoto University 125th Anniversary Fund.
Author contributions
M.D. conceived the project; M.D. and H.O. designed the research; Y.Y., I.M., and K.G. performed experiments
in collaboration with S.D., H.Z., G.S., H.S., and T.M.; M.D. and Y.Y. wrote the paper with input from all authors.
Competing interests The authors declare no competing interests.
Additional information
Supplementary Information The online version contains supplementary material available at https://doi.org/
10.1038/s41598-021-01764-8.
Correspondence and requests for materials should be addressed to H.O. or M.D.
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