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（特に重要な文献については，番号をゴシック体で表記している．）

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Endothelium-dependent Hyperpolarization (EDH) in Hypertension

Kenichi GOTO

Department of Health Sciences, Graduate School of Medical Sciences,

Kyushu University, Fukuoka, Japan

Abstract

Hypertension is one of the major risk factors for cardiovascular disease. While endothelium-derived

nitric oxide is a major vasodilator in large-size vessels, endothelium-dependent hyperpolarization

(EDH) initiated in endothelial cells plays a central role in endothelium-dependent vasodilation in

resistance size arteries. In animal models, EDH ‒mediated relaxations are impaired in hypertension

and antihypertensive treatments restore such impairments. However, the underlying mechanisms of

impaired EDH and its improvement by antihypertensive treatments are poorly understood. Emerging

evidence suggests that alterations of endothelial ion channels such as small conductance Ca2+

-activated K+ (SKCa) and transient receptor potential vanilloid type 4 (TRPV4) channels contribute to

the impaired EDH in hypertension. In this review, we present the current knowledge about changes in

EDH in hypertension. We then explore underlying mechanisms of impaired EDH and potential

therapeutic approaches aimed at the prevention and restoration of impaired EDH in hypertension,

with special reference to the role of endothelial SKCa channels and TRPV4 channels.

Key words : endothelial function, endothelium-dependent hyperpolarization, hypertension, small

conductance Ca2+ -activated K+ channel, transient receptor potential vanilloid type 4

channel

著者プロフィール

後藤 健一（ごとう けんいち）

九州大学教授（大学院医学研究院保健学部門看護学分野）．医学博士．

◆略歴 1968 年福岡県に生まれる．1994 年九州大学医学部卒業．

2000 年九州大学健康科学センター研究生修了．2002 年オーストラリア国立大学ジョン

カーティンスクールオブメディカルリサーチ博士研究員．2009 年九州歯科大学総合内科助

教．2014 年九州大学病院腎高血圧脳血管内科助教．2018 年九州大学病院腎高血圧脳血管

内科講師．2020 年より現職．

◆研究テーマと抱負 高血圧における血管内皮機能障害の機序の解明を目指し，主に電気生理学的

な手法を用いた基礎研究に取り組んできました．職域集団を対象とした高血圧の臨床研究

にも携わっています．今後は多職種連携で高血圧発症予防につながる研究をすすめていき

たいと思っています．

◆趣味 読書，ドライブ

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