Study on the roles of Rumeng Epithelial IGFBP and TLR5 for Adaptation to Rumeng engvironmengtal Changes in Cattle

概要

Taken together, these studies highlight the role of IGFBP and TLR5 during rumen environmental changes in rumen epithelial cells as follows:

1. The downregulation of IGFBP2, IGFBP3, and IGFBP6 may promote the development of rumen papillae during the weaning period.

2. IGFBP2 and IGFBP6 expression may be regulated by SCFA, not low pH, and IGFBP might regulate cell proliferation by inhibiting the role of IGF-I.

3. The TLR5 ligand may stimulate IL-1β paracrine and autocrine mechanisms in rumen epithelial cells and IL-1β may contribute to the maintenance of the homeostasis of rumen epithelial cells by promoting antimicrobial peptides and CXCL8, which inhibit bacterial penetration.