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Acknowledgements
This study was supported in part by JSPS KAKENHI Grant Numbers JP15K08496, JP18H02664, and JP18K19449,
grants from the Takeda Science Foundation, Senri Life Science Foundation, and the Joint Usage/Research Center
Program of Institute for Frontier Life and Medical Sciences, Kyoto University. (T.H.). S.Y. and Y.N. are supported
by the Osaka University Medical Doctor Scientist Training Program.
Author contributions
S.Y., S.N., Y.N. and T.H. conducted the experiments; S.Y., S.N., K.T., K.U. and T.H. analyzed the data; Y.S., Y.K.,
and K.M. established NMR cells; T.H. conceived and designed the study; Y.K. and T.H. wrote the paper.
Competing interests The authors declare no competing interests.
Additional information
Supplementary Information The online version contains supplementary material available at https://doi.
org/10.1038/s41598-021-84962-8.
Correspondence and requests for materials should be addressed to T.H.
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