Royal College of Obstetricians and Gynecologists: The Investigation and
Treatment of Couples with Recurrent First Trimester and Second-Trimester Miscarriage. Green-top Guideline No. 17. London: The Royal
College of Obstetricians and Gynaecologists; 2011.
ESHRE Guideline Group on RPL, Bender Atik R, Christiansen OB,
Elson J, et al. ESHRE guideline: recurrent pregnancy loss. Hum
Reprod Open. 2018;2018:hoy004.
Sugiura-Ogasawara M, Suzuki S, Ozaki Y, et al. Frequency of recurrent spontaneous abortion and its influence on further marital relationship and illness: the Okazaki Cohort Study in Japan. J Obstet
Gynaecol Res. 2013;39:126–131.
Practice Committee of the American Society for Reproductive Medicine. Evaluation and treatment of recurrent pregnancy loss: a committee opinion. Fertil Steril. 2012;98:1103–1111.
Morita K, Ono Y, Takeshita T, et al. Risk factors and outcomes of
recurrent pregnancy loss in Japan. J Obstet Gynaecol Res.
2019;45:1997–2006.
6 Ebina Y, Nishino Y, Deguchi M, Maesawa Y, Nakashima Y,
Yamada H. Natural killer cell activity in women with recurrent miscarriage: etiology and pregnancy outcome. J Reprod Immunol.
2017;120:42–47.
Guerrero B, Hassouneh F, Delgado E, Casado JG, Tarazona RJ.
Natural killer cells in recurrent miscarriage: an overview. J Reprod
Immunol. 2020;142:103209.
www.thelancet.com Vol 50 Month August, 2022
23
24
25
26
27
28
29
Nakashima A, Shima T, Inada K, Ito M, Saito S. The balance of the
immune system between T cells and NK cells in miscarriage. Am
J Reprod Immunol. 2012;67:304–310.
Yamada H, Morikawa M, Furuta I, et al. Intravenous immunoglobulin treatment in women with recurrent abortions: increased cytokine levels and reduced Th1/Th2 lymphocyte ratio in peripheral
blood. Am J Reprod Immunol. 2003;49:84–89.
Lee SK, Kim JY, Lee M, Gilman-Sachs A, Kwak-Kim J. Th17 and
regulatory T cells in women with recurrent pregnancy loss. Am
J Reprod Immunol. 2012;67:311–318.
Wong LF, Porter TF, Scott JR. Immunotherapy for recurrent miscarriage. Cochran Database Syst Rev. 2014;10:CD000112.
Laskin CA, Bombardier C, Hannah ME, et al. Prednisone and aspirin in women with autoantibodies and unexplained recurrent fetal
loss. N Engl J Med. 1997;337:148–153.
de Jong PG, Kaandorp S, Di Nisio M, Goddijn M, Middeldorp S.
Aspirin and/or heparin for women with unexplained recurrent
miscarriage with or without inherited thrombophilia. Cochrane
Database Syst Rev. 2014;7:CD004734.
Coomarasamy A, Williams H, Truchanowicz E, et al. A randomized trial of progesterone in women with recurrent miscarriages. N
Engl J Med. 2015;373:2141–2148.
The German RSA/IVIG Group. Intravenous immunoglobulin in
the prevention of recurrent miscarriage. Br J Obstet Gynaecol.
1994;101:1072–1077.
Christiansen OB, Mathiesen O, Husth M, et al. Placebo-controlled
trial of treatment of unexplained secondary recurrent spontaneous
abortions and recurrent late spontaneous abortions with i.v. immunoglobulin. Hum Reprod. 1995;10:2690–2695.
Coulam CB, Krysa L, Stern JJ, Bustillo M. Intravenous immunoglobulin for treatment of recurrent pregnancy loss. Am J Reprod
Immunol. 1995;34:333–337.
Perino A, Vassiliadis A, Vucetich A, et al. Short-term therapy for
recurrent abortion using intravenous immunoglobulins: results of
a double-blind placebo-controlled Italian study. Hum Reprod.
1997;12:2388–2392.
Stephenson MD, Dreher K, Houlihan E, Wu V. Prevention of unexplained recurrent spontaneous abortion using intravenous immunoglobulin: a prospective, randomized, double-blinded, placebocontrolled trial. Am J Reprod Immunol. 1998;39:82–88.
Jablonowska B, Selbing A, Palfi M, Ernerudh J, Kjellberg S,
Lindton B. Prevention of recurrent spontaneous abortion by intravenous immunoglobulin: a double-blind placebo-controlled study.
Hum Reprod. 1999;14:838–841.
Christiansen OB, Pedersen B, Rosgaard A, Husth M. A randomized, double-blind, placebo-controlled trial of intravenous immunoglobulin in the prevention of recurrent miscarriage: evidence for a
therapeutic effect in women with secondary recurrent miscarriage.
Hum Reprod. 2002;17:809–816.
Stephenson MD, Kutteh WH, Purkiss S, et al. Intravenous immunoglobulin and idiopathic secondary recurrent miscarriage: a
multicentered randomized placebo-controlled trial. Hum Reprod.
2010;25:2203–2209.
Hutton B, Sharma R, Fergusson D, et al. Use of intravenous
immunoglobulin for treatment of recurrent miscarriage: a systematic review. BJOG. 2007;114:134–142.
Christiansen O, Larsen EC, Egerup P, Lunoee L, Egestad L, Nielsen
HS. Intravenous immunoglobulin treatment for secondary recurrent miscarriage: a randomised, double-blind, placebo-controlled
trial. BJOG. 2015;122:500–508.
Yamada H, Kishida T, Kobayashi N, Kato EH, Hoshi N, Fujimoto
S. Massive immunoglobulin treatment in women with four or
more recurrent spontaneous primary abortions of unexplained aetiology. Hum Reprod. 1998;13:2620–2623.
Yamada H, Takeda M, Maezawa Y, et al. A high dose intravenous immunoglobulin therapy for women with four or more
recurrent spontaneous abortions. ISRN Obstet Gynecol.
2012;2012:512732.
Miyakis S, Lockshin MD, Atsumi T, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost. 2006;4:295–306.
Christiansen OB, Kolte AM, Krog MC, et al. Treatment with intravenous immunoglobulin in patients with recurrent pregnancy loss:
an update. J Reprod Immunol. 2019;133:37–42.
Gelfand EW. Intravenous immune globulin in autoimmune and
inflammatory diseases. N Engl J Med. 2012;367:2015–2025.
11
Articles
30
31
12
Galeotti C, Kaveri SV, Bayry J. IVIG-mediated effector functions in
autoimmune and inflammatory diseases. Int Immunol.
2017;29:491–498.
Takeda M, Yamada H, Iwabuchi K, et al. Administration of
high-dose intact immunoglobulin has an anti-resorption effect
in a mouse model of reproductive failure. Mol Hum Reprod.
2007;13:807–814.
32
33
Tanaka J, Kitashoji A, Fukunaga Y, Kashihara J, Nakano A,
Kamizono A. Intravenous immunoglobulin suppresses abortion
relates to an increase in the CD44bright NK subset in recurrent
pregnancy loss model mice. Biol Reprod. 2016;95:37.
Greco E, Minasi MG, Fiorentino F. Healthy babies after intrauterine transfer of mosaic aneuploid blastocysts. N Engl J Med.
2015;373:2089–2090.
www.thelancet.com Vol 50 Month August, 2022
...
論文の公開元へ
