書き出し
Novel Aza‐Michael Addition‐Asymmetric Protonation to α,β‐Unsaturated Carboxylic Acids with Chiral Thiourea‐Boronic Acid Hybrid Catalysts
概要
Novel aza-michael addition-asymmetric protonation to unsaturated carboxylic acids with chiral thiourea-boronic acid hybrid catalysts. #asymmetric protonationIn this study, an efficient method has been developed for controlling carbonyl α-chirality with functionalizing β-position by the conjugate addition-asymmetric protonation (CAAP) of α, β-unsaturated carboxylic acids using chiral thiourea-amino boronic acid hybrid catalysts. In addition, the method is applied to the asymmetric synthesis of biologically active compounds.