Carbonic anhydrase IX enhances tumor cell proliferation and tumor progression in osteosrcoma

1. Mcdonald PC, Winum JY, Supuran CT, Dedhar S. Recent developments

in targeting carbonic anhydrase ix for cancer therapeutics. Oncotarget.

2002;3(1):84–97.

2. Parks SK, Chiche J, Pouyssegur J. pH control mechanisms of tumor

survival and growth. J Cell Physiol. 2011;226(2):299–308.

3. Cianchi F, Vinci MC, Supuran CT, et al. Selective inhibition of carbonic

anhydrase IX decreases cell proliferation and induces ceramide-mediated

apoptosis in human cancer cells. J Pharmacol Exp Ther. 2010;334(3):

710–719.

4. Shin HJ, Rho SB, Jung DC, Han IO, Oh ES, Kim JY. Carbonic anhydrase

IX (CA9) modulates tumor-associated cell migration and invasion. J

Cell Sci. 2011;124(Pt 7):1077–1087.

5. Csaderova L, Debreova M, Radvak P, et al. The effect of carbonic

anhydrase IX on focal contacts during cell spreading and migration.

Front Physiol. 2013;4:271.

6. Matsubara T, Diresta GR, Kakunaga S, Li D, Healey JH. Additive

Influence of Extracellular pH, Oxygen Tension, and Pressure on Invasiveness and Survival of Human Osteosarcoma Cells. Front Oncol.

2013;3:199.

7. Ilie M, Mazure NM, Hofman V, et al. High levels of carbonic anhydrase IX in tumour tissue and plasma are biomarkers of poor prognostic in patients with non-small cell lung cancer. Br J Cancer. 2010;

102(11):1627–1635.

8. Korkeila E, Talvinen K, Jaakkola PM, et al. Expression of carbonic

anhydrase IX suggests poor outcome in rectal cancer. Br J Cancer.

2009;100(6):874–880.

9. Swietach P, Vaughan-Jones RD, Harris AL. Regulation of tumor pH

and the role of carbonic anhydrase 9. Cancer Metastasis Rev. 2007;

26(2):299–310.

10. Lou Y, Mcdonald PC, Oloumi A, et al. Targeting tumor hypoxia:

suppression of breast tumor growth and metastasis by novel carbonic

anhydrase IX inhibitors. Cancer Res. 2011;71(9):3364–3376.

11. Parkkila S, Rajaniemi H, Parkkila AK, et al. Carbonic anhydrase inhibitor suppresses invasion of renal cancer cells in vitro. Proc Natl Acad

Sci U S A. 2000;97(5):2220–2224.

12. Nakazora S, Matsumine A, Iino T, et al. The cleavage of N-cadherin

is essential for chondrocyte differentiation. Biochem Biophys Res

Commun. 2010;400(4):493–499.

13. Shintani K, Matsumine A, Kusuzaki K, et al. Expression of hypoxiainducible factor (HIF)-1alpha as a biomarker of outcome in soft-tissue

sarcomas. Virchows Arch. 2006;449(6):673–681.

14. Li G, Bilal I, Gentil-Perret A, et al. CA9 as a molecular marker for

differential diagnosis of cystic renal tumors. Urol Oncol. 2012;30(4):

463–468.

15. Saarnio J, Parkkila S, Parkkila AK, et al. Immunohistochemical study

of colorectal tumors for expression of a novel transmembrane carbonic

anhydrase, MN/CA IX, with potential value as a marker of cell proliferation. Am J Pathol. 1998;153(1):279–285.

OncoTargets and Therapy 2018:11

CA IX expression in osteosarcoma

16. Giatromanolaki A, Koukourakis MI, Sivridis E, et al. Expression of

hypoxia-inducible carbonic anhydrase-9 relates to angiogenic pathways

and independently to poor outcome in non-small cell lung cancer.

Cancer Res. 2001;61(21):7992–7998.

17. Vermylen P, Roufosse C, Burny A, et al. Carbonic anhydrase IX antigen

differentiates between preneoplastic malignant lesions in non-small

cell lung carcinoma. Eur Respir J. 1999;14(4):806–811.

18. Olive PL, Aquino-Parsons C, Macphail SH, et al. Carbonic anhydrase

9 as an endogenous marker for hypoxic cells in cervical cancer. Cancer

Res. 2001;61(24):8924–8929.

19. Turner KJ, Crew JP, Wykoff CC, et al. The hypoxia-inducible genes

VEGF and CA9 are differentially regulated in superficial vs invasive

bladder cancer. Br J Cancer. 2002;86(8):1276–1282.

20. Hui EP, Chan AT, Pezzella F, et al. Coexpression of hypoxia-inducible

factors 1alpha and 2alpha, carbonic anhydrase IX, and vascular endothelial growth factor in nasopharyngeal carcinoma and relationship to

survival. Clin Cancer Res. 2002;8(8):2595–2604.

21. Span PN, Bussink J, Manders P, Beex LV, Sweep CG. Carbonic

anhydrase-9 expression levels and prognosis in human breast cancer:

association with treatment outcome. Br J Cancer. 2003;89(2):

271–276.

22. Måseide K, Pintilie M, Kandel R, Hill RP. Can sparsely and heterogeneously expressed proteins be detected using tissue microarrays?

A simulation study of the hypoxia marker carbonic anhydrase IX

(CA IX) in human soft tissue sarcoma. Pathol Res Pract. 2008;204(3):

175–183.

23. Wykoff CC, Beasley NJ, Watson PH, et al. Hypoxia-inducible expression of tumor-associated carbonic anhydrases. Cancer Res. 2000;

60(24):7075–7083.

24. Perut F, Carta F, Bonuccelli G, et al. Carbonic anhydrase IX inhibition

is an effective strategy for osteosarcoma treatment. Expert Opin Ther

Targets. 2015;19(12):1593–1605.

25. Cardone RA, Casavola V, Reshkin SJ. The role of disturbed pH

dynamics and the Na+/H+ exchanger in metastasis. Nat Rev Cancer.

2005;5(10):786–795.

26. Sedlakova O, Svastova E, Takacova M, Kopacek J, Pastorek J,

Pastorekova S. Carbonic anhydrase IX, a hypoxia-induced catalytic

component of the pH regulating machinery in tumors. Front Physiol.

2014;4:400.

27. Potter C, Harris AL. Hypoxia inducible carbonic anhydrase IX, marker

of tumour hypoxia, survival pathway and therapy target. Cell Cycle.

2004;3(2):164–167.

28. Svastová E, Hulíková A, Rafajová M, et al. Hypoxia activates the

capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH. FEBS Lett. 2004;577(3):439–445.

29. Vukovic V, Tannock IF. Influence of low pH on cytotoxicity of paclitaxel,

mitoxantrone and topotecan. Br J Cancer. 1997;75(8):1167–1172.

30. Raghunand N, He X, van Sluis R, et al. Enhancement of chemotherapy

by manipulation of tumour pH. Br J Cancer. 1999;80(7):1005–1011.

31. Stubbs M, Mcsheehy PM, Griffiths JR, Bashford CL. Causes and consequences of tumour acidity and implications for treatment. Mol Med

Today. 2000;6(1):15–19.

32. Teicher BA, Liu SD, Liu JT, Holden SA, Herman TS. A carbonic anhydrase inhibitor as a potential modulator of cancer therapies. Anticancer

Res. 1993;13(5A):1549–1556.

33. Thiry A, Dogné JM, Masereel B, Supuran CT. Targeting tumorassociated carbonic anhydrase IX in cancer therapy. Trends Pharmacol

Sci. 2006;27(11):566–573.

34. Svastová E, Zilka N, Zat’ovicová M, et al. Carbonic anhydrase IX

reduces E-cadherin-mediated adhesion of MDCK cells via interaction

with beta-catenin. Exp Cell Res. 2003;290(2):332–345.

35. von Neubeck B, Gondi G, Riganti C, et al. An inhibitory antibody targeting carbonic anhydrase XII abrogates chemoresistance and significantly

reduces lung metastases in an orthotopic breast cancer model in vivo.

Int J Cancer. 2018;143(8):2065–2075.

submit your manuscript | www.dovepress.com

Dovepress

6885

Okuno et al

OncoTargets and Therapy

Publish your work in this journal

OncoTargets and Therapy is an international, peer-reviewed, open

access journal focusing on the pathological basis of all cancers, potential

targets for therapy and treatment protocols employed to improve the

management of cancer patients. The journal also focuses on the impact

of management programs and new therapeutic agents and protocols on

Dovepress

Dovepress

patient perspectives such as quality of life, adherence and satisfaction.

The manuscript management system is completely online and includes

a very quick and fair peer-review system, which is all easy to use. Visit

http://www.dovepress.com/testimonials.php to read real quotes from

published authors.

Submit your manuscript here: http://www.dovepress.com/oncotargets-and-therapy-journal

6886

submit your manuscript | www.dovepress.com

Dovepress

OncoTargets and Therapy 2018:11

...