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Inhibition of VEGF receptors induces pituitary apoplexy: an experimental study in mice

Sugita, Yoshito 京都大学 DOI:10.14989/doctor.k24529

2023.03.23

概要

Anti-angiogenic therapy has been developed for the treatment of a variety of cancers.
Vascular endothelial growth factor A (VEGF-A) is well known to be the main molecular
driver of tumor angiogenesis [1]. Currently, bevacizumab, a recombinant monoclonal
antibody targeting VEGF-A, is widely used for the treatment of high-grade gliomas [2,
3]. Hemorrhage is one of the most common adverse events of anti-VEGF therapy for
cancer [4, 5]. The mechanisms of hemorrhagic complications induced by anti-VEGF
agents are complex and remain to be clarified. ...

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