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Chapter 6

Acknowledgements

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Acknowledgements

Thanks to all Fujita lab members, I could complete my research.

Specially thanks to Professor Fujita. He introduced RIG-I protein and guided me to

innate immune field. Thanks to his massive knowledges and experiment technique, I

was able to try lots of interesting experiments. Especially, his attitude towards

research always inspires me not to lose my own way.

Also, thanks to Professor Shige H. Yoshimura, allowed me to use AFM machine.

I appreciate to Ivana for helping me to plan RIG-I experiments and teaching

experiments including AFM, protein purification, Seong-Wook Oh for advice and

support, and Koshiba-san, who is working for lab as secretary, for many helps.

I appreciate to Prof. Noda and three referees for great helps for reviewing my thesis. I

could study how to present scientific results correctly and how to make precise

statistical analysis.

Lastly, I sincerely appreciate my family for always giving me unstinting support and

love.

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This study was supported by research grants from Japan Agency for Medical Research

and Development: Research Program on Emerging and Re-emerging Infectious

Diseases [jp19fk0108081h1001, jp20fk0108081h1202 to F.T.]; Japan Society for the

Promotion of Science; Fund for the Promotion of Joint International Research:

Fostering Joint International Research (B) [18KK0232 to F.T.]; Core to Core Program:

Grant-in-Aid for Scientific Research ‘B’ [18H02344 to F.T.]. It was also funded by

the Deutsche Forschungsgemeinschaft (German Research Foundation) under

Germany’s Excellence Strategy–EXC2151–390873048 and TRR237, and Deutsche

Forschungsgemeinschaft

(DFG,

German

Research

Foundation)

EXC

2151:

ImmunoSensation2, Project number 390873048; DFG TRR 237, Project number

369799452 (B22). Funding for open access charge: DFG ImmunoSensation2.

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This thesis is based on the material contained in the following scholarly paper:

Mechanisms of length‐dependent recognition of viral double‐stranded RNA by

RIG‐I

Jung Hyun Im, Ivana Duic, Shige H. Yoshimura, Koji Onomoto, Mitsutoshi

Yoneyama, Hiroki Kato and Takashi Fujita

Scientific Reports, Nature Portfolio, volume 13, article number 6318

Published: 18 April 2023

DOI: 10.1038/s41598-023-33208-w

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...