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7. 謝辞
本研究を行う上で有益な御指導、御討論、御助力を賜りました東京大学大学院薬学系研究科
蛋⽩構造生物学教室 清水 敏之 教授に心から御礼申し上げます。
本研究を進めるに当たり、一から実験の御指導、御助言を賜りました東京大学大学院薬学系
研究科蛋⽩構造生物学教室 大⼾ 梅治 准教授に心から御礼申し上げます。
本研究の共同研究者として、レポータージーンアッセイを用いた活性測定を行ってくださ
った東京大学医科学研究所感染・免疫部門感染遺伝学分野 三宅 健介 教授、柴田 琢磨 博
士および佐藤 亮太 博士に心から御礼申し上げます。
本研究の共同研究者として、LC-MS を用いた結晶溶液の分析を行ってくださった首都大学
東京大学院理工学研究科分子物質科学専攻 礒邉 俊明 特任教授、田岡 万悟 博士、山内 芳
雄 博士に心から御礼申し上げます。
本研究の共同研究者として、SV-AUC を用いた TLR7 の分析を行ってくださった大阪大学
大学院工学研究科生命先端工学専攻 内山 進 教授および Elena Krayukhina 博士に心から
御礼申し上げます。
本研究の共同研究者として、IMDQ を提供してくださったミネソタ大学 Sunil A. David 教
授および Nikunj M. Shukla 博士に心から御礼申し上げます。
本研究の共同研究者として、リガンド (Cpd-1~Cpd-7) を提供してくださった大日本住友製
228
薬株式会社 東城慎吾 博士に心から御礼申し上げます。
本研究の共同研究者として、Glacios 電子顕微鏡測定を協力してくださった国立研究開発法
人理化学研究所 放射光科学研究センター 山本 雅貴 部門長および重松 秀樹 博士に心か
ら御礼申し上げます。
本研究の電子顕微鏡測定を協力してくださった東京大学医学系研究科・生体構造学分野 吉
川 雅英 教授、包 明久 博士および坂巻 陽一 技術補佐員に心から御礼申し上げます。
本研究の電子顕微鏡測定を協力してくださった高エネルギー加速器研究機構・Cryo-EM
facility 千田 俊哉 教授、安達 成彦 博士、川崎 政人 博士に心から御礼申し上げます。
本研究の先行研究者として、ベクターの作成などを行ってくださった元東京大学大学院薬
学系研究科蛋⽩構造生物学教室 丹治 裕美 博士に心から御礼申し上げます。
本研究における X 線回折実験において、有益な御助力を賜りました大型放射光施設 Photon
Factory 山田 悠介 博士、篠田 晃 博士およびビームラインスタッフの皆様に心から御礼申
し上げます。
本研究における X 線回折実験において、有益な御助力を賜りました大型放射光施設 SPring8 平田 邦夫 博士およびビームラインスタッフの皆様に心から御礼申し上げます。
東京大学大学院薬学系研究科蛋⽩構造生物学教室の皆様には日頃から大変御世話になりま
した。感謝いたします。
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