Acosta-Alvear D, Zhou Y, Blais A, Tsikitis M, Lents NH, Arias C, Lennon CJ,
Kluger Y, Dynlacht BD (2007) XBP1 controls diverse cell type- and
condition-specific transcriptional regulatory networks. Mol Cell 27:
53–66. doi:10.1016/j.molcel.2007.06.011
Harding HP, Zeng H, Zhang Y, Jungries R, Chung P, Plesken H, Sabatini DD, Ron
D (2001) Diabetes mellitus and exocrine pancreatic dysfunction in
Perk-/- mice reveals a role for translational control in secretory cell
survival. Mol Cell 7: 1153–1163. doi:10.1016/s1097-2765(01)00264-7
Adachi Y, Yamamoto K, Okada T, Yoshida H, Harada A, Mori K (2008) ATF6 is a
transcription factor specializing in the regulation of quality control
Harding HP, Zhang Y, Zeng H, Novoa I, Lu PD, Calfon M, Sadri N, Yun C, Popko B,
Paules R, et al (2003) An integrated stress response regulates amino
XBP1-mediated rescue of heart failure induced by ER stress
https://doi.org/10.26508/lsa.202201771
Jin et al.
vol 6 | no 7 | e202201771
18 of 20
acid metabolism and resistance to oxidative stress. Mol Cell 11:
619–633. doi:10.1016/s1097-2765(03)00105-9
Harris SP, Bartley CR, Hacker TA, McDonald KS, Douglas PS, Greaser ML,
Powers PA, Moss RL (2002) Hypertrophic cardiomyopathy in cardiac
myosin binding protein-C knockout mice. Circ Res 90: 594–601.
doi:10.1161/01.res.0000012222.70819.64
Haze K, Yoshida H, Yanagi H, Yura T, Mori K (1999) Mammalian transcription
factor ATF6 is synthesized as a transmembrane protein and activated
by proteolysis in response to endoplasmic reticulum stress. Mol Biol
Cell 10: 3787–3799. doi:10.1091/mbc.10.11.3787
Haze K, Okada T, Yoshida H, Yanagi H, Yura T, Negishi M, Mori K (2001)
Identification of the G13 (cAMP-response-element-binding proteinrelated protein) gene product related to activating transcription
factor 6 as a transcriptional activator of the mammalian unfolded
protein response. Biochem J 355: 19–28. doi:10.1042/bj3550019
Hetz C, Zhang K, Kaufman RJ (2020) Mechanisms, regulation and functions of
the unfolded protein response. Nat Rev Mol Cell Biol 21: 421–438.
doi:10.1038/s41580-020-0250-z
Hitzel J, Lee E, Zhang Y, Bibli SI, Li X, Zukunft S, Pflüger B, Hu J, Schürmann C,
Vasconez AE, et al (2018) Oxidized phospholipids regulate amino acid
metabolism through MTHFD2 to facilitate nucleotide release in
endothelial cells. Nat Commun 9: 2292. doi:10.1038/s41467-018-046020
Houweling AC, van Borren MM, Moorman AF, Christoffels VM (2005)
Expression and regulation of the atrial natriuretic factor encoding
gene during development and disease. Cardiovasc Res 67: 583–593.
doi:10.1016/j.cardiores.2005.06.013
Ishikawa T, Taniguchi Y, Okada T, Takeda S, Mori K (2011) Vertebrate unfolded
protein response: Mammalian signaling pathways are conserved in
medaka fish. Cell Struct Funct 36: 247–259. doi:10.1247/csf.11036
Ishikawa T, Okada T, Ishikawa-Fujiwara T, Todo T, Kamei Y, Shigenobu S,
Tanaka M, Saito TL, Yoshimura J, Morishita S, et al (2013) ATF6α/
β-mediated adjustment of ER chaperone levels is essential for
development of the notochord in medaka fish. Mol Biol Cell 24:
1387–1395. doi:10.1091/mbc.e12-11-0830
Ishikawa T, Kashima M, Nagano AJ, Ishikawa-Fujiwara T, Kamei Y, Todo T, Mori
K (2017) Unfolded protein response transducer IRE1-mediated
signaling independent of XBP1 mRNA splicing is not required for
growth and development of medaka fish. Elife 6: e26845. doi:10.7554/
elife.26845
Ishikawa T, Ansai S, Kinoshita M, Mori K (2018) A collection of transgenic
medaka strains for efficient site-directed transgenesis mediated by
phiC31 integrase. G3 (Bethesda) 8: 2585–2593. doi:10.1534/
g3.118.200130
Kalra PR, Clague JR, Bolger AP, Anker SD, Poole-Wilson PA, Struthers AD, Coats
AJ (2003) Myocardial production of C-type natriuretic peptide in
chronic heart failure. Circulation 107: 571–573. doi:10.1161/
01.cir.0000047280.15244.eb
Kamemura K, Moriya H, Ukita Y, Okumura M, Miura M, Chihara T (2022)
Endoplasmic reticulum proteins Meigo and Gp93 govern dendrite
targeting by regulating Toll-6 localization. Dev Biol 484: 30–39.
doi:10.1016/j.ydbio.2022.02.002
Kamitani M, Kashima M, Tezuka A, Nagano AJ (2019) Lasy-seq: A highthroughput library preparation method for RNA-seq and its
application in the analysis of plant responses to fluctuating
temperatures. Sci Rep 9: 7091. doi:10.1038/s41598-019-43600-0
Kashima M, Shida Y, Yamashiro T, Hirata H, Kurosaka H (2021) Intracellular
and intercellular gene regulatory network inference from time-course
individual RNA-Seq. Front Bioinform 1: 777299. doi:10.3389/
fbinf.2021.777299
Biophys Res Commun 297: 1332–1338. doi:10.1016/s0006-291x(02)
02254-4
Kinoshita M, Murata K, Naruse K, Tanaka M (2009) Medaka: Biology,
Management, and Experimental Protocols. Ames, IA: Wiley-Blackwell.
Klein MC, Zimmermann K, Schorr S, Landini M, Klemens PAW, Altensell J, Jung
M, Krause E, Nguyen D, Helms V, et al (2018) AXER is an ATP/ADP
exchanger in the membrane of the endoplasmic reticulum. Nat
Commun 9: 3489. doi:10.1038/s41467-018-06003-9
Koibuchi N, Chin MT (2007) CHF1/Hey2 plays a pivotal role in left ventricular
maturation through suppression of ectopic atrial gene expression.
Circ Res 100: 850–855. doi:10.1161/01.res.0000261693.13269.bf
Li H, Durbin R (2009) Fast and accurate short read alignment with BurrowsWheeler transform. Bioinformatics 25: 1754–1760. doi:10.1093/
bioinformatics/btp324
Molkentin JD, Lin Q, Duncan SA, Olson EN (1997) Requirement of the
transcription factor GATA4 for heart tube formation and ventral
morphogenesis. Genes Dev 11: 1061–1072. doi:10.1101/gad.11.8.1061
Mori K (2009) Signalling pathways in the unfolded protein response:
Development from yeast to mammals. J Biochem 146: 743–750.
doi:10.1093/jb/mvp166
Nadanaka S, Yoshida H, Kano F, Murata M, Mori K (2004) Activation of
mammalian unfolded protein response is compatible with the quality
control system operating in the endoplasmic reticulum. Mol Biol Cell
15: 2537–2548. doi:10.1091/mbc.e03-09-0693
Nagata T, Yasukawa H, Kyogoku S, Oba T, Takahashi J, Nohara S, Minami T,
Mawatari K, Sugi Y, Shimozono K, et al (2015) Cardiac-specific SOCS3
deletion prevents in vivo myocardial ischemia reperfusion injury
through sustained activation of cardioprotective signaling molecules.
PLoS One 10: e0127942. doi:10.1371/journal.pone.0127942
Nakagawa Y, Nishikimi T (2022) CNP, the third natriuretic peptide: Its biology
and significance to the cardiovascular system. Biology (Basel) 11: 986.
doi:10.3390/biology11070986
Nakanishi H, Nakayama K, Yokota A, Tachikawa H, Takahashi N, Jigami Y (2001)
Hut1 proteins identified in Saccharomyces cerevisiae and
Schizosaccharomyces pombe are functional homologues involved in
the protein-folding process at the endoplasmic reticulum. Yeast 18:
543–554. doi:10.1002/yea.707
Nandi SS, Mishra PK (2017) H(2)S and homocysteine control a novel feedback
regulation of cystathionine beta synthase and cystathionine gamma
lyase in cardiomyocytes. Sci Rep 7: 3639. doi:10.1038/s41598-017-03776-9
Pandur P, Sirbu IO, Kühl SJ, Philipp M, Kühl M (2013) Islet1-expressing cardiac
progenitor cells: A comparison across species. Dev Genes Evol 223:
117–129. doi:10.1007/s00427-012-0400-1
Patro R, Duggal G, Love MI, Irizarry RA, Kingsford C (2017) Salmon provides fast
and bias-aware quantification of transcript expression. Nat Methods
14: 417–419. doi:10.1038/nmeth.4197
Reimold AM, Etkin A, Clauss I, Perkins A, Friend DS, Zhang J, Horton HF, Scott A,
Orkin SH, Byrne MC, et al (2000) An essential role in liver development
for transcription factor XBP-1. Genes Dev 14: 152–157. doi:10.1101/
gad.14.2.152
Ron D, Walter P (2007) Signal integration in the endoplasmic reticulum
unfolded protein response. Nat Rev Mol Cell Biol 8: 519–529. doi:10.1038/
nrm2199
Sakuma T, Ochiai H, Kaneko T, Mashimo T, Tokumasu D, Sakane Y, Suzuki K,
Miyamoto T, Sakamoto N, Matsuura S, et al (2013) Repeating pattern of
non-RVD variations in DNA-binding modules enhances TALEN activity.
Sci Rep 3: 3379. doi:10.1038/srep03379
Sambrook J, Fritsch EF, Maniatis T (1989) Molecular Cloning: A Laboratory
Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
Kasuga H, Hosogane N, Matsuoka K, Mori I, Sakura Y, Shimakawa K, Shinki T,
Suda T, Taketomi S (2002) Characterization of transgenic rats
constitutively expressing vitamin D-24-hydroxylase gene. Biochem
Sekine SU, Haraguchi S, Chao K, Kato T, Luo L, Miura M, Chihara T (2013) Meigo
governs dendrite targeting specificity by modulating ephrin level and
N-glycosylation. Nat Neurosci 16: 683–691. doi:10.1038/nn.3389
XBP1-mediated rescue of heart failure induced by ER stress
https://doi.org/10.26508/lsa.202201771
Jin et al.
vol 6 | no 7 | e202201771
19 of 20
Sheng JJ, Feng HZ, Pinto JR, Wei H, Jin JP (2016) Increases of desmin and
α-actinin in mouse cardiac myofibrils as a response to diastolic
dysfunction. J Mol Cell Cardiol 99: 218–229. doi:10.1016/
j.yjmcc.2015.10.035
Tinevez JY, Perry N, Schindelin J, Hoopes GM, Reynolds GD, Laplantine E,
Bednarek SY, Shorte SL, Eliceiri KW (2017) TrackMate: An open and
extensible platform for single-particle tracking. Methods 115: 80–90.
doi:10.1016/j.ymeth.2016.09.016
Vincentz JW, Toolan KP, Zhang W, Firulli AB (2017) Hand factor ablation causes
defective left ventricular chamber development and compromised
adult cardiac function. PLoS Genet 13: e1006922. doi:10.1371/
journal.pgen.1006922
Walter P, Ron D (2011) The unfolded protein response: From stress pathway to
homeostatic regulation. Science 334: 1081–1086. doi:10.1126/
science.1209038
Watkins H, McKenna WJ, Thierfelder L, Suk HJ, Anan R, O’Donoghue A, Spirito P,
Matsumori A, Moravec CS, Seidman JG, et al (1995) Mutations in the
genes for cardiac troponin T and alpha-tropomyosin in hypertrophic
cardiomyopathy. N Engl J Med 332: 1058–1065. doi:10.1056/
nejm199504203321603
Watt AJ, Battle MA, Li J, Duncan SA (2004) GATA4 is essential for formation of
the proepicardium and regulates cardiogenesis. Proc Natl Acad Sci U
S A 101: 12573–12578. doi:10.1073/pnas.0400752101
Wu C, Orozco C, Boyer J, Leglise M, Goodale J, Batalov S, Hodge CL, Haase J,
Janes J, Huss JW 3rd, et al (2009) BioGPS: An extensible and
customizable portal for querying and organizing gene annotation
resources. Genome Biol 10: R130. doi:10.1186/gb-2009-10-11-r130
Xia Z, Li J, Yu L, Hong K, Wu Y, Wu Q, Cheng X (2017) Upregulation of plasma
SOCS-3 is associated with poor prognosis of acute myocardial
ingarction. Int J Clin Exp Pathol 10: 1872–1876.
Yamamoto K, Sato T, Matsui T, Sato M, Okada T, Yoshida H, Harada A, Mori K
(2007) Transcriptional induction of mammalian ER quality control
proteins is mediated by single or combined action of ATF6α and XBP1.
Dev Cell 13: 365–376. doi:10.1016/j.devcel.2007.07.018
Yamamoto K, Suzuki N, Wada T, Okada T, Yoshida H, Kaufman RJ, Mori K (2008)
Human HRD1 promoter carries a functional unfolded protein
XBP1-mediated rescue of heart failure induced by ER stress
Jin et al.
response element to which XBP1 but not ATF6 directly binds. J
Biochem 144: 477–486. doi:10.1093/jb/mvn091
Yang G, Cao K, Wu L, Wang R (2004) Cystathionine gamma-lyase
overexpression inhibits cell proliferation via a H2S-dependent
modulation of ERK1/2 phosphorylation and p21Cip/WAK-1. J Biol Chem
279: 49199–49205. doi:10.1074/jbc.m408997200
Yang G, Wu L, Wang R (2006) Pro-apoptotic effect of endogenous H2S on
human aorta smooth muscle cells. FASEB J 20: 553–555. doi:10.1096/
fj.05-4712fje
Yao Y, Hu C, Song Q, Li Y, Da X, Yu Y, Li H, Clark IM, Chen Q, Wang QK (2020)
ADAMTS16 activates latent TGF-β, accentuating fibrosis and
dysfunction of the pressure-overloaded heart. Cardiovasc Res 116:
956–969. doi:10.1093/cvr/cvz187
Ye J, Rawson RB, Komuro R, Chen X, Dave UP, Prywes R, Brown MS, Goldstein JL
(2000) ER stress induces cleavage of membrane-bound ATF6 by the
same proteases that process SREBPs. Mol Cell 6: 1355–1364.
doi:10.1016/s1097-2765(00)00133-7
Yong J, Bischof H, Burgstaller S, Siirin M, Murphy A, Malli R, Kaufman RJ (2019)
Mitochondria supply ATP to the ER through a mechanism antagonized
by cytosolic Ca(2). Elife 8: e49682. doi:10.7554/eLife.49682
Yoshida H, Matsui T, Yamamoto A, Okada T, Mori K (2001) XBP1 mRNA is
induced by ATF6 and spliced by IRE1 in response to ER stress to
produce a highly active transcription factor. Cell 107: 881–891.
doi:10.1016/s0092-8674(01)00611-0
Zandy AJ, Lakhani S, Zheng T, Flavell RA, Bassnett S (2005) Role of the
executioner caspases during lens development. J Biol Chem 280:
30263–30272. doi:10.1074/jbc.m504007200
Zhang J, Wang X, Cui W, Wang W, Zhang H, Liu L, Zhang Z, Li Z, Ying G, Zhang N,
et al (2013) Visualization of caspase-3-like activity in cells using a
genetically encoded fluorescent biosensor activated by protein
cleavage. Nat Commun 4: 2157. doi:10.1038/ncomms3157
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