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大学・研究所にある論文を検索できる 「Bone regeneration using an OCP/collagen composite supplemented with a bFGF drug delivery system: Evaluation in a rat calvarial bone defect model」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。
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Bone regeneration using an OCP/collagen composite supplemented with a bFGF drug delivery system: Evaluation in a rat calvarial bone defect model

南雲 吉祥 近畿大学

2023.01.12

概要

Bone regeneration methods using biomaterials, such as a bioactive ceramic (hydroxyapatite) and bioabsorbable ceramic (β-tricalcium phosphate), have been clinically applied as reconstruction materials for various bone defects. However, bone formation by these ceramics is limited in tissue engineering approaches. An octacalcium phosphate (OCP)/collagen (Col)-conjugated composite is biodegradable and highly osteoconductive, with OCP particles within Col enhancing the migration of osteoblasts, and, thus, it has potential as a new bone regeneration material. However, the application of exogenous osteogenic cytokines with this material has not yet been examined. In the present study, basic fibroblast growth factor (bFGF) delivered by biodegradable gelatin hydrogels for sustained release was incorporated into the OCP/Col composite, and the bone regeneration ability of this system was investigated in a rat calvarial defect model. Histological, immunohistochemical, and CT examinations revealed that new bone formation was markedly greater by the OCP/Col composite with the bFGF drug delivery system than by the OCP/Col composite alone. The present results demonstrate the potential of OCP/Col with the bFGF drug delivery system for the treatment of difficult bone defects.

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