Fig. 5. Change of mRNA expression related Th2 differentiation by LP22A3
treatment. A: The experimental design was almost the same as in Fig. 1, but the
OVA challenge was reduced to three times to make it milder. Values represent
the means ± SE (n = 5). The different letter means significant difference (p
< 0.05).
Ahmad, S., Azid, N. A., Boer, J. C., Lim, J., Chen, X., Plebanski, M., & Mohamud, R.
(2018). The key role of TNF-TNFR2 interactions in the modulation of allergic
inflammation: A review. Frontiers in Immunology, 9, 2572. https://doi.org/10.3389/
fimmu.2018.02572
Brandt, E. B., Strait, R. T., Hershko, D., Wang, Q., Muntel, E. E., Scribner, T. A.,
Zimmermann, N., Finkelman, F. D., & Rothenberg, M. E. (2003). Mast cells are
required for experimental oral allergen-induced diarrhea. The Journal of Clinical
Investigation, 112, 1666–1677. https://doi.org/10.1172/JCI19785
Chu, D. K., Wood, R. A., French, S., Fiocchi, A., Jordana, M., Waserman, S., Bro˙zek, J. L.,
& Schünemann, H. J. (2019). Oral immunotherapy for peanut allergy (PACE): A
systematic review and meta-analysis of efficacy and safety. The Lancet, 393,
2222–2232. https://doi.org/10.1016/S0140-6736(19)30420-9
Halim, T. Y. F., Rana, B. M. J., Walker, J. A., Kerscher, B., Knolle, M. D., Jolin, H. E.,
Serrao, E. M., Haim-Vilmovsky, L., Teichmann, S. A., Rodewald, H. R., Botto, M.,
Vyse, T. J., Fallon, P. G., Li, Z., Withers, D. R., & McKenzie, A. N. J. (2018). Tissue-
symptoms via intestinal barrier function.
Since Th2 cells are known to be a major cellular source of IL-4
release, Th2 cell responses are important for IgE production. As shown
in Fig. 4, mRNA expression of IL-4 was significantly decreased in the
ileum of mice treated with LP22A3 compared to mice treated with OVA
alone. However, T-bet and GATA-3, master regulators of Th1 and Th2
M. Enokida et al.
Food Bioscience 47 (2022) 101785
restricted adaptive type 2 immunity is orchestrated by expression of the
costimulatory molecule OX40L on group 2 innate lymphoid cells. Immunity, 48,
1195–1207. https://doi.org/10.1016/j.immuni.2018.05.003
Jalonen, T. (1991). Identical intestinal permeability changes in children with different
clinical manifestations of cow’s milk allergy. The Journal of Allergy and Clinical
Immunology, 88, 737–742. https://doi.org/10.1016/0091-6749(91)90180-V
Karimi, K., Inman, M. D., Bienenstock, J., & Forsythe, P. (2009). Lactobacillus reuteriinduced regulatory T cells protect against an allergic airway response in mice.
American Journal of Respiratory and Critical Care Medicine, 179, 186–193. https://doi.
org/10.1164/rccm.200806-951OC
Lamubol, J., Ohto, N., Kuwahara, H., & Mizuno, M. (2021). Lactiplantibacillus plantarum
22A-3-induced TGF-β1 secretion from intestinal epithelial cells stimulated CD103
DC and Foxp3+Treg differentiation and amelioration of colitis in mice. Food &
Function, 12, 8044–8055. https://doi.org/10.1039/D1FO00990G
Lei, W., Zeng, D., Liu, G., Zhu, Y., Wang, J., Wu, H., Jiang, J., & Huang, J. (2018). Crucial
role of OX40/OX40L signaling in a murine model of asthma. Molecular Medicine
Reports, 17, 4213–4220. https://doi.org/10.3892/mmr.2018.8453
Lei, W., Zeng, D. X., Zhu, C. H., Liu, G. Q., Zhang, X. Q., Wang, C. G., Wang, Q., &
Huang, J. A. (2014). The upregulated expression of OX40/OX40L and their
promotion of T cells proliferation in the murine model of asthma. Journal of Thoracic
Disease, 6, 979–987. https://doi.org/10.3978/j.issn.2072-1439.2014.06.34
Linton, P. J., Bautista, B., Biederman, E., Bradley, E. S., Harbertson, J., Kondrack, R. M.,
Padrick, R. C., & Bradley, L. M. (2003). Costimulation via OX40L expressed by B cells
is sufficient to determine the extent of primary CD4 cell expansion and Th2 cytokine
secretion in vivo. Journal of Experimental Medicine, 197, 875–883. https://doi.org/
10.1084/jem.20021290
Liu, Y. W., Liao, T. W., Chen, Y. H., Chiang, Y. C., & Tsai, Y. C. (2014). Oral
administration of heat-inactivated Lactobacillus plantarum K37 modulated airway
hyperresponsiveness in ovalbumin-sensitized BALB/c Mice. PLoS One, 9, Article
e100105. https://doi.org/10.1371/journal.pone.0100105
Makabe-Kobayashi, Y., Hori, Y., Adachi, T., Ishigaki-Suzuki, S., Kikuchi, Y., Kagaya, Y.,
Shirato, K., Nagy, A., Ujike, A., Takai, T., Watanabe, T., & Ohtsu, H. (2002). The
control effect of histamine on body temperature and respiratory function in IgEdependent systemic anaphylaxis. The Journal of Allergy and Clinical Immunology, 110,
298–303. https://doi.org/10.1067/mai.2002.125977
Meli, A. P., Font´es, G., Soo, C. L., & King, I. L. (2017). Follicular helper cell–derived IL-4
is required for IgE production during intestinal helminth infection. The Journal of
Immunology, 199, 244–252. http://www.jimmunol.org/content/199/1/244.
Mizuno, M., Ohto, N., & Kuwahara, H. (2021). Lactiplantibacillus plantarum 22A-3
isolated from pickle suppresses ovalbumin-induced food allergy in BALB/c mice and
2,4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice. Journal of
Bioscience and Bioengineering, 132, 271–278. https://doi.org/10.1016/j.
jbiosc.2021.05.001
Mizuno, M., Sakaguchi, K., & Sakane, I. (2020). Oral administration of fucoidan can exert
anti-allergic activity after allergen sensitization by enhancement of galectin-9
secretion in blood. Biomolecules, 10, 258. https://doi.org/10.3390/biom10020258
Morawetz, R. A., Gabriele, L., Rizzo, L. V., Noben-Trauth, N., Kühn, R., Rajewsky, K.,
Müller, W., Doherty, T. M., Finkelman, F., Coffman, R. L., & Morse, H. C., III. (1996).
Interleukin (IL)-4-independent immunoglobulin class switch to immunoglobulin (Ig)
E in the mouse. Journal of Experimental Medicine, 184, 1651–1661. https://doi.org/
10.1084/jem.184.5.1651
Murosaki, S., Yamamoto, Y., Ito, K., Inokuchi, T., Kusaka, H., Ikeda, H., & Yoshikai, Y.
(1998). Heat-killed Lactobacillus plantarum L-137 suppresses naturally fed antigenspecific IgE production by stimulation of IL-12 production in mice. The Journal of
Allergy and Clinical Immunology, 102, 57–64. https://doi.org/10.1016/S0091-6749
(98)70055-7
Ohshima, Y., Tanaka, Y., Tozawa, H., Takahashi, Y., Maliszewski, C., & Delespesse, G.
(1997). Expression and function of OX40 ligand on human dendritic cells. The
Journal of Immunology, 159, 3838–3848.
Ohshima, Y., Yang, L. P., Uchiyama, T., Tanaka, Y., Baum, P., Sergerie, M., Hermann, P.,
& Delespesse, G. (1991). OX40 costimulation enhances interleukin-4 (IL-4)
expression at priming and promotes the differentiation of naive human CD4+T cells
into high IL-4-producing effectors. Blood, 92, 3338–3345. https://doi.org/10.1182/
blood.V92.9.3338
Pizzuti, D., Senzolo, M., Buda, A., Chiarelli, S., Giacomelli, L., Mazzon, E., Curioni, A.,
Faggian, D., & De Lazzari, F. (2011). In vitro model for IgE mediated food allergy.
Scandinavian Journal of Gastroenterology, 46, 177–187. https://doi.org/10.3109/
00365521.2010.525716
Punnonen, J., Yssel, H., & de Vries, J. (1997). The relative contribution of IL-4 and IL-13
to human IgE synthesis induced by activated CD4+ or CD8+ T cells. The Journal of
Allergy and Clinical Immunology, 100, 792–801. https://doi.org/10.1016/S00916749(97)70276-8
Romantsik, O., Tosca, M. A., Zappettini, S., & Calevo, M. G. (2018). Oral and sublingual
immunotherapy for egg allergy. Cochrane Database of Systematic Reviews, 4, 1–46.
https://doi.org/10.1002/14651858.CD010638.pub3
Seshasayee, D., Lee, W. P., Zhou, M., Shu, J., Suto, E., Zhang, J., Diehl, L., Austin, C. D.,
Meng, Y. G., Tan, M., Bullens, S. L., Seeber, S., Fuentes, M. E., Labrijn, A. F.,
Graus, Y. M. F., Miller, L. A., Schelegle, E. S., Hyde, D. M., Wu, L. C.,
Hymowitz, S. G., & Martin, F. (2007). In vivo blockade of OX40 ligand inhibits
thymic stromal lymphopoietin driven atopic inflammation. Journal of Clinical
Investigation, 117, 3868–3878. https://doi.org/10.1172/JCI33559
Shida, K., Takahashi, R., Iwadate, E., Takamizawa, K., Yasui, H., Sato, T., Habu, S.,
Hachimura, S., & Kaminogawa, S. (2002). Lactobacillus casei strain Shirota
suppresses serum immunoglobulin E and immunoglobulin G1 responses and
systemic anaphylaxis in a food allergy model. Clinical and Experimental Allergy, 32,
563–570. https://doi.org/10.1046/j.0954-7894.2002.01354.x, 2002.
Sicherer, S. H., & Simons, F. E. R. (2017). Epinephrine for first-aid management of
anaphylaxis. Pediatrics, 139, Article e20164006. https://doi.org/10.1542/
peds.2016-4006
Suzuki, T. (2020). Regulation of the intestinal barrier by nutrients: The role of tight
junctions. Animal Science Journal, 91, Article e13357. https://doi.org/10.1111/
asj.13357
Tsai, P.-Y., Zhang, B., He, W.-Q., Zha, J.-M., Odenwald, M. A., Singh, G., Tamura, A.,
Shen, L., Sailer, A., Yeruva, S., Kuo, W.-T., Fu, Y.-X., Tsukita, S., & Turner, J. R.
(2017). IL-22 Upregulates epithelial claudin-2 to drive diarrhea and enteric
pathogen clearance. Cell Host & Microbe, 21, 671–681. https://doi.org/10.1016/j.
chom.2017.05.009
Tulyeu, J., Kumagai, H., Jimbo, E., Watanabe, S., Yokoyama, K., Cui, L., Osaka, H.,
Mieno, M., & Yamagata, T. (2019). Probiotics prevents sensitization to oral antigen
and subsequent increases in intestinal tight junction permeability in juvenile–young
adult rats. Microorganisms, 7, 463. https://doi.org/10.3390/
microorganisms7100463
Wang, Y. H., & Liu, Y. J. (2007). OX40-OX40L interactions: A promising therapeutic
target for allergic diseases? Journal of Clinical Investigation, 117, 3655–3657. https://
doi.org/10.1172/JCI34182, 2007.
Xu, W., Tamura, T., & Takatsu, K. (2008). CpG ODN mediated prevention from
ovalbumin-induced anaphylaxis in mouse through B cell pathway. International
Immunopharmacology, 8, 351–361. https://doi.org/10.1016/j.intimp.2007.10.019
Yeom, M., Sur, B. J., Park, J., Cho, S. G., Lee, B., Kim, S. T., Kim, K. S., Lee, H., &
Hahm, D. H. (2015). Oral administration of Lactobacillus casei variety rhamnosus
partially alleviates TMA-induced atopic dermatitis in mice through improving
intestinal microbiota. Journal of Applied Microbiology, 119, 560–570. https://doi.org/
10.1111/jam.12844
Yu, L. C. H. (2012). Intestinal epithelial barrier dysfunction in food hypersensitivity.
Journal of Allergy, 1–11. https://doi.org/10.1155/2012/596081, 2012.
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