1. Cao Y, Chu Q, Ye J (2004) Chromatographic and electrophoretic methods for pharmaceutically active compounds in Rhododendron dauricum. J Chromatog B 812: 231-240
2. Kashiwada Y, Yamazaki K, Ikeshiro Y, Yamagishi T, Fujioka T, Mihashi K, Mizuki K, Cosentino LM, Fowke K, Morris-Natschke SL, Lee KH (2001) Isolation of rhododaurichromanic acid B and the anti-HIV principles rhododaurichromanic acid A and rhododaurichromenic acid from Rhododendron dauricum. Tetrahedron 57: 1559-1563
3. Hashimoto T, Quang DN, Nukada M, Asakawa Y (2005) Isolation, synthesis and biological activity of grifolic acid derivatives from the inedible mushroom Albatrellus dispansus. Heterocycles 65: 2431-2439
4. Tokuyama S, Horikawa M, Morita T, Hashimoto T, Quang DN, Asakawa Y, Kawagishi H (2007) Anti-MRSA and antifungal compounds from the mushroom Albatrellus dispansus (Lloyd) Canf. Et Gilb. (Aphyllophoromycetideae). Int J Med Mush 9: 159-161
5. Iwata N, Kitanaka S (2010) Tetracyclic chromane derivatives from Rhododendron anthopogonoides. J Nat Prod 73: 1203-1206
6. Iwata N, Wang NL, Yao XS, Kitanaka S (2004) Structures and histamine release inhibitory effects of prenylated orcinol derivatives from Rhododendron dauricum. J Nat Prod 67: 1106-1109
7. Lee KH (2010) Discovery and development of natural-product derived chemotherapeutic agents based on a medicinal chemistry approach. J Nat Prod 73: 500-516
8. Bukhari SM, Ali I, Zaidi A, Iqbal N, Noor T, Mehmood R, Chishti MS, Niaz B, Rashid U, Atif M (2015) Pharmacology and synthesis of daurichromenic acid as a potent anti-HIV agent. Acta Pol Pharm 72: 1059-1071
9. Liu K, Woggon WD (2010) Enantioselective synthesis of daurichromenic acid and confluentin. Eur J Org Chem 2010: 1033-1036
10. Beaudry CM, Malerich JP, Trauner D (2005) Biosynthetic and biomimetic electrocyclizations. Chem Rev 105: 4757-4778
11. Taura F, Tanaya R, Sirikantaramas S (2019) Recent advances in cannabinoid biochemistry and biotechnology. Sci Asia 45: 399-407
12. Sirikantaramas S, Morimoto S, Shoyama Y, Ishikawa Y, Wada Y, Shoyama Y, Taura F (2004) The gene controlling marijuana psychoactivity: Molecular cloning and heterologous expression of ∆1-tetrahydrocannabinolic acid synthase from Cannabis sativa L. J Biol Chem 279: 39767-39774
13. Taura F, Sirikantaramas S, Shoyama Y, Yoshikai K, Shoyama Y, Morimoto S (2007) Cannabidiolic-acid synthase, the chemotype-determining enzyme in the fiber-type Cannabis sativa. FEBS Lett 581: 2929-2934
14. Morimoto S, Komatsu K, Taura, F, Shoyama Y (1997) Enzymological evidence for cannabichromenic acid biosynthesis. J Nat Prod 60: 854-857
15. Morimoto S, Komatsu K, Taura F, Shoyama Y (1998) Purification and characterization of cannabichromenic acid synthase from Cannabis sativa. Phytochemistry 49: 1525-1529
16. Taura F, Iijima M, Lee JB, Hashimoto T, Asakawa Y, Kurosaki F (2014) Daurichromenic acid-producing oxidocyclase in the young leaves of Rhododendron dauricum. Nat Prod Commun 9: 1329-1932
17. Davis E, Croteau R (2000) Cyclization enzymes in the biosynthesis of monoterpenes, sesquiterpenes, and diterpenes. In FJ Leeper, JC Vederas, eds, Topics in Current Chemistry: Biosynthesis: Aromatic Polyketides, Isoprenoids, Alkaloids, Springer-Verlag 209: 53-95
18. Fabian J (1965) Simple method of anaerobic cultivation, with removal of oxygen by a buffered glucose oxidase-catalase system. J Bacteriol 89: 921
19. Welle R, Grisebach H (1988) Induction of phytoalexin synthesis in soybean: enzymatic cyclization of prenylated pterocarpans to glyceollin isomers. Arch Biochem Biophys 263: 191-198
20. Larbat R, Kellner S, Specker S, Hehn A, Gontier E, Hans J, Bourgaud F, Matern U (2007) Molecular cloning and functional characterization of psoralen synthase, the first committed monooxygenase of furanocoumarin biosynthesis. J Biol Chem 282: 542-554
21. Donaldson RP, Luster DG (1991) Multiple forms of plant cytochromes P-450. Plant Physiol 96: 669-674
22. Taura F, Morimoto S, Shoyama Y, Mechoulam R (1995) First direct evidence for the mechanism of ∆1-tetrahydrocannabinolic acid biosynthesis. J Am Chem Soc 117: 9766-9767
23. Taura F, Morimoto S, Shoyama Y (1996) Purification and characterization of cannabidiolic-acid synthase from Cannabis sativa L. Biochemical analysis of a novel enzyme that catalyzes the oxidocyclization of cannabigerolic acid to cannabidiolic acid. J Biol Chem 271: 17411-17416
24. Iijima M, Munakata R, Takahashi H, Kenmoku H, Nakagawa R, Kodama T, Asakawa Y, Abe I, Yazaki K, Kurosaki F (2017) Identification and characterization of daurichromenic acid synthase active in anti-HIV biosynthesis. Plant Physiol 174: 2213-2230
25. Leferinka NG, Heuts DP, Fraaije MW, van Berkel WJ (2008) The growing VAO flavoprotein family. Arch Biochem Biophys 474: 292-301
26. Kutchan TM, Dittrich H (1995) Characterization and mechanism of the berberine bridge enzyme, a covalently flavinylated oxidase of benzophenanthridine alkaloid biosynthesis in plants. J Biol Chem 270: 24475-24481
27. Hagel JM, Beaudoin GA, Fossati E, Ekins A, Martin VJ, Facchini PJ (2012) Characterization of a flavoprotein oxidase from opium poppy catalyzing the final steps in sanguinarine and papaverine biosynthesis. J Biol Chem 287: 42972-42983
28. Gesell A, Chávez ML, Kramell R, Piotrowski M, Macheroux P, Kutchan TM (2011) Heterologous expression of two FAD-dependent oxidases with (S)- tetrahydroprotoberberine oxidase activity from Argemone mexicana and Berberis wilsoniae in insect cells. Planta 233: 1185-1197
29. Daniel B, Pavkov-Keller T, Steiner B, Dordic A, Gutmann A, Nidetzky B, Sensen CW, van der Graaff E, Wallner S, Gruber K, Macheroux P (2015) Oxidation of monolignols by members of the berberine bridge enzyme family suggests a role in cell wall metabolism. J Biol Chem 290: 18770-18781.
30. Custers JH, Harrison SJ, Sela-Buurlage MB, van Deventer E, Lageweg W, Howe PW, van der Meijs PJ, Ponstein AS, Simons BH, Melchers LS, Stuiver MH (2004) Isolation and characterization of a class of carbohydrate oxidases from higher plants, with a role in active defence. Plant J 39: 147-60
31. Winkler A, Lyskowski A, Riedl S, Puhl M, Kutchan TM, Macheroux P, Gruber K (2008) A concerted mechanism for berberine bridge enzyme. Nat Chem Biol 4: 739-741
32. Shoyama Y, Tamada T, Kurihara K, Takeuchi A, Taura F, Arai S, Blaber M, Shoyama Y, Morimoto S, Kuroki R (2012) Structure and function of ∆1- tetrahydrocannabinolic acid (THCA) synthase, the enzyme controlling the psychoactivity of Cannabis sativa. J Mol Biol 423: 96-105
33. Huang CH, Lai WL, Lee MH, Chen CJ, Vasella A, Tsai YC, Liaw SH (2005) Crystal structure of glucooligosaccharide oxidase from Acremonium strictum: a novel flavinylation of 6-S-cysteinyl, 8α-N1-histidyl FAD. J Biol Chem 280: 38831- 38838
34. Baunach M, Franke J, Hertweck C (2015) Terpenoid biosynthesis off the beaten track: unconventional cyclases and their impact on biomimetic synthesis. Angew Chem Int Ed Engl 54: 2604-2626
35. Martin J, Bruno VM, Fang Z, Meng X, Blow M, Zhang T, Sherlock G, Snyder M, Wang Z (2010) Rnnotator: an automated de novo transcriptome assembly pipeline from stranded RNA-Seq reads. BMC Genomics 11: 663
36. Sadamoto H, Takahashi H, Okada T, Kenmoku H, Toyota M, Asakawa Y (2012) De novo sequencing and transcriptome analysis of the central nervous system of mollusc Lymnaea stagnalis by deep RNA sequencing. PLoS One 7: e42546
37. Trapnell C, Williams BA, Pertea G, Mortazavi A, Kwan G, van Baren MJ, Salzberg SL, Wold BJ, Pachter L (2010) Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Nat Biotechnol 28: 511-515
38. Weis R, Luiten R, Skranc W, Schwab H, Wubbolts M, Glieder A (2004) Reliable high-throughput screening with Pichia pastoris by limiting yeast cell death phenomena. FEMS Yeast Res 5: 179-189
39. Gaweska HM, Roberts KM, Fitzpatrick PF (2012) Isotope effects suggest a stepwise mechanism for berberine bridge enzyme. Biochemistry 51: 7342-7347
40. Crombie LW, Crombie WML, Firth DF (1988) Synthesis of bibenzyl cannabinoids, hybrids of two biogenetic series found in Cannabis sativa. J Chem Soc Perkin Trans 1: 1263-1270
41. Shoyama Y, Hirano H, Nishioka I (1978) Cannabis XI. Synthesis of cannabigerorcinic-carboxyl-14C acid, cannabigerovarinic-carboxyl-14C acid, cannabidivarinic-carboxyl-14C acid and dl-cannabichromevarinic-carboxyl-14C acid. J Labelled Comp Radiopharm 14: 835-842
42. Shoyama Y, Hirano H, Nishioka I (1984) Biosynthesis of propyl cannabinoid acid and its biosynthetic relationship with pentyl and methyl cannabinoid acids. Phytochemistry 23: 1909-1912
43. Li C, Matsuda Y, Gao H, Hu D, Yao XS, Abe I (2016) Biosynthesis of LL-Z1272β: discovery of a new member of NRPS-like enzymes for aryl-aldehyde formation. ChemBioChem 17: 904-907
44. Saeki H, Hara R, Takahashi H, Iijima M, Munakata R, Kenmoku H, Fuku K, Sekihara A, Yasuno Y, Shinada T, Ueda D, Nishi T, Sato T, Asakawa Y, Kurosaki F, Yazaki K, Taura F (2018) An aromatic farnesyltransferase functions in biosynthesis of the anti-HIV meroterpenoid daurichromenic acid. Plant Physiol 178: 535-551
45. Taura F, Iijima M, Kurosaki F (2018) Daurichromenic acid and grifolic acid: phytotoxic meroterpenoids that induce cell death in cell culture of their producer Rhododendron dauricum. Plant Signal Behav 13: e1422463
46. Desch C Jr. (1983) The Rhododendron leaf scale. J Am Rhododendron Soc 37: 78- 80
47. Doss RE (1984) Role of glandular scales of lepidote Rhododendrons in insect resistance. J Chem Ecol 10: 1787-1798
48. Lange BM (2015) The evolution of plant secretory structures and emergence of terpenoid chemical diversity. Annu Rev Plant Biol 66: 139-159
49. Sirikantaramas S, Taura F, Tanaka Y, Ishikawa Y, Morimoto S, Shoyama Y (2005) Tetrahydrocannabinolic acid synthase, the enzyme controlling marijuana psychoactivity, is secreted into the storage cavity of the glandular trichomes. Plant Cell Physiol 46: 1578-1582
50. Morimoto S, Tanaka Y, Sasaki K, Tanaka H, Fukamizu T, Shoyama Y, Shoyama Y, Taura F (2007) Identification and characterization of cannabinoids that induce cell death through mitochondrial permeability transition in Cannabis leaf cells. J Biol Chem 282: 20739-20751
51. Tissier A (2012) Glandular trichomes: what comes after expressed sequence tags?. Plant J 70: 51-68
52. Sano T, Kuraya Y, Amino S, Nagata T(1999)Phosphate as a limiting factor for the cell division of tobacco BY-2 cells. Plant Cell Physiol 40: 1-8
53. Amino S, Fujimura T, Komamine A ( 1983 ) Synchrony induced by double phosphate starvation in a suspension culture of Catharanthus roseus. Physiol Plant 59: 393-96.
54. Yang T, Fang L, Nopo-Olazabal C, Condori J, Nopo-Olazabal L, Balmaceda C, Medina-Bolivar F (2015) Enhanced production of resveratrol, piceatannol, arachidin-1, and arachidin-3 in hairy root cultures of peanut co-treated with methyl jasmonate and cyclodextrin. J Agric Food Chem 63: 3942-3950
55. De Jong AJ, Hoeberichts FA, Yakimova ET, Maximova E, Woltering EJ (2000) Chemical-induced apoptotic cell death in tomato cells: involvement of caspase-like proteases. Planta 211: 656-662
56. Latrasse D, Benhamed M, Bergounioux C, Raynaud C, Delarue M (2016) Plant programmed cell death from a chromatin point of view. J Exp Bot 67: 5887-5900
57. Gechev TS, Hille J (2005) Hydrogen peroxide as a signal controlling plant programmed cell death. J Cell Biol 168:17-20
58. Cosio C, Dunand C (2009) Specific functions of individual class III peroxidase genes. J Exp Bot 60: 391-408
59. Bennett RN, Wallsgrove RM (1994) Secondary metabolites in plant defence mechanisms. New Phytologist 127: 617-633
60. Sirikantaramas S, Yamazaki M, Saito K (2008) Mechanisms of resistance to self-produced toxic secondary metabolites in plants. Phytochem Rev 7: 467-477
61. Shitan N (2016) Review Secondary metabolites in plants: transport and self- tolerance mechanisms. Biosci Biotechnol Biochem 80: 1283-93
62. Yamamoto H, Yamaguchi M, Inoue K (1996) Absorption and increase in the production of prenylated flavanones in Sophora flavescens cell suspension cultures by cork pieces. Phytochemistry 43: 603-608
63. Voo SS, Grimes HD, Lange BM (2012) Assessing the biosynthetic capabilities of secretory glands in Citrus peel. Plant Physiol 159: 81-94
64. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254
65. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
66. Langmead B, Salzberg S (2012) Fast gapped-read alignment with Bowtie 2. Nat Methods 9: 357-359
67. Tamura K, Stecher G, Peterson D, Filipski A, and Kumar S (2013) MEGA6: Molecular evolutionary genetics analysis version 6.0. Mol Biol Evol 30: 2725-2729
68. Hamilton R, Watanabe CK, de Boer HA (1987) Compilation and comparison of the sequence context around the AUG start codons in Saccharomyces cerevisiae mRNAs. Nucleic Acids Res 15: 3581-393
69. Laemmli UK(1970)Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685
70. Niwa Y, Hirano T, Yoshimoto K, Shimizu M, Kobayashi H (1999) Non-invasive quantitative detection and applications of non-toxic, S65T-type green fluorescent protein in living plants. Plant J 18: 455-463
71. Taura F, Iijima M, Yamanaka E, Takahashi H, Kenmoku H, Saeki H, Morimoto S, Asakawa Y, Kurosaki F, Morita H (2016) A novel class of plant type III polyketide synthase involved in orsellinic acid biosynthesis from Rhododendron dauricum. Front Plant Sci 7: 1452