リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

大学・研究所にある論文を検索できる 「遺伝子編集により単離したネイティブ自己抗原を用いた自己免疫性水疱症の新規診断法」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

コピーが完了しました

URLをコピーしました

論文の公開元へ論文の公開元へ
書き出し

遺伝子編集により単離したネイティブ自己抗原を用いた自己免疫性水疱症の新規診断法

眞井, 翔子 北海道大学

2023.03.23

概要

【背景と目的】類天疱瘡群は、組織学上表皮下水疱形成を特徴とし、その自己抗体
は、皮膚の表皮真皮境界部もしくは粘膜上皮と粘膜固有層間に存在する基底膜部タ
ンパクを標的とする。類天疱瘡群は類天疱瘡と後天性表皮水疱症に大別され、類天
疱瘡はその自己抗原と臨床症状により分類される。主な亜型として, 水疱性天疱瘡
(bullous pemphigoid, BP) 、粘膜類天疱瘡 (mucous membrane pemphigoid, MMP)があ
る。
BP、MMP においてはヘミデスモソーム(HD)タンパクである XVII 型コラーゲン (Type
XVII collagen, COL17) が主要な自己抗原となる。特に BP において、その自己抗体
の主要なエピトープは COL17 の細胞外領域の非コラーゲン領域である 16A(NC16A)
ドメインであるため、大腸菌によって産生された NC16A ドメインのポリペプチドを利用
した enzyme-linked immunosorbent assay (ELISA) は診断に広く利用されている。近年、
本研究室では DDDDK-tag 付きリコンビナント全長 COL17 タンパク(recombinant
COL17、rCOL17)を基質とする ELISA(rCOL17 ELISA)を確立した。rCOL17 ELISA
は、COL17 のあらゆる領域を標的とする抗 COL17 自己抗体が検出可能である。特に
dipeptidyl peptidase-IV 阻害薬 (dipeptidyl peptidase-IV inhibitor、DPP4i)によって誘発
された BP (DPP4i-associated BP、DPP4i-BP) の検出に有用である。しかし、これらに用
いられているようなリコンビナントタンパクは、一般的に翻訳後修飾を欠くため、ネイテ
ィブな自己抗原と同等ではない。これらの違いは、リコンビナントタンパク質を利用した
アッセイにおける自己抗体検出の障害となり得る。そこで、内在性の自己抗原としてネ
イティブな COL17 を用いたアッセイ系の確立を行い、リコンビナントタンパクとの比較を
行うこととした。
近年、clustered regularly interspersed short palindromic repeats (CRISPR)/CRISPRassociated protein 9 (CRISPR/Cas9) による遺伝子編集を利用して、内在性遺伝子座へ
のタグ配列のノックインにより、ネイティブなタンパクへのタグ付けが可能となった。この
付加したタグを利用することで生理的条件下に存在するネイティブなタンパクを取得
可能となる。自己免疫疾患の診断における自己抗体検出アッセイ系においては、従
来の過剰発現させたリコンビナントタンパクを用いた検出系と異なり、ネイティブなタン
パク利用したアッセイ系の構築が可能となる。
よって、本研究ではネイティブな状態の COL17 として、不死化ケラチノサイトである
HaCaT 細胞が内在性に持つ COL17 を取得することを試みた。HaCaT の内在性
COL17 に一般的なタグとして広く用いられている DDDDK-tag を付加し、タグを利用し
た免疫沈降法により精製を行い、取得したタンパクの解析を行うこととした。 ...

この論文で使われている画像

参考文献

Aho, S., and Uitto, J. (1998). Direct interaction between the intracellular domains of

bullous pemphigoid antigen 2 (BP180) and beta 4 integrin, hemidesmosomal components

of basal keratinocytes. Biochem Bioph Res Co 243, 694–699.

Amano, S., Nishiyama, T., and Burgeson, R.E. (1999). A specific and sensitive ELISA

for laminin 5. J Immunol Methods 224, 161–169.

Amber, K.T., Murrell, D.F., Schmidt, E., Joly, P., and Borradori, L. (2018). Autoimmune

Subepidermal Bullous Diseases of the Skin and Mucosae: Clinical Features, Diagnosis,

and Management. Clin Rev Allerg Immu 54, 26–51.

Arai, M., Shirakawa, J., Konishi, H., Sagawa, N., and Terauchi, Y. (2018). Bullous

Pemphigoid and Dipeptidyl Peptidase 4 Inhibitors: A Disproportionality Analysis Based

on the Japanese Adverse Drug Event Report Database. Diabetes Care 41, e130–e132.

Balding, S.D., Prost, C., Diaz, L.A., Bernard, P., Bedane, C., Aberdam, D., and Giudice,

G.J. (1996). Cicatricial Pemphigoid Autoantibodies React with Multiple Sites on the

BP180 Extracellular Domain. J Invest Dermatol 106, 141–146.

Béné, J., Moulis, G., Bennani, I., Auffret, M., Coupe, P., Babai, S., Hillaire‐Buys, D.,

Micallef, J., Gautier, S., and Centres, the F.A. of R.P. (2016). Bullous pemphigoid and

dipeptidyl peptidase IV inhibitors: a case–noncase study in the French Pharmacovigilance

Database. Br J Dermatol 175, 296–301.

Boukamp, P., Petrussevska, R.T., Breitkreutz, D., Hornung, J., Markham, A., and Fusenig,

N.E. (1988). Normal keratinization in a spontaneously immortalized aneuploid human

keratinocyte cell line. J Cell Biology 106, 761–771.

Chan, L.S., Soong, H.K., Foster, C.S., Hammerberg, C., and Cooper, K.D. (1991). Ocular

Cicatricial Pemphigoid Occurring as a Sequela of Stevens-Johnson Syndrome. Jama 266,

1543–1546.

Chan, L.S., Majmudar, A.A., Tran, H.H., Meier, F., Schaumburg-Lever, G., Chen, M.,

Anhalt, G., Woodley, D.T., and Marinkovich, M.P. (1997). Laminin-6 and laminin-5 are

56

recognized by autoantibodies in a subset of cicatricial pemphigoid. J Invest Dermatol 108,

848–853.

Chan, L.S., Vanderlugt, C.J., Hashimoto, T., Nishikawa, T., Zone, J.J., Black, M.M.,

Wojnarowska, F., Stevens, S.R., Chen, M., Fairley, J.A., et al. (1998). Epitope Spreading:

Lessons From Autoimmune Skin Diseases. J Invest Dermatol 110, 103–109.

Chan, L.S., Ahmed, A.R., Anhalt, G.J., Bernauer, W., Cooper, K.D., Elder, M.J., Fine,

J.-D., Foster, C.S., Ghohestani, R., Hashimoto, T., et al. (2002). The first international

consensus on mucous membrane pemphigoid: definition, diagnostic criteria, pathogenic

factors, medical treatment, and prognostic indicators. Arch Dermatol 138, 370–379.

Chan, R.Y., Bhol, K., Tesavibul, N., Letko, E., Simmons, R.K., Foster, C.S., and Ahmed,

A.R. (1999). The role of antibody to human beta4 integrin in conjunctival basement

membrane separation: possible in vitro model for ocular cicatricial pemphigoid. Invest

Ophth Vis Sci 40, 2283–2290.

Condrat, I., He, Y., Cosgarea, R., and Has, C. (2019). Junctional Epidermolysis Bullosa:

Allelic Heterogeneity and Mutation Stratification for Precision Medicine. Frontiers

Medicine 5, 363.

Cozzani, E., Di Zenzo, G., Calabresi, V., Carrozzo, M., Burlando, M., Longanesi, L.,

Cerri, A., Caproni, M., Sera, F., Antiga, E., et al. (2014). Autoantibody Profile of a Cohort

of 78 Italian Patients with Mucous Membrane Pemphigoid: Correlation Between

Reactivity Profile and Clinical Involvement. Acta Dermato Venereol 96, 768–773.

Diaz, L.A., Ratrie, H., Saunders, W.S., Futamura, S., Squiquera, H.L., Anhalt, G.J., and

Giudice, G.J. (1990). Isolation of a human epidermal cDNA corresponding to the 180kD autoantigen recognized by bullous pemphigoid and herpes gestationis sera.

Immunolocalization of this protein to the hemidesmosome. J Clin Invest 86, 1088–1094.

Didona, D., and Di Zenzo, G. (2018). Humoral Epitope Spreading in Autoimmune

Bullous Diseases. Front Immunol 9, 779.

Doyle, H.A., and Mamula, M.J. (2002). Posttranslational protein modifications: new

flavors in the menu of autoantigens. Current Opinion in Rheumatology 14, 244–249.

57

Du, G., Patzelt, S., Beek, N. van, and Schmidt, E. (2022). Mucous membrane pemphigoid.

Autoimmun Rev 21, 103036.

Egami, S., Yamagami, J., and Amagai, M. (2020). Autoimmune bullous skin diseases,

pemphigus and pemphigoid. J Allergy Clin Immun 145, 1031–1047.

Franzke, C., Tasanen, K., Schäcke, H., Zhou, Z., Tryggvason, K., Mauch, C., Zigrino, P.,

Sunnarborg, S., Lee, D.C., Fahrenholz, F., et al. (2002). Transmembrane collagen XVII,

an epithelial adhesion protein, is shed from the cell surface by ADAMs. EMBO J 21,

5026–5035.

Franzke, C.-W., Tasanen, K., Schumann, H., and Bruckner-Tuderman, L. (2003).

Collagenous transmembrane proteins: collagen XVII as a prototype. Matrix Biol 22, 299–

309.

Franzke, C.-W., Bruckner, P., and Bruckner-Tuderman, L. (2005). Collagenous

Transmembrane Proteins: Recent Insights into Biology and Pathology. J Biol Chem 280,

4005–4008.

Gammon, W.R., Briggaman, R.A., Inman, A.O., Queen, L.L., and Wheeler, C.E. (1984).

Differentiating Anti-Lamina Lucida and Anti-Sublamina Densa Anti-BMZ Antibodies

by Indirect Immunofluorescence on 1.0 M Sodium Chloride-Separated Skin. J Invest

Dermatol 82, 139–144.

Ghohestani, R.F., Nicolas, J.F., Rousselle, P., and Claudy, A.L. (1996). Identification of

A 168-kDa Mucosal Antigen In A Subset of Patients With Cicatricial Pemphigoid. J

Invest Dermatol 107, 136–139.

Giudice, G.J., Emery, D.J., and Diaz, L.A. (1992). Cloning and Primary Structural

Analysis of the Bullous Pemphigoid Autoantigen BP180. J Invest Dermatol 99, 243–250.

Giudice, G.J., Emery, D.J., Zelickson, B.D., Anhalt, G.J., Liu, Z., and Diaz, L.A. (1993).

Bullous pemphigoid and herpes gestationis autoantibodies recognize a common noncollagenous site on the BP180 ectodomain. J Immunol Baltim Md 1950 151, 5742–5750.

Hamill, K.J., Hopkinson, S.B., Jonkman, M.F., and Jones, J.C.R. (2011). Type XVII

Collagen Regulates Lamellipod Stability, Cell Motility, and Signaling to Rac1 by

58

Targeting Bullous Pemphigoid Antigen 1e to α6β4 Integrin. J Biol Chem 286, 26768–

26780.

Has, C., Bauer, J.W., Bodemer, C., Bolling, M.C., Bruckner‐Tuderman, L., Diem, A.,

Fine, J. ‐D., Heagerty, A., Hovnanian, A., Marinkovich, M.P., et al. (2020). Consensus

reclassification of inherited epidermolysis bullosa and other disorders with skin fragility.

Br J Dermatol 183, 614–627.

Hayakawa, T., Furumura, M., Fukano, H., Li, X., Ishii, N., Hamada, T., Ohata, C.,

Tsuruta, D., Shimozato, K., and Hashimoto, T. (2014). Diagnosis of oral mucous

membrane pemphigoid by means of combined serologic testing. Oral Surg Oral Medicine

Oral Pathology Oral Radiology 117, 483–496.

Hirako, Y., Usukura, J., Nishizawa, Y., and Owaribe, K. (1996). Demonstration of the

Molecular Shape of BP180, a 180-kDa Bullous Pemphigoid Antigen and Its Potential for

Trimer Formation. J Biol Chem 271, 13739–13745.

Hirako, Y., Yonemoto, Y., Yamauchi, T., Nishizawa, Y., Kawamoto, Y., and Owaribe,

K. (2014). Isolation of a hemidesmosome-rich fraction from a human squamous cell

carcinoma cell line. Exp Cell Res 324, 172–182.

Hofmann, S.C., Thoma-Uszynski, S., Stauber, A., Schuler, G., Hertl, M., Hunziker, T.,

Bernard, P., Koebnick, C., and Borradori, L. (2002). Severity and Phenotype of Bullous

Pemphigoid Relate to Autoantibody Profile Against the NH2- and COOH-Terminal

Regions of the BP180 Ectodomain. J Invest Dermatol 119, 1065–1073.

Hofmann, S.C., Voith, U., Schönau, V., Sorokin, L., Bruckner-Tuderman, L., and

Franzke, C.-W. (2009). Plasmin Plays a Role in the In Vitro Generation of the Linear IgA

Dermatosis Antigen LADB97. J Invest Dermatol 129, 1730–1739.

Hopkinson, S.B., and Jones, J.C.R. (2000). The N Terminus of the Transmembrane

Protein BP180 Interacts with the N-terminal Domain of BP230, Thereby Mediating

Keratin Cytoskeleton Anchorage to the Cell Surface at the Site of the Hemidesmosome.

Mol Biol Cell 11, 277–286.

Hopkinson, S.B., Baker, S.E., and Jones, J.C. (1995). Molecular genetic studies of a

human epidermal autoantigen (the 180-kD bullous pemphigoid antigen/BP180):

identification of functionally important sequences within the BP180 molecule and

59

evidence for an interaction between BP180 and alpha 6 integrin. J Cell Biology 130, 117–

125.

Horikawa, H., Kurihara, Y., Funakoshi, T., Umegaki‐Arao, N., Takahashi, H., Kubo, A.,

Tanikawa, A., Kodani, N., Minami, Y., Meguro, S., et al. (2018). Unique clinical and

serological features of bullous pemphigoid associated with dipeptidyl peptidase‐4

inhibitors. Br J Dermatol 178, 1462–1463.

Inoue, T., Yagami, A., Iwata, Y., Ishii, N., Hashimoto, T., and Matsunaga, K. (2016).

Mucous membrane pemphigoid reactive only with BP230. J Dermatology 43, 1228–1229.

Ishiko, A., Shimizu, H., Kikuchi, A., Ebihara, T., Hashimoto, T., and Nishikawa, T.

(1993). Human autoantibodies against the 230-kD bullous pemphigoid antigen (BPAG1)

bind only to the intracellular domain of the hemidesmosome, whereas those against the

180-kD bullous pemphigoid antigen (BPAG2) bind along the plasma membrane of the

hemidesmosome in normal human and swine skin. J Clin Invest 91, 1608–1615.

Izumi, K., Nishie, W., Mai, Y., Wada, M., Natsuga, K., Ujiie, H., Iwata, H., Yamagami,

J., and Shimizu, H. (2016). Autoantibody Profile Differentiates between Inflammatory

and Noninflammatory Bullous Pemphigoid. J Invest Dermatol 136, 2201–2210.

Izumi, K., Nishie, W., Mai, Y., Ujiie, H., Iwata, H., Natsuga, K., and Shimizu, H. (2017).

Detection of mucous membrane pemphigoid autoantibodies by full-length BP180

enzyme-linked immunosorbent assay. J Dermatol Sci 88, 247–248.

Kamaguchi, M., and Iwata, H. (2019). The Diagnosis and Blistering Mechanisms of

Mucous Membrane Pemphigoid. Front Immunol 10, 34.

Kershenovich, R., Hodak, E., and Mimouni, D. (2014). Diagnosis and classification of

pemphigus and bullous pemphigoid. Autoimmun Rev 13, 477–481.

Kobayashi, M., Amagai, M., Kuroda-Kinoshita, K., Hashimoto, T., Shirakata, Y.,

Hashimoto, K., and Nishikawa, T. (2002). BP180 ELISA using bacterial recombinant

NC16a protein as a diagnostic and monitoring tool for bullous pemphigoid. J Dermatol

Sci 30, 224–232.

60

Koster, J., Geerts, D., Favre, B., Borradori, L., and Sonnenberg, A. (2003). Analysis of

the interactions between BP180, BP230, plectin and the integrin α6β4 important for

hemidesmosome assembly. J Cell Sci 116, 387–399.

Kridin, K., and Bergman, R. (2018). Association of Bullous Pemphigoid With

Dipeptidyl-Peptidase 4 Inhibitors in Patients With Diabetes: Estimating the Risk of the

New Agents and Characterizing the Patients. Jama Dermatol 154, 1152.

Kridin, K., and Cohen, A.D. (2018). Dipeptidyl-peptidase IV inhibitor-associated bullous

pemphigoid: A systematic review and meta-analysis. J Am Acad Dermatol 85, 501–503.

Labib, R.S., Anhalt, G.J., Patel, H.P., Mutasim, D.F., and Diaz, L.A. (1986). Molecular

heterogeneity of the bullous pemphigoid antigens as detected by immunoblotting. J

Immunol Baltim Md 1950 136, 1231–1235.

Lackner, D.H., Carré, A., Guzzardo, P.M., Banning, C., Mangena, R., Henley, T.,

Oberndorfer, S., Gapp, B.V., Nijman, S.M.B., Brummelkamp, T.R., et al. (2015). A

generic strategy for CRISPR-Cas9-mediated gene tagging. Nat Commun 6, 10237.

Leverkus, M., Bhol, K., Hirako, Y., Pas, H., Sitaru, C., Baier, G., Bröcker, E., Jonkman,

M.F., Ahmed, A.R., and Zillikens, D. (2001). Cicatricial pemphigoid with circulating

autoantibodies to β4 integrin, bullous pemphigoid 180 and bullous pemphigoid 230. Br J

Dermatol 145, 998–1004.

Mai, Y., Nishie, W., Izumi, K., Yoshimoto, N., Morita, Y., Watanabe, M., Toyonaga, E.,

Ujiie, H., Iwata, H., Fujita, Y., et al. (2018). Detection of anti‐BP180 NC16A

autoantibodies after the onset of dipeptidyl peptidase‐IV inhibitor‐associated bullous

pemphigoid: a report of three patients. Br J Dermatol 179, 790–791.

Mai, Y., Ujiie, H., Higashi, T., Yamagami, J., Iwata, H., and Shimizu, H. (2019).

Autoantibodies undetectable by chemiluminescent enzyme immunoassay require

extended antigen–antibody reaction time for detection. Br J Dermatol 180, 215–216.

Matsumura, K., Amagai, M., Nishikawa, T., and Hashimoto, T. (1996). The majority of

bullous pemphigoid and herpes gestationis serum samples react with the NC16a domain

of the 180-kDa bullous pemphigoid antigen. Arch Dermatol Res 288, 507–509.

61

McMillan, J.R., Akiyama, M., and Shimizu, H. (2003). Epidermal basement membrane

zone components: ultrastructural distribution and molecular interactions. J Dermatol Sci

31, 169–177.

Murrell, D.F., Daniel, B.S., Joly, P., Borradori, L., Amagai, M., Hashimoto, T., Caux, F.,

Marinovic, B., Sinha, A.A., Hertl, M., et al. (2012). Definitions and outcome measures

for bullous pemphigoid: Recommendations by an international panel of experts. J Am

Acad Dermatol 66, 479–485.

Natsuga, K., Nishie, W., Shinkuma, S., Ujiie, H., Nishimura, M., Sawamura, D., and

Shimizu, H. (2012). Antibodies to Pathogenic Epitopes on Type XVII Collagen Cause

Skin Fragility in a Complement-Dependent and -Independent Manner. J Immunol 188,

5792–5799.

Natsuga, K., Nishie, W., Nishimura, M., Shinkuma, S., Watanabe, M., Izumi, K.,

Nakamura, H., Hirako, Y., and Shimizu, H. (2017). Loss of interaction between plectin

and type XVII collagen results in epidermolysis bullosa simplex. Hum Mutat 38, 1666–

1670.

Nishie, W. (2014). Update on the pathogenesis of bullous pemphigoid: An autoantibodymediated blistering disease targeting collagen XVII. J Dermatol Sci 73, 179–186.

Nishie, W., Sawamura, D., Goto, M., Ito, K., Shibaki, A., McMillan, J.R., Sakai, K.,

Nakamura, H., Olasz, E., Yancey, K.B., et al. (2007). Humanization of autoantigen. Nat

Med 13, 378–383.

Nishie, W., Lamer, S., Schlosser, A., Licarete, E., Franzke, C.-W., Hofmann, S.C.,

Jackow, J., Sitaru, C., and Bruckner-Tuderman, L. (2010). Ectodomain Shedding

Generates Neoepitopes on Collagen XVII, the Major Autoantigen for Bullous

Pemphigoid. J Immunol 185, 4938–4947.

Nishie, W., Kiritsi, D., Nyström, A., Hofmann, S.C., and Bruckner-Tuderman, L. (2011).

Dynamic Interactions of Epidermal Collagen XVII with the Extracellular Matrix Laminin

332 as a Major Binding Partner. Am J Pathology 179, 829–837.

Nishimura, M., Nishie, W., Shirafuji, Y., Shinkuma, S., Natsuga, K., Nakamura, H.,

Sawamura, D., Iwatsuki, K., and Shimizu, H. (2016). Extracellular cleavage of collagen

62

XVII is essential for correct cutaneous basement membrane formation. Hum Mol Genet

25, 328–339.

Nonaka, S., Ishiko, A., Masunaga, T., Nishikawa, T., Akiyama, M., Owaribe, K., and

Shimizu, H. (2000). The Extracellular Domain of BPAG2 has a Loop Structure in the

Carboxy Terminal Flexible Tail In Vivo. J Invest Dermatol 115, 889–892.

Owaribe, K., Nishizawa, Y., and Franke, W.W. (1991). Isolation and characterization of

hemidesmosomes from bovine corneal epithelial cells. Exp Cell Res 192, 622–630.

Oyama, N., Setterfield, J.F., Powell, A.M., Sakuma‐Oyama, Y., Albert, S., Bhogal, B.S.,

Vaughan, R.W., Kaneko, F., Challacombe, S.J., and Black, M.M. (2006). Bullous

pemphigoid antigen II (BP180) and its soluble extracellular domains are major

autoantigens in mucous membrane pemphigoid: the pathogenic relevance to HLA class

II alleles and disease severity. Br J Dermatol 154, 90–98.

Qian, H., Natsuaki, Y., Koga, H., Kawakami, T., Tateishi, C., Tsuruta, D., Ishii, N., Li,

X., and Hashimoto, T. (2021). The Second Study of Clinical and Immunological Findings

in Anti-laminin 332-Type Mucous Membrane Pemphigoid Examined at Kurume

University—Diagnosis Criteria Suggested by Summary of 133 Cases. Front Immunol 12,

771766.

Rashid, K.A., Gürcan, H.M., and Ahmed, A.R. (2006a). Antigen Specificity in Subsets

of Mucous Membrane Pemphigoid. J Invest Dermatol 126, 2631–2636.

Rashid, K.A., Stern, J.N.H., and Ahmed, A.R. (2006b). Identification of an Epitope

within Human Integrin α6 Subunit for the Binding of Autoantibody and Its Role in

Basement Membrane Separation in Oral Pemphigoid. J Immunol 176, 1968–1977.

Schaapveld, R.Q.J., Borradori, L., Geerts, D., Leusden, M.R. van, Kuikman, I., Nievers,

M.G., Niessen, C.M., Steenbergen, R.D.M., Snijders, P.J.F., and Sonnenberg, A. (1998).

Hemidesmosome Formation Is Initiated by the β4 Integrin Subunit, Requires Complex

Formation of β4 and HD1/Plectin, and Involves a Direct Interaction between β4 and the

Bullous Pemphigoid Antigen 180. J Cell Biology 142, 271–284.

Schmidt, E., and Zillikens, D. (2013). Pemphigoid diseases. Lancet 381, 320--332.

63

Schmidt, E., Skrobek, C., Kromminga, A., Hashimoto, T., Messer, G., Bröcker, E.,

Yancey, K.B., and Zillikens, D. (2001). Cicatricial pemphigoid: IgA and IgG

autoantibodies target epitopes on both intra‐ and extracellular domains of bullous

pemphigoid antigen 180. Br J Dermatol 145, 778–783.

Schmitt, J., and Papisch, W. (2002). Recombinant autoantigens. Autoimmun Rev 1, 79–

88.

Skandalis, K., Spirova, M., Gaitanis, G., Tsartsarakis, A., and Bassukas, I.D. (2012).

Drug‐induced bullous pemphigoid in diabetes mellitus patients receiving dipeptidyl

peptidase‐IV inhibitors plus metformin. J Eur Acad Dermatol 26, 249–253.

Smith, E.P., Taylor, T.B., Meyer, L.J., and Zone, J.J. (1993). Identification of a Basement

Membrane Zone Antigen Reactive with Circulating IgA Antibody in Ocular Cicatricial

Pemphigoid. J Invest Dermatol 101, 619–623.

Ständer, S., Schmidt, E., Zillikens, D., Ludwig, R.J., and Kridin, K. (2021). More Severe

Erosive Phenotype Despite Lower Circulating Autoantibody Levels in Dipeptidyl

Peptidase-4 Inhibitor (DPP4i)-Associated Bullous Pemphigoid: A Retrospective Cohort

Study. Am J Clin Dermatol 22, 117–127.

Tasanen, K., Tunggal, L., Chometon, G., Bruckner-Tuderman, L., and Aumailley, M.

(2004). Keratinocytes from Patients Lacking Collagen XVII Display a Migratory

Phenotype. Am J Pathology 164, 2027–2038.

Tasanen, K., Varpuluoma, O., and Nishie, W. (2019). Dipeptidyl Peptidase-4 InhibitorAssociated Bullous Pemphigoid. Front Immunol 10, 1238.

Toyonaga, E., Nishie, W., Izumi, K., Natsuga, K., Ujiie, H., Iwata, H., Yamagami, J.,

Hirako, Y., Sawamura, D., Fujimoto, W., et al. (2017). C-Terminal Processing of

Collagen XVII Induces Neoepitopes for Linear IgA Dermatosis Autoantibodies. J Invest

Dermatol 137, 2552--2559.

Tsunenaga, M., Adachi, E., Amano, S., Burgeson, R.E., and Nishiyama, T. (1998).

Laminin 5 can promote assembly of the lamina densa in the skin equivalent model. Matrix

Biol 17, 603–613.

64

Ujiie, H., Muramatsu, K., Mushiroda, T., Ozeki, T., Miyoshi, H., Iwata, H., Nakamura,

A., Nomoto, H., Cho, K.Y., Sato, N., et al. (2018). HLA-DQB1*03:01 as a Biomarker

for Genetic Susceptibility to Bullous Pemphigoid Induced by DPP-4 Inhibitors. J Invest

Dermatol 138, 1201–1204.

Ujiie, H., Iwata, H., Yamagami, J., Nakama, T., Aoyama, Y., Ikeda, S., Ishii, N., Iwatsuki,

K., Kurosawa, M., Sawamura, D., et al. (2019a). Japanese guidelines for the management

of pemphigoid (including epidermolysis bullosa acquisita). J Dermatology 46, 1102–

1135.

Ujiie, H., Yoshimoto, N., Natsuga, K., Muramatsu, K., Iwata, H., Nishie, W., and Shimizu,

H. (2019b). Immune Reaction to Type XVII Collagen Induces Intramolecular and

Intermolecular Epitope Spreading in Experimental Bullous Pemphigoid Models. Front

Immunol 10, 1410.

Varpuluoma, O., Försti, A.-K., Jokelainen, J., Turpeinen, M., Timonen, M., Huilaja, L.,

and Tasanen, K. (2018). Vildagliptin significantly increases the risk of bullous

pemphigoid: A Finnish nationwide registry study. J Invest Dermatol 138, 1659–1661.

Yasukochi, A., Teye, K., Ishii, N., and Hashimoto, T. (2016). Clinical and Immunological

Studies of 332 Japanese Patients Tentatively Diagnosed as Anti-BP180-type Mucous

Membrane Pemphigoid: A Novel BP180 C-terminal Domain Enzyme-linked

Immunosorbent Assay. Acta Dermato Venereol 96, 762–767.

Yeh, S.W., Usman, A.Q., and Ahmed, A.R. (2004). Profile of autoantibody to basement

membrane zone proteins in patients with mucous membrane pemphigoid: long-term

follow up and influence of therapy. Clin Immunol 112, 268–272.

Di Zenzo, G., Thoma-Uszynski, S., Calabresi, V., Fontao, L., Hofmann, S.C., Lacour, J.P., Sera, F., Bruckner-Tuderman, L., Zambruno, G., Borradori, L., et al. (2011).

Demonstration of Epitope-Spreading Phenomena in Bullous Pemphigoid: Results of a

Prospective Multicenter Study. J Invest Dermatol 131, 2271–2280.

65

...

参考文献をもっと見る

全国の大学の
卒論・修論・学位論文

一発検索!

この論文の関連論文を見る