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A novel role for bone marrow-derived cells to recover damaged keratinocytes from radiation-induced injury.

OKANO Junko 50447968 Nakae Yuki 40638186 NAKAGAWA Takahiko 60641595 KATAGI Miwako 40732459 TERASHIMA Tomoya 40378485 NAGAKUBO Daisuke 10368293 NAKAYAMA Takashi YOSHIE Osamu SUZUKI Yoshihisa 30243025 KOJIMA Hideto 00225434 0000-0002-4781-2052 滋賀医科大学

2021.03.11

概要

Exposure to moderate doses of ionizing radiation (IR), which is sufficient for causing skin injury, can occur during radiation therapy as well as in radiation accidents. Radiation-induced skin injury occasionally recovers, although its underlying mechanism remains unclear. Moderate-dose IR is frequently utilized for bone marrow transplantation in mice; therefore, this mouse model can help understand the mechanism. We had previously reported that bone marrow-derived cells (BMDCs) migrate to the epidermis-dermis junction in response to IR, although their role remains unknown. Here, we investigated the role of BMDCs in radiation-induced skin injury in BMT mice and observed that BMDCs contributed to skin recovery after IR-induced barrier dysfunction. One of the important mechanisms involved the action of CCL17 secreted by BMDCs on irradiated basal cells, leading to accelerated proliferation and recovery of apoptosis caused by IR. Our findings suggest that BMDCs are key players in IR-induced skin injury recovery.

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