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大学・研究所にある論文を検索できる 「ヘアレスマウスの紫外線誘発光老化に対するアスタキサンチン摂取の保護効果」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

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ヘアレスマウスの紫外線誘発光老化に対するアスタキサンチン摂取の保護効果

Li, Xing 李, 興 リ, コウ 神戸大学

2020.03.25

概要

紫外線は皮膚の光老化を誘導し、シワ形成、表皮肥厚、コラーゲンの減少を惹起させる。紫外線による光老化の要因の一つとして活性酸素種の発現が考えらている。一方、アスタキサンチンはカロチノイドであり、プロオキシダントにならない強力な抗酸化を有する食品成分である。そこで、本研究ではアスタキサンチンの摂取が紫外線による皮膚の光老化を防ぐ効果があるかを無毛マウスで検証した。紫外線は皮膚の光老化を促進させ、皮膚における過剰な活性酸素や毛細血管退行を誘導した。一方、アスタキサンチンの摂取は過剰な活性酸素を低下させ、皮膚毛細血管の退行を予防した。この効果により紫外線照射により発生するシワ形成、表皮肥厚、コラーゲンの減少は減衰し、皮膚の光老化を予防した。

本研究の結果からアスタキサンチンは紫外線の光老化を抑制する作用があり、その効果は皮膚中の毛細血管退化の抑制が関与していることが明らかになった。

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