1. Blanpain, C.; Fuchs, E. Epidermal homeostasis: A balancing act of stem cells in the skin. Nat. Rev. Mol. Cell Biol. 2009, 10, 7–17, doi:10.1038/nrm2636.
2. Baker, RuthE.; Murray, P.J. Understanding hair follicle cycling: A systems approach. Curr. Opin. Genet. Dev. 2012, 22, 607–612, doi:10.1016/j.gde.2012.11.007.
3. Gilchrest, B.A.; Yaar, M. Ageing and photoageing of the skin: Observations at the cellular andmolecularlevel. Br. J. Dermatol. 1992, 127, 25–30, doi:10.1111/j.1365-2133.1992.tb16984.
4. Gilchrest, B.A. A review of skin aging and its medical therapy. Br. J. Dermatol. 1996, 135, 867–875, doi:10.1046/j.1365-2133.1996.d01-1088.x
5. Kidd, P. Astaxanthin, cell membrane nutrient with diverse clinical benefits and anti-aging potential. Altern. Med. Rev. 2011, 16, 355–364.
6. Prue H. Hart.; Mary, Norval. Ultraviolet radiation-induced immunosuppression and its relevanceforskin carcinogenesis. Photochem. Photobiol. Sci. 2018, 17, 1872-1884. DOI:10.1039/C7PP00312A.
7. Brenneisen, P.; Sies, H.; Scharffetter-Kochanek, K. Ultraviolet-B irradiation and matrix metalloproteinases: From induction via signaling to initial events. Ann. N. Y. Acad. Sci. 2002, 973, 31–43.
8. Sarasin, A. The molecular pathways of ultraviolet-induced carcinogenesis. Mutat. Res. 1999, 428, 5–10, doi:10.1016/S1383-5742(99)00025-3.
9. Yuan J.P., Peng J., Yin K., Wang J.H. Potential health-promoting effects of astaxanthin: Ahigh-valuecarotenoid mostly from microalgae. Mol. Nutr. Food Res. 2011, 55:150–165.
10. Ambati, R.R.; Phang, S.M.; Ravi, S. Astaxanthin: Sources, extraction, stability, biological activities anditscommercial applications—A review. Mar. Drugs. 2014, 12, 128–152.
11. Komatsu, T.; Sasaki, S.; Manabe, Y.; Hirata, T.; Sugawara, T. Preventive effect of dietary astaxanthinonUV-induced skin photoaging in hairless mice. PLoS ONE. 2017, 12, e0171178.
12. Kielty C.M., Sherratt M.J., Shuttleworth C.A. Elastic fibers. J Cell Sci. 2002, 115:2817–2828.
13. Lorencini, M.; Brohem, C.A.; Dieamant, G.C.; Zanchin, N.I.; Maibach, H.I. Active ingredients against human epidermal aging. Ageing Res. Rev. 2014, 15, 100–115.
14. Kaoru, S.; Miyuki, S.; Yuki, S.; Chiharu, N. Anti-aging and functional improvement effects for theskinbyfunctional foods intakes: Clinical effects on skin by oral ingestion of preparations containing Astaxanthinand Vitamins C and E. Jichi Medical University Journal. 2012, 35, 25-33.
15. Tominaga, K.; Hongo, N.; Karato, M.; Yamashita, E. Cosmetic benefits of astaxanthin on humansubjects. Acta Biochim. Pol. 2012, 59, 43–47, doi:10.1016/j.arr.2014.03.002.
16. Oshiyuki Komatsu,; Suguru Sasaki.; Yuki Manabe.; Tatsuya Sugawara. Preventive effect of dietaryastaxanthin on UVA-induced skin photoaging in hairless mice. PLoS One. 2017; 12(2): e0171178. doi:10. 1371 / journal. ponr.0171178.
17. Kim, H.N.; Gil, C.H.; Kim, Y.R.; Shin, H.K.; Choi, B.T. Anti-photoaging properties of thephosphodiesterase inhibitor cilostazol in ultraviolet B-induced hairless mice. Sci. Rep. 2016, 6, 31169.
18. Ross D. Whitehead.; MSc,Gozde Ozakinci, PhD.; Ian D. Stephen, PhD, and David I.; Perrett, PhD. FRUIT-AND-VEGETABLE CONSUMPTION MAY NOT BE INADEQUATE. Am J Public Health. 2012October; 102(10): e3–e4. doi: 10.2105/AJPH.2012.300942.
19. Kanazashi, M.; Okumura, Y.; Al-Nassan, S.; Murakami, S.; Kondo, H.; Nagatomo, F.; Fujino, H. Protectiveeffects of astaxanthin on capillary regression in atrophied soleus muscle of rats. Acta Physiol. 2013, 207, 405–415, doi: 10.1111/apha.12018. Epub 2012 Oct 22.
20. Marcel Liberman,; Estêvão Bassi,; Marina Kamla Martinatti,; Fábio Cerqueira Lario,; João WosniakJr,; Pablo M.A. Pomerantzeff,; Francisco R.M. Laurindo Oxidant Generation Predominates AroundCalcifying Foci and Enhances Progression of Aortic Valve Calcification. Arteriosclerosis, Thrombosis, andVascular Biology. 2008, 28:463–470. doi.org/10.1161/ATVBAHA.107.156745.
21. Huajun,Jin,; Arthi, Kathasamya,; Vellareddy, Anantharam,; Balaraman, Kalyanaraman,; AnumanthG, Kanthasamy. Mitochondria-targeted antioxidants for treatment of Parkinson's disease: Preclinical andclinical outcomes. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease. 2014, 8, 1282-1294. doi.org/10.1016/j. bbadis. 2013. 09. 007.
22. Roudier E.; Gineste C.; Wazna A.; Dehghan K.; Desplanches D.; Birot O. Angio-adaptationinunloadedskeletal muscle: new insights into an early and muscle type-specific dynamic process. J Physiol.2010, Nov15;588(Pt 22):4579-91. doi: 10.1113/jphysiol.2010.193243.
23. Sergio ,Davinelli.; Michael E. Nielsen,; Giovanni Scapagnini. Astaxanthin in Skin Health, Repair, andDisease. Nutrients, 2018, 10, 522. doi:10.3390/nu10040522.
24. Poljšak, B.; Dahmane, R.G.; Godi´c, A. Intrinsic skin aging: The role of oxidative stress. ActaDermatovenerol. Alp Pannonica Adriat. 2012, 21, 33–36.
25. Campisi, J. Aging, cellular senescence, and cancer. Annu Rev Physiol. 2013, 75:685-705. doi: 1010.1146/ annurev-physiol-030212-183653.
26. P. Corcuffs, J. Rigal, and J. L.Leveque, Skin relief and aging, J.soc. Cosmet. 1983, 34.177-190.
27. D. L. Bissett, D. P. Hannon, and T.W. Orr, An animal model of solar -aged skin: Histological, andvisiblechanges in UV-irradiated hairless mouse skin. Pbotocbem. Pbotobiol. 1987, 46, 367-378.
28. Coelho, S.G.; Choi, W.; Brenner, M.; Miyamura, Y.; Yamaguchi, Y.; Wolber, R.; Smuda, C.; Batzer, J.; Kolbe, L.; Ito, S.; et al. Short-and long-term effects of UV radiation on the pigmentation of humanskin. J. Investig. Dermatol. Symp. Proc. 2009, 14, 32–35, doi:10.1038/jidsymp.
29. Shin, M.H.; Seo, J.E.; Kim, Y.K.; Kim, K.H.; Chung, J.H. Chronic heat treatment causes skinwrinkleformation and oxidative damage in hairless mice. Mech. Aging Dev. 2012, 133, 92–98, doi:10.1016/j.mad.2012.01.006.
30. Lademann, J.; Schanzer, S.; Meinke, M.; Sterry, W. Interaction between carotenoids and free radicalsinhuman skin. Skin Pharmacol. Physiol. 2011, 24, 238–244, doi:10.1159/000326074.
31. Darvin, M.E.; Richter, H.; Ahlberg, S.; Haag, S.F.; Meinke, M.C.; le Quintrec, D.; Doucet, O.; Lademann, J. Influence of sun exposure on the cutaneous collagen/elastin fibers and carotenoids: Negative effectscanbe reduced by application of sunscreen. J. Biophoton. 2014, 7, 735–743, doi:10.1002/jbio.201300171.
32. Takema, Y.; Sakaino, Y.; Imokawa, G. Age-related changes in the mechanical properties andthicknessofhuman facial skin. Br. J. Dermatol. 1994, 131, 641–648, doi:10.1111/j. 1365 - 2133.
33. Meephansan, J.; Rungjang, A.; Yingmema, W.; Deenonpoe, R.; Ponnikorn, S. Effect of astaxanthinoncutaneous wound healing. Clin. Cosmet. Investig. Dermatol. 2017, 10, 259–265.
34. Suganuma, K.; Nakajima, H.; Ohtsuki, M. Astaxanthin attenuates the UVA-induced up-regulationofmatrix-metalloproteinase-1 and skin fibroblast elastase in human dermal fibroblasts. J. Dermatol. Sci. 2010, 58, 136–142, doi:10.1016/j.jdermsci.
35. Sharma, S.D.; Meeran, S.M.; Katiyar.; S.K. Dietary grape seed proanthocyanidins inhibit UVA-inducedoxidative stress and activation of mitogen-activated protein kinases and nuclear factor-kappaBsignalingin in vivo SKH-1 hairless mice. Mol. Cancer Ther. 2007, 6, 995–1005, doi:10.1158/1535-7163.
36. Chou, H.Y.; Lee, C.; Pan, L.; Wen, Z.H.; Huang, S.H.; Lan, C.W.; Liu, W.T.; Hour, T.C.; Hseu, Y.C.; Hwang, B.H.; et al. Enriched Astaxanthin Extract from Haematococcus pluvialis Augments GrowthFactor Secretions to Increase Cell Proliferation and Induces MMP1 Degradation to Enhance CollagenProduction in Human Dermal Fibroblasts. Int. J. Mol. Sci. 2016, 17, 955, doi:10.3390/ijms17060955.
37. Yoon, H.S.; Cho, H.H.; Cho, S.; Lee, S.R.; Shin, M.H.; Chung, J.H. Supplementing withDietaryAstaxanthin Combined with Collagen Hydrolysate Improves Facial Elasticity and Decreases MatrixMetalloproteinase-1and-12 Expression: A Comparative Study with Placebo. J. Med. Food. 2014, 7, 810–816, doi:10.1089/jmf.2013.3060.
38. Danno, K.; Horio, T.; Takigawa, M.; Imamura, S. Role of oxygen intermediates in UV-inducedepidermalcell injury. J. Investig. Dermatol. 1984, 83, 166–168, doi:10.1111/1523-1747.
39. Mitchell, D.L.; Greinert, R.; de, Gruijl, F.R.; Guikers, K.L.; Breitbart, E.W.; Byrom, M.; Gallmeier, M.M.; Lowery, M.G.; Volkmer, B. Effects of chronic low-dose ultraviolet B radiation on DNAdamageandrepair in mouse skin. Cancer Res. 1999, 59, 2875–2884.
40. Muller F. The nature and mechanism of superoxide production by the electron transport chain: Itsrelevance to aging. J Am Aging Assoc. 2000, 23(4): 227-53. doi: 10.1007/s11357-000-0022-9.
41. Han D, Williams E, Cadenas E. Mitochondrial respiratory chain-dependent generation of superoxide anion and its release into the intermembrane space. The Biochemical Journal. 2001, 353(Pt 2): 411–6. doi:10.1042/0264-6021:3530411.
42. Fisher, G.J.; Kang, S.; Varani, J.; Bata-Csorgo, Z.; Wan, Y.; Datta, S.; Voorhees, J.J. Mechanismsofphotoaging and chronological skin aging. Arch. Dermatol. 2002, 138, 1462–1470, doi:10.1001/archderm.
43. Camera, E.; Mastrofrancesco, A.; Fabbri, C.; Daubrawa, F.; Picardo, M.; Sies, H.; Stahl, W. Astaxanthin, canthaxanthin and beta-carotene differently affect UVA-induced oxidative damage and expressionofoxidative stress-responsive enzymes. Exp. Dermatol. 2009, 18, 222–231. doi:10.1111/j.1600-0625.2008.
44. Chalyk, N.E..; Klochkov, V.A.; Bandaletova, T.Y.; Kyle, N.H.; Petyaev, I.M. Continuous astaxanthinintake reduces oxidative stress and reverses age-related morphological changes of residual skinsurfacecomponents in middle-aged volunteers. Nutr. Res. 2017, 48, 40–44. doi:10.1016/j.nutres.2017.10.006.
45. Zhao, J.; Meng, M.; Zhang, J.; Li, L.; Zhu, X.; Zhang, L.; Wang, C.; Gao, M. Astaxanthin amelioratesrenalinterstitial fibrosis and peritubular capillary rarefaction in unilateral ureteral obstruction. Mol. Med. Rep. 2019, 19, 3168–3178. doi: org/10.3892/mmr.2019.9970.
46. Kanazashi, M.; Okumura, Y.; Al-Nassan, S.; Murakami, S.; Kondo, H.; Nagatomo, F.; Fujino, H. Protectiveeffects of astaxanthin on capillary regression in atrophied soleus muscle of rats. Acta Physiol. 2013, 207, 405–415.
47. Fujino, H.; Kohzuki, H.; Takeda, I.; Kiyooka, T.; Miyasaka, T.; Mohri, S.; Shimizu. Regression of capillarynetwork in atrophied soleus muscle induced by hindlimb unweighting. J. Appl. Physiol. 1985, 98, 1407–1413,doi:10.2337/diabets.
48. Deng, M.; Xu, Y.; Yu, Z.; Wang, X.; Cai, Y.; Zheng, H1.; Li, W.; Zhang, W. Protective Effect of Fat Extract on UVA-Induced Photoaging in Vitro and in Vivo. Oxid. Med. Cell. Longev. 2019, 6146942, doi:10.1155/2019/6146942.
49. Xu Y, Zhang J.; Jiang W.; Zhang S. Astaxanthin induces angiogenesis through Wnt/β-catenin signalingpathway. Phytomedicine. 2015;22(7–8):744–751.
50. Toshinori Yoshihara1.;Takao Sugiura.; Tsubasa Shibaguchi.; Hisashi Naito1. JPFSM: ReviewArticleRoleof astaxanthin supplementation in prevention of disuse muscle atrophy: a review. J Phys Fitness SportsMed, 2019, 8(2): 61-71 doi: 10.7600/jpfsm.8.61.