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Synthetic Studies toward Tubiferal A

Yukutake, Yuki 北海道大学

2022.03.24

概要

Many natural organic compounds found in nature exhibit a wide range of biological activities and have long been used as pharmaceuticals, agrochemicals, and useful lead compounds for these purposes. A variety of natural chemical scaffolds, such as terpenes, alkaloids, polyethers, peptides are known as biologically active compounds. In terms of terpenes, Taxol, a diterpenoid isolated from the bark of Taxus brevifolia, has been used as a new drug for antineoplastic activity.1) Solanoeclepin A,2) a terpenoid isolated from the hydroponic solution of potato in 1986, is expected to be a natural pesticide because of its remarkable hatching-promoting activity against potato cyst nematodes. On the other hand, alkaloids also exhibit a wide range of biological activities. Strychnine is an indole alkaloid first discovered from Strychnos ignatia in 1818. Although it is no longer used in medicine due to its extremely high toxicity, it had been used in medicine as a convulsant inducing drug and ghrelin receptor antagonist.3) Morphine is an opium alkaloid found from the Opinium poppy Papaver Somniferum, and has strong analgesic and anesthetic properties.4) In polyether, halichondrin B, a huge molecule with molecular weight of over 1000 found from a marine sponge, Halichondria okadai, possesses a potent anticancer activity.5) Vancomycin, a cyclic peptide isolated from Streptomyces Orientalis, has a bactericidal effect on Gram-positive bacteria and bacteriostatic effect on enterococci. Vancomycin has such potent bioactivity that it has been called the last resort for infectious disease.6)

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参考文献

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