リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

大学・研究所にある論文を検索できる 「磁気共鳴法を用いたイヌの変性性脊髄症の新規診断手法に関する研究」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

コピーが完了しました

URLをコピーしました

論文の公開元へ論文の公開元へ
書き出し

磁気共鳴法を用いたイヌの変性性脊髄症の新規診断手法に関する研究

内藤, 瑛治 岐阜大学

2022.03.25

概要

イヌの変性性脊髄症(DN)は高齢で発症する慢性進行性の致死性神経変性疾患であり、本邦ではペンブローク・ウェルシュ・コーギー(PlC)での発症が多い。PICのDN発症大はスーパーオキンドジスムターゼ1(SODI)遺伝子の変異を変異型ホモ接合体で有するため、変異型S0D1タンパクがDNの病態に深く関与していると考えられている。しかし、SOD/遺伝子の変異型ホモ接合体であってもDNを発症しない個体が存在するため,遺伝子検査だけでDNを診断することはできない。現在,DNの確定診断には脊髄の病理組織学的検査が必要であり、生前診断法は確立されていない。DN発症初期からの病理組織学的特徴として,脊髄白質における髄鞘と軸索の脱落が認められる。さらに、神経根の髄鞘と軸索の脱落や、骨格筋の萎縮と筋線維の変性も認められる。これらに対し,磁気共鳴画像(MRI)の原理を応用した特殊な診断手法が有用である可能性が考えられる。水分子の動きを捉え,脊髄組織の傷害の程度を定量する拡散テンソル画像(DrI)や,水の信号を選択的に励起することで空間分解能を高めることにより,神経組織の描出能を向上させる水選択励起(WE)法はDNの育髄や神経根の解析に利用されている。また、MRI装置は骨格筋の評価にも有用であり,ヒトのSOD7遺伝子変異関連疾患である筋萎縮性側索硬化症(ALs)では,MRIを用いて傍脊柱筋を定性的に評価することで類似疾患との鑑別が可能と報告されている。本研究では,DNに特徴的な病理組織学的変化に着目した,MRIを利用した生前診断手法の開発を行なった。

第1章ではDMにおける脊髄病変をDTTによって検出することを目的に研究を行った。DN発症PIC(DN群)8頭,疾患対照群13頭および対照群6頭の胸腰髄におけるDrIデータを取得し,第8胸髄から第3腰髄の各椎間板レベルの脊髄および第8胸髄から第3腰髄の胸腰部脊髄領域(T8-L3領域)の神経線維束における見かけの拡散係数(ADC)および異方性比率(FA)を定量値として算出した。DN群におけるT8-L3領域のADC値およびFA値は、いずれも疾患対照群および対照群と比較すると有意に低値を示した。さらに,T8-L3領域のADC値はDMの発症期間と負の相関関係を示した。以上のことから、DM発症犬における脊髄変性はDTIにより非侵襲的に定量化が可能でき,生前診断手法として確立できると考えられた。

第2章ではVE法を用いた背根神経節(DRG)の体積定量手法の確立およびDNにおけるDRG体積測定の有用性を評価することを目的に研究を行った。DN群8頭、疾患対照群24頭および対照群8頭の胸腰部におけるWE画像を取得した。第8胸椎から第2腰椎レベルにおけるDRGの体積は,いずれもDN群が疾患対照群および対照群よりも有意に低値を示した。
さらに,DN群における第8胸椎から第2腰椎までのDRG体積の平均値は,疾患対照群および対照群と比較すると有意に低値であった。一方,DRG体積の平均値はDNの発症期間との相関関係を認めなかった。以上の結果より,DM発症犬におけるDRGの萎縮はSE法により描出することができ,病初期からの萎縮を認めるものの,病期の診断には適さないことが明らかとなった。

第3章ではDN発症早期,DM発症後期および対照犬を用いて「1強調画像における傍脊柱筋群の信号強度および筋断面積を評価することを目的とした。DN発症早期(早期DN群)9頭,発症後期(後期DN群)4頭,対照群6頭を用いて,第9胸椎から第3腰椎レベルの傍脊柱筋群における信号強度および断面積を比較した。早期DN群における第9胸椎の多裂筋の信号強度および断面積は対照群と比較して増加していたことから,第9胸椎の多裂筋の変性がT1強調画像上で描出できた可能性がある。また,傍脊柱筋群について後期DN群は早期D群と比較して信号強度は有意に高値を示し、断面積は有意に低値を示した。この結果は,DN臨床ステージが進行すると,筋内への脂肪浸潤による信号強度の増加および廃用性筋萎縮による筋体積の減少が生じたためと考えられた。T1強調画像における傍脊椎筋群の信号強度および断面積の解析は、DMの生前診断および病期の進行度の評価手法として期待できる。

本研究では,WRI装置を用いた解析によりDI発症犬における病理組織学的特徴を非侵襲的に検出でき,DNの生前診断の一助となることが示された。さらに,MRI装置を用いた解析はDの進行状況を把握することができるため,治療のモニタリングマーカーとしての有用性が期待できる。

この論文で使われている画像

参考文献

1) Aikawa, T., Fujita, H., Kanazono, S., Shibata, M. and Yoshigae, Y. (2012). Long-term neurologic outcome of hemilaminectomy and disk fenestration for treatment of dogs with thoracolumbar intervertebral disk herniation: 831 cases (2000-2007). JAm Vet Med Assoc. 241 (12), 1617-26.

2) Atlasi, M. A., Mehdizadeh, M., Bahadori, M. H. and Joghataei, M. T. (2009). Morphological identification of cell death in dorsal root ganglion neurons following peripheral nerve injury and repair in adult rat. Iran Biomed J. 13(2), 65-72.

3) Averill, D. R. (1973). Degenerative myelopathy in the aging German Shepherd dog: clinical and pathologic findings. J Am Vet Med Assoc. 162(12), 1045-51.

4) Awano, T., Johnson, G. S., Wade, C. M., Katz, M. L., Johnson, G. C., Taylor, J. F., Perloski, M., Biagi, T., Baranowska, I., Long, S., March, P. A.,Olby, N. J., Shelton, G. D., Khan, S., O'Brien, D. P., Lindblad Toh, K. and Coates, J. R. (2009). Genome-wide association analysis reveals a SOD1 mutation in canine degenerative myelopathy that resembles amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 106(8), 2794-9.

5) Banaszek, A., Bladowska, J., Pokryszko-Dragan, A., Podemski, R. and Sasiadek, M. J. (2015). Evaluation of the Degradation of the Selected Projectile, Commissural and Association White Matter Tracts Within Normal Appearing White Matter in Patients with Multiple Sclerosis Using Diffusion Tensor MR Imaging - a Preliminary Study. Pol J Radiol. 80, 457-63.

6) Banaszek, A., Bladowska, J., Szewezyk, P., Podgórski, P. and Sasiadek, M. (2014). Usefulness of diffusion tensor MR imaging in the assessment of intramedullary changes of the cervical spinal cord in different stages of degenerative spine disease. Eur Spine J. 23(7), 1523-30.

7) Bendszus, M., Koltzenburg, M., Wessig, C. and Solymosi, L. (2002). Sequential MR imaging of enervated muscle: experimental study. AJNR Am J Neuroradiol. 23(8), 1427-31.

8) Beneke, R., Neuerburg, J. and Bohndorf, K. (1991). Muscle cross- section measurement by magnetic resonance imaging. Eur J Appl Physiol Occup Physiol. 63(6), 424-9.

9) Bergamino, C., Hoey, S. E., de Swarte, M. and Skelly, C. (2019). Improved visualization of the lumbar spine nerve roots in dogs using water excitation (ProSet) as opposed to short tau inversion recovery: A retrospective study of two fat suppression MRI sequences. Vet Radio Ultrasound. 60(3), 323-329.

10) Bredella, M. A., Tirman, P. F., Fritz, R. C., Wischer, T. K., Stork, A. and Genant, H. K. (1999). Denervation syndromes of the shoulder girdle: MR imaging with electrophysiologic correlation. Skeletal Radiol. 28(10), 567-72.

11) Budrewicz, S., Szewezyk, P., Bladowska, J., Podemski, R., Koziorowska-Gawron, E., Ejma, M., Slotwinski, K. and Koszewiez, M. (2016). The possible meaning of fractional anisotropy measurement of the cervical spinal cord in correct diagnosis of amyotrophic lateral sclerosis. Neurol Sci. 37(3), 417-21.

12) Carlson, H. (1978). Histochemical fiber composition of lumbar back muscles in the cat. Acta Physiol Scand. 103(2), 198-209.

13) Carrera, I., Richter, H., Meier, D., Kircher, P. R. and Dennler, M. (2015). Regional metabolite concentrations in the brain of healthy dogs measured by use of short echo time, single voxel proton magnetic resonance spectroscopy at 3.0 Tesla. Am J Vet Res. 76(2), 129-41.

14) Chang, H. S., Kamishina, H., Mizukami, K., Momoi, Y., Katayama, M., Rahman, M. M., Uddin, M. M., Yabuki, A., Kohyama, M. and Yamato, O. (2013). Genotyping assays for the canine degenerative myelopathy-associated c. 118G>A (p.E40K mutation of the SOD1 gene using conventional and real time PCR methods: a high prevalence in the Pembroke Welsh Corgi breed in Japan. J Vet Med Sci. 75(6), 795-8.

15) Choi, S., Song, Y., Lee, K., Lee, Y. and Choi, H. (2016). Multi-voxel magnetic resonance spectroscopy of cerebral metabolites in healthy dogs at 1.5 Tesla. J Vet Sci. 17(2), 217-24.

16) Coates, J. R., March, P. A., Oglesbee, M., Ruaux, C. G., Olby, N. J., Berghaus, R. D., O'Brien, D. P., Keating, J. H., Johnson, G. S. and Williams, D. A. (2007). Clinical characterization of a familial degenerative myelopathy in Pembroke Welsh Corgi dogs. J Vet Intern Med. 21(6), 1323-31.

17) Coates, J. R. and Wininger, F. A. (2010). Canine degenerative myelopathy. Vet Clin North Am Small Anim Pract. 40(5), 929-50.

18) Crisp, M. J., Beckett, J., Coates, J. R. and Miller, T. M. (2013). Canine degenerative myelopathy: biochemical characterization of superoxide dismutase 1 in the first naturally occurring non human amyotrophic lateral sclerosis model. Exp Neurol. 248, 1-9.

19) D'Anjou, M.A. (2018). Principles of computed tomography and magnetic resonance imaging. Textbook of Veterinary Diagnostic Radiology. St Louis, MI, Elsevier. 71.

20) Diamanti, L., Paoletti, M., Vita, U. D., Muzic, S. I., Cereda, C., Ballante, E. and Pichiecchio, A. (2020). MRI study of paraspinal muscles in patients with Amyotrophic Lateral Sclerosis (ALS). J Clin Med. 9(4).

21) Elder, C. P., Apple, D. F., Bickel, C. S., Meyer, R. A. and Dudley, G. A. (2004). Intramuscular fat and glucose tolerance after spinal cord injury a cross-sectional study. Spinal Cord. 42(12), 711-6.

22) Ellingson, B. M., Salamon, N., Grinstead, J. W. and Holly, L. T. (2014). Diffusion tensor imaging predicts functional impairment in mild to moderate cervical spondylotic myelopathy. Spine J. 14(11), 2589-97.

23) Ellingson, B. M., Salamon, N. and Holly, L. T. (2015). Advances in MR imaging for cervical spondylotic myelopathy. Eur Spine J. 24 Suppl 2, 197-208.

24) Elliott, J. M., Galloway, G. J., Jull, G. A., Noteboom, J. T., Centeno, C. J. and Gibbon, W. W. (2005). Magnetic resonance imaging analysis of the upper cervical spine extensor musculature in an asymptomatic cohort: an index of fat within muscle. Clin Radiol. 60(3), 355-63.

25) Feldman, E. L., Callaghan, B. C., Pop-Busui, R., Zochodne, D. W., Wright, D. E., Bennett, D. L., Bril, V., Russell, J. W. and Viswanathan, V. (2019). Diabetic neuropathy. Nat Rev Dis Primers. 5(1), 41.

26) Forsythe, W. B. and Ghoshal, N. G. (1984). Innervation of the canine thoracolumbar vertebral column. Anat Rec. 208(1), 57-63.

27) Gatto, R. G., Li, W. and Magin, R. L. (2018). Diffusion tensor imaging identifies presymptomatic axonal degeneration in the spinal cord of ALS mice. Brain Res. 1679, 45-52.

28) Gorgey, A. S. and Dudley, G. A. (2007). Skeletal muscle atrophy and increased intramuscular fat after incomplete spinal cord injury. Spinal Cord. 45(4), 304-9.

29) Griffiths, I. R. and Duncan, I. D. (1975). Chronic degenerative radiculomyelopathy in the dog. J Small Anim Pract. 16(8), 461-71.

30) Grolez, G., Kyheng, M., Lopes, R., Moreau, C., Timmerman, K., Auger, F., Kuchcinski, G., Duhamel, A., Jissendi Tchofo, P., Besson, P., Laloux, C., Petrault, M., Devedjian, J. C., Pérez, T., Pradat, P. F., Defebvre, L., Bordet, R., Danel-Brunaud, V. and Devos, D. (2018). MRI of the cervical spinal cord predicts respiratory dysfunction in ALS. Sci Rep. 8(1), 1828.

31) Haller, S., Montandon, M. L., Lazeyras, F., Scheffler, M., Meckel, S., Herrmann, F. R., Giannakopoulos, P. and Kövari, E. (2016). Radiologic- Histopathologic Correlation of Cerebral Microbleeds Using Pre-Mortem and Post-Mortem MRI. PLoS One. 11(12), e0167743.

32) Hauger, O., Dumont, E., Chateil, J. F., Moinard, M. and Diard, F. (2002). Water excitation as an alternative to fat saturation in MR imaging preliminary results in musculoskeletal imaging. Radiology. 224(3), 657-63.

33) Hesse, B., Fischer, M. S. and Schilling, N. (2010). Distribution pattern of muscle fiber types in the perivertebral musculature of two different sized species of mice. Anat Rec (Hoboken). 293(3), 446-63.

34) Ishikawa, C., Ito, D., Kitagawa, M. and Watari, T. (2016). Comparison of conventional magnetic resonance imaging and nonenhanced three dimensional time-of-flight magnetic resonance angiography findings between dogs with meningioma and dogs with intracranial histiocytic sarcoma: 19 cases (2010-2014). JAm Vet Med Assoc. 248(10), 1139-47.

35) Ishikawa, C., Ito, D., Tanaka, N. and Kitagawa, M. (2019). Use of three-dimensional time-of-flight magnetic resonance angiography at 1.5 Tesla to evaluate the intracranial arteries of 39 dogs with idiopathic epilepsy. Am J Vet Res. 80(5), 480-9.

36) Ishikawa, T., Asakura, K., Mizutani, Y., Ueda, A., Murate, K. I., Hikichi, C., Shima, S., Kizawa, M., Komori, M., Murayama, K., Toyama, H., Ito, S. and Mutoh, T. (2017). MR neurography for the evaluation of CIDP. Muscle Nerve. 55(4), 483-9.

37) Jenkins, T. M., Alix, J. J. P., David, C., Pearson, E., Rao, D. G., Hoggard, N., O'Brien, E., Baster, K., Bradburn, M., Bigley, J., McDermott, C. J., Wilkinson, I. D. and Shaw, P. J. (2018). Imaging muscle as a potential biomarker of enervation in motor neuron disease. J Neurol Neurosurg Psychiatry. 89(3), 248-55.

38) Johnson, P. J., Miller, A. D., Cheetham, J., Demeter, E. A., Luh, W. M., Loftus, J. P., Stephan, S. L., Dewey, C. W. and Barry, E. F. (2021). In vivo detection of microstructural spinal cord lesions in dogs with degenerative myelopathy using diffusion tensor imaging. J Vet Intern Med. 35(1), 352-62.

39) Johnston, P. E., Barrie, J. A., McCulloch, M. C., Anderson, T. J. and Griffiths, I. R. (2000). Central nervous system pathology in 25 dogs with chronic degenerative radiculomyelopathy. Vet Rec. 146(22), 629-33.

40) Kanda, Y. (2013) Investigation of the freely available easy-to-use software 'EZR' for medical statistics. Bone Marrow Transplant. 48(3), 452-8.

41) Katz, M. L., Jensen, C. A., Student, J. T., Johnson, G. C. and Coates, J. R. (2017). Cervical spinal cord and motor unit pathology in a canine model of SOD1-associated amyotrophic lateral sclerosis. J Neurol Sci. 378, 193-203.

42) Kikuchi, Y., Nakamura, T., Takayama, S., Horiuchi, Y. and Toyama, Y. (2003). MR imaging in the diagnosis of enervated and reinnervated skeletal muscles: experimental study in rats. Radiology. 229(3), 861-7.

43) Kim, J. H., Trinkaus, K., Ozcan, A., Budde, M. D. and Song, S. K. (2007). Postmortem delay does not change regional diffusion anisotropy characteristics in mouse spinal cord white matter. NMR Biomed. 20(3), 352- 9.

44) Kobatake, Y., Sakai, H., Tsukui, T., Yamato, O., Kohyama, M., Sasaki, J., Kato, S., Urushitani, M., Maeda, S. and Kamishina, H. (2017). Localization of a mutant SOD1 protein in E40K-heterozygous dogs: Implications for non- cell-autonomous pathogenesis of degenerative myelopathy. J Neurol Sci. 372, 369-78.

45) Kolasa, M., Hakulinen, U., Brander, A., Hagman, S., Dastidar, P., Elovaara, I. and Sumelahti, M. L. (2019). Diffusion tensor imaging and disability progression in multiple sclerosis: A 4-year follow-up study. Brain Behav. 9(1), e01194.

46) Konishi, Y., Satoh, H., Kuroiwa, Y., Kusaka, M., Yamashita, A., Asada, Y. and Asanuma, T. (2017). Application of fiber tractography and diffusion tensor imaging to evaluate spinal cord diseases in dogs. J Vet Med Sci. 79(2), 418-24.

47)Kuno, S., Katsuta, S., Inouye, T., Anno, I., Matsumoto, K. and Akisada, M. (1988). Relationship between MR relaxation time and muscle fibercomposition. Radiology. 169(2), 567-8.

48) Lee, J. W., Kim, J. H., Park, J. B., Park, K. W., Yeom, J. S., Lee, G. Y. and Kang, H. S. (2011). Diffusion tensor imaging and fiber tractography in cervical compressive myelopathy: preliminary results. Skeletal Radiol. 40(12), 1543-51.

49) Lewis, M. J., Yap, P. T., McCullough, S. and Olby, N. J. (2018). TheRelationship between Lesion Severity Characterized by Diffusion TensorImaging and Motor Function in Chronic Canine Spinal Cord Injury. JNeurotrauma. 35(3), 500-7.

50) March, P. A., Coates, J. R., Abyad, R. J., Williams, D. A., O'Brien, D.P., Olby, N. J., Keating, J. H. and Oglesbee, M. (2009). Degenerativemyelopathy in 18 Pembroke Welsh Corgi dogs. Vet Pathol. 46(2), 241-50.

51) Martin, A. R., Aleksanderek, I., Cohen-Adad, J., Tarmohamed, Z., Tetreault, L., Smith, N., Cadotte, D. W., Crawley, A., Ginsberg, H., Mikulis,D. J. and Fehlings, M. G. (2016). Translating state-of-the-art spinal cord MRItechniques to clinical use: A systematic review of clinical studies utilizing DTI,MT, MWE, MRS, and fMRI. Neuroimage Clin. 10, 192-238.

52) McKay Hart, A., Brannstrom, T., Wiberg, M. and Terenghi, G. (2002).Primary sensory neurons and satellite cells after peripheral axotomy in theadult rat: timecourse of cell death and elimination. Exp Brain Res. 142(3),308-18.

53)Miller, A. D., Barber, R., Porter, B. F., Peters, R. M., Kent, M., Platt,S. R. and Schatzberg, S. J. (2009). Degenerative myelopathy in two Boxerdogs. Vet Pathol. 46(4), 684-7.

54) Moon, H. S., Kim, Y. D., Song, B. H., Cha, Y. D., Song, J. H. and Lee, M. H. (2010). Position of dorsal root ganglia in the lumbosacral region in patients with radiculopathy. Korean J Anesthesiol. 59(6), 398-402.

55) Morgan, B. R., Coates, J. R., Johnson, G. C., Bujnak, A. C. and Katz, M. L. (2013). Characterization of intercostal muscle pathology in canine degenerative myelopathy: a disease model for amyotrophic lateral sclerosis. J Neurosci Res. 91(12), 1639-50.

56) Morgan, B. R., Coates, J. R., Johnson, G. C., Shelton, G. D. and Katz, M. L. (2014). Characterization of thoracic motor and sensory neurons and spinal nerve roots in canine degenerative myelopathy, a potential disease model of amyotrophic lateral sclerosis. J Neurosci Res. 92(4), 531-41.

57) Nair, G., Carew, J. D., Usher, S., Lu, D., Hu, X. P. and Benatar, M. (2010). Diffusion tensor imaging reveals regional differences in the cervical spinal cord in amyotrophic lateral sclerosis. Neuroimage. 53(2), 576-83.

58) Naito, E., Nakata, K., Nakano, Y., Nozue, Y., Kimura, S., Sakai, H., Yamato, O., Islam, M. S., Maeda, S. and Kamishina, H. (2021). Changes of Dorsal Root Ganglion Volume in Dogs with Clinical Signs of Degenerative Myelopathy Detected by Water- Excitation Magnetic Resonance Imaging. Animals (Basel) 11(6).

59) Nakamae, S., Kobatake, Y., Suzuki, R., Tsukui, T., Kato, S., Yamato, O., Sakai, H., Urushitani, M., Maeda, S. and Kamishina, H. (2015). Accumulation and aggregate formation of mutant superoxide dismutase 1 in canine degenerative myelopathy. Neuroscience. 303, 229-40.

60) Ogawa, M., Lester, R., Akima, H. and Gorgey, A. S. (2017). Quantification of intermuscular and intramuscular adipose tissue using magnetic resonance imaging after neurodegenerative disorders. Neural Regen Res. 12(12), 2100-5.

61) Ogawa, M., Uchida, K., Park, E. S., Kamishina, H., Sasaki, J., Chang, H. S., Yamato, O. and Nakayama, H. (2011). Immunohistochemical observation of canine degenerative myelopathy in two Pembroke Welsh Corgi dogs. J Vet Med Sci. 73(10), 1275-9.

62) Okada, M., Kitagawa, M., Kanayama, K., Yamamura, H. and Sakai, T. (2009). Negative MRI findings in a case of degenerative myelopathy in a dog. J S Afr Vet Assoc. 80(4), 254-6.

63) Oyake, K., Kobatake, Y., Shibata, S., Sakai, H., Saito, M., Yamato, O., Kushida, K., Maeda, S. and Kamishina, H. (2016). Changes in respiratory function in Pembroke Welsh Corgi dogs with degenerative myelopathy. J Vet Med Sci. 78(8), 1323-7.

64) Patzig, M., Bochmann, K., Lutz, J., Stahl, R., Küpper, C., Liebig, T., Reilich, P. and Dieterich, M. (2019). Measurement of structural integrity of the spinal cord in patients with amyotrophic lateral sclerosis using diffusion tensor magnetic resonance imaging. PLoS One. 14(10), e0224078.

65) Pierpaoli, C. and Basser, P. J. (1996). Toward a quantitative assessment of diffusion anisotropy. Magn Reson Med. 36(6), 893-906.

66) Querin, G., El Mendili, M. M., Lenglet, T., Delphine, S., Marchand- Pauvert, V., Benali, H. and Pradat, P. F. (2017). Spinal cord multi-parametric magnetic resonance imaging for survival prediction in amyotrophic lateral sclerosis. Eur J Neurol. 24(8), 1040-6.

67) Rosen, D. R. (1993). Mutations in Cu/n superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature. 364(6435), 362.

68) Samagh, S. P., Kramer, E. J., Melkus, G., Laron, D., Bodendorfer, B. M., Natsuhara, K., Kim, H. T., Liu, X. and Feeley, B. T. (2013). MRI quantification of fatty infiltration and muscle atrophy in a mouse model of rotator cuff tears. J Orthop Res. 31(3), 421-6.

69) Schenker, M., Kraftsik, R., Glauser, L., Kuntzer, T., Bogousslavsky, J. and Barakat-Walter, I. (2003). Thyroid hormone reduces the loss of axotomized sensory neurons in dorsal root ganglia after sciatic nerve transection in adult rat. Exp Neurol. 184(1), 225-36.

70) Schäfer, M. K., Bellouze, S., Jacquier, A., Schaller, S., Richard, L., Mathis, S., Vallat, J. M. and Haase, G. (2017). Sensory neuropathy in progressive motor neuronopathy (pmn) mice is associated with defects in microtubule polymerization and axonal transport. Brain Pathol. 27(4), 459- 71.

71) Scott, H. W. and McKee, W. M. (1999). Laminectomy for 34 dogs with thoracolumbar intervertebral disc disease and loss of deep pain perception. J Small Anim Pract. 40(9), 417-22.

72) Shanmuganathan, K., Gullapalli, R. P., Zhuo, J. and Mirvis, S. E. (2008). Diffusion tensor MR imaging in cervical spine trauma. AJNR Am J Neuroradiol. 29(4), 655-9.

73) Shen, J., Wang, H. Y., Chen, J. Y. and Liang, B. L. (2006). Morphologic analysis of normal human lumbar dorsal root ganglion by 3D MR imaging. AJNR Am J Neuroradiol. 27(10), 2098-103.

74) Takahara, T., Hendrikse, J., Yamashita, T., Mali, W. P., Kwee, T. C., Imai, Y. and Luiten, P. R. (2008). Diffusion-weighted MR neurography of the brachial plexus: feasibility study. Radiology. 249(2), 653-60.

75) Takayama, K., Kita, T., Nakamura, H., Kanematsu, F., Yasunami, T., Sakanaka, H. and Yamano, Y. (2016). New Predictive Index for Lumbar Paraspinal Muscle Degeneration Associated With Aging. Spine (Phila Pa 1976). 41(2), E84-90.

76) Tidwell, A. S. and Robertson, I. D. (2011). Magnetic resonance imaging of normal and abnormal brain perfusion. Vet Radio Ultrasound. 52(1 Suppl 1), $62-71.

77) Underwood, C. K., Kurniawan, N. D., Butler, T. J., Cowin, G. J. and Wallace, R. H. (2011). Non-invasive diffusion tensor imaging detects white matter degeneration in the spinal cord of a mouse model of amyotrophic lateral sclerosis. Neuroimage. 55(2), 455-61.

78) Urger, E., Debellis, M. D., Hooper, S. R., Woolley, D. P., Chen, S. and Provenzale, J. M. (2013). Influence of analysis technique on measurement of diffusion tensor imaging parameters. AJR Am J Roentgenol. 200(5), W510-7.

79) Wada, M., Hasegawa, D., Hamamoto, Y., Yu, Y., Fujiwara-Igarashi, A. and Fujita, M. (2017). Comparisons among MRI signs, apparent diffusion coefficient, and fractional anisotropy in dogs with a solitary intracranial meningioma or histiocytic sarcoma. Vet Radiol Ultrasound. 58(4), 422-32.

80) Wang, W., Qin, W., Hao, N., Wang, Y. and Zong, G. (2012). Diffusion tensor imaging in spinal cord compression. Acta Radiol. 53(8), 921-8.

81) West, C. A., Davies, K. A., Hart, A. M., Wiberg, M., Williams, S. R. and Terenghi, G. (2007). Volumetric magnetic resonance imaging of dorsal root ganglia for the objective quantitative assessment of neuron death after peripheral nerve injury. Exp Neurol. 203(1), 22-33.

82) Wilson, A. D., Hart, A., Brannstrom, T., Wiberg, M. and Terenghi, G. (2003). Primary sensory neuronal rescue with systemic acetyl-L-carnitine following peripheral axotomy. A dose-response analysis. Br J Plast Surg. 56(8), 732-9.

83) Wininger, F. A., Zeng, R., Johnson, G. S., Katz, M. L., Johnson, G. C., Bush, W. W., Jarboe, J. M. and Coates, J. R. (2011). Degenerative myelopathy in a Bernese Mountain Dog with a novel SOD1 missense mutation. J Vet Intern Med. 25(5), 1166-70.

84) Yamashita, T., Kwee, T. C. and Takahara, T. (2009). Whole-body magnetic resonance neurography. N Engl J Med. 361(5), 538-9.

85) Yokoyama, Y. (1982) Analyses on the fiber compositions of the lumbar back muscles in mammals. Nihon Seikeigeka Gakkai Zasshi. 56(7), 579-94.

86) Zeng, R., Coates, J. R., Johnson, G. C., Hansen, L., Awano, T., Kolicheski, A., Ivansson, E., Perloski, M., Lindblad-Toh, K., O'Brien, D. P., Guo, J., Katz, M. L. and Johnson, G. S. (2014). Breed distribution of SOD1 alleles previously associated with canine degenerative myelopathy. J Vet Intern Med. 28(2), 515-21.

参考文献をもっと見る

全国の大学の
卒論・修論・学位論文

一発検索!

この論文の関連論文を見る