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Acknowledgements

This work was supported by the Takeda Pharmaceutical Company, Ltd.

and by JSPS KAKENHI grants (nos. JP21H04681, JP23H04912, and

JP22KJ1938) and a JST PRESTO grant (no. JPMJPR19T2). A part of this

work was conducted at the Institute for Molecular Science supported by

ARIM (JPMXP1223MS5012).

Author contributions

K.O., K.N., D.H., and H.O. conceived the project. K.O., D.H., K.N., R.T.,

T.S., N.M., Y. Sa., and H.O. performed the experiments and analyzed the

data. H.S. and Y. Se. performed X-ray crystallography analyses. K.O.,

K.N., D.H., and H.O. co-wrote the manuscript. All authors contributed to

discussions.

Competing interests

The authors declare no competing interests.

Additional information

Supplementary information The online version contains

supplementary material available at

https://doi.org/10.1038/s41467-023-42639-y.

Correspondence and requests for materials should be addressed to

Kazunori Nagao, Dai Hata or Hirohisa Ohmiya.

Peer review information Nature Communications thanks Jie Wu and the

other, anonymous, reviewer(s) for their contribution to the peer review of

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