1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
15.
Goldberg, M.; Farges, J.C.; Lacerda-Pinheiro, S.; Six, N.; Jegat, N.; Decup, F.; Septier, D.; Carrouel, F.; Durand, S.;
Chaussain-Miller, C.; et al. Inflammatory and immunological aspects of dental pulp repair. Pharmacol. Res. 2008, 58,
137–147. [CrossRef]
Tang, W.; Wu, Y.; Smales, R.J. Identifying and reducing risks for potential fractures inendodontically treated teeth. J. Endod. 2010,
36, 609–617. [CrossRef]
Yoshino, K.; Ito, K.; Kuroda, M.; Sugihara, N. Prevalence of vertical root fracture as the reason for tooth extraction in dental clinics.
Clin. Oral Investig. 2015, 19, 1405–1409. [CrossRef]
Zhu, C.; Ju, B.; Ni, R. Clinical outcome of direct pulp capping with MTA or calcium hydroxide: A systematic review and
meta-analysis. Int. J. Clin. Exp. Med. 2015, 8, 17055–17060.
Hilton, T.J.; Ferracane, J.L.; Mancl, L.; Northwest Practice-based Research Collaborative in Evidence-based Dentistry (NWP).
Comparison of CaOH with MTA for direct pulp capping: A PBRN randomized clinical trial. J. Dent. Res. 2013, 92 (Suppl. 7),
16S–22S. [CrossRef]
Farsi, N.; Alamoudi, N.; Balto, K.; Al Mushayt, A. Clinical assessment of mineral trioxide aggregate (MTA) as direct pulp capping
in young permanent teeth. J. Clin. Pediatr. Dent. 2006, 31, 72–76. [CrossRef]
Wynn, T.A.; Vannella, K.M. Macrophages in Tissue Repair, Regeneration, and Fibrosis. Immunity 2016, 44, 450–462. [CrossRef]
Gordon, S. Alternative activation of macrophages. Nat. Rev. Immunol. 2003, 3, 23–35. [CrossRef]
Tarique, A.A.; Logan, J.; Thomas, E.; Holt, P.G.; Sly, P.D.; Fantino, E. Phenotypic, functional, and plasticity features of classical and
alternatively activated human macrophages. Am. J. Respir. Cell Mol. Biol. 2015, 53, 676–688. [CrossRef]
Xing, Z. Current understanding of macrophage type 1 cytokine responses during intracellular infections. Histol. Histopathol. 2000,
15, 199–205. [CrossRef]
Yang, L.; Xiao, L.; Gao, W.; Huang, X.; Wei, F.; Zhang, Q.; Xiao, Y. Macrophages at Low-Inflammatory Status Improved
Osteogenesis via Autophagy Regulation. Tissue Eng. Part A 2021. [CrossRef]
Sica, A.; Erreni, M.; Allavena, P.; Porta, C. Macrophage polarization in pathology. Cell. Mol. Life Sci. 2015, 72, 4111–4126.
[CrossRef]
Mantovani, A.; Sica, A.; Sozzani, S.; Allavena, P.; Vecchi, A.; Locati, M. The chemokine system in diverse forms of macrophage
activation and polarization. Trends Immunol. 2004, 25, 677–686. [CrossRef]
Zhu, L.; Fu, X.; Chen, X.; Han, X.; Dong, P. M2 macrophages induce EMT through the TGF-β/Smad2 signaling pathway. Cell Biol.
Int. 2017, 41, 960–968. [CrossRef]
Vega-Galaviz, D.; Vecchyo-Tenorio, G.D.; Alcántara-Suárez, R.; Méndez-García, L.A.; Sánchez-Del Real, A.L.; Villalobos-Molina, R.;
Fragoso, J.M.; León-Cabrera, S.; Ostoa-Saloma, P.; Pérez-Tamayo, R.; et al. M2 macrophage immunotherapy abolishes glucose
intolerance by increasing IL-10 expression and AKT activation. Immunotherapy 2020, 12, 9–24. [CrossRef]
Life 2022, 12, 1812
16.
17.
18.
19.
20.
21.
22.
23.
24.
25.
26.
27.
28.
29.
30.
31.
32.
33.
34.
35.
36.
37.
38.
39.
40.
41.
10 of 11
R˝oszer, T. Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms. Mediat. Inflamm.
2015, 2015, 816460. [CrossRef]
Funes, S.C.; Rios, M.; Escobar-Vera, J.; Kalergis, A.M. Implications of macrophage polarization in autoimmunity. Immunology
2018, 154, 186–195. [CrossRef]
Kang, M.; Huang, C.C.; Lu, Y.; Shirazi, S.; Gajendrareddy, P.; Ravindran, S.; Cooper, L.F. Bone regeneration is mediated by
macrophage extracellular vesicles. Bone 2020, 141, 115627. [CrossRef]
Nakai, K. Multiple roles of macrophage in skin. J. Dermatol. Sci. 2021, 104, 2–10. [CrossRef]
Yoshida, S.; Wada, N.; Hasegawa, D.; Miyaji, H.; Mitarai, H.; Tomokiyo, A.; Hamano, S.; Maeda, H. Semaphorin 3A Induces
Odontoblastic Phenotype in Dental Pulp Stem Cells. J. Dent. Res. 2016, 95, 1282–1290. [CrossRef]
Yoshida, S.; Sugii, H.; Itoyama, T.; Kadowaki, M.; Hasegawa, D.; Tomokiyo, A.; Hamano, S.; Ipposhi, K.; Yamashita, K.; Maeda, H.
Development of a novel direct dental pulp-capping material using 4-META/MMA-TBB resin with nano hydroxyapatite. Mater.
Sci. Eng. C Mater. Biol. Appl. 2021, 130, 112426. [CrossRef] [PubMed]
Mizumachi, H.; Yoshida, S.; Tomokiyo, A.; Hasegawa, D.; Hamano, S.; Yuda, A.; Sugii, H.; Serita, S.; Mitarai, H.; Koori, K.; et al.
Calcium-sensing receptor-ERK signaling promotes odontoblastic differentiation of human dental pulp cells. Bone 2017, 101,
191–201. [CrossRef] [PubMed]
Koori, K.; Maeda, H.; Fujii, S.; Tomokiyo, A.; Kawachi, G.; Hasegawa, D.; Hamano, S.; Sugii, H.; Wada, N.; Akamine, A. The roles
of calcium-sensing receptor and calcium channel in osteogenic differentiation of undifferentiated periodontal ligament cells. Cell
Tissue Res. 2014, 357, 707–718. [CrossRef] [PubMed]
Chomczynslci, P.; Sacchi, N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol chloroform extraction.
Anal. Biochem. 1987, 162, 156–159. [CrossRef]
Biswas, S.K.; Mantovani, A. Macrophage plasticity and interaction with lymphocyte subsets: Cancer as a paradigm. Nat. Immunol.
2010, 11, 889–896. [CrossRef]
Medzhitov, R. Origin and physiological roles of inflammation. Nature 2008, 454, 428–435. [CrossRef]
Chanput, W.; Mes, J.J.; Savelkoul, H.F.; Wichers, H.J. Characterization of polarized THP-1 macrophages and polarizing ability of
LPS and food compounds. Food Funct. 2013, 4, 266–276. [CrossRef]
Genin, M.; Clement, F.; Fattaccioli, A.; Raes, M.; Michiels, C. M1 and M2 macrophages derived from THP-1 cells differentially
modulate the response of cancer cells to etoposide. BMC Cancer 2015, 15, 577. [CrossRef]
Atri, C.; Guerfali, F.Z.; Laouini, D. Role of Human Macrophage Polarization in Inflammation during Infectious Diseases. Int.
J. Mol. Sci. 2018, 19, 1801. [CrossRef]
Shapouri-Moghaddam, A.; Mohammadian, S.; Vazini, H.; Taghadosi, M.; Esmaeili, S.A.; Mardani, F.; Seifi, B.; Mohammadi, A.;
Afshari, J.T.; Sahebkar, A. Macrophage plasticity, polarization, and function in health and disease. J. Cell. Physiol. 2018, 233,
6425–6440. [CrossRef]
Varela, P.; Sartori, S.; Viebahn, R.; Salber, J.; Ciardelli, G. Macrophage immunomodulation: An indispensable tool to evaluate the
performance of wound dressing biomaterials. J. Appl. Biomater. Funct. Mater. 2019, 17, 2280800019830355. [CrossRef] [PubMed]
Arabpour, M.; Saghazadeh, A.; Rezaei, N. Anti-inflammatory and M2 macrophage polarization-promoting effect of mesenchymal
stem cell-derived exosomes. Int. Immunopharmacol. 2021, 97, 107823. [CrossRef] [PubMed]
Yao, Y.; Xu, X.H.; Jin, L. Macrophage Polarization in Physiological and Pathological Pregnancy. Front. Immunol. 2019, 10, 792.
[CrossRef]
Wang, L.X.; Zhang, S.X.; Wu, H.J.; Rong, X.L.; Guo, J. M2b macrophage polarization and its roles in diseases. J. Leukoc. Biol. 2019,
106, 345–358. [CrossRef]
Zizzo, G.; Hilliard, B.A.; Monestier, M.; Cohen, P.L. Efficient clearance of early apoptotic cells by human macrophages requires
M2c polarization and MerTK induction. J. Immunol. 2012, 189, 3508–3520. [CrossRef] [PubMed]
Ferrante, C.J.; Pinhal-Enfield, G.; Elson, G.; Cronstein, B.N.; Hasko, G.; Outram, S.; Leibovich, S.J. The adenosine-dependent
angiogenic switch of macrophages to an M2-like phenotype is independent of interleukin-4 receptor alpha (IL-4Rα) signaling.
Inflammation 2013, 36, 921–931. [CrossRef] [PubMed]
Jaynes, J.M.; Sable, R.; Ronzetti, M.; Bautista, W.; Knotts, Z.; Abisoye-Ogunniyan, A.; Li, D.; Calvo, R.; Dashnyam, M.;
Singh, A.; et al. Mannose receptor (CD206) activation in tumor-associated macrophages enhances adaptive and innate antitumor immune responses. Sci. Transl. Med. 2020, 12, eaax6337. [CrossRef]
Gensel, J.C.; Zhang, B. Macrophage activation and its role in repair and pathology after spinal cord injury. Brain Res. 2015, 1619,
1–11. [CrossRef]
Camilleri, J.; Montesin, F.E.; Brady, K.; Sweeney, R.; Curtis, R.V.; Ford, T.R. The constitution of mineral trioxide aggregate. Dent.
Mater. 2005, 21, 297–303. [CrossRef]
Yamashita, K.; Tomokiyo, A.; Ono, T.; Ipposhi, K.; Alhasan, M.A.; Tsuchiya, A.; Hamano, S.; Sugii, H.; Yoshida, S.; Itoyama, T.; et al.
Mineral trioxide aggregate immersed in sodium hypochlorite reduce the osteoblastic differentiation of human periodontal
ligament stem cells. Sci. Rep. 2021, 11, 22091. [CrossRef]
Kunert, M.; Lukomska-Szymanska, M. Bio-Inductive Materials in Direct and Indirect Pulp Capping—A Review Article. Materials
2020, 13, 1204. [CrossRef] [PubMed]
Life 2022, 12, 1812
42.
43.
44.
45.
46.
47.
11 of 11
Paula, A.B.; Laranjo, M.; Marto, C.M.; Paulo, S.; Abrantes, A.M.; Casalta-Lopes, J.; Marques-Ferreira, M.; Botelho, M.F.; Carrilho, E.
Direct Pulp Capping: What is the Most Effective Therapy?—Systematic Review and Meta-Analysis. J. Evid. Based Dent. Pract.
2018, 18, 298–314. [CrossRef] [PubMed]
Chicarelli, L.P.G.; Webber, M.B.F.; Amorim, J.P.A.; Rangel, A.; Camilotti, V.; Sinhoreti, M.A.C.; Mendonça, M.J. Effect of Tricalcium
Silicate on Direct Pulp Capping: Experimental Study in Rats. Eur. J. Dent. 2021, 15, 101–108. [CrossRef] [PubMed]
Li, Z.; Cao, L.; Fan, M.; Xu, Q. Direct Pulp Capping with Calcium Hydroxide or Mineral Trioxide Aggregate: A Meta-analysis.
J. Endod. 2015, 41, 1412–1417. [CrossRef] [PubMed]
Serita, S.; Tomokiyo, A.; Hasegawa, D.; Hamano, S.; Sugii, H.; Yoshida, S.; Mizumachi, H.; Mitarai, H.; Monnouchi, S.;
Wada, N.; et al. Transforming growth factor-β-induced gene product-h3 inhibits odontoblastic differentiation of dental pulp cells.
Arch. Oral Biol. 2017, 78, 135–143. [CrossRef]
Jin, S.; He, D.; Luo, D.; Wang, Y.; Yu, M. A Biomimetic Hierarchical Nanointerface Orchestrates Macrophage Polarization and
Mesenchymal Stem Cell Recruitment to Promote Endogenous Bone Regeneration. ACS Nano 2019, 13, 6581–6595. [CrossRef]
Li, X.; He, X.T.; Kong, D.Q.; Xu, X.Y.; Wu, R.X.; Sun, L.-J.; Tian, B.-M.; Chen, F.-M. M2 Macrophages Enhance the Cementoblastic
Differentiation of Periodontal Ligament Stem Cells via the Akt and JNK Pathways. Stem Cells 2019, 37, 1567–1580. [CrossRef]
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