1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
15.
16.
17.
18.
19.
20.
Polzer, I.; Schimmel, M.; Müller, F.; Biffar, R. Edentulism as part of the general health problems of elderly adults. Int. Dent. J. 2010,
60, 143–155. [PubMed]
Fleischmannova, J.; Matalova, E.; Sharpe, P.T.; Misek, I.; Radlanski, R.J. Formation of the tooth-bone interface. J. Dent. Res. 2010,
89, 108–115. [CrossRef] [PubMed]
Kim, M.G.; Park, C.H. Tooth-Supporting Hard Tissue Regeneration Using Biopolymeric Material Fabrication Strategies. Molecules
2020, 25, 4802. [CrossRef] [PubMed]
Tomokiyo, A.; Yoshida, S.; Hamano, S.; Hasegawa, D.; Sugii, H.; Maeda, H. Detection, Characterization, and Clinical Application
of Mesenchymal Stem Cells in Periodontal Ligament Tissue. Stem Cells Int. 2018, 2018, 5450768. [CrossRef]
Ouchi, T.; Nakagawa, T. Mesenchymal stem cell-based tissue regeneration therapies for periodontitis. Regen Ther. 2020, 14, 72–78.
[CrossRef]
Li, X.; Gong, P.; Liao, D. In vitro neural/glial differentiation potential of periodontal ligament stem cells. Arch. Med. Sci. 2010, 6,
678–685. [CrossRef]
Fujii, S.; Maeda, H.; Wada, N.; Tomokiyo, A.; Saito, M.; Akamine, A. Investigating a clonal human periodontal ligament
progenitor/stem cell line in vitro and in vivo. J. Cell Physiol. 2008, 215, 743–749. [CrossRef]
Jin, H.; Choung, H.W.; Lim, K.T.; Jin, B.; Jin, C.; Chung, J.H.; Choung, P.H. Recombinant Human Plasminogen Activator Inhibitor-1
Promotes Cementogenic Differentiation of Human Periodontal Ligament Stem Cells. Tissue Eng. Part A 2015, 21, 2817–2828.
[CrossRef]
Shi, S.; Bartold, P.M.; Miura, M.; Seo, B.M.; Robey, P.G.; Gronthos, S. The efficacy of mesenchymal stem cells to regenerate and
repair dental structures. Orthod. Craniofac. Res. 2005, 8, 191–199. [CrossRef]
Corsi, A.; Xu, T.; Chen, X.D.; Boyde, A.; Liang, J.; Mankani, M.; Sommer, B.; Iozzo, R.V.; Eichstetter, I.; Robey, P.G.; et al.
Phenotypic effects of biglycan deficiency are linked to collagen fibril abnormalities, are synergized by decorin deficiency, and
mimic Ehlers-Danlos-like changes in bone and other connective tissues. J. Bone Miner. Res. 2002, 17, 1180–1189. [CrossRef]
Mohan, R.R.; Tovey, J.C.; Gupta, R.; Sharma, A.; Tandon, A. Decorin biology, expression, function and therapy in the cornea. Curr.
Mol. Med. 2011, 11, 110–128. [CrossRef] [PubMed]
Theocharis, A.D.; Karamanos, N.K. Decreased biglycan expression and differential decorin localization in human abdominal
aortic aneurysms. Atherosclerosis 2002, 165, 221–230. [CrossRef]
Järvinen, T.A.; Ruoslahti, E. Target-seeking antifibrotic compound enhances wound healing and suppresses scar formation in
mice. Proc. Natl. Acad. Sci. USA 2010, 107, 21671–21676. [CrossRef] [PubMed]
Danielson, K.G.; Baribault, H.; Holmes, D.F.; Graham, H.; Kadler, K.E.; Iozzo, R.V. Targeted disruption of decorin leads to
abnormal collagen fibril morphology and skin fragility. J. Cell Biol. 1997, 136, 729–743. [CrossRef] [PubMed]
Järvinen, T.A.; Ruoslahti, E. Targeted Antiscarring Therapy for Tissue Injuries. Adv. Wound Care (New Rochelle) 2013, 2, 50–54.
[CrossRef] [PubMed]
Merline, R.; Moreth, K.; Beckmann, J.; Nastase, M.V.; Zeng-Brouwers, J.; Tralhão, J.G.; Lemarchand, P.; Pfeilschifter, J.; Schaefer,
R.M.; Iozzo, R.V.; et al. Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and
MicroRNA-21. Sci. Signal 2011, 4, ra75. [CrossRef]
Halari, C.D.; Renaud, S.J.; Lala, P.K. Molecular mechanisms in IL-1β-mediated decorin production by decidual cells. Mol. Hum.
Reprod. 2021, 27. [CrossRef]
Adam, M.; Urbanski, H.F.; Garyfallou, V.T.; Welsch, U.; Köhn, F.M.; Ullrich Schwarzer, J.; Strauss, L.; Poutanen, M.; Mayerhofer, A.
High levels of the extracellular matrix proteoglycan decorin are associated with inhibition of testicular function. Int. J. Androl.
2012, 35, 550–561. [CrossRef]
Nikitovic, D.; Aggelidakis, J.; Young, M.F.; Iozzo, R.V.; Karamanos, N.K.; Tzanakakis, G.N. The biology of small leucine-rich
proteoglycans in bone pathophysiology. J. Biol. Chem. 2012, 287, 33926–33933. [CrossRef]
Devlin, H. Early bone healing events following rat molar tooth extraction. Cells Tissues Organs 2000, 167, 33–37. [CrossRef]
Molecules 2022, 27, 8224
21.
22.
23.
24.
25.
26.
27.
28.
29.
30.
31.
32.
33.
34.
35.
36.
37.
38.
39.
40.
41.
42.
43.
44.
45.
46.
47.
48.
15 of 16
He, R.; Lu, Y.; Ren, J.; Wang, Z.; Huang, J.; Zhu, L.; Wang, K. Decreased fibrous encapsulation and enhanced osseointegration
in vitro by decorin-modified titanium surface. Colloids Surf. B Biointerfaces 2017, 155, 17–24. [CrossRef] [PubMed]
Hill, L.J.; Moakes, R.J.A.; Vareechon, C.; Butt, G.; Ng, A.; Brock, K.; Chouhan, G.; Vincent, R.C.; Abbondante, S.; Williams, R.L.;
et al. Sustained release of decorin to the surface of the eye enables scarless corneal regeneration. NPJ Regen. Med. 2018, 3, 23.
[CrossRef] [PubMed]
Ahmed, Z.; Bansal, D.; Tizzard, K.; Surey, S.; Esmaeili, M.; Gonzalez, A.M.; Berry, M.; Logan, A. Decorin blocks scarring and
cystic cavitation in acute and induces scar dissolution in chronic spinal cord wounds. Neurobiol. Dis. 2014, 64, 163–176. [CrossRef]
[PubMed]
Wang, P.; Liu, X.; Xu, P.; Lu, J.; Wang, R.; Mu, W. Decorin reduces hypertrophic scarring through inhibition of the TGF-β1/Smad
signaling pathway in a rat osteomyelitis model. Exp. Ther. Med. 2016, 12, 2102–2108. [CrossRef] [PubMed]
Han, X.G.; Wang, D.K.; Gao, F.; Liu, R.H.; Bi, Z.G. Bone morphogenetic protein 2 and decorin expression in old fracture fragments
and surrounding tissues. Genet. Mol. Res. 2015, 14, 11063–11072. [CrossRef]
Cheng, H.; Caterson, B.; Yamauchi, M. Identification and immunolocalization of chondroitin sulfate proteoglycans in tooth
cementum. Connect Tissue Res. 1999, 40, 37–47. [CrossRef] [PubMed]
Robey, P.G. Vertebrate mineralized matrix proteins: Structure and function. Connect Tissue Res. 1996, 35, 131–136. [CrossRef]
Häkkinen, L.; Oksala, O.; Salo, T.; Rahemtulla, F.; Larjava, H. Immunohistochemical localization of proteoglycans in human
periodontium. J. Histochem. Cytochem. 1993, 41, 1689–1699. [CrossRef]
Hosiriluck, N.; Kashio, H.; Takada, A.; Mizuguchi, I.; Arakawa, T. The profiling and analysis of gene expression in human
periodontal ligament tissue and fibroblasts. Clin. Exp. Dent. Res. 2022, 8, 658–672. [CrossRef]
Matheson, S.; Larjava, H.; Häkkinen, L. Distinctive localization and function for lumican, fibromodulin and decorin to regulate
collagen fibril organization in periodontal tissues. J. Periodontal. Res. 2005, 40, 312–324. [CrossRef]
Häkkinen, L.; Strassburger, S.; Kähäri, V.M.; Scott, P.G.; Eichstetter, I.; Lozzo, R.V.; Larjava, H. A role for decorin in the structural
organization of periodontal ligament. Lab Invest. 2000, 80, 1869–1880. [CrossRef] [PubMed]
Sugii, H.; Maeda, H.; Tomokiyo, A.; Yamamoto, N.; Wada, N.; Koori, K.; Hasegawa, D.; Hamano, S.; Yuda, A.; Monnouchi, S.; et al.
Effects of Activin A on the phenotypic properties of human periodontal ligament cells. Bone 2014, 66, 62–71. [CrossRef] [PubMed]
Yoshida, S.; Yamamoto, N.; Wada, N.; Tomokiyo, A.; Hasegawa, D.; Hamano, S.; Mitarai, H.; Monnouchi, S.; Yuda, A.; Maeda, H.
GDNF From Human Periodontal Ligament Cells Treated With Pro-Inflammatory Cytokines Promotes Neurocytic Differentiation
of PC12 Cells. J. Cell Biochem. 2017, 118, 699–708. [CrossRef]
Lin, J.M.; Yamauchi, M.; Sato, S. Effects of recombinant interleukin-1 beta on decorin gene expression in human periodontal
ligament fibroblast and its possible transcriptional regulation. J. Periodontal. Res. 1997, 32, 225–232. [CrossRef] [PubMed]
Hu, X.; Villodre, E.S.; Larson, R.; Rahal, O.M.; Wang, X.; Gong, Y.; Song, J.; Krishnamurthy, S.; Ueno, N.T.; Tripathy, D.; et al.
Decorin-mediated suppression of tumorigenesis, invasion, and metastasis in inflammatory breast cancer. Commun. Biol. 2021, 4,
72. [CrossRef] [PubMed]
Santra, M.; Santra, S.; Zhang, J.; Chopp, M. Ectopic decorin expression up-regulates VEGF expression in mouse cerebral
endothelial cells via activation of the transcription factors Sp1, HIF1alpha, and Stat3. J. Neurochem. 2008, 105, 324–337. [CrossRef]
Suzuki, K.; Kishioka, Y.; Wakamatsu, J.; Nishimura, T. Decorin activates Akt downstream of IGF-IR and promotes myoblast
differentiation. Anim. Sci. J. 2013, 84, 669–674. [CrossRef]
Singer, A.J.; Clark, R.A. Cutaneous wound healing. N. Engl. J. Med. 1999, 341, 738–746. [CrossRef]
Cho, T.J.; Gerstenfeld, L.C.; Einhorn, T.A. Differential temporal expression of members of the transforming growth factor beta
superfamily during murine fracture healing. J. Bone Miner. Res. 2002, 17, 513–520. [CrossRef]
Maruyama, M.; Rhee, C.; Utsunomiya, T.; Zhang, N.; Ueno, M.; Yao, Z.; Goodman, S.B. Modulation of the Inflammatory Response
and Bone Healing. Front. Endocrinol. (Lausanne) 2020, 11, 386. [CrossRef]
Itoyama, T.; Yoshida, S.; Tomokiyo, A.; Hasegawa, D.; Hamano, S.; Sugii, H.; Ono, T.; Fujino, S.; Maeda, H. Possible function of
GDNF and Schwann cells in wound healing of periodontal tissue. J. Periodontal. Res. 2020, 55, 830–839. [CrossRef] [PubMed]
Beertsen, W.; McCulloch, C.A.; Sodek, J. The periodontal ligament: A unique, multifunctional connective tissue. Periodontol 2000
1997, 13, 20–40. [CrossRef] [PubMed]
Lekic, P.; McCulloch, C.A. Periodontal ligament cell population: The central role of fibroblasts in creating a unique tissue. Anat.
Rec. 1996, 245, 327–341. [CrossRef]
Seo, B.M.; Miura, M.; Gronthos, S.; Bartold, P.M.; Batouli, S.; Brahim, J.; Young, M.; Robey, P.G.; Wang, C.Y.; Shi, S. Investigation of
multipotent postnatal stem cells from human periodontal ligament. Lancet 2004, 364, 149–155. [CrossRef] [PubMed]
Randilini, A.; Fujikawa, K.; Shibata, S. An in situ hybridization study of decorin and biglycan mRNA in mouse osteoblasts in vivo.
Anat. Sci. Int. 2021, 96, 265–272. [CrossRef]
Nemani, N.; Santo, L.; Eda, H.; Cirstea, D.; Mishima, Y.; Patel, C.; O’Donnell, E.; Yee, A.; Raje, N. Role of decorin in multiple
myeloma (MM) bone marrow microenvironment. J. Bone Miner. Res. 2015, 30, 465–470. [CrossRef] [PubMed]
Waddington, R.J.; Roberts, H.C.; Sugars, R.V.; Schönherr, E. Differential roles for small leucine-rich proteoglycans in bone
formation. Eur. Cell Mater. 2003, 6, 12–21, discussion 21. [CrossRef]
Yu, Y.; Mu, J.; Fan, Z.; Lei, G.; Yan, M.; Wang, S.; Tang, C.; Wang, Z.; Yu, J.; Zhang, G. Insulin-like growth factor 1 enhances
the proliferation and osteogenic differentiation of human periodontal ligament stem cells via ERK and JNK MAPK pathways.
Histochem Cell Biol. 2012, 137, 513–525. [CrossRef]
Molecules 2022, 27, 8224
49.
50.
51.
52.
53.
54.
55.
56.
57.
16 of 16
Weinreb, M.; Nemcovsky, C.E. In vitro models for evaluation of periodontal wound healing/regeneration. Periodontol 2000 2015,
68, 41–54. [CrossRef]
Zhou, L.; Jing, J.; Wang, H.; Wu, X.; Lu, Z. Decorin promotes proliferation and migration of ORS keratinocytes and maintains hair
anagen in mice. Exp. Dermatol. 2018, 27, 1237–1244. [CrossRef]
Xu, G.; Guimond, M.J.; Chakraborty, C.; Lala, P.K. Control of proliferation, migration, and invasiveness of human extravillous
trophoblast by decorin, a decidual product. Biol. Reprod. 2002, 67, 681–689. [CrossRef] [PubMed]
Du, S.; Wang, S.; Wu, Q.; Hu, J.; Li, T. Decorin inhibits angiogenic potential of choroid-retinal endothelial cells by downregulating
hypoxia-induced Met, Rac1, HIF-1α and VEGF expression in cocultured retinal pigment epithelial cells. Exp. Eye Res. 2013, 116,
151–160. [CrossRef] [PubMed]
Hasegawa, D.; Wada, N.; Yoshida, S.; Mitarai, H.; Arima, M.; Tomokiyo, A.; Hamano, S.; Sugii, H.; Maeda, H. Wnt5a suppresses
osteoblastic differentiation of human periodontal ligament stem cell-like cells via Ror2/JNK signaling. J. Cell Physiol. 2018, 233,
1752–1762. [CrossRef]
D’Antoni, M.L.; Torregiani, C.; Ferraro, P.; Michoud, M.C.; Mazer, B.; Martin, J.G.; Ludwig, M.S. Effects of decorin and biglycan
on human airway smooth muscle cell proliferation and apoptosis. Am. J. Physiol. Lung Cell Mol. Physiol. 2008, 294, L764–L771.
[CrossRef] [PubMed]
Yoshino, O.; Izumi, G.; Shi, J.; Osuga, Y.; Hirota, Y.; Hirata, T.; Harada, M.; Nishii, O.; Koga, K.; Taketani, Y. Activin-A is induced
by interleukin-1β and tumor necrosis factor-α and enhances the mRNA expression of interleukin-6 and protease-activated
receptor-2 and proliferation of stromal cells from endometrioma. Fertil. Steril 2011, 96, 118–121. [CrossRef] [PubMed]
Arima, M.; Hasegawa, D.; Yoshida, S.; Mitarai, H.; Tomokiyo, A.; Hamano, S.; Sugii, H.; Wada, N.; Maeda, H. R-spondin
2 promotes osteoblastic differentiation of immature human periodontal ligament cells through the Wnt/β-catenin signaling
pathway. J. Periodontal. Res. 2019, 54, 143–153. [CrossRef]
Sugii, H.; Albougha, M.S.; Adachi, O.; Tomita, H.; Tomokiyo, A.; Hamano, S.; Hasegawa, D.; Yoshida, S.; Itoyama, T.; Maeda, H.
Activin A Promotes Osteoblastic Differentiation of Human Preosteoblasts through the ALK1-Smad1/5/9 Pathway. Int. J. Mol. Sci.
2021, 22, 3491. [CrossRef]
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