1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
Carnes, D.L.; Maeder, C.L.; Graves, D.T. Cells with osteoblastic phenotypes can be explanted from human gingiva and periodontal
ligament. J. Periodontol. 1997, 68, 701–707. [CrossRef]
Tomokiyo, A.; Maeda, H.; Fujii, S.; Wada, N.; Shima, K.; Akamine, A. Development of a multipotent clonal human periodontal
ligament cell line. Differentiation 2008, 76, 337–347. [CrossRef]
Seo, B.M.; Miura, M.; Gronthos, S.; Bartold, P.M.; Batouli, S.; Brahim, J.; Young, M.; Robey, P.G.; Wang, C.Y.; Shi, S. Investigation of
multipotent postnatal stem cells from human periodontal ligament. Lancet 2004, 364, 149–155. [CrossRef]
Wada, N.; Menicanin, D.; Shi, S.; Bartold, P.M.; Gronthos, S. Immunomodulatory properties of human periodontal ligament stem
cells. J. Cell Physiol. 2009, 219, 667–676. [CrossRef]
Liu, D.; Xu, J.; Liu, O.; Fan, Z.; Liu, Y.; Wang, F.; Ding, G.; Wei, F.; Zhang, C.; Wang, S. Mesenchymal stem cells derived from
inflamed periodontal ligaments exhibit impaired immunomodulation. J. Clin. Periodontol. 2012, 39, 1174–1182. [CrossRef]
Liu, O.; Xu, J.; Ding, G.; Liu, D.; Fan, Z.; Zhang, C.; Chen, W.; Ding, Y.; Tang, Z.; Wang, S. Periodontal ligament stem cells regulate
B lymphocyte function via programmed cell death protein 1. Stem Cells 2013, 31, 1371–1382. [CrossRef]
Shin, C.; Kim, M.; Han, J.A.; Choi, B.; Hwang, D.; Do, Y.; Yun, J.H. Human periodontal ligament stem cells suppress T-cell
proliferation via down-regulation of non-classical major histocompatibility complex-like glycoprotein CD1b on dendritic cells. J.
Periodontal. Res. 2017, 52, 135–146. [CrossRef]
Shalini, H.S.; Vandana, K.L. Direct application of autologous periodontal ligament stem cell niche in treatment of periodontal
osseous defects: A randomized controlled trial. J. Indian Soc. Periodontol. 2018, 22, 503–512. [CrossRef]
Takahashi, K.; Yamanaka, S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined
factors. Cell 2006, 126, 663–676. [CrossRef]
Shrestha, R. Induced pluripotent stem cells are Japanese brand sources for therapeutic cells to pretrial clinical research. Prog. Stem
Cell 2020, 7, 296–303. [CrossRef]
Sinenko, S.A.; Ponomartsev, S.V.; Tomilin, A.N. Pluripotent stem cell-based gene therapy approach: Human de novo synthesized
chromosomes. Cell. Mol. Life Sci. 2021, 78, 1207–1220. [CrossRef]
Skuratovskaia, D.; Litvinova, L.; Vulf, M.; Zatolokin, P.; Popadin, K.; Mazunin, I. From Normal to Obesity and Back: The
Associations between Mitochondrial DNA Copy Number, Gender, and Body Mass Index. Cells 2019, 8, 430. [CrossRef]
Attwood, S.W.; Edel, M.J. iPS-Cell Technology and the Problem of Genetic Instability-Can It Ever Be Safe for Clinical Use? J. Clin.
Med. 2019, 8, 288. [CrossRef]
Biomedicines 2022, 10, 2366
14.
15.
16.
17.
18.
19.
20.
21.
22.
23.
24.
25.
26.
27.
28.
29.
30.
31.
32.
33.
34.
35.
36.
37.
38.
18 of 20
Denham, M.; Dottori, M. Neural differentiation of induced pluripotent stem cells. Methods Mol. Biol. 2011, 793, 99–110. [CrossRef]
Tsujimoto, H.; Kasahara, T.; Sueta, S.I.; Araoka, T.; Sakamoto, S.; Okada, C.; Mae, S.I.; Nakajima, T.; Okamoto, N.; Taura, D.;
et al. A Modular Differentiation System Maps Multiple Human Kidney Lineages from Pluripotent Stem Cells. Cell Rep. 2020, 31,
107476. [CrossRef]
Karakikes, I.; Ameen, M.; Termglinchan, V.; Wu, J.C. Human induced pluripotent stem cell-derived cardiomyocytes: Insights into
molecular, cellular, and functional phenotypes. Circ. Res. 2015, 117, 80–88. [CrossRef]
Sun, J.; Mandai, M.; Kamao, H.; Hashiguchi, T.; Shikamura, M.; Kawamata, S.; Sugita, S.; Takahashi, M. Protective Effects of
Human iPS-Derived Retinal Pigmented Epithelial Cells in Comparison with Human Mesenchymal Stromal Cells and Human
Neural Stem Cells on the Degenerating Retina in rd1 mice. Stem Cells 2015, 33, 1543–1553. [CrossRef]
Takayama, K.; Negoro, R.; Yamashita, T.; Kawai, K.; Ichikawa, M.; Mori, T.; Nakatsu, N.; Harada, K.; Ito, S.; Yamada, H.; et al.
Generation of Human iPSC-Derived Intestinal Epithelial Cell Monolayers by CDX2 Transduction. Cell. Mol. Gastroenterol. Hepatol.
2019, 8, 513–526. [CrossRef]
El Hokayem, J.; Cukier, H.N.; Dykxhoorn, D.M. Blood Derived Induced Pluripotent Stem Cells (iPSCs): Benefits, Challenges and
the Road Ahead. J. Alzheimers Dis. Parkinsonism 2016, 6, 275. [CrossRef]
Hamano, S.; Tomokiyo, A.; Hasegawa, D.; Yoshida, S.; Sugii, H.; Mitarai, H.; Fujino, S.; Wada, N.; Maeda, H. Extracellular Matrix
from Periodontal Ligament Cells Could Induce the Differentiation of Induced Pluripotent Stem Cells to Periodontal Ligament
Stem Cell-Like Cells. Stem Cells Dev. 2018, 27, 100–111. [CrossRef]
Lu, P.; Takai, K.; Weaver, V.M.; Werb, Z. Extracellular matrix degradation and remodeling in development and disease. Cold
Spring Harb. Perspect. Biol. 2011, 3, a005058. [CrossRef]
Bonnans, C.; Chou, J.; Werb, Z. Remodelling the extracellular matrix in development and disease. Nat. Rev. Mol. Cell Biol. 2014,
15, 786–801. [CrossRef]
Ramakrishnan, P.R.; Lin, W.L.; Sodek, J.; Cho, M.I. Synthesis of noncollagenous extracellular matrix proteins during development
of mineralized nodules by rat periodontal ligament cells in vitro. Calcif. Tissue Int. 1995, 57, 52–59. [CrossRef]
Worapamorn, W.; Li, H.; Haas, H.R.; Pujic, Z.; Girjes, A.A.; Bartold, P.M. Cell surface proteoglycan expression by human
periodontal cells. Connect. Tissue Res. 2000, 41, 57–68. [CrossRef]
Tomokiyo, A.; Yoshida, S.; Hamano, S.; Hasegawa, D.; Sugii, H.; Maeda, H. Detection, Characterization, and Clinical Application
of Mesenchymal Stem Cells in Periodontal Ligament Tissue. Stem Cells Int. 2018, 2018, 5450768. [CrossRef]
Tomokiyo, A.; Wada, N.; Maeda, H. Periodontal Ligament Stem Cells: Regenerative Potency in Periodontium. Stem Cells Dev.
2019, 28, 974–985. [CrossRef]
McKee, T.J.; Perlman, G.; Morris, M.; Komarova, S.V. Extracellular matrix composition of connective tissues: A systematic review
and meta-analysis. Sci. Rep. 2019, 9, 10542. [CrossRef]
Latchman, D.S. Transcription factors: An overview. Int. J. Biochem. Cell Biol. 1997, 29, 1305–1312. [CrossRef]
Chen, S.J.; Yuan, W.; Lo, S.; Trojanowska, M.; Varga, J. Interaction of smad3 with a proximal smad-binding element of the human
alpha2(I) procollagen gene promoter required for transcriptional activation by TGF-beta. J. Cell. Physiol. 2000, 183, 381–392.
[CrossRef]
Larouche, K.; Leclerc, S.; Salesse, C.; Guérin, S.L. Expression of the alpha 5 integrin subunit gene promoter is positively regulated
by the extracellular matrix component fibronectin through the transcription factor Sp1 in corneal epithelial cells in vitro. J. Biol.
Chem. 2000, 275, 39182–39192. [CrossRef]
Rockel, J.S.; Bernier, S.M.; Leask, A. Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNFalphainduced MEK/ERK signalling. Arthritis Res. Ther. 2009, 11, R8. [CrossRef] [PubMed]
Hiebert, P. The Nrf2 transcription factor: A multifaceted regulator of the extracellular matrix. Matrix Biol. Plus 2021, 10, 100057.
[CrossRef] [PubMed]
Xu, R.; Spencer, V.A.; Bissell, M.J. Extracellular matrix-regulated gene expression requires cooperation of SWI/SNF and transcription factors. J. Biol. Chem. 2007, 282, 14992–14999. [CrossRef]
Kook, S.H.; Hwang, J.M.; Park, J.S.; Kim, E.M.; Heo, J.S.; Jeon, Y.M.; Lee, J.C. Mechanical force induces type I collagen expression
in human periodontal ligament fibroblasts through activation of ERK/JNK and AP-1. J. Cell. Biochem. 2009, 106, 1060–1067.
[CrossRef] [PubMed]
Takada, K.; Chiba, T.; Miyazaki, T.; Yagasaki, L.; Nakamichi, R.; Iwata, T.; Moriyama, K.; Harada, H.; Asahara, H. Single Cell
RNA Sequencing Reveals Critical Functions of Mkx in Periodontal Ligament Homeostasis. Front. Cell Dev. Biol. 2022, 10, 795441.
[CrossRef] [PubMed]
Wada, N.; Maeda, H.; Tanabe, K.; Tsuda, E.; Yano, K.; Nakamuta, H.; Akamine, A. Periodontal ligament cells secrete the factor that
inhibits osteoclastic differentiation and function: The factor is osteoprotegerin/osteoclastogenesis inhibitory factor. J. Periodontal.
Res. 2001, 36, 56–63. [CrossRef]
Lee, G.; Chambers, S.M.; Tomishima, M.J.; Studer, L. Derivation of neural crest cells from human pluripotent stem cells. Nat.
Protoc. 2010, 5, 688–701. [CrossRef]
Haberle, V.; Forrest, A.R.; Hayashizaki, Y.; Carninci, P.; Lenhard, B. CAGEr: Precise TSS data retrieval and high-resolution
promoterome mining for integrative analyses. Nucleic Acids Res. 2015, 43, e51. [CrossRef]
Biomedicines 2022, 10, 2366
39.
40.
41.
42.
43.
44.
45.
46.
47.
48.
49.
50.
51.
52.
53.
54.
55.
56.
57.
58.
59.
60.
61.
62.
19 of 20
Mootha, V.K.; Lindgren, C.M.; Eriksson, K.F.; Subramanian, A.; Sihag, S.; Lehar, J.; Puigserver, P.; Carlsson, E.; Ridderstråle, M.;
Laurila, E.; et al. PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human
diabetes. Nat. Genet. 2003, 34, 267–273. [CrossRef]
Subramanian, A.; Tamayo, P.; Mootha, V.K.; Mukherjee, S.; Ebert, B.L.; Gillette, M.A.; Paulovich, A.; Pomeroy, S.L.; Golub, T.R.;
Lander, E.S.; et al. Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles.
Proc. Natl. Acad. Sci. USA 2005, 102, 15545–15550. [CrossRef]
Ipposhi, K.; Tomokiyo, A.; Ono, T.; Yamashita, K.; Alhasan, M.A.; Hasegawa, D.; Hamano, S.; Yoshida, S.; Sugii, H.; Itoyama, T.;
et al. Secreted Frizzled-Related Protein 1 Promotes Odontoblastic Differentiation and Reparative Dentin Formation in Dental
Pulp Cells. Cells 2021, 10, 2491. [CrossRef] [PubMed]
Morgner, J.; Ghatak, S.; Jakobi, T.; Dieterich, C.; Aumailley, M.; Wickström, S.A. Integrin-linked kinase regulates the niche of
quiescent epidermal stem cells. Nat. Commun. 2015, 6, 8198. [CrossRef] [PubMed]
Rammensee, S.; Kang, M.S.; Georgiou, K.; Kumar, S.; Schaffer, D.V. Dynamics of Mechanosensitive Neural Stem Cell Differentiation. Stem Cells 2017, 35, 497–506. [CrossRef] [PubMed]
Wang, X.; Chen, Z.; Zhou, B.; Duan, X.; Weng, W.; Cheng, K.; Wang, H.; Lin, J. Cell-Sheet-Derived ECM Coatings and Their Effects
on BMSCs Responses. ACS Appl. Mater. Interfaces 2018, 10, 11508–11518. [CrossRef]
Liu, Q.; Hu, X.; Zhang, X.; Duan, X.; Yang, P.; Zhao, F.; Ao, Y. Effects of mechanical stress on chondrocyte phenotype and
chondrocyte extracellular matrix expression. Sci. Rep. 2016, 6, 37268. [CrossRef]
He, Q.; Lin, Y.; Liao, B.; Zhou, L.; Ai, J.; Jin, X.; Li, H.; Wang, K. The role of interleukin-6/interleukin-6 receptor signaling in the
mechanical stress-induced extracellular matrix remodeling of bladder smooth muscle. Arch. Biochem. Biophys. 2021, 702, 108674.
[CrossRef]
Tewksbury, C.D.; Callaghan, K.X.; Fulks, B.A.; Gerstner, G.E. Individuality of masticatory performance and of masticatory muscle
temporal parameters. Arch. Oral Biol. 2018, 90, 113–124. [CrossRef]
Xiong, X.; Yang, X.; Dai, H.; Feng, G.; Zhang, Y.; Zhou, J.; Zhou, W. Extracellular matrix derived from human urine-derived stem
cells enhances the expansion, adhesion, spreading, and differentiation of human periodontal ligament stem cells. Stem Cell Res.
Ther. 2019, 10, 396. [CrossRef]
Chen, X.; Li, Y.; Paiboonrungruang, C.; Li, Y.; Peters, H.; Kist, R.; Xiong, Z. PAX9 in Cancer Development. Int. J. Mol. Sci. 2022,
23, 5589. [CrossRef]
Peters, H.; Schuster, G.; Neubüser, A.; Richter, T.; Höfler, H.; Balling, R. Isolation of the Pax9 cDNA from adult human esophagus.
Mamm. Genome 1997, 8, 62–64. [CrossRef]
Bannykh, S.I.; Emery, S.C.; Gerber, J.K.; Jones, K.L.; Benirschke, K.; Masliah, E. Aberrant Pax1 and Pax9 expression in Jarcho-Levin
syndrome: Report of two Caucasian siblings and literature review. Am. J. Med. Genet. A 2003, 120a, 241–246. [CrossRef] [PubMed]
Peters, H.; Neubüser, A.; Kratochwil, K.; Balling, R. Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit
craniofacial and limb abnormalities. Genes Dev. 1998, 12, 2735–2747. [CrossRef] [PubMed]
Nakatomi, M.; Wang, X.P.; Key, D.; Lund, J.J.; Turbe-Doan, A.; Kist, R.; Aw, A.; Chen, Y.; Maas, R.L.; Peters, H. Genetic interactions
between Pax9 and Msx1 regulate lip development and several stages of tooth morphogenesis. Dev. Biol. 2010, 340, 438–449.
[CrossRef]
Seki, D.; Takeshita, N.; Oyanagi, T.; Sasaki, S.; Takano, I.; Hasegawa, M.; Takano-Yamamoto, T. Differentiation of Odontoblast-Like
Cells From Mouse Induced Pluripotent Stem Cells by Pax9 and Bmp4 Transfection. Stem Cells Transl. Med. 2015, 4, 993–997.
[CrossRef]
Sivakamasundari, V.; Kraus, P.; Sun, W.; Hu, X.; Lim, S.L.; Prabhakar, S.; Lufkin, T. A developmental transcriptomic analysis of
Pax1 and Pax9 in embryonic intervertebral disc development. Biol. Open 2017, 6, 187–199. [CrossRef]
Kearns, S.M.; Laywell, E.D.; Kukekov, V.K.; Steindler, D.A. Extracellular matrix effects on neurosphere cell motility. Exp. Neurol.
2003, 182, 240–244. [CrossRef]
Antoon, R.; Yeger, H.; Loai, Y.; Islam, S.; Farhat, W.A. Impact of bladder-derived acellular matrix, growth factors, and extracellular
matrix constituents on the survival and multipotency of marrow-derived mesenchymal stem cells. J. Biomed. Mater. Res. A 2012,
100, 72–83. [CrossRef]
Bi, Y.; Ehirchiou, D.; Kilts, T.M.; Inkson, C.A.; Embree, M.C.; Sonoyama, W.; Li, L.; Leet, A.I.; Seo, B.M.; Zhang, L.; et al.
Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche. Nat. Med. 2007, 13, 1219–1227.
[CrossRef]
Hupe, M.; Li, M.X.; Kneitz, S.; Davydova, D.; Yokota, C.; Kele, J.; Hot, B.; Stenman, J.M.; Gessler, M. Gene expression profiles of
brain endothelial cells during embryonic development at bulk and single-cell levels. Sci. Signal. 2017, 10, eaag2476. [CrossRef]
Ormestad, M.; Astorga, J.; Landgren, H.; Wang, T.; Johansson, B.R.; Miura, N.; Carlsson, P. Foxf1 and Foxf2 control murine gut
development by limiting mesenchymal Wnt signaling and promoting extracellular matrix production. Development 2006, 133,
833–843. [CrossRef]
Wang, T.; Tamakoshi, T.; Uezato, T.; Shu, F.; Kanzaki-Kato, N.; Fu, Y.; Koseki, H.; Yoshida, N.; Sugiyama, T.; Miura, N. Forkhead
transcription factor Foxf2 (LUN)-deficient mice exhibit abnormal development of secondary palate. Dev. Biol. 2003, 259, 83–94.
[CrossRef]
Yu, L.; Wynn, J.; Ma, L.; Guha, S.; Mychaliska, G.B.; Crombleholme, T.M.; Azarow, K.S.; Lim, F.Y.; Chung, D.H.; Potoka, D.; et al.
De novo copy number variants are associated with congenital diaphragmatic hernia. J. Med. Genet. 2012, 49, 650–659. [CrossRef]
Biomedicines 2022, 10, 2366
63.
64.
65.
20 of 20
Neubüser, A.; Peters, H.; Balling, R.; Martin, G.R. Antagonistic interactions between FGF and BMP signaling pathways: A
mechanism for positioning the sites of tooth formation. Cell 1997, 90, 247–255. [CrossRef]
Vieira, A.R.; Meira, R.; Modesto, A.; Murray, J.C. MSX1, PAX9, and TGFA contribute to tooth agenesis in humans. J. Dent. Res.
2004, 83, 723–727. [CrossRef]
Ogawa, T.; Kapadia, H.; Feng, J.Q.; Raghow, R.; Peters, H.; D’Souza, R.N. Functional consequences of interactions between Pax9
and Msx1 genes in normal and abnormal tooth development. J. Biol. Chem. 2006, 281, 18363–18369. [CrossRef]
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