1 Bellani G, Laffey JG, Pham T, Fan E, Brochard L,
Esteban A, et al. Epidemiology, patterns of care, and
mortality for patients with acute respiratory distress
syndrome in intensive care units in 50 Countries.
JAMA. 2016;315:788–800.
2 Sud S, Friedrich JO, Taccone P, Polli F, Adhikari NK,
Latini R, et al. Prone ventilation reduces mortality in
patients with acute respiratory failure and severe
hypoxemia: systematic review and meta-analysis.
Intensive Care Med. 2010;36:585–99.
3 Mercat A, Richard JC, Vielle B, Jaber S, Osman D,
Diehl JL, et al. Positive end-expiratory pressure setting
in adults with acute lung injury and acute respiratory
distress syndrome: a randomized controlled trial.
JAMA. 2008;299:646–55.
4 Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson
ND, Caldwell E, Fan E, et al. Acute respiratory distress
syndrome: the Berlin Definition. JAMA. 2012;307:2526–33.
5 Chaput C, Zychlinsky A. Sepsis: the dark side of
histones. Nat Med. 2009;15:1245–6.
6 Xu J, Zhang X, Pelayo R, Monestier M, Ammollo CT,
Semeraro F, et al. Extracellular histones are major
mediators of death in sepsis. Nat Med. 2009;15:1318–21.
7 Fuchs TA, Brill A, Duerschmied D, Schatzberg D,
Monestier M, Myers DD Jr, et al. Extracellular DNA
traps promote thrombosis. Proc Natl Acad Sci USA.
2010;107:15880–5.
8 Saffarzadeh M, Juenemann C, Queisser MA, Lochnit
G, Barreto G, Galuska SP, et al. Neutrophil
extracellular traps directly induce epithelial and
endothelial cell death: a predominant role of histones.
PLoS One. 2012;7:e32366.
9 Wheeler AP, Bernard GR. Acute lung injury and the
acute respiratory distress syndrome: a clinical review.
Lancet. 2007;369:1553–64.
10 Matthay MA, Ware LB. Plasma protein C levels in
patients with acute lung injury: prognostic significance.
Crit Care Med. 2004;32:S229–32.
11 Wiegner R, Chakraborty S, Huber-Lang M.
Complement-coagulation crosstalk on cellular and
artificial surfaces. Immunobiology. 2016;221:1073–9.
12 Castellano G, Melchiorre R, Loverre A, Ditonno P,
Montinaro V, Rossini M, et al. Therapeutic targeting
of classical and lectin pathways of complement protects
from ischemia-reperfusion-induced renal damage. Am J
Pathol. 2010;176:1648–59.
FEBS Open Bio 12 (2022) 192–202 ª 2021 The Authors. FEBS Open Bio published by John Wiley & Sons Ltd on behalf of
Federation of European Biochemical Societies.
22115463, 2022, 1, Downloaded from https://febs.onlinelibrary.wiley.com/doi/10.1002/2211-5463.13322 by Nagoya University, Wiley Online Library on [15/12/2022]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License
F. Nagano et al.
Expression of Crry is reduced in acute lung injury
13 Poppelaars F, Damman J, de Vrij EL, Burgerhof JG,
Saye J, Daha MR, et al. New insight into the effects of
heparinoids on complement inhibition by C1-inhibitor.
Clin Exp Immunol. 2016;184:378–88.
14 Sartain SE, Turner NA, Moake JL. TNF regulates
essential alternative complement pathway components
and impairs activation of protein C in human
glomerular endothelial cells. J Immunol. 2016;196:832–
45.
15 Roumenina LT, Rayes J, Frimat M, Fremeaux-Bacchi
V. Endothelial cells: source, barrier, and target of
defensive mediators. Immunol Rev. 2016;274:307–29.
16 Quigg RJ, Kozono Y, Berthiaume D, Lim A, Salant
DJ, Weinfeld A, et al. (1998) Blockade of antibodyinduced glomerulonephritis with Crry-Ig, a soluble
murine complement inhibitor. J Immunol.
1950;160:4553–60.
17 Kim YU, Kinoshita T, Molina H, Hourcade D, Seya
T, Wagner LM, et al. Mouse complement regulatory
protein Crry/p65 uses the specific mechanisms of both
human decay-accelerating factor and membrane
cofactor protein. J Exp Med. 1995;181:151–9.
18 Mizuno M, Nishikawa K, Okada N, Matsuo S, Ito K,
Okada H. (1999) Inhibition of a membrane complement
regulatory protein by a monoclonal antibody induces
acute lethal shock in rats primed with
lipopolysaccharide. J Immunol. 1950;162:5477–82.
19 Harkin DW, Marron CD, Rother RP, Romaschin A,
Rubin BB, Lindsay TF. C5 complement inhibition
attenuates shock and acute lung injury in an
experimental model of ruptured abdominal aortic
aneurysm. Br J Surg. 2005;92:1227–34.
20 Bosmann M, Grailer JJ, Ruemmler R, Russkamp NF,
Zetoune FS, Sarma JV, et al. Extracellular histones are
essential effectors of C5aR- and C5L2-mediated tissue
damage and inflammation in acute lung injury. FASEB
J. 2013;27:5010–21.
21 Li Y, Yang Z, Chavko M, Liu B, Aderemi OA,
Simovic MO, et al. Complement inhibition ameliorates
blast-induced acute lung injury in rats: Potential role of
complement in intracellular HMGB1-mediated
inflammation. PLoS One. 2018;13:e0202594.
22 Mena HA, Carestia A, Scotti L, Parborell F, Schattner
M, Negrotto S. Extracellular histones reduce survival
and angiogenic responses of late outgrowth progenitor
and mature endothelial cells. J Thromb Haemost.
2016;14:397–410.
23 Gillrie MR, Lee K, Gowda DC, Davis SP, Monestier
M, Cui L, et al. Plasmodium falciparum histones
induce endothelial proinflammatory response and
barrier dysfunction. Am J Pathol. 2012;180:1028–39.
24 Mizuno T, Mizuno M, Imai M, Suzuki Y, Kushida M,
Noda Y, et al. Anti-C5a complementary peptide
ameliorates acute peritoneal injury induced by
Expression of Crry is reduced in acute lung injury
25
26
27
28
29
30
31
32
33
34
35
36
neutralization of Crry and CD59. Am J Physiol Renal
Physiol. 2013;305:F1603–16.
Zhang Y, Guan L, Yu J, Zhao Z, Mao L, Li S, et al.
Pulmonary endothelial activation caused by
extracellular histones contributes to neutrophil
activation in acute respiratory distress syndrome. Respir
Res. 2016;17:155.
Mizuno T, Yoshioka K, Mizuno M, Shimizu M,
Nagano F, Okuda T, et al. Complement component 5
promotes lethal thrombosis. Sci Rep. 2017;7:42714.
Nagano F, Mizuno T, Mizumoto S, Yoshioka K,
Takahashi K, Tsuboi N, et al. Chondroitin sulfate
protects vascular endothelial cells from toxicities of
extracellular histones. Eur J Pharmacol. 2018;826:48–55.
Bantikassegn A, Song X, Politi K. Isolation of
epithelial, endothelial, and immune cells from lungs of
transgenic mice with oncogene-induced lung
adenocarcinomas. Am J Respir Cell Mol Biol.
2015;52:409–17.
Rynkowski MA, Kim GH, Garrett MC, Zacharia BE,
Otten ML, Sosunov SA, et al. C3a receptor antagonist
attenuates brain injury after intracerebral hemorrhage.
J Cereb Blood Flow Metab. 2009;29:98–107.
Bosma KJ, Lewis JF. Emerging therapies for treatment
of acute lung injury and acute respiratory distress
syndrome. Expert Opin Emerg Drugs. 2007;12:461–77.
Kambas K, Markiewski MM, Pneumatikos IA, Rafail
SS, Theodorou V, Konstantonis D, et al. C5a and
TNF-alpha up-regulate the expression of tissue factor
in intra-alveolar neutrophils of patients with the acute
respiratory distress syndrome. J Immunol.
2008;180:7368–75.
Naito M, Taguchi O, Kobayashi T, Takagi T,
D’Alessandro-Gabazza CN, Matsushima Y, et al.
Thrombin-activatable fibrinolysis inhibitor protects
against acute lung injury by inhibiting the complement
system. Am J Respir Cell Mol Biol. 2013;49:646–53.
Hammerschmidt DE, Weaver LJ, Hudson LD,
Craddock PR, Jacob HS. Association of complement
activation and elevated plasma-C5a with adult
respiratory distress syndrome. Pathophysiological
relevance and possible prognostic value. Lancet.
1980;1:947–9.
Pittet JF, Mackersie RC, Martin TR, Matthay MA.
Biological markers of acute lung injury: prognostic and
pathogenetic significance. Am J Respir Crit Care Med.
1997;155:1187–205.
Solomkin JS, Cotta LA, Satoh PS, Hurst JM, Nelson
RD. Complement activation and clearance in acute
illness and injury: evidence for C5a as a cell-directed
mediator of the adult respiratory distress syndrome in
man. Surgery. 1985;97:668–78.
Zimmerman JL, Dellinger RP, Straube RC, Levin JL.
Phase I trial of the recombinant soluble complement
FEBS Open Bio 12 (2022) 192–202 ª 2021 The Authors. FEBS Open Bio published by John Wiley & Sons Ltd on behalf of
Federation of European Biochemical Societies.
201
22115463, 2022, 1, Downloaded from https://febs.onlinelibrary.wiley.com/doi/10.1002/2211-5463.13322 by Nagoya University, Wiley Online Library on [15/12/2022]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License
F. Nagano et al.
receptor 1 in acute lung injury and acute respiratory
distress syndrome. Crit Care Med. 2000;28:3149–54.
37 Qaddoori Y, Abrams ST, Mould P, Alhamdi Y,
Christmas SE, Wang G, et al. Extracellular histones
inhibit complement activation through interacting with
complement component 4. J Immunol. 2018;200:4125–33.
38 Mizuno M, Nozaki M, Morine N, Suzuki N, Nishikawa
K, Morgan BP, et al. A protein toxin from the sea
anemone Phyllodiscus semoni targets the kidney and
causes a severe renal injury with predominant glomerular
endothelial damage. Am J Pathol. 2007;171:402–14.
Supporting information
Additional supporting information may be found
online in the Supporting Information section at the end
of the article.
202
F. Nagano et al.
Fig. S1. The macroscopic findings at 10–60 min after
calf thymus histones administration. C57BL/6J mice
received a single tail vein injection of calf thymus histones (45 lgg 1 body weight) or saline. Lung samples
were collected at 10 and 30 min after the injection of
calf thymus histones.
Fig. S2. Expression of Crry on the ECs and lung tissue. Lung samples were collected from C57BL/6J mice
(n = 6 per group). Blue, red, and green collars show
nuclear, CD31, Crry, respectively. Microscopic findings are shown through haematoxylin and eosin stains.
White and black bars show 100 lm. The expression of
Crry/p65 of endothelial cells and CD31+Crry/p65+ area
in the whole-section were measured at 10, 30 min after
the injection of calf thymus histones. Values are shown
as experimental means SD. **P < 0.05 vs. vehicle,
††
P < 0.05 vs. 10 min histone (Tukey’s test).
FEBS Open Bio 12 (2022) 192–202 ª 2021 The Authors. FEBS Open Bio published by John Wiley & Sons Ltd on behalf of
Federation of European Biochemical Societies.
22115463, 2022, 1, Downloaded from https://febs.onlinelibrary.wiley.com/doi/10.1002/2211-5463.13322 by Nagoya University, Wiley Online Library on [15/12/2022]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License
Expression of Crry is reduced in acute lung injury
...
論文の公開元へ
