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TLR-MyD88-signaling blockades inhibit refractory B-1b cell immune responses to transplant-related glycan antigens

坂井 寛 広島大学

2020.11.26

概要

Hu
Humor
Humoral
responses to T cell-independent (TI) carbohydrate antigens (Ags) are critical drivers of
the adverse
adv
reactions to ABO-incompatible (ABOi) organ transplantation and the rejection of
xenogeneic
grafts from other species 1,2. Antibodies (Abs) to those TI antigens are thought to be
xen
xenoge
mainly produced by distinguished B cell subpopulations, B-1 cells, which mainly express
ma
germline-encoded antigen-specific B cell receptors (BCRs) that have limited diversity and are
germlin
ger
enriched for specificities that recognize a variety of carbohydrate residues 3. In addition to BCR
enriche
ligation, the activation of pattern-recognition receptors, including Toll-like receptors (TLRs), on
ligation
lig
cells is also thought to be important for their immune responses, i.e. coordinated stimulation
B- cel
B-1
of TLR and BCR signaling has been proven to activates B cells and triggers the rapid induction of
Ag-specific IgM responses 4,5. Although simultaneous or sequential engagement of BCRs and
TI AgTL llikely alter and fine tune B cell activation 6, the details of the crosstalk between those signals
TLRs
the functions of B cells in TI humoral immunity have been poorly defined. ...

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Supporting Information

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Additional supporting information may be found online in the Supporting Information section at

Additio

the

he end of the article.

This article is protected by copyright. All rights reserved

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