論文の公開元へCorrelations of high molecular weight adiponectin, tumor necrosis factor-alpha and vascular endothelial growth factors with occurrence of colonic polyps in the prediabetic population
概要
Prediabetes is defined as the disorders of glucose metabolism, a state between diabetes mellitus
and normal glucose tolerance. It is mainly manifested as impaired fasting plasma glucose (FPG)
level and glucose tolerance.1 The detection rates of colon cancer and colonic polyps in prediabetic
patients aged over 40 years old in China are 4.19% and 49.50%, respectively.2 A colonic polyp,
as a precancerous lesion, is the neoplasm protruding from the mucosal surface of the colon to
the intestinal cavity. It can be pathologically classified into adenoma, hyperplastic tumors and
inflammatory tumors. Most colonic polyps are benign, but some of them may gradually develop
into colon cancer.3,4 Hence, it is crucial to explore easily-operated and sensitive biomarkers for
the early diagnosis of prediabetes complicated with colonic polyps, identification of high-risk
groups of colon cancer and prognostic evaluation.
The onset and progression of colonic polyps have been related to the imbalance of immune
regulation, inflammatory response and vascular damage mediated by inflammatory factors.5
Adiponectin (ADP) can reduce insulin resistance (IR) and regulate glucose and lipid metabolism,
which is the only polypeptide hormone negatively related to inflammation and IR. High molecular
weight ADP (HMW-ADP), the main active form of ADP, can simulate insulin to bind insulin
receptors, thus enhancing insulin sensitivity. Besides, HMW-ADP also inhibits the activation
of nuclear transcription factors by regulating the level of tumor necrosis factor-alpha (TNF-a),
and alleviates inflammatory responses, thus suppressing inflammation-induced mutation of protooncogenes such as K-ras gene.6 Vascular endothelial growth factors (VEGFs) are a class of potent
inducing factors for vascular permeability and angiogenesis, which can significantly enhance
lymphatic permeability and facilitate lymphatic hyperplasia and lymph node metastasis and
infiltration in tumor cells. Besides, VEGF helps stratify colorectal polyps in different progression
risk categories and effectively predicts the occurrence of polypoid adenomas.7 Nonetheless, the
expressions, roles or mechanisms of HMW-ADP and VEGFs in prediabetes complicated with
colonic polyps remain elusive. In this study, therefore, the correlations of HMW-ADP, TNF-a
and VEGFs with the occurrence of colonic polyps in the prediabetic population were assessed,
aiming to provide valuable evidence for future prevention and treatment. ...
この論文で使われている画像
