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Aniseikonia after reduced-fluence photodynamic therapy in patients with central serous chorioretinopathy

Chubachi-Kamimura, Aya Miki, Akiko Hayashida-Hirano, Mayuka Kishimoto-Kishi, Maya Okuda, Mina Matsumiya, Wataru Imai, Hisanori Kusuhara, Sentaro Nakamura, Makoto 神戸大学

2023.10.10

概要

This study investigated aniseikonia after reduced-fluence photodynamic therapy (RFPDT) for central serous chorioretinopathy (CSC). We examined 48 eyes of 48 patients (38 men; mean age, 49.2 ± 9.9 years) with CSC resolved after RFPDT. Horizontal and vertical aniseikonia were measured using the New Aniseikonia Test at baseline, 6 months, and 12 months after RFPDT. The maximum absolute value of the horizontal and vertical measurements indicated the aniseikonia score. The aniseikonia score was 2.2 ± 2.3 at 6 months and 2.2 ± 2.0 at 12 months after RFPDT, both of which improved significantly from the baseline score of 4.1 ± 2.9 (P < 0.05 and P < 0.01, respectively). The 12-month aniseikonia score significantly correlated with the baseline aniseikonia score (P = 0.047), outer nuclear thickness at baseline (P = 0.027) and 12 months after RFPDT (P = 0.014), baseline SRD area (P = 0.005), and ellipsoid zone disruption at 12 months after RFPDT (P = 0.021). In multivariate analysis, baseline serous retinal detachment (SRD) area (P = 0.034) was significantly associated with aniseikonia score at 12 months after RFPDT. Eyes with a larger SRD area might have higher aniseikonia scores even after SRD resolution following RFPDT.

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Acknowledgements

We gratefully acknowledge the work of past and present members of the Kobe University Department of

Ophthalmology.

Author contributions

A.M., M.H.H., and A.C.K. designed the study. A.M., M.H.H., and A.C.K. prepared the manuscript. M.O, M.K.K.,

M.H.H., and A.C.K. collected clinical data. M.H.H. and A.C.K. performed statistical analysis. W.M., H.I., S.K.,

and M.N. supervised the research. All authors reviewed and agreed with the manuscript.

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Competing interests The authors declare no competing interests.

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