リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

大学・研究所にある論文を検索できる 「Superiority of CRP-albumin-lymphocyte index (CALLY index) as a non-invasive prognostic biomarker after hepatectomy for hepatocellular carcinoma.」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。
リケラボ

コピーが完了しました

URLをコピーしました

論文の公開元へ論文の公開元へ
書き出し

Superiority of CRP-albumin-lymphocyte index (CALLY index) as a non-invasive prognostic biomarker after hepatectomy for hepatocellular carcinoma.

IIDA Hiroya 30733901 0000-0001-6245-4583 TANI Masaji 60236677 0000-0003-1270-6003 KOMEDA Koji NOMI Takeo MATSUSHIMA Hideyuki TANAKA Shogo UENO Masaki NAKAI Takuya MAEHIRA Hiromitsu 0000-0003-3064-5216 MORI Haruki 40803945 MATSUI Kosuke HIROKAWA Fumitoshi KAIBORI Masaki 0000-0002-0577-3921 KUBO Shoji 滋賀医科大学

2021.06.22

概要

Background: We aimed to investigate whether a novel biomarker incorporating albumin, lymphocytes, and CRP can predict the prognosis for hepatocellular carcinoma (HCC) after hepatectomy.
Methods: Between January 2011 and December 2013, 384 patients who underwent hepatectomy in four university hospitals in Japan were investigated as a discovery cohort. The CRP-Albumin-Lymphocyte (CALLY index) was defined as (Albumin×Lymphocyte)/(CRP×104). Patients with a CALLY index ≥5 (n=200) were compared to those with an index <5 (n=184). Next, validation was performed using 267 patients from three other university hospitals (external validation cohort).
Results: The number of TNM Stage III and IV patients was significantly higher in the CALLY <5 group than the ≥5 group (p=0.003). There was a significant difference in the 5-year survival rate (CALLY ≥5: 71% vs. <5: 46%; p<0.001). Multivariate analysis identified the CALLY index as an independent factor of overall survival. Similarly, there was a significant difference in the 5-year survival rate between the CALLY ≥5 (73%) and <5 (48%) groups (p<0.001), and the CALLY index was identified as an independent prognostic factor in the external validation cohort.
Discussion: The CALLY index derived from CRP, albumin, and lymphocyte values is a promising predictive biomarker for postoperative prognosis of patients with HCC.

論文の公開元へ

この論文で使われている画像

関連論文

関連論文をもっと見る

参考文献

1. Forrest LM, McMillan DC, McArdle CS, Angerson WJ, Dunlop DJ. (2003) Evaluation of cumulative prognostic scores based on the systemic inflammatory response in patients with inoperable non-small-cell lung cancer. Br J Cancer 89:1028-1030.

2. Zahorec R. (2001) Ratio of neutrophil to lymphocyte counts--rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy 102:5-14.

3. Liao W, Zhang J, Zhu Q, Qin L, Yao W, Lei B et al. (2014) Preoperative neutrophil-to-lymphocyte ratio as a new prognostic marker in hepatocellular carcinoma after curative resection. Transl Oncol 7:248-255.

4. Okamura Y, Ashida R, Ito T, Sugiura T, Mori K, Uesaka K. (2015) Preoperative neutrophil to lymphocyte ratio and prognostic nutritional index predict overall survival after hepatectomy for hepatocellular carcinoma. World J Surg 39:1501-1509.

5. Qi X, Li J, Deng H, Li H, Su C, Guo X. (2016) Neutrophil-to-lymphocyte ratio for the prognostic assessment of hepatocellular carcinoma: A systematic review and meta-analysis of observational studies. Oncotarget 7:45283-45301.

6. Shimoda M, Tago K, Shiraki T, Mori S, Kato M, Aoki T et al. (2016) Risk Factors for Early Recurrence of Single Lesion Hepatocellular Carcinoma After Curative Resection. World J Surg 40:2466-2471.

7. Feng JF, Huang Y, Liu JS. (2013) Combination of neutrophil lymphocyte ratio and platelet lymphocyte ratio is a useful predictor of postoperative survival in patients with esophageal squamous cell carcinoma. Onco Targets Ther 6:1605-1612.

8. Zhao Y, Si G, Zhu F, Hui J, Cai S, Huang C et al. (2017) Prognostic role of platelet to lymphocyte ratio in hepatocellular carcinoma: A systematic review and meta-analysis. Oncotarget 8:22854-22862.

9. Ishizuka M, Kubota K, Kita J, Shimoda M, Kato M, Sawada T. (2012) Impact of an inflammation-based prognostic system on patients undergoing surgery for hepatocellular carcinoma: A retrospective study of 398 Japanese patients. Am J Surg 203:101-106.

10. Kinoshita A, Onoda H, Imai N, Iwaku A, Oishi M, Fushiya N et al. (2012) Comparison of the prognostic value of inflammation-based prognostic scores in patients with hepatocellular carcinoma. Br J Cancer 107:988- 993.

11. Horino K, Beppu T, Kuroki H, Mima K, Okabe H, Nakahara O et al. (2013) Glasgow Prognostic Score as a useful prognostic factor after hepatectomy for hepatocellular carcinoma. Int J Clin Oncol 18:829-838.

12. Kinoshita A, Onoda H, Imai N, Iwaku A, Oishi M, Tanaka K et al. (2013) The Glasgow Prognostic Score, an inflammation based prognostic score, predicts survival in patients with hepatocellular carcinoma. BMC Cancer 13.

13. Huang J, Xu L, Luo Y, He F, Zhang Y, Chen M. (2014) The inflammation- based scores to predict prognosis of patients with hepatocellular carcinoma after hepatectomy. Med Oncol 31.

14. Pan QX, Zhang JH, Su ZJ, Wang CR, Ke SY. (2014) The Glasgow Prognostic Score is an independent prognostic predictor of hepatocellular carcinoma following radical resection. Oncol Res Treat 37:192-197.

15. Yamamura K, Sugimoto H, Kanda M, Yamada S, Nomoto S, Nakayama G et al. (2014) Comparison of inflammation-based prognostic scores as predictors of tumor recurrence in patients with hepatocellular carcinoma after curative resection. J HepatoBiliary Pancreat Sci 21:682-688.

16. Zheng J, Cai J, Li H, Zeng K, He L, Fu H et al. (2017) Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio as Prognostic Predictors for Hepatocellular Carcinoma Patients with Various Treatments: A Meta-Analysis and Systematic Review. Cell Physiol Biochem 44:967-981.

17. Toiyama Y, Miki C, Inoue Y, Tanaka K, Mohri Y, Kusunoki M. (2011) Evaluation of an inflammation-based prognostic score for the identification of patients requiring postoperative adjuvant chemotherapy for stage II colorectal cancer. Exp Ther Med 2:95-101.

18. Buzby GP, Mullen JL, Matthews DC, Hobbs CL, Rosato EF. (1980) Prognostic nutritional index in gastrointestinal surgery. Am J Surg 139:160-167.

19. Onodera T, Goseki N, Kosaki G. (1984) [Prognostic nutritional index in gastrointestinal surgery of malnourished cancer patients]. Nihon Geka Gakkai Zasshi 85:1001-1005.

20. Ottery FD. (1994) Cancer cachexia: prevention, early diagnosis, and management. Cancer pract 2:123-131.

21. Pinato DJ, North BV, Sharma R. (2012) A novel, externally validated inflammation-based prognostic algorithm in hepatocellular carcinoma: The prognostic nutritional index (PNI). Br J Cancer 106:1439-1445.

22. Chan AWH, Chan SL, Wong GLH, Wong VWS, Chong CCN, Lai PBS et al. (2015) Prognostic Nutritional Index (PNI) Predicts Tumor Recurrence of Very Early/Early Stage Hepatocellular Carcinoma After Surgical Resection. Ann Surg Oncol 22:4138-4148.

23. Goh BKP, Kam JH, Lee SY, Chan CY, Allen JC, Jeyaraj P et al. (2016) Significance of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and prognostic nutrition index as preoperative predictors of early mortality after liver resection for huge (≥10 cm) hepatocellular carcinoma. J Surg Oncol 113:621-627.

24. Peng W, Li C, Wen TF, Yan LN, Li B, Wang WT et al. (2016) Postoperative prognostic nutritional index change is an independent predictor of survival in patients with small hepatocellular carcinoma. Am J Surg 212:122-127.

25. Ji F, Liang Y, Fu S, Chen D, Cai X, Li S et al. (2017) Prognostic value of combined preoperative prognostic nutritional index and body mass index in HCC after hepatectomy. HPB 19:695-705.

26. Okamura Y, Sugiura T, Ito T, Yamamoto Y, Ashida R, Uesaka K. (2017) The optimal cut-off value of the preoperative prognostic nutritional index for the survival differs according to the TNM stage in hepatocellular carcinoma. Surg Today 47:986-993.

27. Muto Y, Sato S, Watanabe A, Moriwaki H, Suzuki K, Kato A et al. (2006) Overweight and obesity increase the risk for liver cancer in patients with liver cirrhosis and long-term oral supplementation with branched-chain amino acid granules inhibits liver carcinogenesis in heavier patients with liver cirrhosis. Hepatol Res 35:204-214.

28. Ichikawa K, Okabayashi T, Maeda H, Namikawa T, Iiyama T, Sugimoto T et al. (2013) Oral supplementation of branched-chain amino acids reduces early recurrence after hepatic resection in patients with hepatocellular carcinoma: a prospective study. Surg Today 43:720-726.

29. Zini G. In: Porwit A, McCullough J, Erber W, eds. Blood and Bone Marrow Pathology, second ed. London: Churchil Livingstone 2011;16:247-62.

30. Gomez D, Farid S, Malik HZ, Young AL, Toogood GJ, Lodge JPA et al. (2008) Preoperative neutrophil-to-lymphocyte ratio as a prognostic predictor after curative resection for hepatocellular carcinoma. World J Surg 32:1757-1762.

31. Fu SJ, Shen SL, Li SQ, Hua YP, Hu WJ, Liang LJ et al. (2013) Prognostic value of preoperative peripheral neutrophil-to-lymphocyte ratio in patients with HBV-associated hepatocellular carcinoma after radical hepatectomy. Med Oncol 30.

32. Mano Y, Shirabe K, Yamashita YI, Harimoto N, Tsujita E, Takeishi K et al. (2013) Preoperative neutrophil-to-lymphocyte ratio is a predictor of survival after hepatectomy for hepatocellular carcinoma: A retrospective analysis. Ann Surg 258:301-305.

33. Xiao WK, Chen D, Li SQ, Fu SJ, Peng BG, Liang LJ. (2014) Prognostic significance of neutrophil-lymphocyte ratio in hepatocellular carcinoma: A meta-analysis. BMC Cancer 14.

34. Li C, Wen TF, Yan LN, Li B, Wang WT, Yang JY et al. (2015) Postoperative neutrophil-to-lymphocyte ratio plus platelet-to-lymphocyte ratio predicts the outcomes of hepatocellular carcinoma. J Surg Res 198:73-79.

35. Li X, Chen ZH, Xing YF, Wang TT, Wu DH, Wen JY et al. (2015) Platelet- to-lymphocyte ratio acts as a prognostic factor for patients with advanced hepatocellular carcinoma. Tumor Biol 36:2263-2269.

36. Kinoshita A, Onoda H, Imai N, Iwaku A, Oishi M, Tanaka K et al. (2015) The C-Reactive Protein/Albumin Ratio, a Novel Inflammation-Based Prognostic Score, Predicts Outcomes in Patients with Hepatocellular Carcinoma. Ann Surg Oncol 22:803-810.

37. Okugawa Y, Toiyama Y, Yamamoto A, Shigemori T, Ide S, Kitajima T et al. (2019) Lymphocyte-C-reactive Protein Ratio as Promising New Marker for Predicting Surgical and Oncological Outcomes in Colorectal Cancer. Ann Surg. https://doi.org/10.1097/sla.0000000000003239.

38. Pinato DJ, Stebbing J, Ishizuka M, Khan SA, Wasan HS, North BV et al. (2012) A novel and validated prognostic index in hepatocellular carcinoma: The inflammation based index (IBI). J Hepatol 57:1013-1020.

39. Ni XC, Yi Y, Fu YP, He HW, Cai XY, Wang JX et al. (2015) Prognostic value of the modified glasgow prognostic score in patients undergoing radical surgery for hepatocellular carcinoma. Medicine (United States) 94.

参考文献をもっと見る

全国の大学の
卒論・修論・学位論文
を
一発検索！

この論文の関連論文を見る