論文の公開元へ

書き出し

Refer/BibIX

RIS

BibTeX

TSV

The Combination of Prognostic Nutritional Indicator and Serum Carcinoembryonic Antigen is Useful in Predicting Postoperative Recurrence in Stage II Colorectal Cancer

Uejima, Chihiro Saito, Hiroaki Tada, Yoichiro Tanio, Akimitsu Murakami, Yuki Yamamoto, Manabu Matsunaga, Tomoyuki Fukumoto, Yoji Tokuyasu, Naruo Takano, Shuichi Sakamoto, Teruhisa Honjo, Soichiro Fujiwara, Yoshiyuki 鳥取大学 DOI:10.33160/yam.2021.05.009

2021.05.20

概要

[Background] The efficacy of adjuvant chemotherapy in stage II colorectal cancer (CRC) patients has not been clearly demonstrated. Therefore, identification of robust prognostic factors is crucial for the assessment of recurrence risk in stage II CRC and appropriate adjuvant treatment, in clinical practice. [Methods] We enrolled 135 colorectal adenocarcinoma patients who underwent proctocolectomies and had histologically diagnosed stage II CRC. [Results] Receiver operating characteristic (ROC) analysis, to evaluate the predictive ability of certain serum factors for CRC recurrence, indicated that the prognostic nutritional indicator (PNI), followed by serum carcinoembryonic antigen (CEA) level, were the strongest predictive metrics. Based on cutoff values from ROC analyses, patients were divided as follows; CEAHigh (≥ 4.55 ng/mL), CEALow (< 4.55 ng/mL), PNIHigh (≥ 47.72), and PNILow (< 47.72). The recurrence rates of patients with CEAHigh and PNILow, CEAHigh and PNIHigh, CEALow and PNILow, and CEALow and PNIHigh were 34.3%, 0%, 6.8%, and 2.6%, respectively (a significant difference at P < 0.0001). Logistic regression analysis revealed that the combination of serum CEA level and PNI was an independent predictive indicator of tumor recurrence after operation in stage II CRC patients. The 5-year disease specific survival rates of patients with CEALowPNIHigh, CEAHighPNIHigh, CEALowPNILow, CEAHighPNILow were 100%, 100%, 97.4%, and 77.5%, respectively (P < 0.0001). [Conclusion] The combination of CEA and PNI was useful in predicting postoperative recurrence in stage II CRC patients.

論文の公開元へ

この論文で使われている画像

参考文献

1 Marsoni S; International Multicenter Pooled Analysis of

Colon Cancer Trials Investigators. Efficacy of adjuvant

fluorouracil and leucovorin in stage B2 and C colon cancer.

Semin Oncol. 2001;28(suppl 1):14-9. DOI: 10.1016/S00937754(01)90246-5, PMID: 11273584

182

PNI and CEA in stage II CRC

6 Shibutani M, Maeda K, Nagahara H, Iseki Y, Ikeya T,

Hirakawa K. Prognostic Significance of the Preoperative

Ratio of C-Reactive Protein to Albumin in Patients with

Colorectal Cancer. Anticancer Res. 2016;36:995-1001. PMID:

26976989

7 Yang Y, Gao P, Chen X, Song Y, Shi J, Zhao J, et al. Prognostic significance of preoperative prognostic nutritional

index in colorectal cancer: results from a retrospective cohort

study and a meta-analysis. Oncotarget. 2016;7:58543-52. DOI:

10.18632/oncotarget.10148, PMID: 27344182

8 Rectum JSfCotCa. Japanese Classification of Colorectal

Carcinoma. Tokyo: Kanehara & Co., Ltd; 2013.

9 Onodera T, Goseki N, Kosaki G. [Prognostic nutritional index

in gastrointestinal surgery of malnourished cancer patients].

Nippon Geka Gakkai Zasshi. 1984;85:1001-5. Japanese with

English abstract. PMID: 6438478

10 Ignacio de Ulíbarri J, González-Madroño A, de Villar NG,

González P, González B, Mancha A, et al. CONUT: a tool

for controlling nutritional status. First validation in a hospital

population. Nutr Hosp. 2005;20:38-45. PMID: 15762418

11 Haller DG, Tabernero J, Maroun J, de Braud F, Price T,

Van Cutsem E, et al. Capecitabine plus oxaliplatin compared

with fluorouracil and folinic acid as adjuvant therapy for stage

III colon cancer. J Clin Oncol. 2011;29:1465-71. DOI: 10.1200/

JCO.2010.33.6297, PMID: 21383294

12 Matsuda C, Ishiguro M, Teramukai S, Kajiwara Y, Fujii S,

Kinugasa Y, et al.; SACURA Study Group. A randomisedcontrolled trial of 1-year adjuvant chemotherapy with oral

tegafur–uracil versus surgery alone in stage II colon cancer:

SACURA trial. Eur J Cancer. 2018;96:54-63. DOI: 10.1016/

j.ejca.2018.03.009, PMID: 29677641

13 Gold P, Freedman SO. Specific carcinoembryonic antigens

of the human digestive system. J Exp Med. 1965;122:467-81.

DOI: 10.1084/jem.122.3.467, PMID: 4953873

14 Don BR, Kaysen G. Serum albumin: relationship to inflammation and nutrition. Semin Dial. 2004;17:432-7. DOI:

10.1111/j.0894-0959.2004.17603.x, PMID: 15660573

15 Clark EJ, Connor S, Taylor MA, Madhavan KK, Garden OJ,

Parks RW. Preoperative lymphocyte count as a prognostic

factor in resected pancreatic ductal adenocarcinoma. HPB

(Oxford). 2007;9:456-60. DOI: 10.1080/13651820701774891,

PMID: 18345294

16 Feng JF, Liu JS, Huang Y. Lymphopenia predicts poor

prognosis in patients with esophageal squamous cell carcinoma. Medicine (Baltimore). 2014;93:e257. DOI: 10.1097/

MD.0000000000000257, PMID: 25501097

17 Saroha S, Uzzo RG, Plimack ER, Ruth K, Al-Saleem T.

Lymphopenia is an independent predictor of inferior outcome

in clear cell renal carcinoma. J Urol. 2013;189:454-61. DOI:

10.1016/j.juro.2012.09.166, PMID: 23041457

18 Ray-Coquard I, Cropet C, Van Glabbeke M, Sebban C,

Le Cesne A, Judson I, et al.; European Organization for

Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group. Lymphopenia as a prognostic factor for overall

survival in advanced carcinomas, sarcomas, and lymphomas.

Cancer Res. 2009;69:5383-91. DOI: 10.1158/0008-5472.CAN08-3845, PMID: 19549917

19 Qiu H, Xiao-Jun W, Zhi-Wei Z, Gong C, Guo-Qiang W,

Li-Yi Z, et al. The prognostic significance of peripheral Tlymphocyte subsets and natural killer cells in patients with

colorectal cancer. Hepatogastroenterology. 2009;56:1310-5.

PMID: 19950782

20 Tachibana T, Onodera H, Tsuruyama T, Mori A, Nagayama S,

Hiai H, et al. Increased intratumor Valpha24-positive natural

killer T cells: a prognostic factor for primary colorectal carcinomas. Clin Cancer Res. 2005;11:7322-7. DOI: 10.1158/10780432.CCR-05-0877, PMID: 16243803

21 Berntsson J, Nodin B, Eberhard J, Micke P, Jirström K.

Prognostic impact of tumour-infiltrating B cells and plasma

cells in colorectal cancer. Int J Cancer. 2016;139:1129-39. DOI:

10.1002/ijc.30138, PMID: 27074317

183

...

参考文献をもっと見る

分野

大学

学位論文種類・取得年

言語

The Combination of Prognostic Nutritional Indicator and Serum Carcinoembryonic Antigen is Useful in Predicting Postoperative Recurrence in Stage II Colorectal Cancer

概要

この論文で使われている画像

関連論文

Modified Glasgow prognostic score is a pre-surgical prognostic marker of disease mortality in upper urinary tract urothelial carcinoma

The Elevation in Preoperative Procalcitonin Is Associated with a Poor Prognosis for Patients Undergoing Resection for Colorectal Cancer.

Preoperative neutrophil-to-lymphocyte ratio predicts the prognosis of esophageal squamous cell cancer patients undergoing minimally invasive esophagectomy after neoadjuvant chemotherapy

Superiority of CRP-albumin-lymphocyte index (CALLY index) as a non-invasive prognostic biomarker after hepatectomy for hepatocellular carcinoma.

A High C-Reactive Protein Level on Postoperative Day 7 is Associated with Poor Survival of Patients with Pancreatic Ductal Adenocarcinoma after Resection.

参考文献

分野

大学

学位論文種類・取得年

言語

コピーが完了しました

URLをコピーしました

The Combination of Prognostic Nutritional Indicator and Serum Carcinoembryonic Antigen is Useful in Predicting Postoperative Recurrence in Stage II Colorectal Cancer

概要

この論文で使われている画像

関連論文

Modified Glasgow prognostic score is a pre-surgical prognostic marker of disease mortality in upper urinary tract urothelial carcinoma

The Elevation in Preoperative Procalcitonin Is Associated with a Poor Prognosis for Patients Undergoing Resection for Colorectal Cancer.

Preoperative neutrophil-to-lymphocyte ratio predicts the prognosis of esophageal squamous cell cancer patients undergoing minimally invasive esophagectomy after neoadjuvant chemotherapy

Superiority of CRP-albumin-lymphocyte index (CALLY index) as a non-invasive prognostic biomarker after hepatectomy for hepatocellular carcinoma.

A High C-Reactive Protein Level on Postoperative Day 7 is Associated with Poor Survival of Patients with Pancreatic Ductal Adenocarcinoma after Resection.

参考文献