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BOLD signals are preferentially sensitive to local field potentials,

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The present study has limitations. First, because of the limited

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relatively small. Second, rest-state FC in this study was estimated

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FC under dopaminergic treatment since the treatment effects

may be complex including not only normalization on dopaminedepleted area but also over-stimulation on dopamine-preserved

area.

Dopamine-depleted areas in the striatum exhibited decreased

FC with motor cortices and STN and increased FC within the

posterior striatum in PD patients both during motor-task and

rest-state in this study. In addition, the STN regions that demonstrated reduced FC with striatal dopamine-depleted areas exhibited abnormal temporal synchronicity of fMRI activity with the

lateral premotor and primary motor cortices only during reststate in PD patients. These findings highlight novel therapeutic targets for DBS, including the putamen (Montgomery et al.

2011). Future studies should clarify the key factors linking striatal dopamine depletion and impaired control of activity in the

indirect and hyperdirect pathways in PD patients.

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