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大学・研究所にある論文を検索できる 「Influence of precursor deficiency sites for borate incorporation on the structural and biological properties of boronated hydroxyapatite」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。
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Influence of precursor deficiency sites for borate incorporation on the structural and biological properties of boronated hydroxyapatite

Gokcekaya, Ozkan 大阪大学

2022.10.20

概要

The biological properties of hydroxyapatite (HA) are significantly influenced by its compositional characteristics especially doping elements and/or Ca/P ratio, which can be altered by precursor chemistry. In this study, a group of boronated (B-incorporated) hydroxyapatite (BHA) was synthesized using a precipitation method by setting the Ca/P ratio to the stoichiometric value of HA (1.67), while altering the precursor chemistry by adjusting either (Ca + B)/P (Ca-deficient precursor, BC) or Ca/(P + B) (P-deficient precursor, BP). After heat-treatment, the partial decomposition of the BC was observed, forming tricalcium phosphate as the byproduct, however, the BP showed phase stability at all temperatures. The B-ionic species in the form of (BO₂)⁻ and (BO₃)³⁻ were incorporated into the HA structure at the (PO₄)³⁻ and (OH)⁻ positions, respectively. The incorporation of the B species also facilitated the incorporation of (CO₃)²⁻ groups specifically in the BPs. This is the first finding on BHA reporting that preferential (CO₃)²⁻ incorporation depends on the precursor chemistry used. As a result, osteoblast adhesion was superior on the BPs compared to pure HA owing to the carbonated structure, increasing cell spreading area. As such, this in vitro study highlighted that the present P-deficient precursor approach for synthesizing BHA improved biocompatibility properties and should, thus, be further considered for the next-generation of improved orthopedic applications.

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参考文献

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