1. Aizawa E, Tsuji H, Asahara T, Takahashi T, Teraishi T, Yoshida S, Ota M, Koga N, Hattori K, Kunugi H. 2016. Possible association of Bifidobacterium
and Lactobacillus in the gut microbiota of patients with major depressive disorder. J Affect Disord 202: 254–257. [Medline] [CrossRef]
2. Aschenbrenner K, D’Cruz LM, Vollmann EH, Hinterberger M, Emmerich J, Swee LK, Rolink A, Klein L. 2007. Selection of Foxp3+ regulatory T cells
specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells. Nat Immunol 8: 351–358.
3. Bankole A, Luo X, Husen Z. 2017. A comparative analysis of gut microbiota between systemic lupus erythematosus patients and non-autoimmune
J. Vet. Med. Sci. 85(4): 434–442, 2023
440
NEXT-GENERATION IMMUNOTOXICITY OF CLOTHIANIDIN
controls: a single center cohort experience. Lupus Sci Med 4: A155–A156.
4. Bellavance MA, Rivest S. 2014. The HPA − Immune axis and the immunomodulatory actions of glucocorticoids in the brain. Front Immunol 5: 136.
[Medline] [CrossRef]
5. Benno Y. 1991. Identification and classfication of genus Lactobacillus. Jpn J. Food Microbiol 8: 65–74.
6. Boesmans L, Valles-Colomer M, Wang J, Eeckhaut V, Falony G, Ducatelle R, Van Immerseel F, Raes J, Verbeke K. 2018. Butyrate producers as
potential next-generation probiotics: Safety assessment of the administration of Butyricicoccus pullicaecorum to healthy volunteers. mSystems 3:
e00094–18. [Medline] [CrossRef]
7. Borton MA, Sabag-Daigle A, Wu J, Solden LM, O’Banion BS, Daly RA, Wolfe RA, Gonzalez JF, Wysocki VH, Ahmer BMM, Wrighton KC. 2017.
Chemical and pathogen-induced inflammation disrupt the murine intestinal microbiome. Microbiome 5: 47. [Medline] [CrossRef]
8. Chen B, Lu KH, Ni QB, Li QX, Gao H, Wang H, Chen LB. 2019. Prenatal nicotine exposure increases osteoarthritis susceptibility in male elderly
offspring rats via low-function programming of the TGFβ signaling pathway. Toxicol Lett 314: 18–26. [Medline] [CrossRef]
9. Costas-Ferreira C, Faro LRF. 2021. Neurotoxic effects of neonicotinoids on mammals: what is there beyond the activation of nicotinic acetylcholine
receptors?-A systematic review. Int J Mol Sci 22: 8413. [Medline] [CrossRef]
10. Duncan SH, Aminov RI, Scott KP, Louis P, Stanton TB, Flint HJ. 2006. Proposal of Roseburia faecis sp. nov., Roseburia hominis sp. nov. and
Roseburia inulinivorans sp. nov., based on isolates from human faeces. Int J Syst Evol Microbiol 56: 2437–2441. [Medline] [CrossRef]
11. Farr AG, Dooley JL, Erickson M. 2002. Organization of thymic medullary epithelial heterogeneity: implications for mechanisms of epithelial
differentiation. Immunol Rev 189: 20–27. [Medline] [CrossRef]
12. Fiorentino DF, Zlotnik A, Mosmann TR, Howard M, O’Garra A. 1991. IL-10 inhibits cytokine production by activated macrophages. J Immunol 147:
3815–3822. [Medline] [CrossRef]
13. Food and Agriculture Organization of the United Nations. 2020. FAO Specifications and Evaluations for Agricultural Pesticides Clothianidin. http://
www.fao.org/3/ca7726en/ca7726en.pdf [accessed on November 4, 2020].
14. Furusawa Y, Obata Y, Fukuda S, Endo TA, Nakato G, Takahashi D, Nakanishi Y, Uetake C, Kato K, Kato T, Takahashi M, Fukuda NN, Murakami S,
Miyauchi E, Hino S, Atarashi K, Onawa S, Fujimura Y, Lockett T, Clarke JM, Topping DL, Tomita M, Hori S, Ohara O, Morita T, Koseki H, Kikuchi
J, Honda K, Hase K, Ohno H. 2013. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature 504:
446–450. [Medline] [CrossRef]
15. Gilmour CC, Podar M, Bullock AL, Graham AM, Brown SD, Somenahally AC, Johs A, Hurt RA Jr, Bailey KL, Elias DA. 2013. Mercury methylation
by novel microorganisms from new environments. Environ Sci Technol 47: 11810–11820. [Medline] [CrossRef]
16. Hale LP, Markert ML. 2004. Corticosteroids regulate epithelial cell differentiation and Hassall body formation in the human thymus. J Immunol 172:
617–624. [Medline] [CrossRef]
17. Hirano T, Miyata Y, Kubo S, Ohno S, Onaru K, Maeda M, Kitauchi S, Nishi M, Tabuchi Y, Ikenaka Y, Ichise T, Nakayama SMM, Ishizuka M, Arizono
K, Takahashi K, Kato K, Mantani Y, Yokoyama T, Hoshi N. 2021. Aging-related changes in the sensitivity of behavioral effects of the neonicotinoid
pesticide clothianidin in male mice. Toxicol Lett 342: 95–103. [Medline] [CrossRef]
18. Hirano T, Yanai S, Omotehara T, Hashimoto R, Umemura Y, Kubota N, Minami K, Nagahara D, Matsuo E, Aihara Y, Shinohara R, Furuyashiki T,
Mantani Y, Yokoyama T, Kitagawa H, Hoshi N. 2015. The combined effect of clothianidin and environmental stress on the behavioral and reproductive
function in male mice. J Vet Med Sci 77: 1207–1215. [Medline] [CrossRef]
19. Hirano T, Yanai S, Takada T, Yoneda N, Omotehara T, Kubota N, Minami K, Yamamoto A, Mantani Y, Yokoyama T, Kitagawa H, Hoshi N. 2018.
NOAEL-dose of a neonicotinoid pesticide, clothianidin, acutely induce anxiety-related behavior with human-audible vocalizations in male mice in a
novel environment. Toxicol Lett 282: 57–63. [Medline] [CrossRef]
20. Hofmeister AE, Berger S, Buckel W. 1992. The iron-sulfur-cluster-containing L-serine dehydratase from Peptostreptococcus asaccharolyticus.
Stereochemistry of the deamination of L-threonine. Eur J Biochem 205: 743–749. [Medline] [CrossRef]
21. Hoshi N. 2021. Adverse effects of pesticides on regional biodiversity and their mechanisms. pp. 235–247. In. Risks and Regulation of New Technologies
(Matsuda T, Wolff J, Yanagawa T, eds.), Springer, Singapore.
22. Hoshi N, Hirano T, Omotehara T, Tokumoto J, Umemura Y, Mantani Y, Tanida T, Warita K, Tabuchi Y, Yokoyama T, Kitagawa H. 2014. Insight into
the mechanism of reproductive dysfunction caused by neonicotinoid pesticides. Biol Pharm Bull 37: 1439–1443. [Medline] [CrossRef]
23. Ichikawa G, Kuribayashi R, Ikenaka Y, Ichise T, Nakayama SMM, Ishizuka M, Taira K, Fujioka K, Sairenchi T, Kobashi G, Bonmatin JM, Yoshihara
S. 2019. LC-ESI/MS/MS analysis of neonicotinoids in urine of very low birth weight infants at birth. PLoS One 14: e0219208. [Medline] [CrossRef]
24. Ikenaka Y, Miyabara Y, Ichise T, Nakayama S, Nimako C, Ishizuka M, Tohyama C. 2019. Exposures of children to neonicotinoids in pine wilt disease
control areas. Environ Toxicol Chem 38: 71–79. [Medline] [CrossRef]
25. Jessurun JG, van Harten PN, Egberts TC, Pijl YJ, Wilting I, Tenback DE. 2016. The relation between psychiatric diagnoses and constipation in
hospitalized patients: a cross-sectional study. Psychiatry J 2016: 2459693. [Medline] [CrossRef]
26. Kawashima K, Yoshikawa K, Fujii YX, Moriwaki Y, Misawa H. 2007. Expression and function of genes encoding cholinergic components in murine
immune cells. Life Sci 80: 2314–2319. [Medline] [CrossRef]
27. Kimura-Kuroda J, Komuta Y, Kuroda Y, Hayashi M, Kawano H. 2012. Nicotine-like effects of the neonicotinoid insecticides acetamiprid and
imidacloprid on cerebellar neurons from neonatal rats. PLoS One 7: e32432. [Medline] [CrossRef]
28. Kitauchi S, Maeda M, Hirano T, Ikenaka Y, Nishi M, Shoda A, Murata M, Mantani Y, Yokoyama T, Tabuchi Y, Hoshi N. 2021. Effects of in utero and
lactational exposure to the no-observed-adverse-effect level (NOAEL) dose of the neonicotinoid clothianidin on the reproductive organs of female
mice. J Vet Med Sci 83: 746–753. [Medline] [CrossRef]
29. Kubo S, Hirano T, Miyata Y, Ohno S, Onaru K, Ikenaka Y, Nakayama SMM, Ishizuka M, Mantani Y, Yokoyama T, Hoshi N. 2022. Sex-specific
behavioral effects of acute exposure to the neonicotinoid clothianidin in mice. Toxicol Appl Pharmacol 456: 116283. [Medline] [CrossRef]
30. Li M, Wu Y, Hu Y, Zhao L, Zhang C. 2018. Initial gut microbiota structure affects sensitivity to DSS-induced colitis in a mouse model. Sci China Life
Sci 61: 762–769. [Medline] [CrossRef]
31. Li Z, Zhou J, Liang H, Ye L, Lan L, Lu F, Wang Q, Lei T, Yang X, Cui P, Huang J. 2022. Differences in alpha diversity of gut microbiota in
neurological diseases. Front Neurosci 16: 879318. [Medline] [CrossRef]
32. Maeda M, Kitauchi S, Hirano T, Ikenaka Y, Nishi M, Shoda A, Murata M, Mantani Y, Tabuchi Y, Yokoyama T, Hoshi N. 2021. Fetal and lactational
exposure to the no-observed-adverse-effect level (NOAEL) dose of the neonicotinoid pesticide clothianidin inhibits neurogenesis and induces different
behavioral abnormalities at the developmental stages in male mice. J Vet Med Sci 83: 542–548. [Medline] [CrossRef]
33. Martinez FO, Sica A, Mantovani A, Locati M. 2008. Macrophage activation and polarization. Front Biosci 13: 453–461. [Medline] [CrossRef]
34. Ohno S, Ikenaka Y, Onaru K, Kubo S, Sakata N, Hirano T, Mantani Y, Yokoyama T, Takahashi K, Kato K, Arizono K, Ichise T, Nakayama SMM,
Ishizuka M, Hoshi N. 2020. Quantitative elucidation of maternal-to-fetal transfer of neonicotinoid pesticide clothianidin and its metabolites in mice.
Toxicol Lett 322: 32–38. [Medline] [CrossRef]
J. Vet. Med. Sci. 85(4): 434–442, 2023
441
M MURATA ET AL.
35. Odaka C, Hauri-Hohl M, Takizawa K, Nishikawa Y, Yano M, Matsumoto M, Boyd R, Holländer GA. 2013. TGF-β type II receptor expression in
thymic epithelial cells inhibits the development of Hassall’s corpuscles in mice. Int Immunol 25: 633–642. [Medline] [CrossRef]
36. Onaru K, Ohno S, Kubo S, Nakanishi S, Hirano T, Mantani Y, Yokoyama T, Hoshi N. 2020. Immunotoxicity evaluation by subchronic oral
administration of clothianidin in Sprague-Dawley rats. J Vet Med Sci 82: 360–372. [Medline] [CrossRef]
37. Oya N, Ito Y, Ebara T, Kato S, Ueyama J, Aoi A, Nomasa K, Sato H, Matsuki T, Sugiura-Ogasawara M, Saitoh S, Kamijima M. 2021. Cumulative
exposure assessment of neonicotinoids and an investigation into their intake-related factors in young children in Japan. Sci Total Environ 750: 141630.
[Medline] [CrossRef]
38. Parrish WR, Rosas-Ballina M, Gallowitsch-Puerta M, Ochani M, Ochani K, Yang LH, Hudson L, Lin X, Patel N, Johnson SM, Chavan S, Goldstein
RS, Czura CJ, Miller EJ, Al-Abed Y, Tracey KJ, Pavlov VA. 2008. Modulation of TNF release by choline requires α7 subunit nicotinic acetylcholine
receptor-mediated signaling. Mol Med 14: 567–574. [Medline] [CrossRef]
39. Round JL, Mazmanian SK. 2009. The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol 9: 313–323.
[Medline] [CrossRef]
40. Sallusto F, Lanzavecchia A. 1994. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage
colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J Exp Med 179: 1109–1118 [CrossRef]. [Medline]
41. Sekirov I, Russell SL, Antunes LCM, Finlay BB. 2010. Gut microbiota in health and disease. Physiol Rev 90: 859–904 [CrossRef]. [Medline]
42. Sheng K, Xu Y, Kong X, Wang J, Zha X, Wang Y. 2021. Probiotic Bacillus cereus alleviates dextran sulfate sodium-induced colitis in mice through
improvement of the intestinal barrier function, anti-inflammation, and gut microbiota modulation. J Agric Food Chem 69: 14810–14823. [Medline]
[CrossRef]
43. Shoda A, Nishi M, Murata M, Mantani Y, Yokoyama T, Hirano T, Ikenaka Y, Hoshi N. 2023. Quantitative elucidation of the transfer of the neonicotinoid
pesticide clothianidin to the breast milk in mice. Toxicol Lett 373: 33–40. [Medline] [CrossRef]
44. Soultanova A, Panneck AR, Rafiq A, Kummer W. 2014. Terminally differentiated epithelial cells of the thymic medulla and skin express nicotinic
acetylcholine receptor subunit α 3. BioMed Res Int 2014: 757502. [Medline] [CrossRef]
45. Takada T, Yoneda N, Hirano T, Onaru K, Mantani Y, Yokoyama T, Kitagawa H, Tabuchi Y, Nimako C, Ishizuka M, Ikenaka Y, Hoshi N. 2020.
Combined exposure to dinotefuran and chronic mild stress counteracts the change of the emotional and monoaminergic neuronal activity induced by
either exposure singly despite corticosterone elevation in mice. J Vet Med Sci 82: 350–359. [Medline] [CrossRef]
46. Takada T, Yoneda N, Hirano T, Yanai S, Yamamoto A, Mantani Y, Yokoyama T, Kitagawa H, Tabuchi Y, Hoshi N. 2018. Verification of the causal
relationship between subchronic exposures to dinotefuran and depression-related phenotype in juvenile mice. J Vet Med Sci 80: 720–724. [Medline]
[CrossRef]
47. Tanemoto S, Sujino T, Kanai T. 2017. [Intestinal immune response is regulated by gut microbe]. Nihon Rinsho Meneki Gakkai Kaishi 40: 408–415.
[Medline] [CrossRef]
48. Tokumoto J, Danjo M, Kobayashi Y, Kinoshita K, Omotehara T, Tatsumi A, Hashiguchi M, Sekijima T, Kamisoyama H, Yokoyama T, Kitagawa H,
Hoshi N. 2013. Effects of exposure to clothianidin on the reproductive system of male quails. J Vet Med Sci 75: 755–760. [Medline] [CrossRef]
49. Tomizawa M, Casida JE. 2005. Neonicotinoid insecticide toxicology: mechanisms of selective action. Annu Rev Pharmacol Toxicol 45: 247–268.
[Medline] [CrossRef]
50. Trompette A, Gollwitzer ES, Yadava K, Sichelstiel AK, Sprenger N, Ngom-Bru C, Blanchard C, Junt T, Nicod LP, Harris NL, Marsland BJ. 2014. Gut
microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat Med 20: 159–166. [Medline] [CrossRef]
51. Uneme H, Konobe M, Akayama A, Yokota T, Mizuta K. 2006. Discovery and development of a novel insecticide “clothianidin”. Sumitomo Kagaku
2. pp. 1−14. https://www.sumitomo-chem.co.jp/english/rd/report/files/docs/20060202_h6t.pdf [accessed on November 4, 2020].
52. Vijay A, Valdes AM. 2022. Role of the gut microbiome in chronic diseases: a narrative review. Eur J Clin Nutr 76: 489–501. [Medline] [CrossRef]
53. Vobořil M, Brabec T, Dobeš J, Šplíchalová I, Březina J, Čepková A, Dobešová M, Aidarova A, Kubovčiak J, Tsyklauri O, Štěpánek O, Beneš V,
Sedláček R, Klein L, Kolář M, Filipp D. 2020. Toll-like receptor signaling in thymic epithelium controls monocyte-derived dendritic cell recruitment
and Treg generation. Nat Commun 11: 2361. [Medline] [CrossRef]
54. Wang J, Sekai M, Matsui T, Fujii Y, Matsumoto M, Takeuchi O, Minato N, Hamazaki Y. 2019. Hassall’s corpuscles with cellular-senescence features
maintain IFNα production through neutrophils and pDC activation in the thymus. Int Immunol 31: 127–139. [Medline] [CrossRef]
55. Watanabe N, Wang YH, Lee HK, Ito T, Wang YH, Cao W, Liu YJ. 2005. Hassall’s corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory
T cells in human thymus. Nature 436: 1181–1185. [Medline] [CrossRef]
56. Wu M, Li P, An Y, Ren J, Yan D, Cui J, Li D, Li M, Wang M, Zhong G. 2019. Phloretin ameliorates dextran sulfate sodium-induced ulcerative colitis
in mice by regulating the gut microbiota. Pharmacol Res 150: 104489. [Medline] [CrossRef]
57. Wynn TA, Barron L. 2010. Macrophages: master regulators of inflammation and fibrosis. Semin Liver Dis 30: 245–257. [Medline] [CrossRef]
58. Yanai S, Hirano T, Omotehara T, Takada T, Yoneda N, Kubota N, Yamamoto A, Mantani Y, Yokoyama T, Kitagawa H, Hoshi N. 2017. Prenatal and
early postnatal NOAEL-dose clothianidin exposure leads to a reduction of germ cells in juvenile male mice. J Vet Med Sci 79: 1196–1203. [Medline]
[CrossRef]
59. Yoneda N, Takada T, Hirano T, Yanai S, Yamamoto A, Mantani Y, Yokoyama T, Kitagawa H, Tabuchi Y, Hoshi N. 2018. Peripubertal exposure to
the neonicotinoid pesticide dinotefuran affects dopaminergic neurons and causes hyperactivity in male mice. J Vet Med Sci 80: 634–637. [Medline]
[CrossRef]
60. Zdanowski R, Krzyżowska M, Ujazdowska D, Lewicka A, Lewicki S. 2015. Role of α7 nicotinic receptor in the immune system and intracellular
signaling pathways. Cent Eur J Immunol 40: 373–379. [Medline] [CrossRef]
J. Vet. Med. Sci. 85(4): 434–442, 2023
442
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