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Elucidation of Mechanisms Underlying the Preventive Effects of Olive Fruit-Derived Maslinic Acid on Muscle Atrophy

山内, 優輝 筑波大学 DOI:10.15068/0002008209

2023.09.04

概要

Skeletal muscle accounts for approximately 40% of body weight and 50% of
protein and is the most abundant tissue in the human body. Muscle atrophy can be caused
by sarcopenia, inactivity, and various neuromuscular diseases, and it can be atrophy when
synthesis is inferior to degradation. Sarcopenia is mechanistically implicated in multiple
pathophysiological processes, including inflammation, oxidative stress, mitochondrial
dysfunction, and subsequent activation or inhibition of signaling pathways, including the
mTOR signaling pathway and autophagy-lysosome, and ubiquitin-proteasome system. In
the elderly, low-grade inflammation is considered to be one of the main determinants of
health status (Franceschi et al. 2018) and is suspected to be a favorable environment for
the development of sarcopenia (Argiles et al. 2015). The marked increase in the elderly
population in Japan, where the aging rate is projected to reach approximately 40% by
2040, is concerning. Age-related inflammation is associated with decreased motor
function and muscle mass, as well as with muscle dysfunction (Walston 2012, Wang
and Bai 2012). The loss of muscle mass and strength must be mitigated among the
elderly related muscle wasting is closely related to life expectancy and quality of life
(QOL) (Evans 1995). In Japan, patients suffering from locomotive disorders require
special assistance or nursing care (Fig. 1-1). Sarcopenia is a state in which skeletal
muscle mass gradually decreases, resulting in a loss of muscle mass and strength,
which decreases the overall muscle quality (Cruz-Jentoft et al. 2010). Among the
elderly, sarcopenia is a major health challenge that increases an individual's risk of
disability, falling, fall-related injuries, being hospitalized, dependency, and death
(Senior et al. 2015). ...

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List of Publication

International publications

Yamauchi Y, Ferdousi F, Fukumitsu S, Isoda H. Maslinic Acid Attenuates

Denervation-Induced Loss of Skeletal Muscle Mass and Strength. Nutrients. 2021

Aug 25;13(9):2950. doi: 10.3390/nu13092950. PMID: 34578826; PMCID:

PMC8468537

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