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Visceral Obesity and Lipid Profiles in Chinese Adults with Normal and High Body Mass Index

盧, 雨桐 北海道大学

2023.03.23

概要

The prevalence of obesity across Asia has increased rapidly over the last two decades.
This has become a major health challenge, given the associated elevated risk of disease,
including type-2 diabetes mellitus, hypertension, metabolic syndrome, and an increased
risk of mortality [1,2]. Obesity is defined by the World Health Organization (WHO) as
excessive fat accumulation, which is a detriment to health. It is diagnosed as a body mass
index (BMI) of ≥30 kg/m2. About 13% of the world’s adult population (11% of men and
15% of women) were obese in 2016 [3]. However, while BMI is generally considered the
best measure for assessing obesity, those patients with only central obesity may not be
considered at an increased risk of obesity-related cardiovascular disease risk factors [4].
Accumulating evidence suggests that, for any given BMI, Chinese adults have a greater
percentage of body fat and a higher risk of metabolic syndrome [5]. On this basis, the
Working Group on Obesity in China (WGOC) recommends using a BMI cutoff of 24
kg/m2 for overweight and 28 kg/m2 for obesity [6].
There is evidence for the existence of a population sub-group who, despite having
normal BMI, display clusters of risk factors for metabolic and cardiovascular disease,
such as insulin resistance, dyslipidemia, and increased visceral adipose tissue (VAT) [7].
VAT is important because it is associated with the increased circulation of proinflammatory cytokines and oxidative stress, which may lead to the diseases mentioned
above [8,9]. Accumulating research also indicates that visceral fat is an independent
predictor of the components of metabolic syndrome [10], leading to cardiovascular
disease. Visceral fat is also an independent predictor of all-cause mortality in men and
women [11]. Although quantifying the total visceral adiposity in an individual is timeconsuming, a recent study supports the use of quantitative computed tomography (QCT)
for the measurement of abdominal VAT at the umbilical level and at the level of the
lumbar vertebrae (L2–L3) [12]. In the Chinese population, VAT scores of ≥142 cm2 in
men and >115 cm2 in women are identified as the cutoff points for visceral obesity and
have been associated with a higher prevalence of cardiovascular disease risk factors,
including hypertension, elevated low high-density lipoprotein (HDL) and total cholesterol
(TC), and/or hypertriglyceridemia and hyperglycemia [13]. In overweight and obese
Chinese adults, high visceral fat measured by CT has been associated with an adverse
lipid and glucose profile [14]. However, in adults with normal BMI, visceral obesity and
other early signs of cardiometabolic disease may go undetected, because these individuals
are not usually be referred for cardiometabolic screening. The purpose of the present
study was to explore the prevalence and phenotypic predictors of visceral obesity in
Chinese adults with normal BMI and high BMI and to explore their corresponding lipid
profiles.
2. Materials and Methods
2.1. ...

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参考文献

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List of achievements

1.Book

None.

2.Publication of articles in academic journals or conferences

Ⅰ．Papers

1.Visceral Obesity and Lipid Profiles in Chinese Adults with Normal and High

Body Mass Index. Lu, Y.; Li, N.; Kamishima, T.; Jia, P.; Zhou, D.; Hind, K.;

Sutherland, K.; Cheng, X. Diagnostics . 2022, 12, 2522.

2.Detection of Fine Radiographic Progression in Finger Joint Space Narrowing

Beyond Human Eyes: Phantom Experiment and Clinical Study with Rheumatoid Arthritis

Patients.Kato K, Yasojima N, Tamura K, Ichikawa S, Sutherland K, Kato M, Fukae

J,Tanimura K, Tanaka Y, Okino T, Lu Y, Kamishima T. Sci Rep. 2019 Jun 12;9(1):8526.

3.Quantitative power Doppler signal assessment in the subchondral bone region of

the metacarpophalangeal joint is an effective predictor of radiographic progression in the

hand of rheumatoid arthritis: a pilot study.Fujimori M, Kamishima T, Narita A, Henmi

M, Kato M, Sutherland K, Nishida M, Tanaka Y, Lu Y, Tanimura K, Atsumi T.

Rheumatol Int. 2019 Aug;39(8):1413-1421.

4. Validation of Fully Automatic Quantitative Software for Finger Joint Space

Narrowing Progression for Rheumatoid Arthritis Patients.Narisawa C, Sutherland K, Lu

Y, Furusaki A, Sagawa A, Kamishima T.J Digit Imaging. 2020 Dec;33(6):1387-1392.

Epub 2020 Sep 28.

5. Editorial for "Clinical Potential of UTE-MRI for Assessing the COVID-19:

Patient- and Lesion-Based Comparative Analysis". Kamishima T, An Y, Fang W, Lu

Y.J Magn Reson Imaging. 2020 Sep;52(3):956-957. doi: 10.1002/jmri.27291. Epub

2020 Jul 11.

6. Intravoxel incoherent motion MRI for discrimination of synovial proliferation in

the hand arthritis: A prospective proof-of-concept study.Fujimori M, Murakami

K,Sugimori H, Lu Y, Sutherland K, Oki N, Aoki T, Kamishima T.J Magn Reson

Imaging

Ⅱ．Oral presentation

1.AI approach to improving the quality of MR images of small joints in juvenile

idiopathic arthritis (JIA). Yutong Lu. The 50th anniversary meeting of JSMRM.

Nagoya. 9.9-9.11, 2022.

2.AI approach to improving the quality of MR images of small joints in juvenile

idiopathic arthritis (JIA). Yutong Lu. The 81th Annual Meeting of the Japan

Radiological Society. Yokohama. 4.14-17, 2022.

3.Visceral obesity and lipid profile in Chinese adults with normal body mass index.

- 22 -

Yutong Lu, Na Li, Tamotsu Kamishima, Peng Jia, Zhou Dan, Hind Karen, Xiaoguang

Cheng. The 80th Annual Meeting of the Japan Radiological Society. Yokohama. 4.1518, 2021.

4. Validation of fully automatic quantitative software for finger joint space

narrowing progression in rheumatoid arthritis patients. Chiaki Narisawa, Yutong Lu.

Asian Musculoskeletal Society Annual Scientific Meeting. Hong Kong. 2020.9.

5. Visceral adipose tissue area can be abnormal when BMI in the normal range: a

study from large medical checkup population. Yutong Lu,Tamotsu Kamishima. The 79th

Annual Meeting of the Japan Radiological Society, Online Conference, 2020.5.

3.Review/commentary

None

4.Academic awards

None

5.Others

None

- 23 -

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