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The Analysis of the Action Mechanisms of Novel Steroid Compounds for the Induction of TSLP Production

王, 宇 東北大学

2023.09.25

概要

Autoimmune disease occurs when an immune response attacks our own tissues. There
are at least 80 types of autoimmune diseases, such as inflammatory bowel disease,
juvenile idiopathic arthritis, multiple sclerosis, rheumatoid arthritis, systemic lupus
erythematosus, type 1 diabetes, acquired angioedema (AAE) which can be either systemic
or tissue-specific in nature [1]. Autoimmune diseases are frequently chronic illnesses with
low grade fever and feeling tired, and it is estimated that more than 100 billion dollars are
spent each year in autoimmune patients, which places autoimmunity among the costliest
diseases to diagnose and treat [2].
To suppress the chronic inflammatory reaction caused by autoimmune response,
immunosuppressive drugs are used in clinical treatment [3],[4]. ...

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9. Supplemental Fig.

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TSLP-induced activity

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Supplemental Fig. The compounds structural formula and TSLP-induced activity

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