ヒトケラチノサイトにおける低酸素環境下での TSLP 発現抑制機構の解析

1. He R, Geha RS. (2010) Thymic stromal lymphopoietin. Ann N Y Acad Sci. 1183: 13-24.

2. Friend SL, Hosier S, Nelson A, Foxworthe D, Williams DE, et al. (1994) A thymic stromal cell line supports in vitro development of surface IgM+ B cells and produces a novel growth factor affecting B and T lineage cells. Exp Hematol. 22: 321-8.

3. Soumelis V, Reche PA, Kanzler H, Yuan W, Edward G, et al. (2002) Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat Immunol. 3: 673-80.

4. Ying S, O'Connor B, Ratoff J, Meng Q, Mallett K, et al. (2005) Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity. J Immunol. 174: 8183-90.

5. Brown VI, Hulitt J, Fish J, Sheen C, Bruno M, et al. (2007) Thymic stromal-derived lymphopoietin induces proliferation of pre-B leukemia and antagonizes mTOR inhibitors, suggesting a role for interleukin-7Ralpha signaling. Cancer Res. 67: 9963-70.

6. Jessup HK, Brewer AW, Omori M, Rickel EA, Budelsky AL, et al. (2008) Intradermal administration of thymic stromal lymphopoietin induces a T cell- and eosinophil-dependent systemic Th2 inflammatory response. J Immunol. 181: 4311-9.

7. Guttman-Yassky E, Lowes MA, Fuentes-Duculan J, Whynot J, Novitskaya I, et al. (2007) Major differences in inflammatory dendritic cells and their products distinguish atopic dermatitis from psoriasis. J Allergy Clin Immunol. 119: 1210-7.

8. Li M, Messaddeq N, Teletin M, Pasquali JL, Metzger D, et al. (2005) Retinoid X receptor ablation in adult mouse keratinocytes generates an atopic dermatitis triggered by thymic stromal lymphopoietin. Proc Natl Acad Sci U S A. 102: 14795-800.

9. Omori-Miyake M, Ziegler SF. (2012) Mouse models of allergic diseases: TSLP and its functional roles. Allergol Int. 61: 27-34.

10. Gauvreau GM, O'Byrne PM, Boulet LP, Wang Y, Cockcroft D, et al. (2014) Effects of an anti- TSLP antibody on allergen-induced asthmatic responses. N Engl J Med. 370: 2102-10.

11. Zhou B, Comeau MR, De Smedt T, Liggitt HD, Dahl ME, et al. (2005) Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice. Nat Immunol. 6: 1047-53.

12. Volpe E, Pattarini L, Martinez-Cingolani C, Meller S, Donnadieu MH, et al. (2014) Thymic stromal lymphopoietin links keratinocytes and dendritic cell-derived IL-23 in patients with psoriasis. J Allergy Clin Immunol. 134: 373-81.

13. Christmann RB, Mathes A, Affandi AJ, Padilla C, Nazari B, et al. (2013) Thymic stromal lymphopoietin is up-regulated in the skin of patients with systemic sclerosis and induces profibrotic genes and intracellular signaling that overlap with those induced by interleukin- 13 and transforming growth factor β. Arthritis Rheum. 65: 1335-46.

14. Shin JU, Kim SH, Kim H, Noh JY, Jin S, et al. (2016) TSLP Is a Potential Initiator of Collagen Synthesis and an Activator of CXCR4/SDF-1 Axis in Keloid Pathogenesis. J Invest Dermatol. 136: 507-515.

15. Zak M, Dengler HS, Rajapaksa NS. (2019) Inhaled Janus Kinase (JAK) inhibitors for the treatment of asthma. Bioorg Med Chem Lett. 29: 126658.

16. Varricchi G, Pecoraro A, Marone G, Criscuolo G, Spadaro G, et al. (2018) Thymic Stromal Lymphopoietin Isoforms, Inflammatory Disorders, and Cancer. Front Immunol. 9:1595.

17. Segawa R, Shigeeda K, Hatayama T, Dong J, Mizuno N, et al. (2018) EGFR transactivation is involved in TNF-α-induced expression of thymic stromal lymphopoietin in human keratinocyte cell line. J Dermatol Sci. 89: 290-298.

18. Segawa R, Hirasawa N. (2014) Exacerbation of allergic diseases by chemicals: role of TSLP.J Pharmacol Sci. 124: 301-6.

19. Tsilingiri K, Fornasa G, Rescigno M. (2017) Thymic Stromal Lymphopoietin: To Cut a Long Story Short. Cell Mol Gastroenterol Hepatol. 3: 174-182.

20. Briot A, Deraison C, Lacroix M, Bonnart C, Robin A, et al. (2009) Kallikrein 5 induces atopic dermatitis-like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome. J Exp Med. 206: 1135-47.

21. Li M, Hener P, Zhang Z, Kato S, Metzger D, et al. (2006) Topical vitamin D3 and low- calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis. Proc Natl Acad Sci U S A. 103: 11736-41.

22. Hatayama T, Segawa R, Mizuno N, Eguchi S, Akamatsu H, et al. (2018) All-Trans Retinoic Acid Enhances Antibody Production by Inducing the Expression of Thymic Stromal Lymphopoietin Protein. J Immunol. 200: 2670-2676.

23. Segawa R, Mizuno N, Hatayama T, Jiangxu D, Hiratsuka M, et al. (2016) Lipopolysaccharide-Activated Leukocytes Enhance Thymic Stromal Lymphopoietin Production in a Mouse Air-Pouch-Type Inflammation Model. Inflammation. 39: 1527-37.

24. Segawa R, Yamashita S, Mizuno N, Shiraki M, Hatayama T, et al. (2014) Identification of a cell line producing high levels of TSLP: advantages for screening of anti-allergic drugs. J Immunol Methods. 402: 9-14.

25. Evans SM, Schrlau AE, Chalian AA, Zhang P, Koch CJ. (2006) Oxygen levels in normal and previously irradiated human skin as assessed by EF5 binding. J Invest Dermatol. 126: 2596- 606.

26. Park JY, Jung JY, Kim HJ, Bae IH, Kim DY, et al. (2016) Hypoxia leads to abnormal epidermal differentiation via HIF-independent pathways. Biochem Biophys Res Commun. 469: 251-6.

27. Salnikow K, Donald SP, Bruick RK, Zhitkovich A, Phang JM, et al. (2004) Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress. J Biol Chem. 279: 40337-44.

28. O'Shaughnessy RFL, Brown SJ. (2015) Insight from the air-skin interface. J Invest Dermatol.135: 331-333.

29. Befani C, Mylonis I, Gkotinakou IM, Georgoulias P, Hu CJ, et al. (2013) Cobalt stimulates HIF-1-dependent but inhibits HIF-2-dependent gene expression in liver cancer cells. Int J Biochem Cell Biol. 45: 2359-68.

30. Wong WJ, Richardson T, Seykora JT, Cotsarelis G, Simon MC. (2015) Hypoxia-inducible factors regulate filaggrin expression and epidermal barrier function. J Invest Dermatol. 135: 454-461.

31. Cui XY, Tinholt M, Stavik B, Dahm AE, Kanse S, et al. (2016) Effect of hypoxia on tissue factor pathway inhibitor expression in breast cancer. J Thromb Haemost. 14: 387-96.

32. Cui XY, Skretting G, Tinholt M, Stavik B, Dahm AEA, et al. (2017) A novel hypoxia response element regulates oxygen-related repression of tissue factor pathway inhibitor in the breast cancer cell line MCF-7. Thromb Res. 157: 111-116.

33. Loboda A, Jozkowicz A, Dulak J. (2010) HIF-1 and HIF-2 transcription factors--similar but not identical. Mol Cells. 29: 435-42.

34. Manresa MC, Smith L, Casals-Diaz L, Fagundes RR, Brown E, et al. (2019) Pharmacologic inhibition of hypoxia-inducible factor (HIF)-hydroxylases ameliorates allergic contact dermatitis. Allergy. 74: 753-766.

35. Yuan Y, Hilliard G, Ferguson T, Millhorn DE. (2003) Cobalt inhibits the interaction between hypoxia-inducible factor-alpha and von Hippel-Lindau protein by direct binding to hypoxia- inducible factor-alpha. J Biol Chem. 278: 15911-6.

36. Zhao J, Du F, Shen G, Zheng F, Xu B. (2015) The role of hypoxia-inducible factor-2 in digestive system cancers. Cell Death Dis. 6: e1600

37. Cheng-Jun Hu, Li-Yi Wang, Lewis A. Chodosh, Brian Keith, and M. Celeste Simon. (2003) Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation. Mol Cell Biol. 23: 9361–9374.

38. Koh MY, Spivak-Kroizman T, Venturini S, Welsh S, Williams RR, et al. (2008) Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1alpha. Mol Cancer Ther. 7: 90-100.

39. Scheuermann TH, Li Q, Ma HW, Key J, Zhang L, et al. (2013) Allosteric inhibition of hypoxia inducible factor-2 with small molecules. Nat Chem Biol. 9: 271-6.

40. Jang Y, Jeong SH, Park YH, Bae HC, Lee H, et al. (2013) UVB induces HIF-1α-dependent TSLP expression via the JNK and ERK pathways. J Invest Dermatol. 133: 2601-2608.

41. Hindryckx P, De Vos M, Jacques P, Ferdinande L, Peeters H, et al. (2010) Hydroxylase inhibition abrogates TNF-alpha-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD. J Immunol. 185: 6306-16.

42. Zheng W, Kuhlicke J, Jäckel K, Eltzschig HK, Singh A, et al. (2009) Hypoxia inducible factor-1 (HIF-1)-mediated repression of cystic fibrosis trans-membrane conductance regulator (CFTR) in the intestinal epithelium. FASEB J. 23: 204-13.

43. Morote-Garcia JC, Rosenberger P, Nivillac NM, Coe IR, Eltzschig HK, et al. (2009) Hypoxia- inducible factor-dependent repression of equilibrative nucleoside trans-porter 2 attenuates mucosal inflammation during intestinal hypoxia. Gastroenterology. 136: 607-18.

44. Stavik B, Espada S, Cui XY, Iversen N, Holm S, et al. (2016) EPAS1/HIF-2 alpha-mediated downregulation of tissue factor pathway inhibitor leads to a pro-thrombotic potential in endothelial cells. 1862: 670-678.

45. Adams DF, Watkins MS, Durette L, Laliberté J, Goulet F, et al. (2019) Carcinogenicity Assessment of Daprodustat (GSK1278863), a Hypoxia-Inducible Factor (HIF)-Prolyl Hydroxylase Inhibitor. Toxicol Pathol. 22: 192623319880445.