リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

大学・研究所にある論文を検索できる 「Proton radiotherapy as a treatment strategy to increase survival in locally advanced pancreatic cancer in the body and tail: a retrospective study」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

コピーが完了しました

URLをコピーしました

論文の公開元へ論文の公開元へ
書き出し

Proton radiotherapy as a treatment strategy to increase survival in locally advanced pancreatic cancer in the body and tail: a retrospective study

Ami, Katsuya Terashima, Kazuki Ishida, Jun Suga, Masaki Okawa, Taisuke Takahashi, Daiki Park, SungChul Matsuo, Yoshiro Nanno, Yoshihide Tokumaru, Sunao Okimoto, Tomoaki Toyama, Hirochika Fukumoto, Takumi 神戸大学

2023.08.08

概要

Background: Long-term outcomes and prognostic factors of proton radiotherapy for locally advanced pancreatic cancer (LAPC) in the body and tail are still unknown. The aim of this study was to determine the prognostic factors after proton radiotherapy in a large group of patients with LAPC in the body and tail. Methods: The medical records of 200 patients with LAPC in the body and tail who underwent proton radiotherapy between February 2009 and January 2021 at the Hyogo Ion Beam Medical Center were retrospectively reviewed to identify prognostic factors that contribute to long-term survival. Results: The overall survival rate at 1- and 2-year after PT was 69.6% and 35.4% with a median overall survival of 18.4 months. The 1- and 2-year local progression-free, and progression-free survival rates were 84.3% and 68.0%, and 44.3% and 19.4%, respectively. In multivariate analysis, superior mesenteric artery (SMA) invasion (SMA only invasion vs. celiac artery only invasion; P = 0.049: SMA and celiac artery invasion vs. celiac artery only invasion; P = 0.017), carbohydrate antigen 19-9 (CA 19-9) level ≥ 231.9 U/mL (P = 0.001), anterior peripancreatic invasion (P = 0.006), and incomplete scheduled concurrent chemotherapy (P = 0.009) were statistically significant prognostic factors for overall survival. There was no significant difference in local progression-free survival; however, distant metastasis-free survival was statistically worse in patients with prognostic factors than in those without. Conclusions: Proton radiotherapy for LAPC in the body and tail may be a valuable multidisciplinary treatment option. Patients with SMA invasion, higher pre-proton radiotherapy serum CA 19-9 level, anterior peripancreatic invasion, or incomplete scheduled concurrent chemotherapy had worse overall survival because of worse distant metastasis-free survival, suggesting that distant metastases have a significant impact on overall survival in such patients.

この論文で使われている画像

参考文献

1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin.

2019;69:7–34.

2. Mizrahi JD, Surana R, Valle JW, Shroff RT. Pancreatic cancer. Lancet.

2020;395:2008–20.

3. Tempero MA, Malafa MP, Al-Hawary M, Behrman SW, Benson AB, Cardin

DB, et al. Pancreatic adenocarcinoma, version 2.2021, NCCN clinical practice guidelines in oncology. J Natl Compr Cancer Netw. 2021;19:439–57.

4. Iacobuzio-Donahue CA, Fu B, Yachida S, Luo M, Abe H, Henderson

CM, et al. DPC4 gene status of the primary carcinoma correlates with

patterns of failure in patients with pancreatic cancer. J Clin Oncol.

2009;27:1806–13.

5. Peixoto RD, Speers C, McGahan CE, Renouf DJ, Schaeffer DF, Kennecke

HF. Prognostic factors and sites of metastasis in unresectable locally

advanced pancreatic cancer. Cancer Med. 2015;4:1171–7.

6. Burnet NG, Mee T, Gaito S, Kirkby NF, Aitkenhead AH, Anandadas

CN, et al. Estimating the percentage of patients who might benefit

from proton beam therapy instead of X-ray radiotherapy. Br J Radiol.

2022;95:20211175.

7. Gaito S, Marvaso G, Ortiz R, Crellin A, Aznar MC, Indelicato DJ, et al. Proton

beam therapy in the oligometastatic/oligorecurrent setting: Is there a

role? A literature review. Cancers (Basel). 2023;15:2489.

8. Greco C, Wolden S. Current status of radiotherapy with proton and light

ion beams. Cancer. 2007;109:1227–38.

9. Gaito S, Hwang EJ, France A, Aznar MC, Burnet N, Crellin A, et al. Outcomes of patients treated in the UK proton overseas programme: central nervous system group. Clin Oncol (R Coll Radiol). 2023;35:283–91.

10. Hwang E, Gaito S, France A, Crellin AM, Thwaites DI, Ahern V, et al.

Outcomes of patients treated in the UK proton overseas programme:

non-central nervous system group. Clin Oncol (R Coll Radiol).

2023;35:292–300.

11. Terashima K, Demizu Y, Hashimoto N, Jin D, Mima M, Fujii O, et al. A

phase I/II study of gemcitabine-concurrent proton radiotherapy for

locally advanced pancreatic cancer without distant metastasis. Radiother Oncol. 2012;103:25–31.

12. Sachsman S, Nichols RC, Morris CG, Zaiden R, Johnson EA, Awad

Z, et al. Proton therapy and concomitant capecitabine for nonmetastatic unresectable pancreatic adenocarcinoma. Int J Part Ther.

2014;1:692–701.

13. Hiroshima Y, Fukumitsu N, Saito T, Numajiri H, Murofushi KN, Ohnishi K,

et al. Concurrent chemoradiotherapy using proton beams for unresectable locally advanced pancreatic cancer. Radiother Oncol. 2019;136:37–43.

Ami et al. Radiation Oncology

(2023) 18:131

14. Kawashiro S, Yamada S, Okamoto M, Ohno T, Nakano T, Shinoto M,

et al. Multi-institutional study of carbon-ion radiotherapy for locally

advanced pancreatic cancer: Japan Carbon-ion Radiation Oncology

Study Group (J-CROS) study 1403 pancreas. Int J Radiat Oncol Biol

Phys. 2018;101:1212–21.

15. Ogura Y, Terashima K, Nanno Y, Park S, Suga M, Takahashi D, et al. Factors associated with long-term survival in gemcitabine-concurrent

proton radiotherapy for non-metastatic locally advanced pancreatic

cancer: a single-center retrospective study. Radiat Oncol. 2022;17:32.

16. Kagawa K, Murakami M, Hishikawa Y, Abe M, Akagi T, Yanou T, et al. Preclinical biological assessment of proton and carbon ion beams at Hyogo

Ion Beam Medical Center. Int J Radiat Oncol Biol Phys. 2002;54:928–38.

17. Philip PA, Lacy J, Portales F, Sobrero A, Pazo-Cid R, Manzano Mozo JL, et al.

Nab-paclitaxel plus gemcitabine in patients with locally advanced pancreatic cancer (LAPACT): a multicentre, open-label phase 2 study. Lancet

Gastroenterol Hepatol. 2020;5:285–94.

18. Suker M, Beumer BR, Sadot E, Marthey L, Faris JE, Mellon EA, et al. FOLFIRINOX for locally advanced pancreatic cancer: a systematic review and

patient-level meta-analysis. Lancet Oncol. 2016;17:801–10.

19. Takeda T, Sasaki T, Mie T, Furukawa T, Yamada Y, Kasuga A, et al. The prognostic impact of tumour location and first-line chemotherapy regimen in

locally advanced pancreatic cancer. Jpn J Clin Oncol. 2021;51:728–36.

20. Auclin E, Marthey L, Abdallah R, Mas L, Francois E, Saint A, et al. Role of

FOLFIRINOX and chemoradiotherapy in locally advanced and borderline

resectable pancreatic adenocarcinoma: update of the AGEO cohort. Br J

Cancer. 2021;124:1941–8.

21. Takada R, Ikezawa K, Daiku K, Maeda S, Abe Y, Urabe M, et al. The survival

benefit of chemoradiotherapy following induction chemotherapy with

gemcitabine plus nab-paclitaxel for unresectable locally advanced pancreatic cancer. Cancers (Basel). 2021;13:4733.

22. Shi Z, Yang J, Kong W, Qiu X, Lu C, Liu J, et al. Use of nab-paclitaxel plus

gemcitabine followed by hypofractionated tomotherapy with simultaneous integrated boost in patients with locally advanced pancreatic cancer.

Front Oncol. 2022;12:782730.

23. Su YY, Chiu YF, Li CP, Yang SH, Lin J, Lin SJ, et al. A phase II randomised trial

of induction chemotherapy followed by concurrent chemoradiotherapy

in locally advanced pancreatic cancer: the Taiwan Cooperative Oncology

Group T2212 study. Br J Cancer. 2022;126:1018–26.

24. Sofue K, Tsurusaki M, Murakami T, Onoe S, Tokue H, Shibamoto K, et al.

Does Gadoxetic acid-enhanced 3.0T MRI in addition to 64-detectorrow contrast-enhanced CT provide better diagnostic performance and

change the therapeutic strategy for the preoperative evaluation of

colorectal liver metastases? Eur Radiol. 2014;24:2532–9.

25. Karabicak I, Satoi S, Yanagimoto H, Yamamoto T, Hirooka S, Yamaki S, et al.

Risk factors for latent distant organ metastasis detected by staging laparoscopy in patients with radiologically defined locally advanced pancreatic ductal adenocarcinoma. J Hepatobiliary Pancreat Sci. 2016;23:750–5.

26. Satoi S, Yanagimoto H, Yamamoto T, Toyokawa H, Hirooka S, Yamaki S,

et al. A clinical role of staging laparoscopy in patients with radiographically defined locally advanced pancreatic ductal adenocarcinoma. World

J Surg Oncol. 2016;14:14.

27. Suker M, Koerkamp BG, Coene PP, van der Harst E, Bonsing BA, Vahrmeijer

AL, et al. Yield of staging laparoscopy before treatment of locally

advanced pancreatic cancer to detect occult metastases. Eur J Surg

Oncol. 2019;45:1906–11.

28. Takadate T, Morikawa T, Ishida M, Aoki S, Hata T, Iseki M, et al. Staging

laparoscopy is mandatory for the treatment of pancreatic cancer to avoid

missing radiologically negative metastases. Surg Today. 2021;51:686–94.

29. Lawrence TS, Chang EY, Hahn TM, Hertel LW, Shewach DS. Radiosensitization of pancreatic cancer cells by 2′,2′-difluoro-2′-deoxycytidine. Int J

Radiat Oncol Biol Phys. 1996;34:867–72.

30. Ueno H, Ioka T, Ikeda M, Ohkawa S, Yanagimoto H, Boku N, et al. Randomized phase III study of gemcitabine plus S-1, S-1 alone, or gemcitabine

alone in patients with locally advanced and metastatic pancreatic cancer

in Japan and Taiwan: GEST study. J Clin Oncol. 2013;31:1640–8.

31. Mahadevan A, Miksad R, Goldstein M, Sullivan R, Bullock A, Buchbinder

E, et al. Induction gemcitabine and stereotactic body radiotherapy for

locally advanced nonmetastatic pancreas cancer. Int J Radiat Oncol Biol

Phys. 2011;81:e615–22.

32. Kim JS, Lim JH, Kim JH, Im SA, Chie EK, Hwang JH, et al. Phase II clinical

trial of induction chemotherapy with fixed dose rate gemcitabine and

Page 10 of 10

33. 34. 35. 36. 37. 38. 39. cisplatin followed by concurrent chemoradiotherapy with capecitabine

for locally advanced pancreatic cancer. Cancer Chemother Pharmacol.

2012;70:381–9.

Mukherjee S, Hurt CN, Bridgewater J, Falk S, Cummins S, Wasan H, et al.

Gemcitabine-based or capecitabine-based chemoradiotherapy for locally

advanced pancreatic cancer (SCALOP): a multicentre, randomised, phase

2 trial. Lancet Oncol. 2013;14:317–26.

Oba A, Ho F, Bao QR, Al-Musawi MH, Schulick RD, Del Chiaro M. Neoadjuvant treatment in pancreatic cancer. Front Oncol. 2020;10:245.

Chung SY, Chang JS, Lee BM, Kim KH, Lee KJ, Seong J. Dose escalation

in locally advanced pancreatic cancer patients receiving chemoradiotherapy. Radiother Oncol. 2017;123:438–45.

Reyngold M, Parikh P, Crane CH. Ablative radiation therapy for locally

advanced pancreatic cancer: techniques and results. Radiat Oncol.

2019;14:95.

Abi Jaoude J, Kouzy R, Nguyen ND, Lin D, Noticewala SS, Ludmir EB,

et al. Radiation therapy for patients with locally advanced pancreatic

cancer: evolving techniques and treatment strategies. Curr Probl Cancer.

2020;44:100607.

Lee D, Komatsu S, Terashima K, Toyama H, Matsuo Y, Takahashi D, et al.

Surgical spacer placement for proton radiotherapy in locally advanced

pancreatic body and tail cancers: initial clinical results. Radiat Oncol.

2021;16:3.

Sasaki R, Demizu Y, Yamashita T, Komatsu S, Akasaka H, Miyawaki D, et al.

First-in-human phase 1 study of a nonwoven fabric bioabsorbable spacer

for particle therapy: space-making particle therapy (SMPT). Adv Radiat

Oncol. 2019;4:729–37.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Ready to submit your research ? Choose BMC and benefit from:

• fast, convenient online submission

• thorough peer review by experienced researchers in your field

• rapid publication on acceptance

• support for research data, including large and complex data types

• gold Open Access which fosters wider collaboration and increased citations

• maximum visibility for your research: over 100M website views per year

At BMC, research is always in progress.

Learn more biomedcentral.com/submissions

...

参考文献をもっと見る

全国の大学の
卒論・修論・学位論文

一発検索!

この論文の関連論文を見る