1.
B. Alberts et al., Molecular Biology of the Cell (Garland Science, New York, ed. 5,
2008).
2.
M. B. Elowitz, A. J. Levine, E. D. Siggia, P. S. Swain, Stochastic gene expression in a
single cell. Science 297, 1183-1186 (2002).
3.
P. S. Swain, M. B. Elowitz, E. D. Siggia, Intrinsic and extrinsic contributions to
stochasticity in gene expression. Proc. Natl. Acad. Sci. U.S.A. 99, 12795–12800 (2002).
4.
C. E. Shannon, A Mathematical Theory of Communication. Bell Syst. Tech. J. 27,
379–423 (1948).
5.
C. E. Shannon, A Mathematical Theory of Communication. Bell Syst. Tech. J. 27,
623–656 (1948).
6.
P. J. Thomas, D. J. Spencer, S. K. Hampton, P. Park, J. P. Zurkus, paper presented at
Neural Information Processing Systems, NIPS2003, Vancouver, British Columbia,
Canada, 8 to 13 December 2003.
7.
G. Tkačik, C. G. Callan Jr., W. Bialek, Information flow and optimization in
transcriptional regulation. Proc. Natl. Acad. Sci. U.S.A. 105, 12265–12270 (2008).
8.
G. Tkačik, C. G. Callan Jr., W. Bialek, Information capacity of genetic regulatory
elements. Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 78, 011910 (2008).
72
9.
R. C. Yu, C. G. Pesce, A. Colman-Lerner, L. Lok, D. Pincus, E. Serra, M. Holl, K.
Benjamin, A. Gordon, R. Brent, Negative feedback that improves information
transmission in yeast signalling. Nature 456, 755–761 (2008).
10. T. Lenaerts, J. Ferkinghoff-Borg, J. Schymkowitz, F. Rousseau, Information theoretical
quantification of cooperativity in signalling complexes. BMC Syst. Biol. 3, 9 (2009).
11. P. Mehta, S. Goyal, T. Long, B. L. Bassler, N. S. Wingreen, Information processing and
signal integration in bacterial quorum sensing. Mol. Syst. Biol. 5, 325 (2009).
12. I. Lestas, G. Vinnicombe, J. Paulsson, Fundamental limits on the suppression of
molecular fluctuations. Nature 467, 174–178 (2010).
13. Tostevin, P. R. ten Wolde, Mutual information in time-varying biochemical systems.
Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 81, 061917 (2010).
14. R. Cheong, A. Rhee, C. J. Wang, I. Nemenman, A. Levchenko, Information transduction
capacity of noisy biochemical signaling networks. Science 334, 354–358 (2011).
15. C. Waltermann, E. Klipp, Information theory based approaches to cellular signaling.
Biochim. Biophys. Acta 1810, 924–932 (2011).
16. S. Uda, T. H. Saito, T. Kudo, T. Kokaji, T. Tsuchiya, H. Kubota, Y. Komori, Y. Ozaki, S.
Kuroda, Robustness and compensation of information transmission of signaling
pathways. Science 341, 558–561 (2013).
73
17. M. Voliotis, R. M. Perrett, C. McWilliams, C. A. McArdle, C. G. Bowsher, Information
transfer by leaky, heterogeneous, protein kinase signaling systems. Proc. Natl. Acad. Sci.
U.S.A. 111, E326–E333 (2014).
18. J. Selimkhanov, B. Taylor, J. Yao, A. Pilko, J. Albeck, A. Hoffmann, L. Tsimring, R.
Wollman, Accurate information transmission through dynamic biochemical signaling
networks. Science 346, 1370–1373 (2014).
19. K. L. Garner, R. M. Perrett, M. Voliotis, C. Bowsher, G. R. Pope, T. Pham, C. J. Caunt,
K. Tsaneva-Atanasova, C. A. McArdle, Information transfer in gonadotropin-releasing
hormone (GnRH) signaling: extracelluar signal-regulated kinase (ERK)-mediated
feedback loops control hormone sensing. J. Biol. Chem. 291, 2246-2259 (2016).
20. G. D. Potter, T. A. Byrd, A. Mugler, B. Sun, Dynamic sampling and information
encoding in biochemical networks. Biophys. J. 112, 795-804 (2017).
21. R. Suderman, J. A. Bachman, A. Smith, P. K. Sorger, E. J. Deeds, Fundamental
trade-offs between information flow in single cells and cellular populations. Proc. Natl.
Acad. Sci. U.S.A. 114, 5755-5760 (2017).
22. A. A. Granados, J. M. J. Pietsch, S. A. Cepeda-Humerez, I. L. Farquhar, G. Tkacik, P. S.
Swain, Distributed and dynamic intracellular organization of extracellular information.
Proc. Natl. Acad. Sci. U.S.A. 115, 6088-6093 (2018).
74
23. A. Keshelava, G. P. Solis, M. Hersch, A. Koval, M. Kryuchkov, S. Bergmann, V. L.
Katanaev, High capacity in G protein-coupled receptor signaling. Nat Commun. 9, 876
(2018).
24. R. E. Burke, D. N. Levine, F. E. Zajac, P. Tsairis, W. K. Engel, Mammalian motor units:
physiological-histochemical correlation in three types in cat gastrocnemius. Science. 174,
709–12 (1971).
25. T. W. Chen, T. J. Wardill, Y. Sun, S. R. Pulver, S. L. Renninger, A. Baohan, E. R.
Schreiter, R. A. Kerr, M. B. Orger, V. Jayaraman, L. L. Looger, K. Svoboda, D. S. Kim,
Ultrasensitive fluorescent proteins for imaging neuronal activity. Nature 499, 295–300
(2013).
26. K. Yusa, R. Rad, J. Takeda, A. Bradley, Generation of transgene-free induced pluripotent
mouse stem cells by the piggyBac transposon, Nat. Methods, 6, 5363–369 (2009).
27. S. J. Odelberg, A. Kollhoff, M. T. Keating, Dedifferentiation of mammalian myotubes
induced by msx1. Cell, 103(7), 1099–1109 (2000).
28. G. Shefer, Z. Yablonka-Reuven, Isolation and culture of skeletal muscle myofibers as a
means to analyze satellite cells. Methods Mol. Biol. 290, 281-304 (2005).
29. Y. Manabe, S. Miyatake, M. Takagi, M. Nakamura, A. Okeda, T. Nakano, M. F.
Hirshman, L. J. Goodyear, N. L. Fujii, Characterization of an acute muscle contraction
model using cultured C2C12 myotubes. PLoS ONE 7(12): e52592 (2012).
75
30. Y. Manabe, S. Ogino, M. Ito, Y. Furuichi, M. Takagi, M. Yamada, N. Goto-Inoue, Y. Ono,
N. L.Fujii. Evaluation of an in vitro muscle contraction model in mouse primary cultured
myotubes. Anal Biochem. 497, 36-38 (2016).
31. G. A. Darbellay, I. Vajda, Estimation of the information by an adaptive partitioning of the
observation space. IEEE Trans. Inf. Theory 45, 1315–1321 (1999).
32. S. Arimoto, An algorithm for computing the capacity of arbitrary discrete memoryless
channels. IEEE Trans. Inf. Theory 18, 14–20 (1972).
33. R. E. Blahut, Computation of channel capacity and rate-distortion functions. IEEE Trans.
Inf. Theory 18, 460–473 (1972).
34. H. Nakatomi, H. Miyazaki, M. Tanaka, , T. Kin, M. Yoshino, H. Oyama, M. Usui, H.
Moriyama, H. Kojima, K. Kaga, N. Saito. Improved preservation of function during
acoustic neuroma surgery. J. Neurosurg., 122, 24-33 (2015).
35. M. Amano, M. Kohno, O. Nagata, M. Taniguchi, S. Sora, H. Sato, Intraoperative
continuous monitoring of evoked facial nerve electromyograms in acoustic neuroma
surgery. Acta Neurochir. 153, 1059–1067 (2011).
36. C. J. Heckman, R. M. Enoka, Motor unit, Compr. Physiol., 2, 2629–2682 (2012).
37. L. Gammaitoni, P. Hänggi, P. Jung, F. Marchesoni, Stochastic resonance. Rev. Mod. Phys.
70, 223–287 (1998).
38. J. E. Ferrell, E. M. Machleder, The Biochemical basis of an all-or-none cell fate switch in
Xenopus oocytes. Science. 280, 895–898 (1998).
76
39. H. Dueck, J. Eberwine, J. Kim, Variation is function: Are single cell differences
functionally important? BioEssays. 38, 172–180 (2016).
77
6. Acknowledgments
I thank my laboratory members for critically reading this manuscript and for their technical
assistance with the experiments. Especially, I would like to express my greatest appreciation
to Professor Shinya Kuroda for teaching principles of scientific research throughout my
graduate study. This thesis is the result of the joint research of Mr. Mitustaka Wataya, Dr.
Miki Eto, Dr. Daisuke Hoshino, Dr. Katsuyuki Kunida and me in the experiments of
differentiated C2C12 myotubes, and Dr. Haruki Inoue, Mr. Mitustaka Wataya, Dr. Masashi
Fujii and me in image analysis, Dr. ken-ichi Hironaka, Mr. Mitustaka Wataya, Dr. Masashi
Fujii, Dr. Shinsuke Uda, Dr. Hiroyuki Kubota and me in computational analysis, Mr. Hiroki
Hamaguchi, Dr. Yasuro Furuichi, Dr. Yasuko Manabe, and Dr. Nobuharu L. Fujii in Tokyo
Metropolitan University in the experiments of isolated skeletal muscle fibers, Dr. Tsuguto
Takizawa, Dr. Yasuaki Karasawa, Dr. Hirofumi.Nakatomi, and Dr. Nobuhito Saito in Tokyo
University Hospital in intraoperative neurophysiological monitoring. This manuscript was
edited by Nancy R. Gough (BioSerendipity, LLC).
This work was supported by the Creation of Fundamental Technologies for Understanding
and Control of Biosystem Dynamics, CREST (JPMJCR12W3) from the Japan Science and
Technology Agency (JST) and by the Japan Society for the Promotion of Science (JSPS)
KAKENHI Grant Number (JP17H06299, JP17H06300, JP18H03979, JP19K22860).
78
...
論文の公開元へ
